Pros1 (protein S) - Rat Genome Database

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Gene: Pros1 (protein S) Rattus norvegicus
Analyze
Symbol: Pros1
Name: protein S
RGD ID: 620971
Description: Predicted to have calcium ion binding activity. Involved in several processes, including liver development; positive regulation of phagocytosis; and response to lipopolysaccharide. Localizes to extracellular space and protein-containing complex. Human ortholog(s) of this gene implicated in autosomal dominant thrombophilia due to protein S deficiency; autosomal recessive thrombophilia due to protein S deficiency; cerebral infarction; and protein S deficiency. Orthologous to human PROS1 (protein S); PARTICIPATES IN protein C anticoagulant pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Pros; protein S (alpha); vitamin K-dependent protein S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.211230,597 - 311,288 (+)NCBI
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.071,206,648 - 1,288,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.071,199,864 - 1,279,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13237,157 - 317,730 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3-chloropropane-1,2-diol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
desogestrel  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dienogest  (ISO)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
gestodene  (ISO)
glafenine  (EXP)
isotretinoin  (ISO)
L-ascorbic acid  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
norgestimate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin K  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Alhenc-Gelas M, etal., Thromb Haemost. 2016 Feb 29;115(3):570-9. doi: 10.1160/TH15-05-0391. Epub 2015 Oct 15.
2. Andersen BD, etal., Thromb Haemost. 2001 Dec;86(6):1392-9.
3. Beauchamp NJ, etal., Thromb Haemost. 1998 Jun;79(6):1086-91.
4. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
5. Burstyn-Cohen T, etal., J Clin Invest. 2009 Oct;119(10):2942-53. doi: 10.1172/JCI39325.
6. Duchemin J, etal., Blood. 1995 Nov 1;86(9):3436-43.
7. Duebgen S, etal., Am J Clin Pathol. 2012 Feb;137(2):178-84. doi: 10.1309/AJCP40UXNBTXGKUX.
8. Esmon CT, Chest. 2003 Sep;124(3 Suppl):26S-32S.
9. Fujii K, etal., J Thromb Haemost. 2006 Dec;4(12):2607-15. Epub 2006 Sep 22.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Hall MO, etal., Exp Eye Res. 2005 Nov;81(5):581-91. Epub 2005 Jun 9.
12. Hayashi T, etal., J Thromb Haemost. 2006 Aug;4(8):1763-73.
13. Jamison CS, etal., Thromb Res 1995 Jun 1;78(5):407-19.
14. Knoll B, etal., Thromb Res. 2001 Jul 1;103(1):3-8.
15. Leung TW, etal., Neurology. 2010 Dec 14;75(24):2185-9. doi: 10.1212/WNL.0b013e3182020379.
16. MGD data from the GO Consortium
17. NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline
19. Petitot F, etal., Exp Cell Res 2003 May 15;286(1):30-9.
20. Pintao MC, etal., Hum Genet. 2009 Sep;126(3):449-56. doi: 10.1007/s00439-009-0687-9. Epub 2009 May 23.
21. Pipeline to import KEGG annotations from KEGG into RGD
22. Rezende SM, etal., Blood. 2004 Feb 15;103(4):1192-201. Epub 2003 Aug 7.
23. RGD automated data pipeline
24. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. RGD automated import pipeline for gene-chemical interactions
26. Sere KM, etal., Biochemistry 2001 Jul 31;40(30):8852-60.
27. Simmonds RE, etal., Ann Intern Med. 1998 Jan 1;128(1):8-14.
28. ten Kate MK, etal., Haematologica. 2006 Aug;91(8):1151-2.
29. Yasuda F, etal., J Biochem. 1995 Feb;117(2):374-83.
30. Zhong F, etal., J Am Soc Nephrol. 2018 Mar 6. pii: ASN.2017030234. doi: 10.1681/ASN.2017030234.
Additional References at PubMed
PMID:1299299   PMID:1302274   PMID:12477932   PMID:14607961   PMID:22516433   PMID:23533145   PMID:24006456   PMID:31028740  


Genomics

Comparative Map Data
Pros1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.211230,597 - 311,288 (+)NCBI
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.071,206,648 - 1,288,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.071,199,864 - 1,279,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13237,157 - 317,730 (+)NCBICelera
Cytogenetic Map7q11NCBI
PROS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl393,873,033 - 93,980,003 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl393,873,051 - 93,980,003 (-)EnsemblGRCh38hg38GRCh38
GRCh38393,873,051 - 93,973,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37393,591,895 - 93,692,740 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36395,074,647 - 95,175,395 (-)NCBINCBI36hg18NCBI36
Build 34395,074,646 - 95,175,395NCBI
Celera391,974,425 - 92,076,408 (-)NCBI
Cytogenetic Map3q11.1NCBI
HuRef390,954,621 - 91,055,633 (-)NCBIHuRef
CHM1_1393,558,922 - 93,656,016 (-)NCBICHM1_1
Pros1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391662,674,670 - 62,749,709 (+)NCBIGRCm39mm39
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)Ensembl
GRCm381662,854,307 - 62,929,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv371662,854,160 - 62,929,166 (+)NCBIGRCm37mm9NCBIm37
MGSCv361662,796,624 - 62,871,347 (+)NCBImm8
Celera1663,162,946 - 63,237,718 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
Pros1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554073,535,388 - 3,565,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554073,514,900 - 3,566,165 (+)NCBIChiLan1.0ChiLan1.0
PROS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1397,615,734 - 97,719,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl397,615,734 - 97,718,756 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0390,934,641 - 91,039,059 (-)NCBIMhudiblu_PPA_v0panPan3
PROS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,628,074 - 1,691,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,628,105 - 1,692,058 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,807,559 - 1,871,177 (-)NCBI
ROS_Cfam_1.0331,727,844 - 1,791,314 (-)NCBI
UMICH_Zoey_3.1331,637,294 - 1,700,492 (-)NCBI
UNSW_CanFamBas_1.0331,671,507 - 1,735,141 (-)NCBI
UU_Cfam_GSD_1.0331,896,104 - 1,960,217 (-)NCBI
Pros1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602155,405,321 - 155,496,524 (+)NCBI
SpeTri2.0NW_00493666618,303 - 110,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13165,911,366 - 165,999,811 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113165,915,298 - 165,999,118 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PROS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12286,728,089 - 86,840,413 (+)NCBI
ChlSab1.1 Ensembl2286,728,339 - 86,840,356 (+)Ensembl
Pros1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247896,621,803 - 6,704,033 (-)NCBI

Position Markers
D0Got467  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.071,268,153 - 1,268,342NCBIRnor6.0
Rnor_5.071,260,009 - 1,260,198UniSTSRnor5.0
Celera13297,743 - 297,932UniSTS
Cytogenetic Map11q21UniSTS
RH128863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211310,057 - 310,240 (+)MAPPER
Rnor_6.071,286,910 - 1,287,092NCBIRnor6.0
Rnor_5.071,278,766 - 1,278,948UniSTSRnor5.0
Celera13316,500 - 316,682UniSTS
Cytogenetic Map11q21UniSTS
AU048234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211291,305 - 291,440 (+)MAPPER
Rnor_6.071,268,158 - 1,268,292NCBIRnor6.0
Rnor_5.071,260,014 - 1,260,148UniSTSRnor5.0
Celera13297,748 - 297,882UniSTS
Cytogenetic Map11q21UniSTS
RH140134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211310,572 - 310,774 (+)MAPPER
Rnor_6.071,287,425 - 1,287,626NCBIRnor6.0
Rnor_5.071,279,281 - 1,279,482UniSTSRnor5.0
Celera13317,015 - 317,216UniSTS
Cytogenetic Map11q21UniSTS
RH141031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.211310,976 - 311,178 (+)MAPPER
Rnor_6.071,287,829 - 1,288,030NCBIRnor6.0
Rnor_5.071,279,685 - 1,279,886UniSTSRnor5.0
Celera13317,419 - 317,620UniSTS
Cytogenetic Map11q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:89
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000073689
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 40 51 41 13 41 4 4 16 35 36 11 4
Low 2 3 6 6 4 7 58 5 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073689   ⟹   ENSRNOP00000064737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)Ensembl
RefSeq Acc Id: NM_031086   ⟹   NP_112348
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.211230,721 - 311,288 (+)NCBI
Rnor_6.071,206,648 - 1,288,140 (+)NCBI
Rnor_5.071,199,864 - 1,279,998 (+)NCBI
Celera13237,157 - 317,730 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240719   ⟹   XP_006240781
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.071,244,331 - 1,288,140 (+)NCBI
Rnor_5.071,199,864 - 1,279,998 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765045   ⟹   XP_008763267
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.071,240,227 - 1,288,140 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088635   ⟹   XP_038944563
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.211263,546 - 311,288 (+)NCBI
RefSeq Acc Id: XM_039088636   ⟹   XP_038944564
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.211284,412 - 311,288 (+)NCBI
RefSeq Acc Id: XR_005491058
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.211230,597 - 311,288 (+)NCBI
Protein Sequences
Protein RefSeqs NP_112348 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944563 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944564 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83250 (Get FASTA)   NCBI Sequence Viewer  
  EDL83251 (Get FASTA)   NCBI Sequence Viewer  
  P53813 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_112348   ⟸   NM_031086
- Peptide Label: precursor
- UniProtKB: M0R5R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240781   ⟸   XM_006240719
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008763267   ⟸   XM_008765045
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000064737   ⟸   ENSRNOT00000073689
RefSeq Acc Id: XP_038944563   ⟸   XM_039088635
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944564   ⟸   XM_039088636
- Peptide Label: isoform X2
Protein Domains
EGF-like   Gla   LAM_G_DOMAIN   Laminin G-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694914
Promoter ID:EPDNEW_R5439
Type:initiation region
Name:Pros1_1
Description:protein S
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.071,206,630 - 1,206,690EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620971 AgrOrtholog
Ensembl Genes ENSRNOG00000048723 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064737 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073689 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 4.10.740.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81750 UniProtKB/TrEMBL
NCBI Gene 81750 ENTREZGENE
PANTHER PTHR24040:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gla UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PROS1 RGD
PhenoGen Pros1 PhenoGen
PRINTS GLABLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt M0R5R0 ENTREZGENE, UniProtKB/TrEMBL
  P53813 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Pros1  protein S  Pros1  protein S (alpha)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pros1  protein S (alpha)    protein S  Name updated 1299863 APPROVED
2002-08-07 Pros1  protein S      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology human homolog interacts with factor Xa, factor Va, and phospholipids to inhibit prothrombin activation 1299299