Pros1 (protein S (alpha)) - Rat Genome Database

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Gene: Pros1 (protein S (alpha)) Mus musculus
Analyze
Symbol: Pros1
Name: protein S (alpha)
RGD ID: 1550610
MGI Page MGI
Description: Predicted to enable calcium ion binding activity. Involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in extracellular space. Is expressed in several structures, including brain; frenulum; liver; and tooth. Human ortholog(s) of this gene implicated in autosomal dominant thrombophilia due to protein S deficiency; autosomal recessive thrombophilia due to protein S deficiency; cerebral infarction; and protein S deficiency. Orthologous to human PROS1 (protein S).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AW214361; vitamin K-dependent protein S
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391662,674,670 - 62,749,709 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)EnsemblGRCm39 Ensembl
GRCm381662,854,307 - 62,929,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv371662,854,160 - 62,929,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361662,796,624 - 62,871,347 (+)NCBIMGSCv36mm8
Celera1663,162,946 - 63,237,718 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1636.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Pros1Mouseblood coagulation disease  IMP 11250417 RGD 
Pros1Mousecerebral infarction  ISORGD:134278111250416DNA:missense mutation:exon:p.R355C (1063C>T) (human)RGD 
Pros1MouseDiabetic Nephropathies severityIMP 13515131associated with diabetes mellitus, experimentalRGD 
Pros1MouseDiabetic Nephropathies treatmentISORGD:134278113515131associated with diabetes mellitus, experimentalRGD 
Pros1MouseDiabetic Nephropathies  ISORGD:134278113515131protein:increased expression:kidney, glomerulusRGD 
Pros1MouseDiabetic Nephropathies  ISORGD:62097113515131associated with diabetes mellitus, experimental;mRNA, protein:increased expression:kidney, glomerulusRGD 
Pros1MouseExperimental Liver Cirrhosis  ISORGD:6209712300011mRNA, protein:decreased expression:liver, plasmaRGD 
Pros1Mouseprotein S deficiency  ISORGD:134278111251677DNA:frameshift mutation:exon:c.1113T>G (human)RGD 
Pros1Mouseprotein S deficiency  ISORGD:134278111250419DNA:missense, nonsense, deletions: :multipleRGD 
Pros1Mouseprotein S deficiency  ISORGD:134278111250415DNA:missense mutation:exon:p.S460P (human)RGD 
Pros1Mouseprotein S deficiency no_associationISORGD:134278111250419DNA:SNPs: : c.1016T>A, c.1138A>C (human)RGD 
Pros1Mouseprotein S deficiency  ISORGD:134278111250418DNA:deletions, duplication:exon, intronRGD 
Pros1Mouseprotein S deficiency  ISORGD:13427811599209 RGD 
Pros1Mouseprotein S deficiency  ISORGD:13427811578677 RGD 
Pros1Mouseprotein S deficiency  ISORGD:134278111251679DNA:missense mutations, deletion: :multipleRGD 
Pros1Mousepulmonary embolism  ISORGD:13427811578677 RGD 
Pros1Mousethrombophlebitis  ISORGD:13427811578677 RGD 
Pros1Mousevascular disease  IMP 11250417 RGD 
Pros1MouseVenous Thromboembolism  ISORGD:134278111251678 RGD 
Pros1MouseVenous Thromboembolism  ISORGD:134278111099984 RGD 
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Original Reference(s)
Pros1Mouseautosomal dominant thrombophilia due to protein S deficiency  ISORGD:13427818554872ClinVar Annotator: match by term: PROS1-related condition | ClinVar Annotator: match by term: Thrombophilia due more ...ClinVarPMID:10063989|PMID:10447256|PMID:10456456|PMID:10613647|PMID:10669162|PMID:10706858|PMID:10790208|PMID:10811787|PMID:10887114|PMID:11127877|PMID:11858485|PMID:12351389|PMID:12960605|PMID:15147381|PMID:15175796|PMID:15238143|PMID:1547381|PMID:15712227|PMID:15978566|PMID:16100035|PMID:16199547|PMID:16461766|PMID:16953283|PMID:16961607|PMID:16961608|PMID:17157360|PMID:17576681|PMID:18322254|PMID:18435454|PMID:18841302|PMID:18954896|PMID:19826897|PMID:20811787|PMID:20880255|PMID:21172841|PMID:21285903|PMID:2143091|PMID:21486865|PMID:21764424|PMID:21764702|PMID:21811774|PMID:22166512|PMID:22261441|PMID:22273984|PMID:22627591|PMID:22951146|PMID:23813890|PMID:24014240|PMID:24033266|PMID:24055113|PMID:24119292|PMID:24162787|PMID:24233386|PMID:24365770|PMID:2526663|PMID:25272994|PMID:25525159|PMID:25637381|PMID:25741868|PMID:26046366|PMID:26251307|PMID:26466767|PMID:26985940|PMID:27535533|PMID:27652279|PMID:27660039|PMID:27667277|PMID:27748013|PMID:27838551|PMID:28174134|PMID:28374852|PMID:28492532|PMID:28607330|PMID:29225857|PMID:29321366|PMID:29748776|PMID:29883906|PMID:30349894|PMID:30543986|PMID:30669159|PMID:31019283|PMID:31064749|PMID:31068512|PMID:31335064|PMID:32964666|PMID:34355501|PMID:34426522|PMID:34533296|PMID:34729451|PMID:35815065|PMID:36034607|PMID:37647632|PMID:7545463|PMID:7579448|PMID:7579449|PMID:7803790|PMID:8113388|PMID:8298131|PMID:8639833|PMID:8765219|PMID:8781426|PMID:8865520|PMID:8943854|PMID:9241758|PMID:9536098|PMID:9651142|PMID:9657428
Pros1Mouseautosomal recessive thrombophilia due to protein S deficiency  ISORGD:13427818554872ClinVar Annotator: match by term: Thrombophilia due to protein S deficiency, autosomal recessiveClinVarPMID:10063989|PMID:10447256|PMID:10456456|PMID:10613646|PMID:10613647|PMID:10669162|PMID:10706858|PMID:10790208|PMID:10811787|PMID:10887114|PMID:11127877|PMID:11776305|PMID:11858485|PMID:12351389|PMID:12960605|PMID:15147381|PMID:15175796|PMID:15238143|PMID:1547381|PMID:15712227|PMID:15712777|PMID:15978566|PMID:16100035|PMID:16199547|PMID:16363235|PMID:16461766|PMID:1671337|PMID:16953283|PMID:16961607|PMID:16961608|PMID:17157360|PMID:17576681|PMID:18242167|PMID:18322254|PMID:18435454|PMID:18841302|PMID:18954896|PMID:19826897|PMID:20181378|PMID:20421270|PMID:20484936|PMID:20811787|PMID:20880255|PMID:21172841|PMID:21285903|PMID:2143091|PMID:21486865|PMID:21764424|PMID:21764702|PMID:21811774|PMID:22166512|PMID:22261441|PMID:22273984|PMID:22290026|PMID:2231208|PMID:22627591|PMID:22627709|PMID:22951146|PMID:23813890|PMID:24014240|PMID:24033266|PMID:24055113|PMID:24119292|PMID:24162787|PMID:24233386|PMID:24365770|PMID:2521801|PMID:2526663|PMID:25272994|PMID:25525159|PMID:25637381|PMID:25640679|PMID:25741868|PMID:26046366|PMID:26251307|PMID:26466767|PMID:26985940|PMID:27535533|PMID:27652279|PMID:27660039|PMID:27667277|PMID:27748013|PMID:27838551|PMID:28088608|PMID:28174134|PMID:28374852|PMID:28492532|PMID:28607330|PMID:29225857|PMID:29321366|PMID:29748776|PMID:29883906|PMID:30349894|PMID:30543986|PMID:30669159|PMID:31019283|PMID:31064749|PMID:31068512|PMID:31335064|PMID:31422373|PMID:32964666|PMID:34355501|PMID:34426522|PMID:34533296|PMID:34729451|PMID:35815065|PMID:37647632|PMID:7545463|PMID:7579448|PMID:7579449|PMID:7803790|PMID:7974339|PMID:8298131|PMID:8616098|PMID:8639833|PMID:8765219|PMID:8781426|PMID:8841302|PMID:8865520|PMID:8943854|PMID:9031442|PMID:9031443|PMID:9241758|PMID:9536098|PMID:9651142
Pros1Mousefundus dystrophy  ISORGD:13427818554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:10669162|PMID:10790208|PMID:10887114|PMID:11127877|PMID:11858485|PMID:12960605|PMID:15147381|PMID:15175796|PMID:1547381|PMID:15712227|PMID:16100035|PMID:18322254|PMID:18435454|PMID:18841302|PMID:20880255|PMID:2143091|PMID:21764424|PMID:22273984|PMID:22627591|PMID:24014240|PMID:24033266|PMID:24055113|PMID:24119292|PMID:24365770|PMID:2526663|PMID:25637381|PMID:25741868|PMID:27535533|PMID:27838551|PMID:28374852|PMID:28492532|PMID:28607330|PMID:29883906|PMID:31019283|PMID:31064749|PMID:34355501|PMID:34426522|PMID:34533296|PMID:34729451|PMID:7579448|PMID:7803790|PMID:8765219
Pros1Mousegenetic disease  ISORGD:13427818554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10077735|PMID:20880255|PMID:25741868|PMID:28492532
Pros1Mousehemorrhagic disease  ISORGD:13427818554872ClinVar Annotator: match by term: Abnormal bleedingClinVarPMID:20880255|PMID:25741868|PMID:28492532|PMID:31064749|PMID:37647632|PMID:8943854|PMID:9651142
Pros1MouseJoubert syndrome 8  ISORGD:13427818554872ClinVar Annotator: match by term: Joubert syndrome 8ClinVarPMID:28492532
Pros1Mousenephrotic syndrome type 1  ISORGD:13427818554872ClinVar Annotator: match by term: Congenital nephrotic syndrome 1ClinVarPMID:10790208|PMID:11127877|PMID:11858485|PMID:18322254|PMID:20880255|PMID:24014240|PMID:24055113|PMID:25637381|PMID:25741868|PMID:27535533|PMID:28492532|PMID:31064749
Pros1Mouseoptic atrophy  ISORGD:13427818554872ClinVar Annotator: match by term: Optic atrophyClinVarPMID:10669162|PMID:10887114|PMID:12960605|PMID:15147381|PMID:15175796|PMID:1547381|PMID:16100035|PMID:18435454|PMID:18841302|PMID:20880255|PMID:2143091|PMID:21764424|PMID:22273984|PMID:24014240|PMID:24033266|PMID:24119292|PMID:24365770|PMID:2526663|PMID:25741868|PMID:27838551|PMID:28374852|PMID:28492532|PMID:28607330|PMID:29883906|PMID:31019283|PMID:31064749|PMID:34355501|PMID:34533296|PMID:34729451|PMID:7579448|PMID:8765219
Pros1Mouseprotein S deficiency  ISORGD:13427818554872ClinVar Annotator: match by term: Protein S deficiency diseaseClinVarPMID:10063989|PMID:10447256|PMID:10706858|PMID:10790208|PMID:11127877|PMID:11858485|PMID:12351389|PMID:15712227|PMID:17576681|PMID:17596203|PMID:18322254|PMID:20484936|PMID:20880255|PMID:22166512|PMID:22261441|PMID:22951146|PMID:23813890|PMID:24014240|PMID:24055113|PMID:25272994|PMID:25637381|PMID:25741868|PMID:26466767|PMID:27535533|PMID:27652279|PMID:28492532|PMID:29321366|PMID:29748776|PMID:30543986|PMID:30669159|PMID:30925296|PMID:31064749|PMID:31335064|PMID:32581362|PMID:32964666|PMID:34355501|PMID:34729451|PMID:35815065|PMID:37647632|PMID:7579449|PMID:7803790|PMID:8765219|PMID:8865520|PMID:8943854|PMID:9031443|PMID:9241758|PMID:9536098
Pros1MouseThromboembolism  ISORGD:13427818554872ClinVar Annotator: match by term: ThromboembolismClinVarPMID:25741868|PMID:28492532|PMID:31064749
Pros1MouseVenous Thrombosis  ISORGD:13427818554872ClinVar Annotator: match by term: Deep vein thrombosisClinVarPMID:12351389|PMID:20880255|PMID:22261441|PMID:25741868|PMID:28492532|PMID:31064749|PMID:31335064|PMID:32964666|PMID:34729451|PMID:7803790
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Original Reference(s)
Pros1Mouseadult respiratory distress syndrome  ISORGD:134278111554173CTD Direct Evidence: marker/mechanismCTDPMID:25070658
Pros1Mouseautosomal dominant thrombophilia due to protein S deficiency  ISORGD:134278111554173CTD Direct Evidence: marker/mechanismCTD 
Pros1Mouseautosomal recessive thrombophilia due to protein S deficiency  ISORGD:134278111554173CTD Direct Evidence: marker/mechanismCTD 
Pros1Mousejuvenile rheumatoid arthritis  ISORGD:134278111554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
Pros1Mousesagittal sinus thrombosis  ISORGD:134278111554173CTD Direct Evidence: marker/mechanismCTDPMID:18382986
Pros1MouseStevens-Johnson syndrome  ISORGD:134278111554173CTD Direct Evidence: marker/mechanismCTDPMID:34142820
Pros1MouseThromboembolism  ISORGD:134278111554173CTD Direct Evidence: marker/mechanismCTDPMID:8052960
Pros1Mousethrombophilia due to activated protein C resistance  ISORGD:134278111554173CTD Direct Evidence: marker/mechanismCTDPMID:11703344
Pros1Mousethrombosis  ISORGD:134278111554173CTD Direct Evidence: marker/mechanismCTDPMID:10706858|PMID:11132655
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Original Reference(s)
Pros1Mouseautosomal dominant thrombophilia due to protein S deficiency  ISORGD:13427817240710 OMIM 
Pros1Mouseautosomal recessive thrombophilia due to protein S deficiency  ISORGD:13427817240710 OMIM 

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Original Reference(s)
Pros1Mouse(+)-schisandrin B multiple interactionsISORGD:6209716480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PROS1 mRNA]CTDPMID:31150632
Pros1Mouse1,2-dimethylhydrazine multiple interactionsEXP 6480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PROS1 mRNACTDPMID:22206623
Pros1Mouse1,2-dimethylhydrazine decreases expressionEXP 64804641,2-Dimethylhydrazine results in decreased expression of PROS1 mRNACTDPMID:22206623
Pros1Mouse1-naphthyl isothiocyanate multiple interactionsISORGD:13427816480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of PROS1 mRNACTDPMID:27344345
Pros1Mouse17alpha-ethynylestradiol multiple interactionsISORGD:13427816480464[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of PROS1 mRNA; [Ethinyl Estradiol co-treated more ...CTDPMID:11720199|PMID:11994571|PMID:12618251|PMID:14551147|PMID:15288212|PMID:15669648|PMID:16522526|PMID:27344345|PMID:8950781
Pros1Mouse17alpha-ethynylestradiol decreases expressionISORGD:13427816480464Ethinyl Estradiol results in decreased expression of PROS1 proteinCTDPMID:17374706|PMID:8950781
Pros1Mouse17beta-estradiol multiple interactionsISORGD:13427816480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PROS1 mRNA; [Estradiol co-treated with TGFB1 more ...CTDPMID:19619570|PMID:30165855
Pros1Mouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of PROS1 mRNACTDPMID:19484750
Pros1Mouse17beta-estradiol increases expressionISORGD:13427816480464Estradiol results in increased expression of PROS1 mRNACTDPMID:19619570
Pros1Mouse17beta-estradiol decreases expressionISORGD:13427816480464Estradiol results in decreased expression of PROS1 proteinCTDPMID:12730085
Pros1Mouse2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISORGD:134278164804642,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of PROS1 mRNACTDPMID:19095052
Pros1Mouse2,3',4,4',5-Pentachlorobiphenyl decreases expressionEXP 64804642,3',4,4',5-pentachlorobiphenyl results in decreased expression of PROS1 mRNACTDPMID:31388691
Pros1Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:13427816480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PROS1 mRNACTDPMID:19619570
Pros1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:6209716480464Tetrachlorodibenzodioxin results in decreased expression of PROS1 mRNACTDPMID:34747641
Pros1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PROS1 mRNACTDPMID:21570461|PMID:26377647
Pros1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PROS1 mRNACTDPMID:18796159|PMID:26290441
Pros1Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin affects the methylation of PROS1 intron] which results in decreased expression of PROS1 mRNA; more ...CTDPMID:16214954|PMID:33017471
Pros1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:13427816480464Tetrachlorodibenzodioxin results in decreased expression of PROS1 mRNACTDPMID:19619570
Pros1Mouse2,4-dinitrotoluene affects expressionISORGD:62097164804642,4-dinitrotoluene affects the expression of PROS1 mRNACTDPMID:21346803
Pros1Mouse2,6-dinitrotoluene affects expressionISORGD:62097164804642,6-dinitrotoluene affects the expression of PROS1 mRNACTDPMID:21346803

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Biological Process
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Original Reference(s)
Pros1Mouseblood coagulation involved_inIEAUniProtKB-KW:KW-00942290270 UniProtGO_REF:0000043
Pros1Mousefibrinolysis involved_inIEAUniProtKB-KW:KW-02802290270 UniProtGO_REF:0000043
Pros1Mouseliver development  ISORGD:6209719068941 RGDPMID:7660357|REF_RGD_ID:1299299
Pros1Mousenegative regulation of coagulation  ISORGD:6209719068941 RGDPMID:7608128|REF_RGD_ID:2300015
Pros1Mousenegative regulation of coagulation involved_inISORGD:6209712290270 GO_CentralGO_REF:0000096
Pros1Mousepositive regulation of phagocytosis involved_inISORGD:6209712290270 GO_CentralGO_REF:0000096
Pros1Mousepositive regulation of phagocytosis  ISORGD:6209719068941 RGDPMID:15949798|REF_RGD_ID:2300013
Pros1Mousepositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_inIDA 2290270 PMID:21084607UniProtPMID:21084607
Pros1Mouseresponse to axon injury  ISORGD:6209719068941 RGDPMID:20187850|REF_RGD_ID:151665810
Pros1Mouseresponse to lipopolysaccharide  ISORGD:6209719068941 RGDPMID:16879219|REF_RGD_ID:2300012
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Cellular Component

  
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Pros1Mouseextracellular space located_inISOUniProtKB:P072252290270 GO_CentralGO_REF:0000119
Pros1Mouseextracellular space located_inHDA 2290270 PMID:24006456BHF-UCLPMID:24006456
Pros1Mouseextracellular space located_inISORGD:6209712290270 GO_CentralGO_REF:0000096
Pros1Mouseextracellular space is_active_inIBAPANTHER:PTN002778777|RGD:620971|UniProtKB:P072252290270 GO_CentralGO_REF:0000033
Pros1Mouseextracellular space  ISORGD:6209719068941 RGDPMID:16995903|REF_RGD_ID:2300011
Pros1Mouseprotein-containing complex  ISORGD:6209719068941 RGDPMID:7608128|REF_RGD_ID:2300015
Pros1Mouseprotein-containing complex part_ofISORGD:6209712290270 GO_CentralGO_REF:0000096

Molecular Function

  
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Original Reference(s)
Pros1Mousecalcium ion binding enablesIEAInterPro:IPR000294|InterPro:IPR001881|InterPro:IPR018097|InterPro:IPR0359722290270 InterProGO_REF:0000002
Pros1Mouseprotein binding enablesISOUniProtKB:P17252|UniProtKB:P61981|UniProtKB:P62937-2|UniProtKB:Q15047-2|UniProtKB:Q5SUL5|UniProtKB:Q8TAP4-4|UniProtKB:Q92993|UniProtKB:Q96CV99068941 PMID:32814053IntActPMID:32814053
Pros1Mouseprotein-containing complex binding enablesISORGD:6209712290270 GO_CentralGO_REF:0000096
Pros1Mouseprotein-containing complex binding  ISORGD:6209719068941 RGDPMID:7608128|REF_RGD_ID:2300015

RGD Manual Annotations


  
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Original Reference(s)
Pros1Mouseprotein C anticoagulant pathway   ISS 1578508 RGD 
Pros1Mouseprotein C anticoagulant pathway   ISORGD:134278111352294 RGD 

Imported Annotations - KEGG (archival)

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Pros1Mousecoagulation cascade pathway   IEA 6907045 KEGGmmu:04610
Pros1Mousecomplement system pathway  IEA 6907045 KEGGmmu:04610
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Original Reference(s)
Pros1Mouseabnormal blood coagulation  IAGP 5509061 MGIPMID:19729839
Pros1Mouseabnormal blood vessel morphology  IAGP 5509061 MGIPMID:19729839
Pros1Mouseabnormal brain vasculature morphology  IAGP 5509061 MGIPMID:19729839
Pros1Mouseabnormal neocortex morphology  IAGP 5509061 MGIPMID:19729839
Pros1Mouseabnormal response/metabolism to endogenous compounds  IAGP 5509061 MGIPMID:19567881
Pros1Mouseabnormal thrombosis  IAGP 5509061 MGIPMID:19567881
Pros1Mouseabnormal thrombosis  IAGP 5509061 MGIPMID:19729839
Pros1Mouseabnormal vitelline vasculature morphology  IAGP 5509061 MGIPMID:19729839
Pros1Mouseblood vessel congestion  IAGP 5509061 MGIPMID:19729839
Pros1Mousebrain vascular congestion  IAGP 5509061 MGIPMID:19729839
Pros1Mousebruising  IAGP 5509061 MGIPMID:19567881
Pros1Mousedecreased bleeding time  IAGP 5509061 MGIPMID:19729839
Pros1Mousedecreased hepatocyte number  IAGP 5509061 MGIPMID:19567881
Pros1Mouseenlarged brain ventricles  IAGP 5509061 MGIPMID:19729839
Pros1Mousehemorrhage  IAGP 5509061 MGIPMID:19567881
Pros1Mousehemorrhage  IAGP 5509061 MGIPMID:19729839
Pros1Mousehepatic necrosis  IAGP 5509061 MGIPMID:19567881
Pros1Mouseincreased megakaryocyte cell number  IAGP 5509061 MGIPMID:19567881
Pros1Mouseincreased susceptibility to induced morbidity/mortality  IAGP 5509061 MGIPMID:19567881
Pros1Mouseincreased susceptibility to induced thrombosis  IAGP 5509061 MGIPMID:19567881
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Reference Title
Reference Citation
1. PROS1 genotype phenotype relationships in a large cohort of adults with suspicion of inherited quantitative protein S deficiency. Alhenc-Gelas M, etal., Thromb Haemost. 2016 Feb 29;115(3):570-9. doi: 10.1160/TH15-05-0391. Epub 2015 Oct 15.
2. Characterization and structural impact of five novel PROS1 mutations in eleven protein S-deficient families. Andersen BD, etal., Thromb Haemost. 2001 Dec;86(6):1392-9.
3. A novel mutation in intron K of the PROS1 gene causes aberrant RNA splicing and is a common cause of protein S deficiency in a UK thrombophilia cohort. Beauchamp NJ, etal., Thromb Haemost. 1998 Jun;79(6):1086-91.
4. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
5. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. Burstyn-Cohen T, etal., J Clin Invest. 2009 Oct;119(10):2942-53. doi: 10.1172/JCI39325.
6. The Ser 460 to Pro substitution of the protein S alpha (PROS1) gene is a frequent mutation associated with free protein S (type IIa) deficiency. Duchemin J, etal., Blood. 1995 Nov 1;86(9):3436-43.
7. Genotype and laboratory and clinical phenotypes of protein s deficiency. Duebgen S, etal., Am J Clin Pathol. 2012 Feb;137(2):178-84. doi: 10.1309/AJCP40UXNBTXGKUX.
8. The protein C pathway. Esmon CT, Chest. 2003 Sep;124(3 Suppl):26S-32S.
9. Differential regulation of protein S expression in hepatocytes and sinusoidal endothelial cells in rats with cirrhosis. Fujii K, etal., J Thromb Haemost. 2006 Dec;4(12):2607-15. Epub 2006 Sep 22.
10. Combined occurrence of a heterozygous missense mutation in the protein C gene and allelic exclusion of one protein S allele leading to severe venous thrombosis. Knoll B, etal., Thromb Res. 2001 Jul 1;103(1):3-8.
11. Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation. Leung TW, etal., Neurology. 2010 Dec 14;75(24):2185-9. doi: 10.1212/WNL.0b013e3182020379.
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Early embryonic expression of murine coagulation system components. Ong K, etal., Thromb Haemost 2000 Dec;84(6):1023-30.
16. Gross deletions/duplications in PROS1 are relatively common in point mutation-negative hereditary protein S deficiency. Pintao MC, etal., Hum Genet. 2009 Sep;126(3):449-56. doi: 10.1007/s00439-009-0687-9. Epub 2009 May 23.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex. Rezende SM, etal., Blood. 2004 Feb 15;103(4):1192-201. Epub 2003 Aug 7.
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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PMID:8029814   PMID:8148380   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11130978   PMID:11217851   PMID:12477932   PMID:12520002   PMID:12904583  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16910173   PMID:19036061   PMID:19567881   PMID:19815836   PMID:20348395   PMID:21084607   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:22043818   PMID:23259948   PMID:23850380   PMID:24006456   PMID:24952961   PMID:25265470   PMID:25308179   PMID:26251307   PMID:27034374   PMID:27049947   PMID:27207541   PMID:27753164  
PMID:28512399   PMID:28686706   PMID:29317453   PMID:29419409   PMID:29545796   PMID:29706963   PMID:29708510   PMID:29721990   PMID:29871951   PMID:30735494   PMID:32276277   PMID:33848267  
PMID:36951067   PMID:36989576   PMID:37277061  



Pros1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391662,674,670 - 62,749,709 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)EnsemblGRCm39 Ensembl
GRCm381662,854,307 - 62,929,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv371662,854,160 - 62,929,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361662,796,624 - 62,871,347 (+)NCBIMGSCv36mm8
Celera1663,162,946 - 63,237,718 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1636.43NCBI
PROS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38393,873,051 - 93,973,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl393,873,051 - 93,980,003 (-)EnsemblGRCh38hg38GRCh38
GRCh37393,591,895 - 93,692,740 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36395,074,647 - 95,175,395 (-)NCBINCBI36Build 36hg18NCBI36
Build 34395,074,646 - 95,175,395NCBI
Celera391,974,425 - 92,076,408 (-)NCBICelera
Cytogenetic Map3q11.1NCBI
HuRef390,954,621 - 91,055,633 (-)NCBIHuRef
CHM1_1393,558,922 - 93,656,016 (-)NCBICHM1_1
T2T-CHM13v2.0396,571,223 - 96,678,047 (-)NCBIT2T-CHM13v2.0
Pros1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81113,676,310 - 13,757,858 (+)NCBIGRCr8
mRatBN7.211230,597 - 311,288 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl11230,696 - 311,286 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx118,826,855 - 8,907,393 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0111,620,112 - 1,700,666 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.011724,894 - 805,450 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.071,206,648 - 1,288,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.071,199,864 - 1,279,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13237,157 - 317,730 (+)NCBICelera
Cytogenetic Map11p12NCBI
Pros1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554073,535,388 - 3,565,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554073,514,900 - 3,566,165 (+)NCBIChiLan1.0ChiLan1.0
PROS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2291,781,226 - 91,886,734 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1391,785,656 - 91,890,489 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0390,934,641 - 91,039,059 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1397,615,734 - 97,719,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl397,615,734 - 97,718,756 (-)Ensemblpanpan1.1panPan2
PROS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,628,074 - 1,691,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,628,105 - 1,692,058 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,807,559 - 1,871,177 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0331,727,844 - 1,791,314 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl331,727,846 - 1,791,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1331,637,294 - 1,700,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0331,671,507 - 1,735,141 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0331,896,104 - 1,960,217 (-)NCBIUU_Cfam_GSD_1.0
Pros1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602155,405,321 - 155,496,524 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493666619,387 - 110,014 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493666618,303 - 110,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13165,911,366 - 165,999,811 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113165,915,298 - 165,999,118 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PROS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12286,728,089 - 86,840,413 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2286,728,339 - 86,840,356 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604179,820,400 - 79,954,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pros1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247896,621,803 - 6,704,033 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Pros1
2377 total Variants

Predicted Target Of
Summary Value
Count of predictions:431
Count of miRNA genes:345
Interacting mature miRNAs:376
Transcripts:ENSMUST00000023629, ENSMUST00000127502, ENSMUST00000155940
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 24 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164059392374594076Mouse
1301394Eae11_msusceptibility to experimental allergic encephalomyelitis 11 (mouse)Not determined165356189187562035Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
4141212Imraq3_mimmune response to AAV2 QTL 3 (mouse)Not determined164438335078383506Mouse
1558836Dice1b_mdetermination of interleukin 4 commitment 1b (mouse)Not determined164551100072274485Mouse
1301719Remslp3_mrapid eye movement sleep 3 (mouse)Not determined164438335078383506Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse

1 to 10 of 24 rows
AW214361  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381662,928,953 - 62,929,047UniSTSGRCm38
GRCm381118,452,038 - 18,452,131UniSTSGRCm38
MGSCv371662,928,779 - 62,928,873UniSTSGRCm37
MGSCv371118,352,041 - 18,352,134UniSTSGRCm37
Celera1663,237,331 - 63,237,425UniSTS
Cytogenetic Map16C1.3UniSTS
Whitehead/MRC_RH16721.72UniSTS
L27439  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381662,928,347 - 62,928,539UniSTSGRCm38
MGSCv371662,928,173 - 62,928,365UniSTSGRCm37
Celera1663,236,725 - 63,236,917UniSTS
Cytogenetic Map16C1.3UniSTS
Whitehead/MRC_RH16720.81UniSTS
Whitehead_YAC16 UniSTS
Pros1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C1.3UniSTS
cM Map16 UniSTS
L27439  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381662,928,791 - 62,928,932UniSTSGRCm38
MGSCv371662,928,617 - 62,928,758UniSTSGRCm37
Celera1663,237,169 - 63,237,310UniSTS
Cytogenetic Map16C1.3UniSTS
Whitehead/MRC_RH16720.81UniSTS







Ensembl Acc Id: ENSMUST00000023629   ⟹   ENSMUSP00000023629
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)Ensembl
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1662,741,830 - 62,748,753 (+)Ensembl
GRCm38.p6 Ensembl1662,921,467 - 62,928,390 (+)Ensembl
Ensembl Acc Id: ENSMUST00000155940
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1662,718,512 - 62,720,737 (+)Ensembl
GRCm38.p6 Ensembl1662,898,149 - 62,900,374 (+)Ensembl
RefSeq Acc Id: NM_011173   ⟹   NP_035303
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391662,674,670 - 62,749,707 (+)NCBI
GRCm381662,854,307 - 62,929,344 (+)NCBI
MGSCv371662,854,160 - 62,929,166 (+)RGD
Celera1663,162,946 - 63,237,718 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011245843   ⟹   XP_011244145
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391662,710,759 - 62,749,709 (+)NCBI
GRCm381662,890,334 - 62,929,346 (+)NCBI
Sequence:
RefSeq Acc Id: NP_035303   ⟸   NM_011173
- Peptide Label: preproprotein
- UniProtKB: P43483 (UniProtKB/Swiss-Prot),   Q08761 (UniProtKB/Swiss-Prot),   Q3TR66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244145   ⟸   XM_011245843
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000023629   ⟸   ENSMUST00000023629
EGF-like   Gla   Laminin G   Laminin G-like

Name Modeler Protein Id AA Range Protein Structure
AF-Q08761-F1-model_v2 AlphaFold Q08761 1-675 view protein structure

RGD ID:6827383
Promoter ID:MM_KWN:21368
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000067401
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361662,853,859 - 62,854,359 (+)MPROMDB
RGD ID:13674212
Promoter ID:EPDNEW_M21255
Type:initiation region
Name:Pros1_1
Description:Mus musculus protein S , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381662,854,326 - 62,854,386EPDNEW


1 to 40 of 50 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000022912 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000023629 ENTREZGENE
  ENSMUST00000023629.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
  4.10.740.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro Coagulation_fac-like_Gla_dom UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  GAS-SHBG-PROS UniProtKB/Swiss-Prot
  GLA-like_dom_SF UniProtKB/Swiss-Prot
  GLA_domain UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
KEGG Report mmu:19128 UniProtKB/Swiss-Prot
MGD MGI:1095733 ENTREZGENE
NCBI Gene 19128 ENTREZGENE
PANTHER LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  PTHR24040:SF0 UniProtKB/Swiss-Prot
Pfam EGF_CA UniProtKB/Swiss-Prot
  FXa_inhibition UniProtKB/Swiss-Prot
  Gla UniProtKB/Swiss-Prot
  Laminin_G_1 UniProtKB/Swiss-Prot
PharmGKB PROS1 RGD
PhenoGen Pros1 PhenoGen
PRINTS GLABLOOD UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  GLA_1 UniProtKB/Swiss-Prot
  GLA_2 UniProtKB/Swiss-Prot
  LAM_G_DOMAIN UniProtKB/Swiss-Prot
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
1 to 40 of 50 rows