Cdon (cell adhesion associated, oncogene regulated) - Rat Genome Database

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Pathways
Gene: Cdon (cell adhesion associated, oncogene regulated) Rattus norvegicus
Analyze
Symbol: Cdon
Name: cell adhesion associated, oncogene regulated
RGD ID: 708433
Description: Predicted to enable coreceptor activity. Involved in cell adhesion. Acts upstream of or within smoothened signaling pathway. Located in cell surface. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated); PARTICIPATES IN Hedgehog signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cdo; Cdon homolog; Cdon homolog (mouse); cell adhesion molecule-related/down-regulated by oncogenes; immunoglobulin superfamily member
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8842,032,921 - 42,119,451 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl842,033,042 - 42,119,345 (+)EnsemblGRCr8
mRatBN7.2833,775,123 - 33,861,635 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl833,806,183 - 33,859,033 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx837,882,852 - 37,935,670 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0836,165,909 - 36,218,724 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0834,028,733 - 34,081,547 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0836,625,757 - 36,712,091 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl836,625,733 - 36,710,949 (+)Ensemblrn6Rnor6.0
Rnor_5.0836,642,905 - 36,728,577 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4835,238,899 - 35,291,743 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera835,227,303 - 35,280,140 (+)NCBICelera
RGSC_v3.1835,247,664 - 35,300,509 (+)NCBI
Cytogenetic Map8q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (ISO)
C60 fullerene  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
S-nitrosoglutathione  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
coreceptor activity  (IEA,ISO)
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. Bae GU, etal., Am J Hum Genet. 2011 Aug 12;89(2):231-40. doi: 10.1016/j.ajhg.2011.07.001. Epub 2011 Jul 28.
2. Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation. Bae GU, etal., Mol Cell Biol. 2009 Aug;29(15):4130-43. doi: 10.1128/MCB.00199-09. Epub 2009 May 26.
3. Interactions between Hedgehog proteins and their binding partners come into view. Beachy PA, etal., Genes Dev. 2010 Sep 15;24(18):2001-12.
4. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia. Kahn BM, etal., Dis Model Mech. 2017 Jan 1;10(1):29-37. doi: 10.1242/dmm.026195. Epub 2016 Nov 24.
7. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. Kang JS, etal., J Cell Biol 1997 Jul 14;138(1):203-13.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer. Sun M, etal., J Med Genet. 2008 Sep;45(9):589-95. doi: 10.1136/jmg.2008.057646. Epub 2008 Apr 16.
15. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Zhang W, etal., Dev Cell. 2006 May;10(5):657-65. Epub 2006 Apr 27.
Additional References at PubMed
PMID:15520228   PMID:15572127   PMID:16647304   PMID:16648472   PMID:17504941   PMID:19244314   PMID:19754878   PMID:20160094  


Genomics

Comparative Map Data
Cdon
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8842,032,921 - 42,119,451 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl842,033,042 - 42,119,345 (+)EnsemblGRCr8
mRatBN7.2833,775,123 - 33,861,635 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl833,806,183 - 33,859,033 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx837,882,852 - 37,935,670 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0836,165,909 - 36,218,724 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0834,028,733 - 34,081,547 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0836,625,757 - 36,712,091 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl836,625,733 - 36,710,949 (+)Ensemblrn6Rnor6.0
Rnor_5.0836,642,905 - 36,728,577 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4835,238,899 - 35,291,743 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera835,227,303 - 35,280,140 (+)NCBICelera
RGSC_v3.1835,247,664 - 35,300,509 (+)NCBI
Cytogenetic Map8q21NCBI
CDON
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811125,956,821 - 126,063,335 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11125,955,796 - 126,063,335 (-)Ensemblhg38GRCh38
GRCh3711125,826,716 - 125,933,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611125,331,923 - 125,438,397 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411125,335,783 - 125,438,397NCBI
Celera11122,988,054 - 123,098,575 (-)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11121,768,684 - 121,875,085 (-)NCBIHuRef
CHM1_111125,713,444 - 125,819,847 (-)NCBICHM1_1
T2T-CHM13v2.011125,985,675 - 126,092,146 (-)NCBIT2T-CHM13v2.0
Cdon
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39935,332,836 - 35,418,948 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl935,332,424 - 35,418,948 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38935,421,528 - 35,507,652 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl935,421,128 - 35,507,652 (+)Ensemblmm10GRCm38
MGSCv37935,259,661 - 35,315,237 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36935,201,747 - 35,254,013 (+)NCBIMGSCv36mm8
Celera932,686,755 - 32,744,725 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.24NCBI
Cdon
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541227,003,919 - 27,065,989 (-)Ensembl
ChiLan1.0NW_00495541227,004,391 - 27,093,968 (-)NCBIChiLan1.0ChiLan1.0
CDON
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29126,641,095 - 126,746,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111127,750,426 - 127,853,585 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011120,772,160 - 120,877,529 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111124,685,084 - 124,789,649 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11124,685,084 - 124,786,091 (-)EnsemblpanPan2panpan1.1
CDON
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.158,439,606 - 8,536,088 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl58,446,346 - 8,533,426 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha58,496,514 - 8,595,988 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.058,391,957 - 8,491,851 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl58,391,716 - 8,489,974 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.158,460,126 - 8,560,018 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.058,434,443 - 8,534,264 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.058,468,718 - 8,568,231 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdon
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947108,178,109 - 108,358,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365726,176,255 - 6,272,260 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365726,176,267 - 6,268,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDON
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl953,079,550 - 53,178,881 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1953,079,543 - 53,178,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CDON
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11117,091,778 - 117,255,354 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1117,092,178 - 117,152,030 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660438,742,602 - 8,983,460 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdon
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624812109,405 - 203,519 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624812107,632 - 203,791 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdon
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1830,961,969 - 31,048,020 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdon
578 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:420
Count of miRNA genes:196
Interacting mature miRNAs:232
Transcripts:ENSRNOT00000016248, ENSRNOT00000065358
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625851589833Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83910625849610361Rat

Markers in Region
AF090866  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2833,858,256 - 33,858,336 (+)MAPPERmRatBN7.2
Rnor_6.0836,708,714 - 36,708,793NCBIRnor6.0
Rnor_5.0836,725,200 - 36,725,279UniSTSRnor5.0
RGSC_v3.4835,290,967 - 35,291,046UniSTSRGSC3.4
Celera835,279,364 - 35,279,443UniSTS
Cytogenetic Map8q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 171 91 90 59 92 59 6 356 192 11 150 81 92 31 22 22

Sequence


Ensembl Acc Id: ENSRNOT00000016248   ⟹   ENSRNOP00000016247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl842,033,042 - 42,119,345 (+)Ensembl
mRatBN7.2 Ensembl833,806,183 - 33,859,033 (+)Ensembl
Rnor_6.0 Ensembl836,625,733 - 36,710,949 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103041   ⟹   ENSRNOP00000085481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl842,033,042 - 42,119,345 (+)Ensembl
mRatBN7.2 Ensembl833,806,183 - 33,859,033 (+)Ensembl
RefSeq Acc Id: NM_017358   ⟹   NP_059054
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8842,064,002 - 42,116,850 (+)NCBI
mRatBN7.2833,806,183 - 33,859,033 (+)NCBI
Rnor_6.0836,656,644 - 36,709,490 (+)NCBI
Rnor_5.0836,642,905 - 36,728,577 (+)NCBI
RGSC_v3.4835,238,899 - 35,291,743 (+)RGD
Celera835,227,303 - 35,280,140 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242791   ⟹   XP_006242853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8842,032,921 - 42,119,451 (+)NCBI
mRatBN7.2833,775,124 - 33,861,635 (+)NCBI
Rnor_6.0836,625,757 - 36,712,091 (+)NCBI
Rnor_5.0836,642,905 - 36,728,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242792   ⟹   XP_006242854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8842,033,216 - 42,119,451 (+)NCBI
mRatBN7.2833,782,440 - 33,859,033 (+)NCBI
Rnor_6.0836,632,877 - 36,712,091 (+)NCBI
Rnor_5.0836,642,905 - 36,728,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242793   ⟹   XP_006242855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8842,032,932 - 42,119,451 (+)NCBI
mRatBN7.2833,775,123 - 33,861,635 (+)NCBI
Rnor_6.0836,625,757 - 36,712,091 (+)NCBI
Rnor_5.0836,642,905 - 36,728,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082008   ⟹   XP_038937936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8842,033,216 - 42,119,451 (+)NCBI
mRatBN7.2833,777,248 - 33,859,033 (+)NCBI
RefSeq Acc Id: XM_063266036   ⟹   XP_063122106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8842,033,216 - 42,119,451 (+)NCBI
RefSeq Acc Id: XR_005487905
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8842,032,929 - 42,089,177 (+)NCBI
mRatBN7.2833,775,123 - 33,831,356 (+)NCBI
RefSeq Acc Id: NP_059054   ⟸   NM_017358
- Peptide Label: precursor
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   G3V7K7 (UniProtKB/TrEMBL),   A6JYK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242853   ⟸   XM_006242791
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006242855   ⟸   XM_006242793
- Peptide Label: isoform X2
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   A0A8I6A2E2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242854   ⟸   XM_006242792
- Peptide Label: isoform X1
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   G3V7K7 (UniProtKB/TrEMBL),   A6JYK5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016247   ⟸   ENSRNOT00000016248
RefSeq Acc Id: XP_038937936   ⟸   XM_039082008
- Peptide Label: isoform X1
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   G3V7K7 (UniProtKB/TrEMBL),   A6JYK5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085481   ⟸   ENSRNOT00000103041
RefSeq Acc Id: XP_063122106   ⟸   XM_063266036
- Peptide Label: isoform X1
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   A6JYK5 (UniProtKB/TrEMBL),   G3V7K7 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35158-F1-model_v2 AlphaFold O35158 1-1256 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708433 AgrOrtholog
BioCyc Gene G2FUF-31174 BioCyc
Ensembl Genes ENSRNOG00000011789 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016248 ENTREZGENE
  ENSRNOT00000103041 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
KEGG Report rno:50938 UniProtKB/Swiss-Prot
NCBI Gene 50938 ENTREZGENE
PANTHER CELL ADHESION MOLECULE-RELATED_DOWN-REGULATED BY ONCOGENES UniProtKB/Swiss-Prot
  PROTEIN SIDEKICK UniProtKB/Swiss-Prot
Pfam fn3 UniProtKB/Swiss-Prot
  I-set UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
PhenoGen Cdon PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011789 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot
  IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
UniProt A0A8I6A2E2 ENTREZGENE, UniProtKB/TrEMBL
  A6JYK5 ENTREZGENE, UniProtKB/TrEMBL
  CDON_RAT UniProtKB/Swiss-Prot
  G3V7K7 ENTREZGENE, UniProtKB/TrEMBL
  O35158 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Cdon  cell adhesion associated, oncogene regulated  Cdon  Cdon homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Cdon  Cdon homolog (mouse)  Cdon  cell adhesion molecule-related/down-regulated by oncogenes  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cdon  cell adhesion molecule-related/down-regulated by oncogenes  Cdo  immunoglobulin superfamily member  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at low levels in most adult rat tissues 1299440
gene_regulation rapidly and transiently down-regulated by serum stimulation and constitutively down-regulated in oncogene-transformed cells 1299440