F2r (coagulation factor II (thrombin) receptor) - Rat Genome Database

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Gene: F2r (coagulation factor II (thrombin) receptor) Rattus norvegicus
Analyze
Symbol: F2r
Name: coagulation factor II (thrombin) receptor
RGD ID: 2586
Description: Predicted to enable several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and thrombin-activated receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; establishment of synaptic specificity at neuromuscular junction; and negative regulation of glomerular filtration. Located in neuromuscular junction and postsynaptic membrane. Used to study hypertension. Biomarker of brain edema and brain ischemia. Orthologous to human F2R (coagulation factor II thrombin receptor); PARTICIPATES IN G protein mediated signaling pathway; protease mediated signaling via protease-activated receptor 1; calcium/calcium-mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coagulation factor II receptor; MGC93622; PAR-1; Par1; protease-activated receptor 1; proteinase-activated receptor 1; Thrombin receptor; TRGPC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: F2rem1Mcwi  
Genetic Models: T2DN-F2rem1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2226,869,343 - 26,885,856 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,868,404 - 26,885,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,907,656 - 33,924,163 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0232,007,753 - 32,024,260 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0226,823,845 - 26,840,377 (-)NCBIRnor_WKY
Rnor_6.0226,118,760 - 26,135,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,118,760 - 26,135,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,254,489 - 45,257,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,985,800 - 25,989,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,906,181 - 25,909,441 (-)NCBI
Celera222,933,182 - 22,949,696 (-)NCBICelera
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bivalirudin  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etonogestrel  (EXP)
etoposide  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gestodene  (EXP)
glucose  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
lenalidomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
methylparaben  (ISO)
mifepristone  (EXP)
mitomycin C  (ISO)
N-nitrosodimethylamine  (EXP)
nicotinic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
quercetin  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rebaudioside A  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
steviol  (ISO)
stevioside  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
Thrombin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO,ISS)
blood coagulation  (TAS)
cell-cell junction maintenance  (IEA,ISO)
connective tissue replacement involved in inflammatory response wound healing  (IEA,ISO,ISS)
dendritic cell homeostasis  (IEA,ISO)
establishment of synaptic specificity at neuromuscular junction  (IDA)
G protein-coupled receptor signaling pathway  (IDA)
homeostasis of number of cells within a tissue  (IEA,ISO,ISS)
inflammatory response  (ISO,ISS)
negative regulation of cell population proliferation  (IEA,ISO,ISS)
negative regulation of glomerular filtration  (IDA)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of renin secretion into blood stream  (IEA,ISO,ISS)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
platelet activation  (IEA,ISO,ISS)
positive regulation of blood coagulation  (IBA,IEA,ISO,ISS)
positive regulation of calcium ion transport  (IMP)
positive regulation of cell migration  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IDA)
positive regulation of collagen biosynthetic process  (IEA,ISO,ISS)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO,ISS)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IBA,IMP)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
positive regulation of GTPase activity  (IEA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO,ISS)
positive regulation of interleukin-6 production  (IEA,ISO,ISS)
positive regulation of interleukin-8 production  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (IMP,ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA,ISO,ISS)
positive regulation of receptor signaling pathway via JAK-STAT  (ISS)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISO,ISS)
positive regulation of Rho protein signal transduction  (IBA,IEA,ISO,ISS)
positive regulation of smooth muscle contraction  (IDA)
positive regulation of vasoconstriction  (IDA,IEA,ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IMP)
regulation of blood coagulation  (ISO)
regulation of interleukin-1 beta production  (IEA,ISO,ISS)
regulation of sensory perception of pain  (IDA)
release of sequestered calcium ion into cytosol  (IMP)
response to lipopolysaccharide  (IEA,ISO,ISS)
response to wounding  (ISO,ISS)
thrombin-activated receptor signaling pathway  (IEA,ISO,ISS)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (IEA,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Development of proteinase-activated receptor 1 antagonists as therapeutic agents for thrombosis, restenosis and inflammatory diseases. Ahn HS, etal., Curr Pharm Des. 2003;9(28):2349-65.
2. Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli. Asfaha S, etal., Br J Pharmacol. 2002 Mar;135(5):1101-6.
3. Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway. Bouwens EA, etal., J Thromb Haemost. 2013 Jun;11 Suppl 1:242-53. doi: 10.1111/jth.12247.
4. Vascular thrombin receptor regulation in hypertensive rats. Capers Q 4th, etal., Circ Res. 1997 Jun;80(6):838-44.
5. Protease-activated receptor 1 suppresses Helicobacter pylori gastritis via the inhibition of macrophage cytokine secretion and interferon regulatory factor 5. Chionh YT, etal., Mucosal Immunol. 2015 Jan;8(1):68-79. doi: 10.1038/mi.2014.43. Epub 2014 May 28.
6. Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin. Fang M, etal., J Physiol. 2003 Jun 15;549(Pt 3):903-17. Epub 2003 Apr 25.
7. Cross Talk Pathways Between Coagulation and Inflammation. Foley JH and Conway EM, Circ Res. 2016 Apr 29;118(9):1392-408. doi: 10.1161/CIRCRESAHA.116.306853.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Bidirectional regulation of renal hemodynamics by activation of PAR1 and PAR2 in isolated perfused rat kidney. Gui Y, etal., Am J Physiol Renal Physiol. 2003 Jul;285(1):F95-104. Epub 2003 Mar 18.
11. Thrombin-receptor activation and thrombin-induced brain tolerance. Jiang Y, etal., J Cereb Blood Flow Metab. 2002 Apr;22(4):404-10.
12. A protective role of protease-activated receptor 1 in rat gastric mucosa. Kawabata A, etal., Gastroenterology. 2004 Jan;126(1):208-19.
13. Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms. Kawabata A, etal., Life Sci. 2004 Oct 15;75(22):2689-702.
14. The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats. Kawabata A, etal., Peptides. 2002 Jun;23(6):1181-3.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Role and expression of thrombin receptor PAR-1 in muscle cells and neuromuscular junctions during the synapse elimination period in the neonatal rat. Lanuza MA, etal., J Neurosci Res. 2003 Jul 1;73(1):10-21.
17. Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways. Martin L, etal., Pain. 2009 Nov;146(1-2):121-9. doi: 10.1016/j.pain.2009.07.016. Epub 2009 Aug 11.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Thrombin receptor expression in normal and atherosclerotic human arteries. Nelken NA, etal., J Clin Invest. 1992 Oct;90(4):1614-21.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors. Riek-Burchardt M, etal., Neurosci Lett 2002 Aug 30;329(2):181-4.
25. Protease-activated receptor subtype expression in developing eye and adult retina of the rat after optic nerve crush. Rohatgi T, etal., J Neurosci Res 2003 Jul 15;73(2):246-54.
26. Transient focal ischemia in rat brain differentially regulates mRNA expression of protease-activated receptors 1 to 4. Rohatgi T, etal., J Neurosci Res 2004 Jan 15;75(2):273-9.
27. Proteinase-activated receptor (PAR)-1 and -2 agonists induce mediator release from mast cells by pathways distinct from PAR-1 and PAR-2. Stenton GR, etal., J Pharmacol Exp Ther 2002 Aug;302(2):466-74.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways. Wang H, etal., Am J Physiol Cell Physiol 2002 Nov;283(5):C1351-64.
30. Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis. Wang J, etal., Am J Pathol 2002 Jun;160(6):2063-72.
31. Expression of thrombin receptors in endothelial cells and neutrophils from normal and preeclamptic pregnancies. Wang Y, etal., J Clin Endocrinol Metab. 2002 Aug;87(8):3728-34.
32. Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling. Wang Y, etal., Neuroscience. 2004;126(1):69-82.
33. Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema. Wu H, etal., Neurochem Int. 2010 Oct;57(3):248-53. Epub 2010 Jun 10.
34. Molecular cloning of the rat vascular smooth muscle thrombin receptor. Evidence for in vitro regulation by basic fibroblast growth factor. Zhong C, etal., J Biol Chem 1992 Aug 25;267(24):16975-9.
Additional References at PubMed
PMID:1672265   PMID:9038223   PMID:9639571   PMID:9701242   PMID:10692450   PMID:11447194   PMID:12477932   PMID:12761501   PMID:12767046   PMID:15637325   PMID:15829229   PMID:16403464  
PMID:16934779   PMID:16942465   PMID:17023547   PMID:17136598   PMID:17324513   PMID:17360912   PMID:17404307   PMID:17468933   PMID:17623652   PMID:17848177   PMID:17940541   PMID:18035722  
PMID:18083763   PMID:18224254   PMID:18305483   PMID:18398001   PMID:18502312   PMID:18620539   PMID:19092124   PMID:19263282   PMID:19278590   PMID:19427359   PMID:19625519   PMID:19639229  
PMID:19937805   PMID:20164183   PMID:20215560   PMID:20511551   PMID:20819545   PMID:20875131   PMID:21162277   PMID:21209875   PMID:21302496   PMID:21414931   PMID:21827709   PMID:21854391  
PMID:21859963   PMID:22547407   PMID:22831762   PMID:22859370   PMID:22889888   PMID:22952817   PMID:23202369   PMID:23564130   PMID:23937416   PMID:24732013   PMID:24916589   PMID:25843668  
PMID:25931468   PMID:27012211   PMID:27385592   PMID:27910893   PMID:28059686   PMID:30391321   PMID:30566391   PMID:32583327   PMID:32726124   PMID:33176506   PMID:34831181   PMID:35923090  
PMID:36809978  


Genomics

Comparative Map Data
F2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2226,869,343 - 26,885,856 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,868,404 - 26,885,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,907,656 - 33,924,163 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0232,007,753 - 32,024,260 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0226,823,845 - 26,840,377 (-)NCBIRnor_WKY
Rnor_6.0226,118,760 - 26,135,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,118,760 - 26,135,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,254,489 - 45,257,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,985,800 - 25,989,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,906,181 - 25,909,441 (-)NCBI
Celera222,933,182 - 22,949,696 (-)NCBICelera
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
F2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,716,126 - 76,735,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl576,716,126 - 76,735,770 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,011,951 - 76,031,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,047,542 - 76,067,054 (+)NCBINCBI36Build 36hg18NCBI36
Build 34576,047,546 - 76,067,054NCBI
Celera571,905,802 - 71,925,529 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,219,384 - 71,239,536 (+)NCBIHuRef
CHM1_1575,445,069 - 75,464,798 (+)NCBICHM1_1
T2T-CHM13v2.0577,198,009 - 77,217,657 (+)NCBIT2T-CHM13v2.0
F2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,738,288 - 95,754,974 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,738,311 - 95,754,995 (-)EnsemblGRCm39 Ensembl
GRCm381395,601,780 - 95,618,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,601,803 - 95,618,487 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,371,744 - 96,388,388 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,702,488 - 96,719,132 (-)NCBIMGSCv36mm8
Celera1399,218,583 - 99,235,265 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.21NCBI
F2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542524,144,905 - 24,164,498 (-)NCBIChiLan1.0ChiLan1.0
F2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1539,110,170 - 39,129,688 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,110,170 - 39,129,688 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0538,565,957 - 38,585,725 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
F2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,870,159 - 29,889,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,872,155 - 29,889,687 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,109,597 - 31,128,481 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,789,482 - 29,809,069 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,789,492 - 29,813,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,726,270 - 29,745,147 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,706,677 - 29,725,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,076,456 - 30,095,361 (-)NCBIUU_Cfam_GSD_1.0
F2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,611,944 - 190,631,736 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549225,371 - 247,042 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936549226,508 - 247,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,641,474 - 85,656,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,642,794 - 85,659,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,279,785 - 87,296,140 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F2R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1470,992,406 - 71,010,512 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl470,992,477 - 71,009,456 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,823,537 - 19,842,658 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F2r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,181,354 - 1,200,664 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248691,181,288 - 1,200,751 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F2r
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:85
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000074626
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat

Markers in Region
RH94524  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,870,257 - 26,870,436 (+)MAPPERmRatBN7.2
Rnor_6.0226,119,675 - 26,119,853NCBIRnor6.0
Rnor_5.0245,255,404 - 45,255,582UniSTSRnor5.0
RGSC_v3.4225,986,715 - 25,986,893UniSTSRGSC3.4
Celera222,934,097 - 22,934,275UniSTS
RH 3.4 Map213.3UniSTS
Cytogenetic Map2q12UniSTS
RH140970  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,869,682 - 26,869,867 (+)MAPPERmRatBN7.2
Rnor_6.0226,119,100 - 26,119,284NCBIRnor6.0
Rnor_5.0245,254,829 - 45,255,013UniSTSRnor5.0
RGSC_v3.4225,986,140 - 25,986,324UniSTSRGSC3.4
Celera222,933,522 - 22,933,706UniSTS
RH 3.4 Map213.3UniSTS
Cytogenetic Map2q12UniSTS
PMC156147P9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,871,915 - 26,872,025 (+)MAPPERmRatBN7.2
Rnor_6.0226,121,333 - 26,121,442NCBIRnor6.0
Rnor_5.0245,257,062 - 45,257,171UniSTSRnor5.0
RGSC_v3.4225,988,373 - 25,988,482UniSTSRGSC3.4
Celera222,935,755 - 22,935,864UniSTS
Cytogenetic Map2q12UniSTS


Genetic Models
This gene F2r is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 38 22 19 22 1 1 67 35 34 11 1
Low 11 19 19 19 7 10 7 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000074626   ⟹   ENSRNOP00000065624
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,868,404 - 26,885,870 (-)Ensembl
Rnor_6.0 Ensembl226,118,760 - 26,135,340 (-)Ensembl
RefSeq Acc Id: NM_012950   ⟹   NP_037082
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2226,869,343 - 26,885,856 (-)NCBI
Rnor_6.0226,118,760 - 26,135,340 (-)NCBI
Rnor_5.0245,254,489 - 45,257,761 (-)NCBI
RGSC_v3.4225,985,800 - 25,989,072 (-)RGD
Celera222,933,182 - 22,949,696 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037082 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42274 (Get FASTA)   NCBI Sequence Viewer  
  AAH85759 (Get FASTA)   NCBI Sequence Viewer  
  EDM10103 (Get FASTA)   NCBI Sequence Viewer  
  P26824 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037082   ⟸   NM_012950
- Peptide Label: precursor
- UniProtKB: Q5U324 (UniProtKB/TrEMBL),   M0R834 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065624   ⟸   ENSRNOT00000074626
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26824-F1-model_v2 AlphaFold P26824 1-432 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691077
Promoter ID:EPDNEW_R1602
Type:multiple initiation site
Name:F2r_1
Description:coagulation factor II receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0226,135,365 - 26,135,425EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2586 AgrOrtholog
BioCyc Gene G2FUF-54803 BioCyc
Ensembl Genes ENSRNOG00000048043 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000065624 ENTREZGENE
  ENSRNOP00000065624.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074626 ENTREZGENE
  ENSRNOT00000074626.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106133 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrmbn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25439 UniProtKB/TrEMBL
MGC_CLONE MGC:93622 IMAGE-MGC_LOAD
NCBI Gene 25439 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEINASE-ACTIVATED RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB F2R RGD
PhenoGen F2r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASEAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THROMBINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228443
UniProt M0R834 ENTREZGENE
  P26824 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5U324 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary M0R834 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 F2r  coagulation factor II (thrombin) receptor    coagulation factor II receptor  Name updated 1299863 APPROVED
2002-11-06 F2r  coagulation factor II receptor    Coagulation factor II (thrombin) receptor  Name updated 625702 APPROVED
2001-10-23 F2r  Thrombin receptor      Name withdrawn 68913 WITHDRAWN
2001-10-23 F2r  Coagulation factor II (thrombin) receptor      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED