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Gene: F2r (coagulation factor II (thrombin) receptor) Mus musculus
Symbol: F2r
Name: coagulation factor II (thrombin) receptor
RGD ID: 10556
Description: Exhibits G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; regulation of blood circulation; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Predicted to localize to several cellular components, including caveola; endosome; and platelet dense tubular network. Is expressed in several structures, including cardiovascular system; central nervous system; exocrine gland; lung; and thyroid gland. Orthologous to human F2R (coagulation factor II thrombin receptor); PARTICIPATES IN G protein mediated signaling pathway; protease mediated signaling via protease-activated receptor 1; coagulation cascade pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI482343; Cf2; Cf2r; MGC28086; P; PAR-1; Par1; proteinase-activated receptor 1; Th; thrombin receptor; ThrR
Homo sapiens (human) : F2R (coagulation factor II thrombin receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : F2r (coagulation factor II (thrombin) receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2r (coagulation factor II thrombin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : F2R (coagulation factor II thrombin receptor)
Canis lupus familiaris (dog) : F2R (coagulation factor II thrombin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2r (coagulation factor II thrombin receptor)
Sus scrofa (pig) : F2R (coagulation factor II thrombin receptor)
Chlorocebus sabaeus (African green monkey) : F2R (coagulation factor II thrombin receptor)
Heterocephalus glaber (naked mole-rat) : F2r (coagulation factor II thrombin receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391395,738,288 - 95,754,974 (-)NCBI
GRCm381395,601,780 - 95,618,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,601,803 - 95,618,487 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,371,744 - 96,388,388 (-)NCBIGRCm37mm9NCBIm37
MGSCv361396,702,488 - 96,719,132 (-)NCBImm8
Celera1399,218,583 - 99,235,265 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on F2r
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10556
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.