Pros1 (protein S) - Rat Genome Database

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Gene: Pros1 (protein S) Rattus norvegicus
Analyze
Symbol: Pros1
Name: protein S
RGD ID: 620971
Description: Predicted to enable calcium ion binding activity. Involved in several processes, including liver development; positive regulation of phagocytosis; and response to lipopolysaccharide. Located in extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in autosomal dominant thrombophilia due to protein S deficiency; autosomal recessive thrombophilia due to protein S deficiency; cerebral infarction; and protein S deficiency. Orthologous to human PROS1 (protein S); PARTICIPATES IN protein C anticoagulant pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Pros; protein S (alpha); vitamin K-dependent protein S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.211230,597 - 311,288 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl11230,696 - 311,286 (+)Ensembl
Rnor_6.071,206,648 - 1,288,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.071,199,864 - 1,279,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13237,157 - 317,730 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3-chloropropane-1,2-diol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
aristolochic acid  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
desogestrel  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dienogest  (ISO)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gestodene  (ISO)
glafenine  (EXP)
isotretinoin  (ISO)
L-ascorbic acid  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
norgestimate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin K  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Alhenc-Gelas M, etal., Thromb Haemost. 2016 Feb 29;115(3):570-9. doi: 10.1160/TH15-05-0391. Epub 2015 Oct 15.
2. Andersen BD, etal., Thromb Haemost. 2001 Dec;86(6):1392-9.
3. Beauchamp NJ, etal., Thromb Haemost. 1998 Jun;79(6):1086-91.
4. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
5. Burstyn-Cohen T, etal., J Clin Invest. 2009 Oct;119(10):2942-53. doi: 10.1172/JCI39325.
6. Duchemin J, etal., Blood. 1995 Nov 1;86(9):3436-43.
7. Duebgen S, etal., Am J Clin Pathol. 2012 Feb;137(2):178-84. doi: 10.1309/AJCP40UXNBTXGKUX.
8. Esmon CT, Chest. 2003 Sep;124(3 Suppl):26S-32S.
9. Fujii K, etal., J Thromb Haemost. 2006 Dec;4(12):2607-15. Epub 2006 Sep 22.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Hall MO, etal., Exp Eye Res. 2005 Nov;81(5):581-91. Epub 2005 Jun 9.
12. Hayashi T, etal., J Thromb Haemost. 2006 Aug;4(8):1763-73.
13. Jamison CS, etal., Thromb Res 1995 Jun 1;78(5):407-19.
14. Knoll B, etal., Thromb Res. 2001 Jul 1;103(1):3-8.
15. Leung TW, etal., Neurology. 2010 Dec 14;75(24):2185-9. doi: 10.1212/WNL.0b013e3182020379.
16. Lindqvist N, etal., Ups J Med Sci. 2010 Feb;115(1):65-80. doi: 10.3109/03009731003597119.
17. MGD data from the GO Consortium
18. NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline
20. Petitot F, etal., Exp Cell Res 2003 May 15;286(1):30-9.
21. Pintao MC, etal., Hum Genet. 2009 Sep;126(3):449-56. doi: 10.1007/s00439-009-0687-9. Epub 2009 May 23.
22. Pipeline to import KEGG annotations from KEGG into RGD
23. Rezende SM, etal., Blood. 2004 Feb 15;103(4):1192-201. Epub 2003 Aug 7.
24. RGD automated data pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Sere KM, etal., Biochemistry 2001 Jul 31;40(30):8852-60.
28. Simmonds RE, etal., Ann Intern Med. 1998 Jan 1;128(1):8-14.
29. ten Kate MK, etal., Haematologica. 2006 Aug;91(8):1151-2.
30. Yasuda F, etal., J Biochem. 1995 Feb;117(2):374-83.
31. Zhong F, etal., J Am Soc Nephrol. 2018 Mar 6. pii: ASN.2017030234. doi: 10.1681/ASN.2017030234.
Additional References at PubMed
PMID:1299299   PMID:1302274   PMID:12477932   PMID:14607961   PMID:22516433   PMID:23533145   PMID:24006456   PMID:31028740  


Genomics

Comparative Map Data
Pros1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.211230,597 - 311,288 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl11230,696 - 311,286 (+)Ensembl
Rnor_6.071,206,648 - 1,288,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.071,199,864 - 1,279,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13237,157 - 317,730 (+)NCBICelera
Cytogenetic Map7q11NCBI
PROS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38393,873,051 - 93,973,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl393,873,051 - 93,980,003 (-)EnsemblGRCh38hg38GRCh38
GRCh37393,591,895 - 93,692,740 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36395,074,647 - 95,175,395 (-)NCBINCBI36hg18NCBI36
Build 34395,074,646 - 95,175,395NCBI
Celera391,974,425 - 92,076,408 (-)NCBI
Cytogenetic Map3q11.1NCBI
HuRef390,954,621 - 91,055,633 (-)NCBIHuRef
CHM1_1393,558,922 - 93,656,016 (-)NCBICHM1_1
T2T-CHM13v2.0396,571,223 - 96,672,021 (-)NCBI
Pros1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391662,674,670 - 62,749,709 (+)NCBIGRCm39mm39
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)Ensembl
GRCm381662,854,307 - 62,929,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv371662,854,160 - 62,929,166 (+)NCBIGRCm37mm9NCBIm37
MGSCv361662,796,624 - 62,871,347 (+)NCBImm8
Celera1663,162,946 - 63,237,718 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
Pros1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554073,535,388 - 3,565,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554073,514,900 - 3,566,165 (+)NCBIChiLan1.0ChiLan1.0
PROS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1397,615,734 - 97,719,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl397,615,734 - 97,718,756 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0390,934,641 - 91,039,059 (-)NCBIMhudiblu_PPA_v0panPan3
PROS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,628,074 - 1,691,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,628,105 - 1,692,058 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,807,559 - 1,871,177 (-)NCBI
ROS_Cfam_1.0331,727,844 - 1,791,314 (-)NCBI
ROS_Cfam_1.0 Ensembl331,727,846 - 1,791,431 (-)Ensembl
UMICH_Zoey_3.1331,637,294 - 1,700,492 (-)NCBI
UNSW_CanFamBas_1.0331,671,507 - 1,735,141 (-)NCBI
UU_Cfam_GSD_1.0331,896,104 - 1,960,217 (-)NCBI
Pros1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602155,405,321 - 155,496,524 (+)NCBI
SpeTri2.0NW_00493666618,303 - 110,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13165,911,366 - 165,999,811 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113165,915,298 - 165,999,118 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PROS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12286,728,089 - 86,840,413 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2286,728,339 - 86,840,356 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604179,820,400 - 79,954,563 (-)NCBIVero_WHO_p1.0
Pros1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247896,621,803 - 6,704,033 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D0Got467  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.071,268,153 - 1,268,342NCBIRnor6.0
Rnor_5.071,260,009 - 1,260,198UniSTSRnor5.0
Celera13297,743 - 297,932UniSTS
Cytogenetic Map11q21UniSTS
RH128863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211310,057 - 310,240 (+)MAPPERmRatBN7.2
Rnor_6.071,286,910 - 1,287,092NCBIRnor6.0
Rnor_5.071,278,766 - 1,278,948UniSTSRnor5.0
Celera13316,500 - 316,682UniSTS
Cytogenetic Map11q21UniSTS
AU048234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211291,305 - 291,440 (+)MAPPERmRatBN7.2
Rnor_6.071,268,158 - 1,268,292NCBIRnor6.0
Rnor_5.071,260,014 - 1,260,148UniSTSRnor5.0
Celera13297,748 - 297,882UniSTS
Cytogenetic Map11q21UniSTS
RH140134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211310,572 - 310,774 (+)MAPPERmRatBN7.2
Rnor_6.071,287,425 - 1,287,626NCBIRnor6.0
Rnor_5.071,279,281 - 1,279,482UniSTSRnor5.0
Celera13317,015 - 317,216UniSTS
Cytogenetic Map11q21UniSTS
RH141031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211310,976 - 311,178 (+)MAPPERmRatBN7.2
Rnor_6.071,287,829 - 1,288,030NCBIRnor6.0
Rnor_5.071,279,685 - 1,279,886UniSTSRnor5.0
Celera13317,419 - 317,620UniSTS
Cytogenetic Map11q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:89
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000073689
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 40 51 41 13 41 4 4 16 35 36 11 4
Low 2 3 6 6 4 7 58 5 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073689   ⟹   ENSRNOP00000064737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl11230,696 - 311,286 (+)Ensembl
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096661   ⟹   ENSRNOP00000091181
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl11263,481 - 311,286 (+)Ensembl
RefSeq Acc Id: NM_031086   ⟹   NP_112348
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.211230,721 - 311,288 (+)NCBI
Rnor_6.071,206,648 - 1,288,140 (+)NCBI
Rnor_5.071,199,864 - 1,279,998 (+)NCBI
Celera13237,157 - 317,730 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088635   ⟹   XP_038944563
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.211263,546 - 311,288 (+)NCBI
RefSeq Acc Id: XM_039088636   ⟹   XP_038944564
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.211284,412 - 311,288 (+)NCBI
RefSeq Acc Id: XR_005491058
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.211230,597 - 311,288 (+)NCBI
Protein Sequences
Protein RefSeqs NP_112348 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944563 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944564 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83250 (Get FASTA)   NCBI Sequence Viewer  
  EDL83251 (Get FASTA)   NCBI Sequence Viewer  
  P53813 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_112348   ⟸   NM_031086
- Peptide Label: precursor
- UniProtKB: M0R5R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064737   ⟸   ENSRNOT00000073689
RefSeq Acc Id: XP_038944563   ⟸   XM_039088635
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944564   ⟸   XM_039088636
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000091181   ⟸   ENSRNOT00000096661
Protein Domains
EGF-like   Gla   LAM_G_DOMAIN   Laminin G-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53813-F1-model_v2 AlphaFold P53813 1-675 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694914
Promoter ID:EPDNEW_R5439
Type:initiation region
Name:Pros1_1
Description:protein S
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.071,206,630 - 1,206,690EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620971 AgrOrtholog
BioCyc Gene G2FUF-22336 BioCyc
Ensembl Genes ENSRNOG00000048723 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064737 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000091181 ENTREZGENE
Ensembl Transcript ENSRNOT00000073689 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000096661 ENTREZGENE
Gene3D-CATH 4.10.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81750 UniProtKB/TrEMBL
NCBI Gene 81750 ENTREZGENE
PANTHER PTHR24040:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PROS1 RGD
PhenoGen Pros1 PhenoGen
PRINTS GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt M0R5R0 ENTREZGENE, UniProtKB/TrEMBL
  P53813 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Pros1  protein S  Pros1  protein S (alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pros1  protein S (alpha)    protein S  Name updated 1299863 APPROVED
2002-08-07 Pros1  protein S      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology human homolog interacts with factor Xa, factor Va, and phospholipids to inhibit prothrombin activation 1299299