F2R (coagulation factor II thrombin receptor) - Rat Genome Database
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Gene: F2R (coagulation factor II thrombin receptor) Homo sapiens
Analyze
Symbol: F2R
Name: coagulation factor II thrombin receptor
RGD ID: 735960
HGNC Page HGNC
Description: Exhibits signaling receptor binding activity and thrombin-activated receptor activity. Involved in several processes, including connective tissue replacement involved in inflammatory response wound healing; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including caveola; endosome; and platelet dense tubular network. Biomarker of pre-eclampsia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CF2R; coagulation factor II (thrombin) receptor; HTR; PAR-1; PAR1; protease activated receptor 1; protease-activated receptor 1; proteinase-activated receptor 1; thrombin receptor; TR
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl576,716,126 - 76,735,770 (+)EnsemblGRCh38hg38GRCh38
GRCh38576,716,126 - 76,735,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37576,011,868 - 76,031,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,047,542 - 76,067,054 (+)NCBINCBI36hg18NCBI36
Build 34576,047,546 - 76,067,054NCBI
Celera571,905,802 - 71,925,529 (+)NCBI
Cytogenetic Map5q13.3NCBI
HuRef571,219,384 - 71,239,536 (+)NCBIHuRef
CHM1_1575,445,069 - 75,464,808 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atropine  (ISO)
avobenzone  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bivalirudin  (EXP)
butanal  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chloropicrin  (EXP)
choline  (ISO)
cisplatin  (ISO)
clopidogrel  (EXP)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (EXP)
elemental selenium  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
etonogestrel  (ISO)
etoposide  (EXP)
fenamidone  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
genistein  (EXP)
gentamycin  (ISO)
gestodene  (ISO)
glucose  (EXP)
heparin  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(II) chloride  (EXP)
lenalidomide  (EXP)
medroxyprogesterone acetate  (EXP,ISO)
methylparaben  (EXP)
mifepristone  (ISO)
mitomycin C  (EXP)
N-nitrosodimethylamine  (ISO)
nicotinic acid  (EXP)
oxaliplatin  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
quercetin  (EXP)
quinoline  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
rebaudioside A  (EXP)
resveratrol  (EXP)
selenium atom  (EXP)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
steviol  (EXP)
stevioside  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
Thrombin  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (EXP)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
activation of MAPKK activity  (ISS)
anatomical structure morphogenesis  (TAS)
blood coagulation  (TAS)
cell-cell junction maintenance  (IMP)
connective tissue replacement involved in inflammatory response wound healing  (IDA)
establishment of synaptic specificity at neuromuscular junction  (ISS)
G protein-coupled receptor signaling pathway  (ISS,TAS)
homeostasis of number of cells within a tissue  (ISS)
inflammatory response  (ISS)
negative regulation of cell population proliferation  (IDA)
negative regulation of glomerular filtration  (ISS)
negative regulation of neuron apoptotic process  (ISS)
negative regulation of renin secretion into blood stream  (ISS)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA)
platelet activation  (IDA,TAS)
platelet dense granule organization  (IC)
positive regulation of blood coagulation  (IBA,IDA)
positive regulation of calcium ion transport  (ISS)
positive regulation of cell migration  (IMP)
positive regulation of cell population proliferation  (ISS)
positive regulation of collagen biosynthetic process  (IDA)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
positive regulation of cytosolic calcium ion concentration  (ISS)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IBA,ISS)
positive regulation of ERK1 and ERK2 cascade  (ISS)
positive regulation of GTPase activity  (IMP)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEP)
positive regulation of interleukin-6 production  (IDA)
positive regulation of interleukin-8 production  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISS)
positive regulation of receptor signaling pathway via JAK-STAT  (NAS)
positive regulation of release of sequestered calcium ion into cytosol  (IDA)
positive regulation of Rho protein signal transduction  (IBA,ISS)
positive regulation of smooth muscle contraction  (ISS)
positive regulation of transcription, DNA-templated  (IDA)
positive regulation of vasoconstriction  (ISS)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISS)
regulation of blood coagulation  (IDA)
regulation of interleukin-1 beta production  (ISS)
regulation of sensory perception of pain  (ISS)
release of sequestered calcium ion into cytosol  (ISS)
response to lipopolysaccharide  (ISS)
response to wounding  (IDA)
thrombin-activated receptor signaling pathway  (IEA)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (IEA)

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1310691   PMID:1672265   PMID:1851174   PMID:7834643   PMID:7961693   PMID:8136362   PMID:8290554   PMID:8395550   PMID:8395910   PMID:8621593   PMID:8824285   PMID:8955127  
PMID:8982657   PMID:9038223   PMID:9058715   PMID:9102146   PMID:9207393   PMID:9639571   PMID:9701242   PMID:10079109   PMID:10391209   PMID:10477691   PMID:10583385   PMID:10644723  
PMID:10692450   PMID:10922491   PMID:10978167   PMID:11278329   PMID:11447194   PMID:11816709   PMID:11888681   PMID:11907122   PMID:11964083   PMID:11986954   PMID:12023853   PMID:12039967  
PMID:12052963   PMID:12058063   PMID:12084570   PMID:12195707   PMID:12370395   PMID:12372769   PMID:12406873   PMID:12477932   PMID:12505789   PMID:12522081   PMID:12534282   PMID:12563219  
PMID:12586611   PMID:12594292   PMID:12637343   PMID:12707033   PMID:12737439   PMID:12761501   PMID:12789289   PMID:12805069   PMID:12832443   PMID:12883880   PMID:12975361   PMID:13680213  
PMID:14507634   PMID:14521606   PMID:14623891   PMID:14632180   PMID:14642534   PMID:14961162   PMID:14966279   PMID:14982936   PMID:15023990   PMID:15045135   PMID:15078882   PMID:15099288  
PMID:15183114   PMID:15191806   PMID:15247268   PMID:15280447   PMID:15313016   PMID:15383630   PMID:15452121   PMID:15455382   PMID:15489334   PMID:15492257   PMID:15522964   PMID:15548541  
PMID:15550696   PMID:15559761   PMID:15561975   PMID:15563688   PMID:15582715   PMID:15625067   PMID:15626732   PMID:15707890   PMID:15755869   PMID:15769747   PMID:15821019   PMID:15860737  
PMID:15869604   PMID:15878870   PMID:15891109   PMID:15923186   PMID:16021575   PMID:16052512   PMID:16087677   PMID:16102047   PMID:16141404   PMID:16194864   PMID:16341594   PMID:16344560  
PMID:16354200   PMID:16354660   PMID:16359518   PMID:16407403   PMID:16409451   PMID:16606835   PMID:16709572   PMID:16803467   PMID:16837456   PMID:16839349   PMID:16946713   PMID:16952995  
PMID:17015787   PMID:17267663   PMID:17294805   PMID:17299037   PMID:17303701   PMID:17323377   PMID:17347481   PMID:17373694   PMID:17374729   PMID:17376866   PMID:17384202   PMID:17404307  
PMID:17414212   PMID:17470200   PMID:17492768   PMID:17623652   PMID:17675516   PMID:17706138   PMID:17721620   PMID:17823308   PMID:17848177   PMID:17883592   PMID:17895623   PMID:17935246  
PMID:18005014   PMID:18064407   PMID:18089851   PMID:18174463   PMID:18179608   PMID:18278202   PMID:18284602   PMID:18308730   PMID:18314110   PMID:18363813   PMID:18372913   PMID:18384756  
PMID:18386288   PMID:18537828   PMID:18570113   PMID:18577758   PMID:18612544   PMID:18657231   PMID:18682394   PMID:18687805   PMID:18820708   PMID:18832729   PMID:18974842   PMID:18983479  
PMID:18988801   PMID:19040205   PMID:19053259   PMID:19064814   PMID:19064940   PMID:19080851   PMID:19162217   PMID:19307610   PMID:19332793   PMID:19379698   PMID:19404549   PMID:19424642  
PMID:19460777   PMID:19538737   PMID:19567485   PMID:19608609   PMID:19622587   PMID:19679555   PMID:19690217   PMID:19694963   PMID:19703903   PMID:19764478   PMID:19795418   PMID:19858310  
PMID:19879874   PMID:19895674   PMID:19907018   PMID:19913121   PMID:19929245   PMID:19969492   PMID:20056842   PMID:20084489   PMID:20101173   PMID:20140262   PMID:20155436   PMID:20164183  
PMID:20175118   PMID:20230207   PMID:20236938   PMID:20237496   PMID:20368337   PMID:20388375   PMID:20404340   PMID:20442298   PMID:20482314   PMID:20506163   PMID:20559570   PMID:20571025  
PMID:20585578   PMID:20628086   PMID:20691446   PMID:20697725   PMID:20723226   PMID:20807173   PMID:20819545   PMID:20826780   PMID:20945373   PMID:21037076   PMID:21127289   PMID:21149441  
PMID:21187389   PMID:21209875   PMID:21216163   PMID:21252088   PMID:21375587   PMID:21536369   PMID:21550978   PMID:21586224   PMID:21591259   PMID:21605334   PMID:21649850   PMID:21673343  
PMID:21753781   PMID:21760880   PMID:21822552   PMID:21835828   PMID:21873635   PMID:21905006   PMID:21909684   PMID:21965661   PMID:21966428   PMID:21988832   PMID:21993564   PMID:22009534  
PMID:22106258   PMID:22139419   PMID:22212092   PMID:22278285   PMID:22283974   PMID:22291441   PMID:22541814   PMID:22547407   PMID:22552271   PMID:22562397   PMID:22573325   PMID:22593082  
PMID:22610965   PMID:22645275   PMID:22659187   PMID:22685255   PMID:22810586   PMID:22833563   PMID:22952809   PMID:22952817   PMID:22993310   PMID:23065128   PMID:23113835   PMID:23155052  
PMID:23202369   PMID:23204166   PMID:23222541   PMID:23242308   PMID:23280079   PMID:23293110   PMID:23307185   PMID:23395513   PMID:23406164   PMID:23421536   PMID:23436459   PMID:23476015  
PMID:23512987   PMID:23517743   PMID:23548249   PMID:23580642   PMID:23625915   PMID:23739922   PMID:23773523   PMID:23814055   PMID:23919450   PMID:23921961   PMID:24009311   PMID:24177339  
PMID:24297163   PMID:24405508   PMID:24435325   PMID:24612435   PMID:24620969   PMID:24624928   PMID:24637088   PMID:24717606   PMID:24732013   PMID:24740120   PMID:24776597   PMID:24805876  
PMID:24830314   PMID:24842054   PMID:24973402   PMID:25007158   PMID:25119598   PMID:25241761   PMID:25294586   PMID:25297082   PMID:25495701   PMID:25496845   PMID:25552512   PMID:25589770  
PMID:25689283   PMID:25846512   PMID:25934391   PMID:25986685   PMID:26020638   PMID:26037286   PMID:26068939   PMID:26082997   PMID:26083907   PMID:26084674   PMID:26092994   PMID:26100877  
PMID:26120939   PMID:26149041   PMID:26165842   PMID:26170698   PMID:26238780   PMID:26244666   PMID:26278396   PMID:26283733   PMID:26391660   PMID:26424552   PMID:26446588   PMID:26475502  
PMID:26490116   PMID:26566265   PMID:26600192   PMID:26616854   PMID:26635365   PMID:26681756   PMID:26729042   PMID:26875892   PMID:27023670   PMID:27108773   PMID:27181591   PMID:27561318  
PMID:27566553   PMID:27784794   PMID:27819671   PMID:27979585   PMID:27992120   PMID:28173772   PMID:28447716   PMID:28514442   PMID:28631887   PMID:28834159   PMID:28844979   PMID:28881236  
PMID:29141676   PMID:29484413   PMID:29529042   PMID:29622563   PMID:29848718   PMID:30204129   PMID:30221796   PMID:30314721   PMID:30903857   PMID:31467874   PMID:31914657   PMID:31959953  


Genomics

Comparative Map Data
F2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl576,716,126 - 76,735,770 (+)EnsemblGRCh38hg38GRCh38
GRCh38576,716,126 - 76,735,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37576,011,868 - 76,031,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,047,542 - 76,067,054 (+)NCBINCBI36hg18NCBI36
Build 34576,047,546 - 76,067,054NCBI
Celera571,905,802 - 71,925,529 (+)NCBI
Cytogenetic Map5q13.3NCBI
HuRef571,219,384 - 71,239,536 (+)NCBIHuRef
CHM1_1575,445,069 - 75,464,808 (+)NCBICHM1_1
F2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,738,288 - 95,754,974 (-)NCBIGRCm39mm39
GRCm381395,601,780 - 95,618,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,601,803 - 95,618,487 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,371,744 - 96,388,388 (-)NCBIGRCm37mm9NCBIm37
MGSCv361396,702,488 - 96,719,132 (-)NCBImm8
Celera1399,218,583 - 99,235,265 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.21NCBI
F2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0226,118,760 - 26,135,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,118,760 - 26,135,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,254,489 - 45,257,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,985,800 - 25,989,072 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1225,906,181 - 25,909,441 (-)NCBI
Celera222,933,182 - 22,949,696 (-)NCBICelera
Cytogenetic Map2q12NCBI
RH 3.4 Map213.3RGD
F2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542524,144,905 - 24,164,498 (-)NCBIChiLan1.0ChiLan1.0
F2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1539,110,170 - 39,129,688 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,110,170 - 39,129,688 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0538,565,957 - 38,585,725 (-)NCBIMhudiblu_PPA_v0panPan3
F2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl329,872,155 - 29,889,687 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1329,870,159 - 29,889,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
F2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936549226,508 - 247,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,641,474 - 85,656,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,642,794 - 85,659,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,279,785 - 87,296,140 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F2R
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1470,992,406 - 71,010,512 (+)NCBI
ChlSab1.1 Ensembl470,992,477 - 71,009,456 (+)Ensembl
F2r
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248691,181,288 - 1,200,751 (+)NCBI

Position Markers
WI-14632  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37576,030,409 - 76,030,545UniSTSGRCh37
Build 36576,066,165 - 76,066,301RGDNCBI36
Celera571,924,343 - 71,924,479RGD
Cytogenetic Map5q13UniSTS
HuRef571,238,350 - 71,238,486UniSTS
GeneMap99-GB4 RH Map5368.59UniSTS
Whitehead-RH Map5269.9UniSTS
NCBI RH Map5363.9UniSTS
PMC98608P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37576,030,248 - 76,030,955UniSTSGRCh37
Build 36576,066,004 - 76,066,711RGDNCBI36
Celera571,924,182 - 71,924,889RGD
Cytogenetic Map5q13UniSTS
HuRef571,238,189 - 71,238,896UniSTS
STS-N35000  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37576,031,449 - 76,031,605UniSTSGRCh37
Build 36576,067,205 - 76,067,361RGDNCBI36
Celera571,925,383 - 71,925,539RGD
Cytogenetic Map5q13UniSTS
HuRef571,239,390 - 71,239,546UniSTS
GeneMap99-GB4 RH Map5367.28UniSTS
NCBI RH Map5352.8UniSTS
D8S2279  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.12UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map3p22-p21.3UniSTS
Cytogenetic Map1q21.1UniSTS
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Cytogenetic Map5p13.1UniSTS
Cytogenetic Map8q11.2UniSTS
Cytogenetic Map3q28-q29UniSTS
Cytogenetic Map7p14-p13UniSTS
Cytogenetic Map12q24.2UniSTS
Cytogenetic Map6p22.2UniSTS
Cytogenetic Map7q22-qterUniSTS
Cytogenetic Map12q24.2-q24.31UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic Map1q32.2-q41UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map12q23-q24.1UniSTS
Cytogenetic Map5p15.1-p14.3UniSTS
Cytogenetic Map16p13.11UniSTS
Cytogenetic Map6q22-q23UniSTS
Cytogenetic Map9p21UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map3p12.1UniSTS
Cytogenetic Map9q21.11UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map14q21UniSTS
Cytogenetic Map11p15UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map15q11-q13UniSTS
Cytogenetic Map13q12-q14UniSTS
Cytogenetic Map18q21.1UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map3q28UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic MapXq22.2UniSTS
Cytogenetic Map7p12.3UniSTS
Cytogenetic Map7p15.1UniSTS
Cytogenetic Map2q37.2UniSTS
Cytogenetic Map18q22.3UniSTS
Cytogenetic Map14q32.13UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map16p13.1UniSTS
Cytogenetic Map7q31.3UniSTS
Cytogenetic Map20q13.2-q13.3UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map14q32.2UniSTS
Cytogenetic Map13q13.3UniSTS
Cytogenetic Map10p12.31UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map5q33.2UniSTS
Cytogenetic Map13q32.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map8q21.2UniSTS
Cytogenetic Map2q24.1UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map2q23.3UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map1q42.13UniSTS
Cytogenetic Map14q31UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map8p12-p11UniSTS
Cytogenetic Map18p11.2UniSTS
Cytogenetic Map7p11.1UniSTS
Cytogenetic Map1q31-q32UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map3p21.32UniSTS
Cytogenetic Map2p24.2UniSTS
Cytogenetic Map2q33-q34UniSTS
Cytogenetic Map6q24.1UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map15q13.3UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map10q23.33UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map17q11-q21UniSTS
Cytogenetic Map12q23UniSTS
Cytogenetic Map6p24-p22.3UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic Map7q31.1-q31.2UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map3p26.1-p25.1UniSTS
Cytogenetic Map5q35UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map6q16.3UniSTS
Cytogenetic Map17q24-q25UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic MapXq27.1UniSTS
Cytogenetic Map8q12.3UniSTS
Cytogenetic Map5q21.2UniSTS
Cytogenetic Map5q15UniSTS
Cytogenetic Map5q35.1UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map4q35.2UniSTS
Cytogenetic Map3p26.1UniSTS
Cytogenetic Map3p11.1UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map2q21.2UniSTS
Cytogenetic Map19p13.13UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map18p11.3UniSTS
Cytogenetic Map17q11.1UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map13q12.3UniSTS
Cytogenetic Map12q23.2UniSTS
Cytogenetic Map12q12-q13UniSTS
Cytogenetic Map12q14UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map2q32-q34UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic Map2p15-p13UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map19q13.33-q13.41UniSTS
Cytogenetic Map20p11UniSTS
Cytogenetic Map6q23-q24UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map2p13UniSTS
Cytogenetic Map13q11-q12UniSTS
Cytogenetic Map6p12.3-p11.2UniSTS
Cytogenetic Map6q16.1-q16.3UniSTS
Cytogenetic Map22q11UniSTS
Cytogenetic Map7q31.2UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map3q25.2UniSTS
Cytogenetic Map3p21.1-p14.3UniSTS
Cytogenetic Map6p12.1UniSTS
Cytogenetic Map3q23-q24UniSTS
Cytogenetic Map3q12UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map3q22.3UniSTS
Cytogenetic Map7q21.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map22q12-q13UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map6q16.1UniSTS
Cytogenetic Map13q14.13UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map8p11UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map1q24.3UniSTS
Cytogenetic Map9q33.1UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map2p16.2UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map1p36.2UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map1q22-q23UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map13q12.2UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map1q23UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map11q13.3UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map11q12.1UniSTS
Cytogenetic Map3p26UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8p21UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map1p33-p32UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map10q26.1UniSTS
Cytogenetic Map9q32-q33.3UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q33-q34UniSTS
Cytogenetic Map5q11.2-q13.2UniSTS
Cytogenetic Map13q32UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map4q28.1UniSTS
Cytogenetic Map5q22UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic MapXq13.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map3p26.3UniSTS
Cytogenetic Map2q11.1UniSTS
Cytogenetic Map21q11.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.2UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic MapXp22.31UniSTS
Cytogenetic MapXp21.3UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map20q13.2UniSTS
Cytogenetic Map14q11.2-q12UniSTS
Cytogenetic Map3p24UniSTS
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3q25.1UniSTS
Cytogenetic Map8q13UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map8q23.3UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map11cen-q12UniSTS
Cytogenetic Map11q25UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map7q22-q31UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map5p15.3UniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map4p13-p12UniSTS
Cytogenetic Map10q21-q22UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map7p13-p11.1UniSTS
Cytogenetic Map9q31-q34UniSTS
Cytogenetic Map7q21.1-q22UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3q13.13-q13.2UniSTS
Cytogenetic MapXp22.13UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1pUniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map2qUniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map5q14.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map2p24.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map9p21.1UniSTS
Cytogenetic Map9q34.2-q34.3UniSTS
D11S3316  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p21UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map10q11.1UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map1q23.1UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map7p15-p14UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map4p12UniSTS
Cytogenetic Map1q42.1UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map2p12-p11.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map12q13-q14UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map11q12-q13.2UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map4q31.3UniSTS
Cytogenetic Map20q13.1UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map12q13.11-q14.3UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map6p22.2UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map8q24.11UniSTS
Cytogenetic Map15q13.1UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map6p21.31UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map10q26.1UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map13q13.1UniSTS
Cytogenetic Map6p21.2UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map7q21-q22UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map14q31UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:936
Count of miRNA genes:666
Interacting mature miRNAs:740
Transcripts:ENST00000319211, ENST00000505600
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 2 1 1
Medium 950 1818 1039 313 712 163 3089 595 471 294 744 1413 161 878 1636 1
Low 1460 1148 683 309 1128 301 1248 1577 2358 120 696 161 11 326 1135 4
Below cutoff 24 24 3 1 94 1 17 22 882 5 14 38 3 1 17 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_032906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001311313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC025188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF054633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF391809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY771596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM994328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA799420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M62424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  N35000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U35634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U36755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000319211   ⟹   ENSP00000321326
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl576,716,126 - 76,735,770 (+)Ensembl
RefSeq Acc Id: ENST00000505600   ⟹   ENSP00000426398
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl576,716,199 - 76,716,788 (+)Ensembl
RefSeq Acc Id: NM_001311313   ⟹   NP_001298242
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38576,716,126 - 76,735,770 (+)NCBI
CHM1_1575,445,069 - 75,464,808 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001992   ⟹   NP_001983
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38576,716,126 - 76,735,770 (+)NCBI
GRCh37576,011,868 - 76,031,595 (+)ENTREZGENE
Build 36576,047,542 - 76,067,054 (+)NCBI Archive
HuRef571,219,384 - 71,239,536 (+)ENTREZGENE
CHM1_1575,445,069 - 75,464,808 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001983   ⟸   NM_001992
- Peptide Label: isoform 1 precursor
- UniProtKB: P25116 (UniProtKB/Swiss-Prot),   A0A024RAP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001298242   ⟸   NM_001311313
- Peptide Label: isoform 2
- UniProtKB: P25116 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000426398   ⟸   ENST00000505600
RefSeq Acc Id: ENSP00000321326   ⟸   ENST00000319211
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6803099
Promoter ID:HG_KWN:50507
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   K562,   Lymphoblastoid
Transcripts:ENST00000396233,   OTTHUMT00000254068
Position:
Human AssemblyChrPosition (strand)Source
Build 36576,047,341 - 76,047,842 (+)MPROMDB
RGD ID:6814741
Promoter ID:HG_XEF:6375
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_001085783,   NM_001114846
Position:
Human AssemblyChrPosition (strand)Source
Build 36576,064,541 - 76,065,041 (+)MPROMDB
RGD ID:6869918
Promoter ID:EPDNEW_H8124
Type:initiation region
Name:F2R_2
Description:coagulation factor II thrombin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8125  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38576,715,822 - 76,715,882EPDNEW
RGD ID:6869920
Promoter ID:EPDNEW_H8125
Type:initiation region
Name:F2R_1
Description:coagulation factor II thrombin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H8124  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38576,716,135 - 76,716,195EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q13.3-22.1(chr5:74163186-110809453)x3 copy number gain See cases [RCV000051839] Chr5:74163186..110809453 [GRCh38]
Chr5:73459011..110145153 [GRCh37]
Chr5:73494767..110173052 [NCBI36]
Chr5:5q13.3-22.1
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q13.3(chr5:75792479-76012937)x1 copy number loss See cases [RCV000445841] Chr5:75792479..76012937 [GRCh37]
Chr5:5q13.3
likely benign
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NM_001992.5(F2R):c.738G>A (p.Val246=) single nucleotide variant not provided [RCV000949283] Chr5:76732963 [GRCh38]
Chr5:76028788 [GRCh37]
Chr5:5q13.3
benign
NM_001992.5(F2R):c.516T>G (p.Ser172=) single nucleotide variant not provided [RCV000963323] Chr5:76732741 [GRCh38]
Chr5:76028566 [GRCh37]
Chr5:5q13.3
benign
NM_001992.5(F2R):c.798C>T (p.Tyr266=) single nucleotide variant not provided [RCV000929807] Chr5:76733023 [GRCh38]
Chr5:76028848 [GRCh37]
Chr5:5q13.3
likely benign
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
GRCh37/hg19 5q13.3(chr5:75327560-76140898)x1 copy number loss not provided [RCV000848077] Chr5:75327560..76140898 [GRCh37]
Chr5:5q13.3
uncertain significance
NM_001992.5(F2R):c.1142A>G (p.Tyr381Cys) single nucleotide variant not provided [RCV000966949] Chr5:76733367 [GRCh38]
Chr5:76029192 [GRCh37]
Chr5:5q13.3
benign
NM_001992.5(F2R):c.114A>G (p.Leu38=) single nucleotide variant not provided [RCV000887348] Chr5:76732339 [GRCh38]
Chr5:76028164 [GRCh37]
Chr5:5q13.3
benign
GRCh37/hg19 5q13.2-15(chr5:72790061-97478870)x3 copy number gain not provided [RCV001005683] Chr5:72790061..97478870 [GRCh37]
Chr5:5q13.2-15
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3537 AgrOrtholog
COSMIC F2R COSMIC
Ensembl Genes ENSG00000181104 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000321326 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000426398 UniProtKB/TrEMBL
Ensembl Transcript ENST00000319211 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000505600 UniProtKB/TrEMBL
GTEx ENSG00000181104 GTEx
HGNC ID HGNC:3537 ENTREZGENE
Human Proteome Map F2R Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thrmbn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2149 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2149 ENTREZGENE
OMIM 187930 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB F2R RGD, PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASEAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THROMBINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.482562 ENTREZGENE
UniProt A0A024RAP7 ENTREZGENE, UniProtKB/TrEMBL
  G3XAL6_HUMAN UniProtKB/TrEMBL
  P25116 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q53XV0 UniProtKB/Swiss-Prot
  Q96RF7 UniProtKB/Swiss-Prot
  Q9BUN4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 F2R  coagulation factor II thrombin receptor    coagulation factor II (thrombin) receptor  Symbol and/or name change 5135510 APPROVED