F8 (coagulation factor VIII) - Rat Genome Database
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Gene: F8 (coagulation factor VIII) Rattus norvegicus
Analyze
Symbol: F8
Name: coagulation factor VIII
RGD ID: 727845
Description: Predicted to have copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Localizes to extracellular space. Used to study factor VIII deficiency and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: coagulation factor VIII, procoagulant component
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: F8m1Ycb   F8em1Sage   F8em1Mcwi  
Genetic Models: SD/Novo-F8em1Sage-/- SD/Novo-F8em1Sage SD/Novo-F8em1Sage+/- SS-F8em1Mcwi WAG-F8m1Ycb
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.018367,862 - 399,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18367,862 - 399,242 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018413,447 - 444,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418121,134 - 162,008 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.118121,133 - 162,008 (+)NCBI
Celera18135,235 - 166,779 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amphibole asbestos  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Ethyl icosapentate  (EXP)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (ISO)
gestodene  (ISO)
glycine betaine  (ISO)
irinotecan  (ISO)
levonorgestrel  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
norgestimate  (ISO)
orphenadrine  (EXP)
paracetamol  (ISO)
phenobarbital  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
sodium dodecyl sulfate  (ISO)
tamoxifen  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. Akkarapatumwong V, etal., Hum Mutat. 2000 Jan;15(1):117-8.
2. Bank I, etal., J Thromb Haemost. 2005 Jan;3(1):79-84.
3. Booth CJ, etal., J Thromb Haemost. 2010 Nov;8(11):2472-7. doi: 10.1111/j.1538-7836.2010.03978.x.
4. Cangoz E, etal., Pediatr Hematol Oncol. 2004 Apr-May;21(3):255-60.
5. Ebbesen LS and Ingerslev J, J Nutr. 2005 Aug;135(8):1836-40.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Guillet B, etal., Hum Mutat. 2006 Jul;27(7):676-85.
8. Hellman L, etal., Br J Haematol. 1989 Nov;73(3):348-55.
9. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
10. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
11. MGD data from the GO Consortium
12. NCBI rat LocusLink and RefSeq merged data October 15, 2003
13. Nielsen LN, etal., J Thromb Haemost. 2014 Aug;12(8):1274-82. doi: 10.1111/jth.12635.
14. Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101.
15. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
16. OMIM Disease Annotation Pipeline
17. Pipeline to import KEGG annotations from KEGG into RGD
18. Pipeline to import SMPDB annotations from SMPDB into RGD
19. RGD automated data pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
23. VandenDriessche T, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10379-84.
24. Watzka M, etal., Thromb Haemost 2004 Jan;91(1):38-42.
25. Yamaguchi K, etal., Shock. 2000 Nov;14(5):535-43.
26. Zhang YJ, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Feb;13(1):110-3.
Additional References at PubMed
PMID:27681457  


Genomics

Comparative Map Data
F8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.018367,862 - 399,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18367,862 - 399,242 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018413,447 - 444,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418121,134 - 162,008 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.118121,133 - 162,008 (+)NCBI
Celera18135,235 - 166,779 (+)NCBICelera
Cytogenetic Map18p13NCBI
F8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX154,835,788 - 155,026,940 (-)EnsemblGRCh38hg38GRCh38
GRCh38X154,835,792 - 155,022,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X154,064,063 - 154,255,351 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,717,260 - 153,904,192 (-)NCBINCBI36hg18NCBI36
Build 34X153,627,773 - 153,678,176NCBI
CeleraX154,222,608 - 154,409,733 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,607,715 - 142,796,096 (-)NCBIHuRef
CHM1_1X153,975,773 - 154,162,623 (-)NCBICHM1_1
F8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,213,950 - 74,426,342 (-)NCBIGRCm39mm39
GRCm38X75,170,344 - 75,382,738 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,172,715 - 75,382,615 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X72,418,054 - 72,625,380 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X71,425,450 - 71,632,761 (-)NCBImm8
CeleraX66,576,966 - 66,780,957 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.17NCBI
F8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594658,523 - 802,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955594658,686 - 800,101 (+)NCBIChiLan1.0ChiLan1.0
F8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X154,156,864 - 154,345,635 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX154,156,873 - 154,341,317 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X144,316,192 - 144,505,773 (-)NCBIMhudiblu_PPA_v0panPan3
F8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX122,885,162 - 123,043,414 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X122,894,974 - 123,046,343 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
F8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936927189,359 - 301,791 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,265,337 - 125,350,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,265,330 - 125,350,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,132,160 - 143,217,828 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 EnsemblX129,088,611 - 129,312,909 (-)Ensembl
ChlSab1.1X129,090,140 - 129,315,343 (-)NCBI
F8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624963252,943 - 424,718 (+)NCBI

Position Markers
RH139018  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.018391,522 - 391,729NCBIRnor6.0
Rnor_5.018437,107 - 437,314UniSTSRnor5.0
RGSC_v3.418137,921 - 138,128UniSTSRGSC3.4
Celera18142,944 - 143,151UniSTS
Cytogenetic Map18p13UniSTS
RH 3.4 Map101072.6UniSTS
BI275668  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.018367,555 - 367,644NCBIRnor6.0
Rnor_5.018413,140 - 413,229UniSTSRnor5.0
RGSC_v3.418162,226 - 162,315UniSTSRGSC3.4
Celera18166,997 - 167,086UniSTS
Cytogenetic Map18p13UniSTS
RH 3.4 Map1835.0UniSTS
AI234173  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.018367,416 - 367,578NCBIRnor6.0
Rnor_5.018413,001 - 413,163UniSTSRnor5.0
RGSC_v3.418162,292 - 162,454UniSTSRGSC3.4
Celera18167,063 - 167,225UniSTS
Cytogenetic Map18p13UniSTS
RH 3.4 Map1835.0UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125999214Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125999214Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135097280Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18138195967Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18138195967Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18138753381Rat


Genetic Models
This gene F8 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:138
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000045926
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 10 2 12 2 20 18 32 11
Low 3 41 47 39 7 39 8 11 54 17 9 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045926   ⟹   ENSRNOP00000050792
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl18367,862 - 399,242 (-)Ensembl
RefSeq Acc Id: NM_183331   ⟹   NP_899160
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.018367,862 - 399,242 (-)NCBI
Rnor_5.018413,447 - 444,491 (-)NCBI
RGSC_v3.418121,134 - 162,008 (+)RGD
Celera18135,235 - 166,779 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_899160 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ21580 (Get FASTA)   NCBI Sequence Viewer  
  ADU79112 (Get FASTA)   NCBI Sequence Viewer  
  ADU79113 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_899160   ⟸   NM_183331
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000050792   ⟸   ENSRNOT00000045926
Protein Domains
F5/8 type C

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700623
Promoter ID:EPDNEW_R11147
Type:initiation region
Name:F8_1
Description:coagulation factor VIII
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.018399,292 - 399,352EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727845 AgrOrtholog
Ensembl Genes ENSRNOG00000031197 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050792 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045926 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.260 UniProtKB/TrEMBL
  2.60.40.420 UniProtKB/TrEMBL
InterPro Coagulation_factor_5/8-type_C UniProtKB/TrEMBL
  Cu-oxidase_2 UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/TrEMBL
  Cu_oxidase_CS UniProtKB/TrEMBL
  Cupredoxin UniProtKB/TrEMBL
  Factor_5/8_like UniProtKB/TrEMBL
  Factor_8 UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
KEGG Report rno:302470 UniProtKB/TrEMBL
NCBI Gene 302470 ENTREZGENE
PANTHER PTHR24543:SF249 UniProtKB/TrEMBL
Pfam Cu-oxidase_2 UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/TrEMBL
PharmGKB F8 RGD
PhenoGen F8 PhenoGen
PIRSF Factors_V_VIII UniProtKB/TrEMBL
PROSITE FA58C_1 UniProtKB/TrEMBL
  FA58C_2 UniProtKB/TrEMBL
  FA58C_3 UniProtKB/TrEMBL
  MULTICOPPER_OXIDASE1 UniProtKB/TrEMBL
SMART FA58C UniProtKB/TrEMBL
Superfamily-SCOP Cupredoxin UniProtKB/TrEMBL
  Gal_bind_like UniProtKB/TrEMBL
UniGene Rn.95452 ENTREZGENE
UniProt D3ZEB1_RAT UniProtKB/TrEMBL
  Q7TN96_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 F8  coagulation factor VIII  F8  coagulation factor VIII  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-20 F8  coagulation factor VIII  F8  coagulation factor VIII, procoagulant component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 F8  coagulation factor VIII, procoagulant component  F8  coagulation factor VIII  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED