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Gene: F2r (coagulation factor II (thrombin) receptor) Mus musculus
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Symbol: F2r
Name: coagulation factor II (thrombin) receptor
Description: Exhibits G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of blood circulation; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Predicted to localize to several cellular components, including the caveola; endosome; and platelet dense tubular network. Is expressed in several structures, including cardiovascular system; central nervous system; exocrine gland; lung; and thyroid gland. Orthologous to human F2R (coagulation factor II thrombin receptor); PARTICIPATES IN protease mediated signaling via protease-activated receptor 1; coagulation cascade pathway; complement system pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-hydroxy-5alpha-androstan-3-one; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI482343; Cf2r; MGC28086; PAR-1; Par1; proteinase-activated receptor 1; thrombin receptor; ThrR
Orthologs:
Homo sapiens (human) : F2R (coagulation factor II thrombin receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : F2r (coagulation factor II (thrombin) receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2r (coagulation factor II thrombin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : F2R (coagulation factor II thrombin receptor)
Canis lupus familiaris (dog) : F2R (coagulation factor II thrombin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2r (coagulation factor II thrombin receptor)
Sus scrofa (pig) : F2R (coagulation factor II thrombin receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381395,601,780 - 95,618,466 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371396,371,744 - 96,388,388 (-)NCBIGRCm37mm9NCBIm37
MGSCv361396,702,488 - 96,719,132 (-)NCBImm8
Celera1399,218,583 - 99,235,265 (-)NCBICelera
Cytogenetic Map13 D1NCBI
cM Map1350.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on F2r
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10556
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.