Cdon (cell adhesion associated, oncogene regulated) - Rat Genome Database

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Gene: Cdon (cell adhesion associated, oncogene regulated) Rattus norvegicus
Analyze
Symbol: Cdon
Name: cell adhesion associated, oncogene regulated
RGD ID: 708433
Description: Involved in cell adhesion. Acts upstream of or within smoothened signaling pathway. Located in cell surface. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated); PARTICIPATES IN Hedgehog signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cdo; Cdon homolog; Cdon homolog (mouse); cell adhesion molecule-related/down-regulated by oncogenes; immunoglobulin superfamily member
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2833,775,123 - 33,861,635 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl833,806,183 - 33,859,033 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx837,882,852 - 37,935,670 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0836,165,909 - 36,218,724 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0834,028,733 - 34,081,547 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0836,625,757 - 36,712,091 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl836,625,733 - 36,710,949 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0836,642,905 - 36,728,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4835,238,899 - 35,291,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1835,247,664 - 35,300,509 (+)NCBI
Celera835,227,303 - 35,280,140 (+)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. Bae GU, etal., Am J Hum Genet. 2011 Aug 12;89(2):231-40. doi: 10.1016/j.ajhg.2011.07.001. Epub 2011 Jul 28.
2. Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation. Bae GU, etal., Mol Cell Biol. 2009 Aug;29(15):4130-43. doi: 10.1128/MCB.00199-09. Epub 2009 May 26.
3. Interactions between Hedgehog proteins and their binding partners come into view. Beachy PA, etal., Genes Dev. 2010 Sep 15;24(18):2001-12.
4. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia. Kahn BM, etal., Dis Model Mech. 2017 Jan 1;10(1):29-37. doi: 10.1242/dmm.026195. Epub 2016 Nov 24.
7. CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family. Kang JS, etal., J Cell Biol 1997 Jul 14;138(1):203-13.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Triphalangeal thumb-polysyndactyly syndrome and syndactyly type IV are caused by genomic duplications involving the long range, limb-specific SHH enhancer. Sun M, etal., J Med Genet. 2008 Sep;45(9):589-95. doi: 10.1136/jmg.2008.057646. Epub 2008 Apr 16.
15. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Zhang W, etal., Dev Cell. 2006 May;10(5):657-65. Epub 2006 Apr 27.
Additional References at PubMed
PMID:15520228   PMID:15572127   PMID:16647304   PMID:16648472   PMID:17504941   PMID:19244314   PMID:19754878   PMID:20160094  


Genomics

Comparative Map Data
Cdon
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2833,775,123 - 33,861,635 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl833,806,183 - 33,859,033 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx837,882,852 - 37,935,670 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0836,165,909 - 36,218,724 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0834,028,733 - 34,081,547 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0836,625,757 - 36,712,091 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl836,625,733 - 36,710,949 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0836,642,905 - 36,728,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4835,238,899 - 35,291,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1835,247,664 - 35,300,509 (+)NCBI
Celera835,227,303 - 35,280,140 (+)NCBICelera
Cytogenetic Map8q21NCBI
CDON
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811125,956,821 - 126,063,352 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11125,955,796 - 126,063,335 (-)EnsemblGRCh38hg38GRCh38
GRCh3711125,826,716 - 125,933,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611125,331,923 - 125,438,397 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411125,335,783 - 125,438,397NCBI
Celera11122,988,054 - 123,098,575 (-)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11121,768,684 - 121,875,085 (-)NCBIHuRef
CHM1_111125,713,444 - 125,819,847 (-)NCBICHM1_1
T2T-CHM13v2.011125,985,675 - 126,092,163 (-)NCBIT2T-CHM13v2.0
Cdon
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39935,332,836 - 35,418,948 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl935,332,424 - 35,418,948 (+)EnsemblGRCm39 Ensembl
GRCm38935,421,528 - 35,507,652 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl935,421,128 - 35,507,652 (+)EnsemblGRCm38mm10GRCm38
MGSCv37935,259,661 - 35,315,237 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36935,201,747 - 35,254,013 (+)NCBIMGSCv36mm8
Celera932,686,755 - 32,744,725 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.24NCBI
Cdon
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541227,003,919 - 27,065,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541227,004,391 - 27,093,968 (-)NCBIChiLan1.0ChiLan1.0
CDON
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan111127,750,426 - 127,853,585 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011120,772,160 - 120,877,529 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111124,685,084 - 124,789,649 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11124,685,084 - 124,786,091 (-)Ensemblpanpan1.1panPan2
CDON
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.158,439,606 - 8,536,088 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl58,446,346 - 8,533,426 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha58,496,514 - 8,595,988 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.058,391,957 - 8,491,851 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl58,391,716 - 8,489,974 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.158,460,126 - 8,560,018 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.058,434,443 - 8,534,264 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.058,468,718 - 8,568,231 (+)NCBIUU_Cfam_GSD_1.0
Cdon
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947108,178,109 - 108,358,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365726,176,255 - 6,272,260 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365726,176,267 - 6,268,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDON
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl953,079,550 - 53,178,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1953,079,543 - 53,178,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CDON
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11117,091,778 - 117,255,354 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1117,092,178 - 117,152,030 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660438,742,602 - 8,983,460 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdon
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624812109,405 - 203,519 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624812107,632 - 203,791 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdon
265 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:420
Count of miRNA genes:196
Interacting mature miRNAs:232
Transcripts:ENSRNOT00000016248, ENSRNOT00000065358
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83084815440713225Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat

Markers in Region
AF090866  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2833,858,256 - 33,858,336 (+)MAPPERmRatBN7.2
Rnor_6.0836,708,714 - 36,708,793NCBIRnor6.0
Rnor_5.0836,725,200 - 36,725,279UniSTSRnor5.0
RGSC_v3.4835,290,967 - 35,291,046UniSTSRGSC3.4
Celera835,279,364 - 35,279,443UniSTS
Cytogenetic Map8q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 10 4 2 4 3 3 52 18 33 11 3
Low 3 19 47 37 17 37 5 8 22 17 7 5
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016248   ⟹   ENSRNOP00000016247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl833,806,183 - 33,859,033 (+)Ensembl
Rnor_6.0 Ensembl836,625,733 - 36,710,949 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103041   ⟹   ENSRNOP00000085481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl833,806,183 - 33,859,033 (+)Ensembl
RefSeq Acc Id: NM_017358   ⟹   NP_059054
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2833,806,183 - 33,859,033 (+)NCBI
Rnor_6.0836,656,644 - 36,709,490 (+)NCBI
Rnor_5.0836,642,905 - 36,728,577 (+)NCBI
RGSC_v3.4835,238,899 - 35,291,743 (+)RGD
Celera835,227,303 - 35,280,140 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242791   ⟹   XP_006242853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2833,775,124 - 33,861,635 (+)NCBI
Rnor_6.0836,625,757 - 36,712,091 (+)NCBI
Rnor_5.0836,642,905 - 36,728,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242792   ⟹   XP_006242854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2833,782,440 - 33,859,033 (+)NCBI
Rnor_6.0836,632,877 - 36,712,091 (+)NCBI
Rnor_5.0836,642,905 - 36,728,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242793   ⟹   XP_006242855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2833,775,123 - 33,861,635 (+)NCBI
Rnor_6.0836,625,757 - 36,712,091 (+)NCBI
Rnor_5.0836,642,905 - 36,728,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082008   ⟹   XP_038937936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2833,777,248 - 33,859,033 (+)NCBI
RefSeq Acc Id: XR_005487905
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2833,775,123 - 33,831,356 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_059054   ⟸   NM_017358
- Peptide Label: precursor
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   G3V7K7 (UniProtKB/TrEMBL),   A6JYK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242853   ⟸   XM_006242791
- Peptide Label: isoform X1
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   G3V7K7 (UniProtKB/TrEMBL),   A6JYK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242855   ⟸   XM_006242793
- Peptide Label: isoform X2
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   A0A8I6A2E2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242854   ⟸   XM_006242792
- Peptide Label: isoform X1
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   G3V7K7 (UniProtKB/TrEMBL),   A6JYK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016247   ⟸   ENSRNOT00000016248
RefSeq Acc Id: XP_038937936   ⟸   XM_039082008
- Peptide Label: isoform X1
- UniProtKB: O35158 (UniProtKB/Swiss-Prot),   G3V7K7 (UniProtKB/TrEMBL),   A6JYK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085481   ⟸   ENSRNOT00000103041
Protein Domains
Fibronectin type-III   Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35158-F1-model_v2 AlphaFold O35158 1-1256 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708433 AgrOrtholog
BioCyc Gene G2FUF-31174 BioCyc
Ensembl Genes ENSRNOG00000011789 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016247 ENTREZGENE
  ENSRNOP00000016247.1 UniProtKB/TrEMBL
  ENSRNOP00000085481 ENTREZGENE
  ENSRNOP00000085481.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016248 ENTREZGENE
  ENSRNOT00000016248.5 UniProtKB/TrEMBL
  ENSRNOT00000103041 ENTREZGENE
  ENSRNOT00000103041.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50938 UniProtKB/Swiss-Prot
NCBI Gene 50938 ENTREZGENE
PANTHER PROTEIN SIDEKICK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR44170:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdon PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2E2 ENTREZGENE, UniProtKB/TrEMBL
  A6JYK5 ENTREZGENE, UniProtKB/TrEMBL
  CDON_RAT UniProtKB/Swiss-Prot
  G3V7K7 ENTREZGENE, UniProtKB/TrEMBL
  O35158 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Cdon  cell adhesion associated, oncogene regulated  Cdon  Cdon homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Cdon  Cdon homolog (mouse)  Cdon  cell adhesion molecule-related/down-regulated by oncogenes  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cdon  cell adhesion molecule-related/down-regulated by oncogenes  Cdo  immunoglobulin superfamily member  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at low levels in most adult rat tissues 1299440
gene_regulation rapidly and transiently down-regulated by serum stimulation and constitutively down-regulated in oncogene-transformed cells 1299440