F2r (coagulation factor II thrombin receptor) - Rat Genome Database

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Pathways
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Gene: F2r (coagulation factor II thrombin receptor) Ictidomys tridecemlineatus
Analyze
Symbol: F2r
Name: coagulation factor II thrombin receptor
RGD ID: 12639567
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); G-protein alpha-subunit binding (inferred); G-protein beta-subunit binding (inferred); INVOLVED IN dendritic cell homeostasis (ortholog); establishment of synaptic specificity at neuromuscular junction (ortholog); G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN G protein mediated signaling pathway; protease mediated signaling via protease-activated receptor 1; ASSOCIATED WITH brain edema (ortholog); brain ischemia (ortholog); Experimental Arthritis (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: proteinase-activated receptor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,611,944 - 190,631,736 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549225,371 - 247,042 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936549226,508 - 247,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood coagulation  (IEA)
cell-cell junction maintenance  (IEA)
connective tissue replacement involved in inflammatory response wound healing  (IEA)
dendritic cell homeostasis  (IEA,ISO)
establishment of synaptic specificity at neuromuscular junction  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
hemostasis  (IEA)
homeostasis of number of cells within a tissue  (IEA,ISO)
inflammatory response  (IEA,ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of glomerular filtration  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of renin secretion into blood stream  (IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
platelet activation  (IEA)
positive regulation of blood coagulation  (IEA,ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of collagen biosynthetic process  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of release of sequestered calcium ion into cytosol  (IEA)
positive regulation of Rho protein signal transduction  (IEA)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of vasoconstriction  (IEA,ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of blood coagulation  (IEA)
regulation of interleukin-1 beta production  (IEA,ISO)
regulation of synaptic plasticity  (IEA)
release of sequestered calcium ion into cytosol  (ISO)
response to lipopolysaccharide  (IEA,ISO)
response to wounding  (IEA)
signal transduction  (IEA)
thrombin-activated receptor signaling pathway  (IEA,ISO)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
F2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,611,944 - 190,631,736 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549225,371 - 247,042 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936549226,508 - 247,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,716,126 - 76,735,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,716,126 - 76,735,770 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,011,951 - 76,031,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,047,542 - 76,067,054 (+)NCBINCBI36Build 36hg18NCBI36
Build 34576,047,546 - 76,067,054NCBI
Celera571,905,802 - 71,925,529 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,219,384 - 71,239,536 (+)NCBIHuRef
CHM1_1575,445,069 - 75,464,798 (+)NCBICHM1_1
T2T-CHM13v2.0577,198,009 - 77,217,657 (+)NCBIT2T-CHM13v2.0
F2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,738,288 - 95,754,974 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,738,311 - 95,754,995 (-)EnsemblGRCm39 Ensembl
GRCm381395,601,780 - 95,618,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,601,803 - 95,618,487 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,371,744 - 96,388,388 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,702,488 - 96,719,132 (-)NCBIMGSCv36mm8
Celera1399,218,583 - 99,235,265 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.21NCBI
F2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,604,066 - 28,620,579 (-)NCBIGRCr8
mRatBN7.2226,869,343 - 26,885,856 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,868,404 - 26,885,870 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx233,907,656 - 33,924,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0232,007,753 - 32,024,260 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,823,845 - 26,840,377 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0226,118,760 - 26,135,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,118,760 - 26,135,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,254,489 - 45,257,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,985,800 - 25,989,072 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,906,181 - 25,909,441 (-)NCBI
Celera222,933,182 - 22,949,696 (-)NCBICelera
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
F2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542524,144,905 - 24,164,498 (-)NCBIChiLan1.0ChiLan1.0
F2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,870,159 - 29,889,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,872,155 - 29,889,687 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,109,597 - 31,128,481 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,789,482 - 29,809,069 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,789,492 - 29,813,913 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,726,270 - 29,745,147 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,706,677 - 29,725,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,076,456 - 30,095,361 (-)NCBIUU_Cfam_GSD_1.0
F2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,641,474 - 85,656,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,642,794 - 85,659,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,279,785 - 87,296,140 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F2R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1470,992,406 - 71,010,512 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl470,992,477 - 71,009,456 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,823,537 - 19,842,658 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F2r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,181,354 - 1,200,664 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248691,181,288 - 1,200,751 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005328939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010002273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000008240   ⟹   ENSSTOP00000007382
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936549225,371 - 247,042 (-)Ensembl
RefSeq Acc Id: XM_005328939   ⟹   XP_005328996
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213190,611,944 - 190,631,736 (+)NCBI
SpeTri2.0NW_004936549226,508 - 247,024 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005328996 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007382.2
GenBank Protein KAG3266543 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005328996   ⟸   XM_005328939
- UniProtKB: I3MB99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000007382   ⟸   ENSSTOT00000008240
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008252 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008240.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/TrEMBL
  Thrmbn_rcpt UniProtKB/TrEMBL
NCBI Gene F2r ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PROTEINASE-ACTIVATED RECEPTOR 1 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PROTEASEAR UniProtKB/TrEMBL
  THROMBINR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt I3MB99 ENTREZGENE, UniProtKB/TrEMBL