F2R (coagulation factor II thrombin receptor)

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Gene: F2R (coagulation factor II thrombin receptor) Chlorocebus sabaeus

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Symbol:

F2R

Name:

coagulation factor II thrombin receptor

RGD ID:

18752771

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); G-protein alpha-subunit binding (inferred); G-protein beta-subunit binding (inferred); INVOLVED IN dendritic cell homeostasis (ortholog); establishment of synaptic specificity at neuromuscular junction (ortholog); G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN G protein mediated signaling pathway; protease mediated signaling via protease-activated receptor 1; ASSOCIATED WITH brain edema (ortholog); brain ischemia (ortholog); Experimental Arthritis (ortholog); FOUND IN neuromuscular junction (ortholog); postsynaptic membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

proteinase-activated receptor 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	70,992,406 - 71,010,512 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	70,992,477 - 71,009,456 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	19,823,537 - 19,842,658 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

brain edema (ISO)

brain ischemia (ISO)

Experimental Arthritis (ISO)

Experimental Liver Cirrhosis (ISO)

Experimental Neoplasms (ISO)

Helicobacter Infections (ISO)

hepatitis (ISO)

Hyperalgesia (ISO)

hypertension (ISO)

Inflammation (ISO)

liver cirrhosis (ISO)

Neurodevelopmental Disorders (ISO)

pre-eclampsia (ISO)

steatotic liver disease (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA)

cell-cell junction maintenance (IEA)

connective tissue replacement involved in inflammatory response wound healing (IEA)

dendritic cell homeostasis (IEA,ISO)

establishment of synaptic specificity at neuromuscular junction (ISO)

G protein-coupled receptor signaling pathway (IEA,ISO)

homeostasis of number of cells within a tissue (IEA,ISO)

inflammatory response (IEA,ISO)

negative regulation of cell population proliferation (IEA)

negative regulation of glomerular filtration (ISO)

negative regulation of neuron apoptotic process (ISO)

negative regulation of renin secretion into blood stream (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA,ISO)

platelet activation (IEA)

positive regulation of apoptotic process (ISO)

positive regulation of blood coagulation (IEA,ISO)

positive regulation of calcium ion transport (ISO)

positive regulation of canonical NF-kappaB signal transduction (IEA)

positive regulation of cell migration (IEA)

positive regulation of cell population proliferation (ISO)

positive regulation of collagen biosynthetic process (IEA)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of GTPase activity (ISO)

positive regulation of interleukin-6 production (IEA)

positive regulation of interleukin-8 production (IEA)

positive regulation of MAPK cascade (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

positive regulation of release of sequestered calcium ion into cytosol (IEA)

positive regulation of Rho protein signal transduction (IEA)

positive regulation of smooth muscle contraction (ISO)

positive regulation of vasoconstriction (IEA,ISO)

regulation of biological quality (IEA)

regulation of blood coagulation (IEA)

regulation of interleukin-1 beta production (IEA,ISO)

regulation of synaptic plasticity (IEA)

release of sequestered calcium ion into cytosol (ISO)

response to lipopolysaccharide (IEA,ISO)

response to wounding (IEA)

thrombin-activated receptor signaling pathway (IEA,ISO)

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission (IEA)

Cellular Component

caveola (IEA)

cell surface (IEA)

early endosome (IEA)

late endosome (IEA)

membrane (IEA)

neuromuscular junction (ISO)

plasma membrane (IEA)

platelet dense tubular network (IEA)

postsynaptic membrane (ISO)

synapse (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

G-protein alpha-subunit binding (IEA)

G-protein beta-subunit binding (IEA)

protein binding (ISO)

signaling receptor binding (IEA)

thrombin-activated receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

G protein mediated signaling pathway (ISO)

protease mediated signaling via protease-activated receptor 1 (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

F2R
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	70,992,406 - 71,010,512 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	70,992,477 - 71,009,456 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	19,823,537 - 19,842,658 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

F2R
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	76,716,126 - 76,735,770 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	76,716,126 - 76,735,770 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	76,011,951 - 76,031,595 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	76,047,542 - 76,067,054 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	76,047,546 - 76,067,054	NCBI
Celera	5	71,905,802 - 71,925,529 (+)	NCBI		Celera
Cytogenetic Map	5	q13.3	NCBI
HuRef	5	71,219,384 - 71,239,536 (+)	NCBI		HuRef
CHM1_1	5	75,445,069 - 75,464,798 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	77,198,009 - 77,217,657 (+)	NCBI		T2T-CHM13v2.0

F2r
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	95,738,288 - 95,754,974 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	95,738,311 - 95,754,995 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	95,601,780 - 95,618,466 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	95,601,803 - 95,618,487 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	96,371,744 - 96,388,388 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	96,702,488 - 96,719,132 (-)	NCBI		MGSCv36	mm8
Celera	13	99,218,583 - 99,235,265 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	50.21	NCBI

F2r
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	28,604,066 - 28,620,579 (-)	NCBI		GRCr8
mRatBN7.2	2	26,869,343 - 26,885,856 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	26,868,404 - 26,885,870 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	33,907,656 - 33,924,163 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	32,007,753 - 32,024,260 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	26,823,845 - 26,840,377 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	26,118,760 - 26,135,340 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	26,118,760 - 26,135,340 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	45,254,489 - 45,257,761 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	25,985,800 - 25,989,072 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	25,906,181 - 25,909,441 (-)	NCBI
Celera	2	22,933,182 - 22,949,696 (-)	NCBI		Celera
RH 3.4 Map	2	13.3	RGD
Cytogenetic Map	2	q12	NCBI

F2r
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955425	24,144,905 - 24,164,498 (-)	NCBI	ChiLan1.0	ChiLan1.0

F2R
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	29,870,159 - 29,889,837 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	29,872,155 - 29,889,687 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	31,109,597 - 31,128,481 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	29,789,482 - 29,809,069 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	29,789,492 - 29,813,913 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	29,726,270 - 29,745,147 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	29,706,677 - 29,725,998 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	30,076,456 - 30,095,361 (-)	NCBI		UU_Cfam_GSD_1.0

F2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	190,611,944 - 190,631,736 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936549	225,371 - 247,042 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936549	226,508 - 247,024 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

F2R
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	85,641,474 - 85,656,636 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	85,642,794 - 85,659,133 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	87,279,785 - 87,296,140 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

F2r
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624869	1,181,354 - 1,200,664 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624869	1,181,288 - 1,200,751 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007975883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000013441 ⟹ ENSCSAP00000011441

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	4	70,992,477 - 71,009,456 (+)	Ensembl

RefSeq Acc Id:

XM_007975883 ⟹ XP_007974074

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	4	70,992,406 - 71,010,512 (+)	NCBI
Vero_WHO_p1.0	NW_023666049	19,823,537 - 19,842,658 (+)	NCBI

Sequence:

show sequence

GCGCCCGCGCGCTCGCGCGCCCCAGTCCCGCCCCGCCTGGCGCACCGCGCCAGACACAGAGCTC
GCCGGGGGTCGCTCGGACCCTGATCTTGCCCGCGGGCACCCCGCGCTCTGCCTGCCGCGACGAC
CAGCTGCCCGACCAGCAGAAGTTGGGAGAGAGGGTGGAACGGAGCAGCCCGAGGCGGGGCACCT
CCTGGAGCAGCGCAGTGCGGATCCCGGGACAATGGGGCCGCGGCGGCTGCTGCTGGTGGCCGCC
TGCCTCTGTCTGTGCGGCCCGCTGTTGTCCGCCCGCACGCGGGCCCGCAGGCCAGCATCAAAAG
CAACAAATGCCACCTTAGATCCCCGGTCATTTCTTCTCAGGAATCCCAATGATAAATATGAACC
ATTTTGGGAGGATGAGGAGAAAAATGAAAGTGGGTTAACTGAATACAGATTAGTCTCCATCAAT
AAAAGCAGTCCTCTTCAAAAACCACTTCCTGCGTTCATCTCAGAAGATGCCTCCGGATATCTGA
CCAGCTCCTGGCTGACACTCTTTGTCCCATCTGTGTACACCGGGGTGTTTGTAGTCAGCCTCCC
GCTAAACATCATGGCCATCGTTGTGTTCATCCTGAAAATGAAGGTCAAGAAGCCGGCGGTGGTG
TACATGCTGCACCTGGCCACGGCAGATGTGCTCTTTGTGTCTGTGCTCCCCTTTAAGATCAGCT
ATTACTTTTCCGGCAGTGATTGGCAGTTTGGGTCTGAATTGTGTCGCTTTGTCACTGCAGCATT
TTACTGTAACATGTACGCCTCTATCTTGCTCATGACAGTCATAAGCATCGACCGGTTTCTGGCT
GTGGTGTATCCCATGCAGTCCCTCTCCTGGCGTACTCTGGGAAGGGCTTCCTTCACTTGTCTGG
CCATTTGGGCTTTGGCCATTGCAGGGGTAGTGCCTCTGCTCCTCAAGGAGCAAACCATCCAGGT
GCCCGGGCTCAACATCACCACCTGTCATGATGTACTCAATGAAACCTTGCTCGAAGGCTATTAT
GCCTACTACTTCTCAGCCTTCTCTGCTGTCTTCTTTTTTGTGCCGCTGATCATTTCCACGGTCT
GTTATGTGTCTATCATTCGATGTCTTAGCTCTTCCACAGTTGCCAACCGCAGCAAGAAGTCCCG
GGCTTTGTTCCTGTCAGCTGCTGTTTTCTGCATCTTCATCATTTGCTTCGGACCCACAAACATC
CTCCTGATTGCGCATTACTCATTCCTTTCTCACACTTCCACCACAGAGGCTGCCTACTTTGCCT
ACCTCCTCTGTGTCTGTGTCAGCAGCATAAGCTGCTGCATCGACCCCCTCATTTACTATTACGC
TTCCTCTGAGTGCCAGAGGTACATCTACAGTATCTTATGCTGCAAAGAAAGTTCTGATCCCAGC
AGTTATAACAGCAGTGGGCAGTTGATGGCAAGTAAAATGGATACCTGCTCTAGTAACCTGAATA
ACAGCATATACAAAAAGCTGTTAACTTAGGAAAAGGGACTGCTGGGAGGTTAAAAAGAAAAGTT
TATGGAAGTGAATAACTTGAGGATTCTGTTAGTCCCCACCCAAACTGTATTGACTTCACCTCCT
AAAACAACAGATGTACAACTTGCATGCCTGCTTTTTATGGGAGCCATCATGCATGTATTTTTGT
CAGTTACCAGAAAGATAACAGGATGAGATGACTGTGTTATTCCAAGGGAATATTGCCAATGCTA
CAGTAATAACTGAATGTCACTTTTGTATATAGCTAGGTGACATACGCATATTTATATGTGTGTA
TATGTAGACGTATGCACACACGTATATTATTTGTAGTGCAGTGTAGAATAGGCACTTTAAAACA
CTCTTTTCCCCCCAACTCCAGCAATTATGGAAATAATCTCTGATTCCCTGATTTAATATGCAAA
GTCTAGGTTGGTAGAGTTTAACCCTGAACATTTGATGGTGTTCATCAACAGTGAGAGACTCCGT
AGTTTGGGCTTGTACCACTTTTGCAAATAAGTGTATTTTGAAGTTGTTTGACAGCAAGGTTTAA
GTTATTAAGGGATAAGACTTACTACTATCTGTGTGTAGAAGTTCTAGTGTTTTCAGTTTTAAAC
ATATCCAAGTTTGAATTCCTAAAATTATGGAAACAGATGAAAAGCCCCTATTTTGATATGGGTA
GTATTTTTTACATTTTACACACTGTATACATAAGCCAAAACTGAGCATCAGTCCTCTAGTGAAT
GTAGGCTGGCTTTCAGAGTAGCCTATTCCTGAGAGCTGCATGCGTCCGCCCCTGATGGAGGACT
CCAAGCAGCAGACACCTGCCAGGGCCATGTTAGACACAGATTGACCAGAGACCTTCCTGCTGAA
CCTCACAGAAAGCAATGAGACTGGGGCCACCACATGTGCTCCATCCTCCTAGGATTGGCTGAGA
ACTGATCATGTTTATGAGAAACTGGCAAAGCAGAATGTGATATCCTAGGAGGTAATGACCATGA
AAGACTTCTCTACCCATCTTAAAAACAACGAAAGAAGGCATGGACTTCTGGATGCCCATCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_007974074	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000011441
	ENSCSAP00000011441.1

RefSeq Acc Id:	XP_007974074 ⟸ XM_007975883
- UniProtKB:	A0A0D9RS52 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000011441 ⟸ ENSCSAT00000013441

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000015345	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000013441.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Protea_act_rcpt	UniProtKB/TrEMBL
	Thrmbn_rcpt	UniProtKB/TrEMBL
KEGG Report	csab:103223358	UniProtKB/TrEMBL
NCBI Gene	F2R	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	PROTEINASE-ACTIVATED RECEPTOR 1	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	PROTEASEAR	UniProtKB/TrEMBL
	THROMBINR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A0D9RS52	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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