RGD Reference Report - Cross Talk Pathways Between Coagulation and Inflammation. - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Cross Talk Pathways Between Coagulation and Inflammation.

Authors: Foley, JH  Conway, EM 
Citation: Foley JH and Conway EM, Circ Res. 2016 Apr 29;118(9):1392-408. doi: 10.1161/CIRCRESAHA.116.306853.
RGD ID: 11352286
Pubmed: PMID:27126649   (View Abstract at PubMed)
DOI: DOI:10.1161/CIRCRESAHA.116.306853   (Journal Full-text)

Anatomic pathology studies performed over 150 years ago revealed that excessive activation of coagulation occurs in the setting of inflammation. However, it has taken over a century since these seminal observations were made to delineate the molecular mechanisms by which these systems interact and the extent to which they participate in the pathogenesis of multiple diseases. There is, in fact, extensive cross talk between coagulation and inflammation, whereby activation of one system may amplify activation of the other, a situation that, if unopposed, may result in tissue damage or even multiorgan failure. Characterizing the common triggers and pathways are key for the strategic design of effective therapeutic interventions. In this review, we highlight some of the key molecular interactions, some of which are already showing promise as therapeutic targets for inflammatory and thrombotic disorders.



Objects Annotated

Genes (Rattus norvegicus)
F10  (coagulation factor X)
F2  (coagulation factor II, thrombin)
F2r  (coagulation factor II (thrombin) receptor)
F2rl1  (F2R like trypsin receptor 1)
F2rl2  (coagulation factor II (thrombin) receptor-like 2)
F2rl3  (F2R like thrombin or trypsin receptor 3)

Genes (Mus musculus)
F10  (coagulation factor X)
F2  (coagulation factor II)
F2r  (coagulation factor II thrombin receptor)
F2rl1  (F2R like trypsin receptor 1)
F2rl2  (coagulation factor II thrombin receptor like 2)
F2rl3  (F2R like thrombin or trypsin receptor 3)

Genes (Homo sapiens)
F10  (coagulation factor X)
F2  (coagulation factor II, thrombin)
F2R  (coagulation factor II thrombin receptor)
F2RL1  (F2R like trypsin receptor 1)
F2RL2  (coagulation factor II thrombin receptor like 2)
F2RL3  (F2R like thrombin or trypsin receptor 3)


Additional Information