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Gene: F2r (coagulation factor II (thrombin) receptor) Rattus norvegicus
Symbol: F2r
Name: coagulation factor II (thrombin) receptor
RGD ID: 2586
Description: Predicted to have several functions, including G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and thrombin-activated receptor activity. Involved in several processes, including establishment of synaptic specificity at neuromuscular junction; positive regulation of cytosolic calcium ion concentration; and protein kinase C-activating G protein-coupled receptor signaling pathway. Localizes to neuromuscular junction and postsynaptic membrane. Used to study hypertension. Biomarker of brain edema and brain ischemia. Orthologous to human F2R (coagulation factor II thrombin receptor); PARTICIPATES IN G protein mediated signaling pathway; protease mediated signaling via protease-activated receptor 1; calcium/calcium-mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: coagulation factor II receptor; MGC93622; PAR-1; Par1; protease-activated receptor 1; proteinase-activated receptor 1; Thrombin receptor; TRGPC
Homo sapiens (human) : F2R (coagulation factor II thrombin receptor)  HGNC  Alliance
Mus musculus (house mouse) : F2r (coagulation factor II (thrombin) receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2r (coagulation factor II thrombin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : F2R (coagulation factor II thrombin receptor)
Canis lupus familiaris (dog) : F2R (coagulation factor II thrombin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2r (coagulation factor II thrombin receptor)
Sus scrofa (pig) : F2R (coagulation factor II thrombin receptor)
Chlorocebus sabaeus (African green monkey) : F2R (coagulation factor II thrombin receptor)
Heterocephalus glaber (naked mole-rat) : F2r (coagulation factor II thrombin receptor)
more info ...
Allele / Splice: F2rem1Mcwi  
Genetic Models: T2DN-F2rem1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0226,118,760 - 26,135,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,118,760 - 26,135,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,254,489 - 45,257,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,985,800 - 25,989,072 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1225,906,181 - 25,909,441 (-)NCBI
Celera222,933,182 - 22,949,696 (-)NCBICelera
Cytogenetic Map2q12NCBI
RH 3.4 Map213.3RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on F2r
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2586
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.