Stk26 (serine/threonine kinase 26) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Stk26 (serine/threonine kinase 26) Rattus norvegicus
Analyze
Symbol: Stk26
Name: serine/threonine kinase 26
RGD ID: 1563568
Description: Predicted to enable ion binding activity; protein homodimerization activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including microvillus assembly; response to hydrogen peroxide; and stress-activated protein kinase signaling cascade. Located in Golgi membrane. Orthologous to human STK26 (serine/threonine kinase 26); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC317589; Mask; Mst4; RGD1563568; serine/threonine protein kinase 26; serine/threonine protein kinase MST4; serine/threonine-protein kinase 26; serine/threonine-protein kinase MST4; similar to serine/threonine protein kinase MST4a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X135,195,176 - 135,259,994 (+)NCBIGRCr8
mRatBN7.2X130,325,064 - 130,375,674 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX130,310,885 - 130,374,291 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX132,445,297 - 132,495,904 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X136,027,191 - 136,077,794 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X133,590,437 - 133,641,092 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X138,032,356 - 138,096,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX138,046,494 - 138,096,669 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X138,091,166 - 138,155,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X137,577,961 - 137,627,511 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX129,243,275 - 129,292,475 (+)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation. Fidalgo M, etal., J Cell Sci. 2010 Apr 15;123(Pt 8):1274-84. doi: 10.1242/jcs.061341. Epub 2010 Mar 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11641781   PMID:11741893   PMID:15037601   PMID:17360971   PMID:21561863   PMID:22291017   PMID:22797597   PMID:23533145   PMID:27807006  


Genomics

Comparative Map Data
Stk26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X135,195,176 - 135,259,994 (+)NCBIGRCr8
mRatBN7.2X130,325,064 - 130,375,674 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX130,310,885 - 130,374,291 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX132,445,297 - 132,495,904 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X136,027,191 - 136,077,794 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X133,590,437 - 133,641,092 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X138,032,356 - 138,096,632 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX138,046,494 - 138,096,669 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X138,091,166 - 138,155,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X137,577,961 - 137,627,511 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX129,243,275 - 129,292,475 (+)NCBICelera
Cytogenetic MapXq36NCBI
STK26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X132,023,302 - 132,075,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX132,023,302 - 132,075,943 (+)EnsemblGRCh38hg38GRCh38
GRCh37X131,157,330 - 131,209,971 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X130,984,926 - 131,037,652 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX131,543,656 - 131,596,380 (+)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX120,561,932 - 120,614,415 (+)NCBIHuRef
CHM1_1X131,068,821 - 131,121,548 (+)NCBICHM1_1
T2T-CHM13v2.0X130,347,539 - 130,400,176 (+)NCBIT2T-CHM13v2.0
Stk26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X49,930,052 - 49,981,980 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX49,929,924 - 49,981,974 (+)EnsemblGRCm39 Ensembl
GRCm38X50,841,174 - 50,893,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX50,841,047 - 50,893,097 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X48,194,613 - 48,245,033 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X47,086,063 - 47,136,483 (+)NCBIMGSCv36mm8
CeleraX38,259,039 - 38,309,780 (+)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX27.5NCBI
Stk26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554732,819,585 - 2,878,561 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554732,819,644 - 2,878,561 (-)NCBIChiLan1.0ChiLan1.0
STK26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X131,449,104 - 131,501,584 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X131,452,713 - 131,505,193 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X121,155,443 - 121,207,906 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X131,462,895 - 131,515,429 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX131,463,187 - 131,515,429 (+)Ensemblpanpan1.1panPan2
STK26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X102,962,012 - 103,026,278 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX102,961,648 - 103,024,503 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX89,134,974 - 89,199,270 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X104,849,346 - 104,886,322 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX104,836,856 - 104,886,320 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X102,232,961 - 102,297,253 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X104,109,765 - 104,173,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X103,880,672 - 103,944,681 (+)NCBIUU_Cfam_GSD_1.0
Stk26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X101,130,295 - 101,199,432 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366912,757,934 - 2,811,937 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366912,757,934 - 2,811,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX108,178,698 - 108,239,042 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X108,179,230 - 108,237,669 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X124,210,635 - 124,230,967 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X107,179,800 - 107,233,336 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX107,181,020 - 107,233,332 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606544,641,530 - 44,693,955 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479711,714,508 - 11,768,800 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479711,714,548 - 11,768,712 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stk26
140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:58
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000010596
Prediction methods:Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 12 14 6 19 6 2 18 31 4
Low 1 29 36 28 28 8 8 72 17 10 7 8
Below cutoff 2 7 7 7 3

Sequence


RefSeq Acc Id: ENSRNOT00000010596   ⟹   ENSRNOP00000010596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX130,325,066 - 130,374,291 (+)Ensembl
Rnor_6.0 EnsemblX138,046,494 - 138,096,669 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099912   ⟹   ENSRNOP00000084325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX130,310,885 - 130,374,291 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104737   ⟹   ENSRNOP00000082800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX130,352,955 - 130,372,258 (+)Ensembl
RefSeq Acc Id: NM_001191736   ⟹   NP_001178665
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X135,209,386 - 135,259,994 (+)NCBI
mRatBN7.2X130,325,064 - 130,375,674 (+)NCBI
Rnor_6.0X138,046,539 - 138,095,249 (+)NCBI
Rnor_5.0X138,091,166 - 138,155,429 (+)NCBI
CeleraX129,243,275 - 129,292,475 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063280092   ⟹   XP_063136162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X135,195,176 - 135,259,994 (+)NCBI
RefSeq Acc Id: XM_063280093   ⟹   XP_063136163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X135,195,176 - 135,259,994 (+)NCBI
RefSeq Acc Id: NP_001178665   ⟸   NM_001191736
- UniProtKB: A6JMS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010596   ⟸   ENSRNOT00000010596
RefSeq Acc Id: ENSRNOP00000082800   ⟸   ENSRNOT00000104737
RefSeq Acc Id: ENSRNOP00000084325   ⟸   ENSRNOT00000099912
RefSeq Acc Id: XP_063136162   ⟸   XM_063280092
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136163   ⟸   XM_063280093
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LXV3-F1-model_v2 AlphaFold F1LXV3 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702017
Promoter ID:EPDNEW_R12541
Type:initiation region
Name:Stk26_1
Description:serine/threonine kinase 26
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X138,046,540 - 138,046,600EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563568 AgrOrtholog
BioCyc Gene G2FUF-1053 BioCyc
Ensembl Genes ENSRNOG00000007879 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010596 ENTREZGENE
  ENSRNOT00000010596.8 UniProtKB/TrEMBL
  ENSRNOT00000099912.1 UniProtKB/TrEMBL
  ENSRNOT00000104737.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.12.70 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  PDC10_dimerisation_sf UniProtKB/TrEMBL
  PDCD10_N UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  STK_MST4 UniProtKB/TrEMBL
NCBI Gene 317589 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE 26 UniProtKB/TrEMBL
  STERILE20-LIKE KINASE, ISOFORM B-RELATED UniProtKB/TrEMBL
Pfam PDCD10_N UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Stk26 PhenoGen
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007879 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZV99_RAT UniProtKB/TrEMBL
  A0A8I6GBQ0_RAT UniProtKB/TrEMBL
  A6JMS9 ENTREZGENE, UniProtKB/TrEMBL
  F1LXV3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-03 Stk26  serine/threonine kinase 26  Stk26  serine/threonine protein kinase 26  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-09-24 Stk26  serine/threonine protein kinase 26  Mst4  serine/threonine protein kinase MST4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-02-04 Mst4  serine/threonine protein kinase MST4  Mask  serine/threonine protein kinase MST4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-01-14 Mask  serine/threonine protein kinase MST4  Mst4  serine/threonine protein kinase MST4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Mst4  serine/threonine protein kinase MST4  RGD1563568_predicted  similar to serine/threonine protein kinase MST4a (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563568_predicted  similar to serine/threonine protein kinase MST4a (predicted)  LOC317589  similar to serine/threonine protein kinase MST4a  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317589  similar to serine/threonine protein kinase MST4a      Symbol and Name status set to provisional 70820 PROVISIONAL