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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3438
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgis
Name: prostaglandin I2 synthase
Acc ID: CHEBI:16347
Term: (R)-carnitine
Definition: The (R)-enantiomer of carnitine.
Chemical ID: MESH:D002331
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgisincreases expressionEXP 6480464CTDCarnitine results in increased expression of PTGIS mRNAPMID:19491382
Ptgisincreases response to substanceEXP 6480464CTDPTGIS protein results in increased susceptibility to CarnitinePMID:19491382
Ptgismultiple interactionsEXP 6480464CTD[Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alphaPMID:19491382
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