F2r (coagulation factor II thrombin receptor) - Rat Genome Database

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Gene: F2r (coagulation factor II thrombin receptor) Chinchilla lanigera
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Symbol: F2r
Name: coagulation factor II thrombin receptor
RGD ID: 8785220
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); G-protein alpha-subunit binding (ortholog); G-protein beta-subunit binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); cell-cell junction maintenance (ortholog); connective tissue replacement involved in inflammatory response wound healing (ortholog); PARTICIPATES IN G protein mediated signaling pathway; protease mediated signaling via protease-activated receptor 1; ASSOCIATED WITH brain edema (ortholog); brain ischemia (ortholog); Experimental Arthritis (ortholog); FOUND IN caveola (ortholog); cell surface (ortholog); early endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: coagulation factor II (thrombin) receptor; proteinase-activated receptor 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542524,144,905 - 24,164,498 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
cell-cell junction maintenance  (ISO)
connective tissue replacement involved in inflammatory response wound healing  (ISO)
dendritic cell homeostasis  (ISO)
establishment of synaptic specificity at neuromuscular junction  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
homeostasis of number of cells within a tissue  (ISO)
inflammatory response  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of glomerular filtration  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of renin secretion into blood stream  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
platelet activation  (ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of Rho protein signal transduction  (ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vasoconstriction  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of blood coagulation  (ISO)
regulation of interleukin-1 beta production  (ISO)
regulation of sensory perception of pain  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to lipopolysaccharide  (ISO)
response to wounding  (ISO)
thrombin-activated receptor signaling pathway  (ISO)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
F2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542524,144,905 - 24,164,498 (-)NCBIChiLan1.0ChiLan1.0
F2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,716,126 - 76,735,770 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl576,716,126 - 76,735,770 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,011,951 - 76,031,595 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,047,542 - 76,067,054 (+)NCBINCBI36hg18NCBI36
Build 34576,047,546 - 76,067,054NCBI
Celera571,905,802 - 71,925,529 (+)NCBI
Cytogenetic Map5q13.3NCBI
HuRef571,219,384 - 71,239,536 (+)NCBIHuRef
CHM1_1575,445,069 - 75,464,798 (+)NCBICHM1_1
T2T-CHM13v2.0577,198,009 - 77,217,657 (+)NCBI
F2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,738,288 - 95,754,974 (-)NCBIGRCm39mm39
GRCm39 Ensembl1395,738,311 - 95,754,995 (-)Ensembl
GRCm381395,601,780 - 95,618,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,601,803 - 95,618,487 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,371,744 - 96,388,388 (-)NCBIGRCm37mm9NCBIm37
MGSCv361396,702,488 - 96,719,132 (-)NCBImm8
Celera1399,218,583 - 99,235,265 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.21NCBI
F2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2226,869,343 - 26,885,856 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl226,868,404 - 26,885,870 (-)Ensembl
Rnor_6.0226,118,760 - 26,135,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,118,760 - 26,135,340 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,254,489 - 45,257,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,985,800 - 25,989,072 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1225,906,181 - 25,909,441 (-)NCBI
Celera222,933,182 - 22,949,696 (-)NCBICelera
RH 3.4 Map213.3RGD
Cytogenetic Map2q12NCBI
F2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1539,110,170 - 39,129,688 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,110,170 - 39,129,688 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0538,565,957 - 38,585,725 (-)NCBIMhudiblu_PPA_v0panPan3
F2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,870,159 - 29,889,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,872,155 - 29,889,687 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,109,597 - 31,128,481 (-)NCBI
ROS_Cfam_1.0329,789,482 - 29,809,069 (-)NCBI
ROS_Cfam_1.0 Ensembl329,789,492 - 29,813,913 (-)Ensembl
UMICH_Zoey_3.1329,726,270 - 29,745,147 (-)NCBI
UNSW_CanFamBas_1.0329,706,677 - 29,725,998 (-)NCBI
UU_Cfam_GSD_1.0330,076,456 - 30,095,361 (-)NCBI
F2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,611,944 - 190,631,736 (+)NCBI
SpeTri2.0NW_004936549226,508 - 247,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,641,474 - 85,656,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,642,794 - 85,659,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,279,785 - 87,296,140 (-)NCBISscrofa10.2Sscrofa10.2susScr3
F2R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1470,992,406 - 71,010,512 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl470,992,477 - 71,009,456 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604919,823,537 - 19,842,658 (+)NCBIVero_WHO_p1.0
F2r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,181,354 - 1,200,664 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248691,181,288 - 1,200,751 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005386038   ⟹   XP_005386095
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542524,144,905 - 24,164,498 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005386095 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005386095   ⟸   XM_005386038
- Sequence:


Additional Information

Database Acc Id Source(s)
NCBI Gene F2r ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 F2r  coagulation factor II thrombin receptor    coagulation factor II (thrombin) receptor  Symbol and/or name change 5135510 APPROVED