F11 (coagulation factor XI) - Rat Genome Database

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Gene: F11 (coagulation factor XI) Rattus norvegicus
Analyze
Symbol: F11
Name: coagulation factor XI
RGD ID: 1309364
Description: Enables serine-type aminopeptidase activity. Predicted to be involved in blood coagulation; plasminogen activation; and positive regulation of fibrinolysis. Predicted to act upstream of or within regulation of blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in factor XI deficiency and thrombosis. Orthologous to human F11 (coagulation factor XI); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290757; LRRGT00086
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,720,502 - 53,741,547 (+)NCBIGRCr8
mRatBN7.21646,987,988 - 47,009,015 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,986,107 - 47,008,437 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1652,378,899 - 52,400,805 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,756,360 - 55,778,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01651,018,291 - 51,040,195 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,179,458 - 50,201,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,179,458 - 50,201,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,902,415 - 49,924,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,276,330 - 50,298,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11650,287,001 - 50,298,978 (+)NCBI
Celera1644,976,615 - 44,998,530 (+)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Factor XI (plasma thromboplastin antecedent) deficiency in Ashkenazi Jews is a bleeding disorder that can result from three types of point mutations. Asakai R, etal., Proc Natl Acad Sci U S A. 1989 Oct;86(20):7667-71.
2. Noonan syndrome: partial factor XI deficiency. de Haan M, etal., Am J Med Genet. 1988 Feb;29(2):277-82.
3. A monoclonal antibody to high-molecular weight kininogen is therapeutic in a rodent model of reactive arthritis. Espinola RG, etal., Am J Pathol. 2004 Sep;165(3):969-76.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. Kleinschnitz C, etal., J Exp Med. 2006 Mar 20;203(3):513-8. Epub 2006 Mar 13.
6. Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. Laudes IJ, etal., Am J Pathol. 2002 May;160(5):1867-75.
7. Genetic variants associated with deep vein thrombosis: the F11 locus. Li Y, etal., J Thromb Haemost. 2009 Nov;7(11):1802-8. doi: 10.1111/j.1538-7836.2009.03544.x. Epub 2009 Jul 6.
8. The F11 rs2289252 polymorphism is associated with FXI activity levels and APTT ratio in women with thrombosis. Lunghi B, etal., Thromb Res. 2012 Sep;130(3):563-4. doi: 10.1016/j.thromres.2012.05.004. Epub 2012 May 25.
9. High levels of coagulation factor XI as a risk factor for venous thrombosis. Meijers JC, etal., N Engl J Med. 2000 Mar 9;342(10):696-701.
10. Age-related changes in coagulation, fibrinolysis, and platelet aggregation in male WBN/Kob rats. Nobukata H, etal., Thromb Res. 2000 Jun 15;98(6):507-16.
11. Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats. Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101.
12. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. A novel mutation that leads to a congenital factor XI deficiency in a Japanese family. Sato E, etal., Am J Hematol. 2000 Apr;63(4):165-9.
19. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
20. Activity of coagulation factor XI in patients with spontaneous miscarriage: the presence of risk alleles. Sokol J, etal., J Obstet Gynaecol. 2015;35(6):621-4. doi: 10.3109/01443615.2014.991284. Epub 2014 Dec 17.
21. Molecular genetic analysis of factor XI deficiency: identification of five novel gene alterations and the origin of type II mutation in Portuguese families. Ventura C, etal., Thromb Haemost. 2000 Nov;84(5):833-40.
Additional References at PubMed
PMID:89876   PMID:9169594   PMID:16699514   PMID:17884987   PMID:19056867   PMID:23376485  


Genomics

Comparative Map Data
F11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,720,502 - 53,741,547 (+)NCBIGRCr8
mRatBN7.21646,987,988 - 47,009,015 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,986,107 - 47,008,437 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1652,378,899 - 52,400,805 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,756,360 - 55,778,414 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01651,018,291 - 51,040,195 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,179,458 - 50,201,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,179,458 - 50,201,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,902,415 - 49,924,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,276,330 - 50,298,903 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11650,287,001 - 50,298,978 (+)NCBI
Celera1644,976,615 - 44,998,530 (+)NCBICelera
Cytogenetic Map16q11NCBI
F11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384186,266,189 - 186,289,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4186,266,189 - 186,289,681 (+)EnsemblGRCh38hg38GRCh38
GRCh374187,187,343 - 187,210,835 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,424,112 - 187,447,829 (+)NCBINCBI36Build 36hg18NCBI36
Build 344187,562,426 - 187,585,083NCBI
Celera4184,511,477 - 184,537,546 (+)NCBICelera
Cytogenetic Map4q35.2NCBI
HuRef4182,938,469 - 182,962,233 (+)NCBIHuRef
CHM1_14187,163,556 - 187,187,273 (+)NCBICHM1_1
T2T-CHM13v2.04189,606,162 - 189,629,664 (+)NCBIT2T-CHM13v2.0
F11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,693,696 - 45,715,092 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl845,694,211 - 45,715,068 (-)EnsemblGRCm39 Ensembl
GRCm38845,240,659 - 45,262,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,241,174 - 45,262,031 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,326,524 - 46,347,385 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36846,739,987 - 46,760,848 (-)NCBIMGSCv36mm8
Celera847,928,261 - 47,949,034 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map825.14NCBI
F11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,811,380 - 22,830,563 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,811,211 - 22,830,281 (-)NCBIChiLan1.0ChiLan1.0
F11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23184,008,843 - 184,033,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14184,357,677 - 184,381,996 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04178,436,865 - 178,459,568 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14190,643,733 - 190,666,512 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,643,733 - 190,666,512 (+)Ensemblpanpan1.1panPan2
F11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,469,609 - 44,492,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1644,469,632 - 44,540,292 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1644,956,542 - 44,972,975 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01646,683,089 - 46,700,923 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1646,683,106 - 46,700,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11644,652,096 - 44,668,510 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01645,264,846 - 45,281,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01645,395,778 - 45,412,243 (-)NCBIUU_Cfam_GSD_1.0
LOC101967202
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,886,563 - 34,903,578 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365543,205,539 - 3,219,311 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365543,205,539 - 3,223,228 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,046,002 - 9,073,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,045,990 - 9,073,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
F11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17132,180,026 - 132,207,081 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7132,180,336 - 132,208,155 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037112,505,568 - 112,530,733 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476917,094,169 - 17,115,222 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476917,093,643 - 17,115,716 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F11
284 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:103
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000041946
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 128 128 128 25
Low 27 7 12 7 5 3 3 16 22 3
Below cutoff 15 40 52 12 45 12 20 25 170 31 89 18

Sequence


Ensembl Acc Id: ENSRNOT00000041946   ⟹   ENSRNOP00000044970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,986,107 - 47,008,437 (+)Ensembl
Rnor_6.0 Ensembl1650,179,458 - 50,201,373 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077662   ⟹   ENSRNOP00000073061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,987,902 - 47,008,437 (+)Ensembl
Rnor_6.0 Ensembl1650,181,316 - 50,201,698 (+)Ensembl
RefSeq Acc Id: NM_001411666   ⟹   NP_001398595
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,720,502 - 53,740,949 (+)NCBI
mRatBN7.21646,987,988 - 47,008,435 (+)NCBI
RefSeq Acc Id: XM_006253145   ⟹   XP_006253207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,728,414 - 53,741,547 (+)NCBI
mRatBN7.21646,995,900 - 47,009,015 (+)NCBI
Rnor_6.01650,189,642 - 50,201,644 (+)NCBI
Rnor_5.01649,902,415 - 49,924,601 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001398595 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253207 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ91042 (Get FASTA)   NCBI Sequence Viewer  
  EDL78852 (Get FASTA)   NCBI Sequence Viewer  
  EDL78853 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044970.1
  ENSRNOP00000073061.2
RefSeq Acc Id: XP_006253207   ⟸   XM_006253145
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4I9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073061   ⟸   ENSRNOT00000077662
Ensembl Acc Id: ENSRNOP00000044970   ⟸   ENSRNOT00000041946
RefSeq Acc Id: NP_001398595   ⟸   NM_001411666
- Peptide Label: precursor
- UniProtKB: A0A0G2K4I9 (UniProtKB/TrEMBL)
Protein Domains
Apple   Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4I9-F1-model_v2 AlphaFold A0A0G2K4I9 1-622 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700114
Promoter ID:EPDNEW_R10635
Type:initiation region
Name:F11_1
Description:coagulation factor XI
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01650,181,306 - 50,181,366EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309364 AgrOrtholog
BioCyc Gene G2FUF-11310 BioCyc
Ensembl Genes ENSRNOG00000013684 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041946.3 UniProtKB/TrEMBL
  ENSRNOT00000077662.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  Hepatocyte Growth Factor UniProtKB/TrEMBL
InterPro Apple UniProtKB/TrEMBL
  Pan_app UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene 290757 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  COAGULATION FACTOR XI UniProtKB/TrEMBL
  HYALIN UniProtKB/TrEMBL
  PTHR33946 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE 3-LIKE UniProtKB/TrEMBL
Pfam PAN_1 UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PhenoGen F11 PhenoGen
PRINTS APPLEDOMAIN UniProtKB/TrEMBL
  CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE APPLE UniProtKB/TrEMBL
  PAN UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013684 RatGTEx
SMART APPLE UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Hairpin loop containing domain-like UniProtKB/TrEMBL
  Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A0A0G2K4I9 ENTREZGENE, UniProtKB/TrEMBL
  A6JPR9_RAT UniProtKB/TrEMBL
  A6JPS0_RAT UniProtKB/TrEMBL
  Q6TUF8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 F11  coagulation factor XI  F11_predicted  coagulation factor XI (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 F11_predicted  coagulation factor XI (predicted)      Symbol and Name status set to approved 70820 APPROVED