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Gene: F8 (coagulation factor VIII) Rattus norvegicus
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Symbol: F8
Name: coagulation factor VIII
Description: Predicted to have copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Localizes to the extracellular space. Used to study factor VIII deficiency and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: coagulation factor VIII, procoagulant component
Orthologs:
Homo sapiens (human) : F8 (coagulation factor VIII)  HGNC  Alliance
Mus musculus (house mouse) : F8 (coagulation factor VIII)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F8 (coagulation factor VIII)
Pan paniscus (bonobo/pygmy chimpanzee) : F8 (coagulation factor VIII)
Canis lupus familiaris (dog) : F8 (coagulation factor VIII)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F8 (coagulation factor VIII)
Sus scrofa (pig) : F8 (coagulation factor VIII)
more info ...
Allele / Splice: F8m1Ycb   F8em1Sage   F8em1Mcwi  
Genetic Models: SD/Novo-F8em1Sage-/- SD/Novo-F8em1Sage SD/Novo-F8em1Sage+/- SS-F8em1Mcwi WAG-F8m1Ycb
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.018367,862 - 399,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18367,862 - 399,242 (-)Ensembl
Rnor_5.018413,447 - 444,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418121,134 - 162,008 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.118121,133 - 162,008 (+)NCBI
Celera18135,235 - 166,779 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on F8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 727845
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.