PROS1 (protein S) - Rat Genome Database

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Gene: PROS1 (protein S) Canis lupus familiaris
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Symbol: PROS1
Name: protein S
RGD ID: 12289646
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN liver development (ortholog); negative regulation of coagulation (ortholog); positive regulation of phagocytosis (ortholog); PARTICIPATES IN protein C anticoagulant pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); autosomal dominant thrombophilia due to protein S deficiency (ortholog); autosomal recessive thrombophilia due to protein S deficiency (ortholog); FOUND IN extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: vitamin K-dependent protein S
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,628,074 - 1,691,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,628,105 - 1,692,058 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,807,559 - 1,871,177 (-)NCBI
ROS_Cfam_1.0331,727,844 - 1,791,314 (-)NCBI
UMICH_Zoey_3.1331,637,294 - 1,700,492 (-)NCBI
UNSW_CanFamBas_1.0331,671,507 - 1,735,141 (-)NCBI
UU_Cfam_GSD_1.0331,896,104 - 1,960,217 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PROS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1331,628,074 - 1,691,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl331,628,105 - 1,692,058 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,807,559 - 1,871,177 (-)NCBI
ROS_Cfam_1.0331,727,844 - 1,791,314 (-)NCBI
UMICH_Zoey_3.1331,637,294 - 1,700,492 (-)NCBI
UNSW_CanFamBas_1.0331,671,507 - 1,735,141 (-)NCBI
UU_Cfam_GSD_1.0331,896,104 - 1,960,217 (-)NCBI
PROS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl393,873,051 - 93,980,003 (-)EnsemblGRCh38hg38GRCh38
GRCh38393,873,051 - 93,973,896 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37393,591,895 - 93,692,740 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36395,074,647 - 95,175,395 (-)NCBINCBI36hg18NCBI36
Build 34395,074,646 - 95,175,395NCBI
Celera391,974,425 - 92,076,408 (-)NCBI
Cytogenetic Map3q11.1NCBI
HuRef390,954,621 - 91,055,633 (-)NCBIHuRef
CHM1_1393,558,922 - 93,656,016 (-)NCBICHM1_1
Pros1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391662,674,670 - 62,749,709 (+)NCBIGRCm39mm39
GRCm39 Ensembl1662,674,670 - 62,749,709 (+)Ensembl
GRCm381662,854,307 - 62,929,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1662,854,307 - 62,929,346 (+)EnsemblGRCm38mm10GRCm38
MGSCv371662,854,160 - 62,929,166 (+)NCBIGRCm37mm9NCBIm37
MGSCv361662,796,624 - 62,871,347 (+)NCBImm8
Celera1663,162,946 - 63,237,718 (+)NCBICelera
Cytogenetic Map16C1.3NCBI
Pros1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.211230,597 - 311,288 (+)NCBI
Rnor_6.0 Ensembl71,206,648 - 1,288,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.071,206,648 - 1,288,140 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.071,199,864 - 1,279,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera13237,157 - 317,730 (+)NCBICelera
Cytogenetic Map7q11NCBI
Pros1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554073,535,388 - 3,565,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554073,514,900 - 3,566,165 (+)NCBIChiLan1.0ChiLan1.0
PROS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1397,615,734 - 97,719,057 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl397,615,734 - 97,718,756 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0390,934,641 - 91,039,059 (-)NCBIMhudiblu_PPA_v0panPan3
Pros1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602155,405,321 - 155,496,524 (+)NCBI
SpeTri2.0NW_00493666618,303 - 110,357 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13165,911,366 - 165,999,811 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113165,915,298 - 165,999,118 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PROS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12286,728,089 - 86,840,413 (+)NCBI
ChlSab1.1 Ensembl2286,728,339 - 86,840,356 (+)Ensembl
Vero_WHO_p1.0NW_02366604179,820,400 - 79,954,563 (-)NCBI
Pros1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247896,621,803 - 6,704,033 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 22 6 6 6 6 7 8 10 6
Low 1 5 6 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000014302   ⟹   ENSCAFP00000013225
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl331,628,105 - 1,692,058 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000067342   ⟹   ENSCAFP00000062217
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl331,628,531 - 1,692,058 (-)Ensembl
RefSeq Acc Id: XM_022413745   ⟹   XP_022269453
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1331,628,074 - 1,691,441 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038444647   ⟹   XP_038300575
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0331,727,844 - 1,791,314 (-)NCBI
RefSeq Acc Id: XM_038462469   ⟹   XP_038318397
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha331,807,559 - 1,871,177 (-)NCBI
RefSeq Acc Id: XM_038518987   ⟹   XP_038374915
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1331,637,294 - 1,700,492 (-)NCBI
RefSeq Acc Id: XM_038582503   ⟹   XP_038438431
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0331,896,104 - 1,960,217 (-)NCBI
RefSeq Acc Id: XM_038646931   ⟹   XP_038502859
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0331,671,507 - 1,735,141 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_022269453   ⟸   XM_022413745
- Sequence:
RefSeq Acc Id: ENSCAFP00000013225   ⟸   ENSCAFT00000014302
RefSeq Acc Id: ENSCAFP00000062217   ⟸   ENSCAFT00000067342
RefSeq Acc Id: XP_038374915   ⟸   XM_038518987
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038502859   ⟸   XM_038646931
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038300575   ⟸   XM_038444647
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038318397   ⟸   XM_038462469
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038438431   ⟸   XM_038582503
- Peptide Label: isoform X1
Protein Domains
EGF-like   Gla   LAM_G_DOMAIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008999 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000013225 UniProtKB/TrEMBL
  ENSCAFP00000062217 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014302 UniProtKB/TrEMBL
  ENSCAFT00000067342 UniProtKB/TrEMBL
Gene3D-CATH 4.10.740.10 UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  PROS1 UniProtKB/TrEMBL
NCBI Gene PROS1 ENTREZGENE
PANTHER PTHR24040:SF0 UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  Gla UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PRINTS GLABLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF57630 UniProtKB/TrEMBL
UniProt A0A5F4D8W3_CANLF UniProtKB/TrEMBL
  F1PSS8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:53085 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-15 PROS1  protein S    protein S (alpha)  Symbol and/or name change 5135510 APPROVED