RGD Reference Report - Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. - Rat Genome Database

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Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction.

Authors: Xie, Xiang  Ma, Yi-tong  Fu, Zhen-yan  Yang, Yi-ning  Ma, Xiang  Chen, Bang-dang  Wang, Ying-hong  Liu, Fen 
Citation: Xie X, etal., Clin Chem Lab Med. 2009;47(3):347-52. doi: 10.1515/CCLM.2009.078.
RGD ID: 401901155
Pubmed: PMID:19327107   (View Abstract at PubMed)
DOI: DOI:10.1515/CCLM.2009.078   (Journal Full-text)


BACKGROUND: Cyclooxygenase-2 (COX-2) and prostacyclin synthase (PGIS) are enzymes involved in prostaglandin and prostacyclin synthesis, which have been linked to cardiovascular disease risk. We hypothesized that genetic variations altering the function of these enzymes would modify the risk of myocardial infarction (MI).
METHODS: In a Chinese case control study of MI patients (n=356) and healthy controls (n=350), we investigated the roles of polymorphisms in the PGIS gene (CYP8A1) and the COX-2 gene (PTGS2) using polymerase chain reaction-restriction fragment length polymorphism analysis.
RESULTS: The CC genotype of CYP8A1 and the -765CC genotype of PTGS2 were more common in the MI patients than in the control subjects (p=0.041, p=0.012, respectively). The odds ratio (OR) estimated by the combined analysis for the CYP8A1 CC and PTGS2-765CC genotypes [OR =5.44; 95% confidence interval (CI): 3.12-7.23] was markedly higher than that estimated separately for the CYP8A1 CC genotype (OR=1.37; 95% CI: 0.95-2.85) or the PTGS2 -765CC genotype (OR=2.92; 95% CI: 1.78-5.76) alone.
CONCLUSIONS: The CC genotype of CYP8A1 or the -765CC genotype of PTGS2 is associated with MI, respectively. Furthermore, the significantly combined effects of these two gene variants in the arachidonic acid metabolic pathway indicate that combining the effects of a modest number of genes, whose products are known to act in a pathophysiological manner, could be a useful method to explore the association of genetic polymorphisms and polygenic inheritance disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGISHumanmyocardial infarction  IAGP DNA:SNP::1117C>A (human)RGD 
PtgisRatmyocardial infarction  ISOPTGIS (Homo sapiens)DNA:SNP::1117C>A (human)RGD 
PtgisMousemyocardial infarction  ISOPTGIS (Homo sapiens)DNA:SNP::1117C>A (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGISHumanMyocardial infarction  IAGP DNA:SNP::1117C>ARGD 
Objects Annotated

Genes (Rattus norvegicus)
Ptgis  (prostaglandin I2 synthase)

Genes (Mus musculus)
Ptgis  (prostaglandin I2 (prostacyclin) synthase)

Genes (Homo sapiens)
PTGIS  (prostaglandin I2 synthase)


Additional Information