 Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | ISO | RGD:62145 | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of GPC1 mRNA | CTD | PMID:22206623 | 1,3,5-trinitro-1,3,5-triazinane | increases expression | EXP | | 6480464 | cyclonite results in increased expression of GPC1 mRNA | CTD | PMID:25559034 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:62145 | 6480464 | Ethinyl Estradiol results in increased expression of GPC1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of GPC1 mRNA | CTD | PMID:17557909 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:62145 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPC1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | affects expression | ISO | RGD:730930 | 6480464 | Estradiol affects the expression of GPC1 mRNA | CTD | PMID:22574217 | 17beta-estradiol | multiple interactions | ISO | RGD:730930 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of GPC1 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:62145 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPC1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62145 | 6480464 | Tetrachlorodibenzodioxin affects the expression of GPC1 mRNA | CTD | PMID:21570461, PMID:28922406 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62145 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GPC1 mRNA | CTD | PMID:15667827 more ... | 2,4-diaminotoluene | increases expression | ISO | RGD:62145 | 6480464 | 2, 4-diaminotoluene results in increased expression of GPC1 mRNA | CTD | PMID:20713471 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:62145 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GPC1 mRNA | CTD | PMID:16054899 | 3-methylcholanthrene | increases expression | ISO | RGD:62145 | 6480464 | Methylcholanthrene results in increased expression of GPC1 mRNA | CTD | PMID:20713471 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:62145 | 6480464 | 4, 4'-diaminodiphenylmethane results in increased expression of GPC1 mRNA | CTD | PMID:18648102 | 4-hydroxyphenyl retinamide | decreases expression | ISO | RGD:62145 | 6480464 | Fenretinide results in decreased expression of GPC1 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of GPC1 mRNA | CTD | PMID:25825206 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of GPC1 mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases expression | ISO | RGD:730930 | 6480464 | Aflatoxin B1 results in increased expression of GPC1 mRNA | CTD | PMID:21632981, PMID:21641981 | aflatoxin B1 | increases methylation | ISO | RGD:730930 | 6480464 | Aflatoxin B1 results in increased methylation of GPC1 intron | CTD | PMID:30157460 | arsenite(3-) | multiple interactions | ISO | RGD:62145 | 6480464 | [arsenite co-treated with Benzo(a)pyrene] results in increased expression of GPC1 mRNA | CTD | PMID:15894712 | arsenite(3-) | increases expression | ISO | RGD:62145 | 6480464 | arsenite results in increased expression of GPC1 mRNA | CTD | PMID:15894712 | arsenous acid | increases expression | ISO | RGD:730930 | 6480464 | Arsenic Trioxide results in increased expression of GPC1 mRNA | CTD | PMID:25555879 | benzo[a]pyrene | increases expression | ISO | RGD:62145 | 6480464 | Benzo(a)pyrene results in increased expression of GPC1 mRNA | CTD | PMID:15894712, PMID:20713471 | benzo[a]pyrene | increases methylation | ISO | RGD:730930 | 6480464 | Benzo(a)pyrene results in increased methylation of GPC1 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | RGD:730930 | 6480464 | Benzo(a)pyrene results in increased expression of GPC1 mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:62145 | 6480464 | Benzo(a)pyrene results in decreased expression of GPC1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:62145 | 6480464 | [arsenite co-treated with Benzo(a)pyrene] results in increased expression of GPC1 mRNA | CTD | PMID:15894712 | bicalutamide | decreases expression | ISO | RGD:730930 | 6480464 | bicalutamide results in decreased expression of GPC1 mRNA | CTD | PMID:15638997 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of GPC1 mRNA | CTD | PMID:25181051 | butan-1-ol | multiple interactions | ISO | RGD:730930 | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of GPC1 mRNA | CTD | PMID:29432896 | cadmium atom | decreases expression | ISO | RGD:62145 | 6480464 | Cadmium results in decreased expression of GPC1 mRNA | CTD | PMID:23358151 | cadmium atom | increases expression | ISO | RGD:730930 | 6480464 | Cadmium results in increased expression of GPC1 mRNA | CTD | PMID:24376830 | carbon nanotube | increases expression | ISO | RGD:62145 | 6480464 | Nanotubes, Carbon results in increased expression of GPC1 mRNA | CTD | PMID:25554681 | choline | multiple interactions | ISO | RGD:62145 | 6480464 | [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of GPC1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPC1 mRNA | CTD | PMID:20938992, PMID:29127188 | cisplatin | multiple interactions | ISO | RGD:730930 | 6480464 | [Piroxicam co-treated with Cisplatin] results in increased expression of GPC1 mRNA | CTD | PMID:21858171 | clofibrate | decreases expression | ISO | RGD:62145 | 6480464 | Clofibrate results in decreased expression of GPC1 mRNA | CTD | PMID:17585979 | copper atom | multiple interactions | ISO | RGD:62145 | 6480464 | [APLP2 protein co-treated with Copper] results in decreased degradation of GPC1 protein modified form more ... | CTD | PMID:15677459 more ... | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of GPC1 mRNA | CTD | PMID:30556269 | copper atom | affects binding | ISO | RGD:62145 | 6480464 | GPC1 protein binds to Copper | CTD | PMID:12732622 | copper atom | increases oxidation | ISO | RGD:62145 | 6480464 | GPC1 protein results in increased oxidation of Copper | CTD | PMID:12732622 | copper atom | increases reduction | ISO | RGD:62145 | 6480464 | GPC1 protein modified form results in increased reduction of Copper | CTD | PMID:12732622 | copper(0) | multiple interactions | ISO | RGD:62145 | 6480464 | [APLP2 protein co-treated with Copper] results in decreased degradation of GPC1 protein modified form more ... | CTD | PMID:15677459 more ... | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of GPC1 mRNA | CTD | PMID:30556269 | copper(0) | affects binding | ISO | RGD:62145 | 6480464 | GPC1 protein binds to Copper | CTD | PMID:12732622 | copper(0) | increases oxidation | ISO | RGD:62145 | 6480464 | GPC1 protein results in increased oxidation of Copper | CTD | PMID:12732622 | copper(0) | increases reduction | ISO | RGD:62145 | 6480464 | GPC1 protein modified form results in increased reduction of Copper | CTD | PMID:12732622 | crocidolite asbestos | increases expression | ISO | RGD:730930 | 6480464 | Asbestos, Crocidolite results in increased expression of GPC1 protein | CTD | PMID:29553831 | cyclosporin A | increases expression | ISO | RGD:730930 | 6480464 | Cyclosporine results in increased expression of GPC1 mRNA | CTD | PMID:20106945, PMID:25562108 | dexamethasone | multiple interactions | ISO | RGD:62145 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GPC1 mRNA | CTD | PMID:16054899 | diarsenic trioxide | increases expression | ISO | RGD:730930 | 6480464 | Arsenic Trioxide results in increased expression of GPC1 mRNA | CTD | PMID:25555879 | diazinon | increases methylation | ISO | RGD:730930 | 6480464 | Diazinon results in increased methylation of GPC1 gene | CTD | PMID:22964155 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of GPC1 mRNA | CTD | PMID:21266533 | dioxygen | increases expression | ISO | RGD:62145 | 6480464 | Oxygen deficiency results in increased expression of GPC1 mRNA | CTD | PMID:24205000 | disodium selenite | increases expression | ISO | RGD:730930 | 6480464 | Sodium Selenite results in increased expression of GPC1 mRNA | CTD | PMID:18175754 | doxorubicin | decreases expression | ISO | RGD:62145 | 6480464 | Doxorubicin results in decreased expression of GPC1 mRNA | CTD | PMID:19073829 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of GPC1 mRNA | CTD | PMID:29391264 | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of GPC1 mRNA | CTD | PMID:28454766 | ethanol | multiple interactions | ISO | RGD:730930 | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of GPC1 mRNA | CTD | PMID:29432896 | ethanol | affects expression | ISO | RGD:62145 | 6480464 | Ethanol affects the expression of GPC1 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | RGD:62145 | 6480464 | [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of GPC1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPC1 mRNA | CTD | PMID:20938992, PMID:29127188 | heparan sulfate | affects binding | ISO | RGD:62145 | 6480464 | GPC1 protein binds to Heparitin Sulfate | CTD | PMID:12732622 | heparan sulfate | multiple interactions | ISO | RGD:62145 | 6480464 | GPC1 protein modified form results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate] more ... | CTD | PMID:12732622 | isobutanol | multiple interactions | ISO | RGD:730930 | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of GPC1 mRNA | CTD | PMID:29432896 | L-ascorbic acid | multiple interactions | ISO | RGD:62145 | 6480464 | [Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form, Zinc promotes the reaction [[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form] | CTD | PMID:15677459 | L-ascorbic acid | increases degradation | ISO | RGD:62145 | 6480464 | Ascorbic Acid results in increased degradation of GPC1 protein | CTD | PMID:21642435 | L-ascorbic acid | increases expression | ISO | RGD:730930 | 6480464 | Ascorbic Acid results in increased expression of GPC1 mRNA | CTD | PMID:25555879 | L-methionine | multiple interactions | ISO | RGD:62145 | 6480464 | [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of GPC1 mRNA, [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPC1 mRNA | CTD | PMID:20938992, PMID:29127188 | lead(0) | decreases expression | ISO | RGD:730930 | 6480464 | Lead results in decreased expression of GPC1 mRNA | CTD | PMID:19921347 | lead(0) | affects expression | ISO | RGD:730930 | 6480464 | Lead affects the expression of GPC1 mRNA | CTD | PMID:28903495 | lead(2+) | decreases expression | ISO | RGD:730930 | 6480464 | Lead results in decreased expression of GPC1 mRNA | CTD | PMID:19921347 | lead(2+) | affects expression | ISO | RGD:730930 | 6480464 | Lead affects the expression of GPC1 mRNA | CTD | PMID:28903495 | linuron | decreases expression | EXP | | 6480464 | Linuron results in decreased expression of GPC1 mRNA | CTD | PMID:12730624 | nitric oxide | increases nitrosation | ISO | RGD:62145 | 6480464 | Nitric Oxide results in increased nitrosation of GPC1 protein | CTD | PMID:16923158 | nitric oxide | multiple interactions | ISO | RGD:62145 | 6480464 | [Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form, Zinc promotes the reaction [[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form] | CTD | PMID:15677459 | nitroxyl | multiple interactions | ISO | RGD:62145 | 6480464 | nitroxyl affects the reaction [GPC1 protein results in increased cleavage of [GPC1 protein binds to Heparitin Sulfate]] | CTD | PMID:12732622 | ochratoxin A | multiple interactions | ISO | RGD:730930 | 6480464 | [ochratoxin A results in increased acetylation of GPC1 promoter] which results in increased expression of GPC1 mRNA | CTD | PMID:29098329 | ochratoxin A | increases acetylation | ISO | RGD:730930 | 6480464 | ochratoxin A results in increased acetylation of GPC1 promoter | CTD | PMID:29098329 | ochratoxin A | increases expression | ISO | RGD:730930 | 6480464 | ochratoxin A results in increased expression of GPC1 mRNA | CTD | PMID:29098329 | oxaliplatin | increases expression | EXP | | 6480464 | oxaliplatin results in increased expression of GPC1 mRNA | CTD | PMID:25729387 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of GPC1 mRNA | CTD | PMID:25729387 | ozone | decreases expression | EXP | | 6480464 | Ozone results in decreased expression of GPC1 mRNA | CTD | PMID:16330353 | paracetamol | increases expression | ISO | RGD:730930 | 6480464 | Acetaminophen results in increased expression of GPC1 mRNA | CTD | PMID:22230336, PMID:29067470 | paraquat | affects expression | EXP | | 6480464 | Paraquat affects the expression of GPC1 mRNA | CTD | PMID:15206577 | phenobarbital | multiple interactions | ISO | RGD:62145 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GPC1 mRNA] | CTD | PMID:19482888 | phenobarbital | affects expression | ISO | RGD:62145 | 6480464 | Phenobarbital affects the expression of GPC1 mRNA | CTD | PMID:23091169 | phenobarbital | decreases expression | ISO | RGD:62145 | 6480464 | Phenobarbital results in decreased expression of GPC1 mRNA | CTD | PMID:19482888 | piroxicam | multiple interactions | ISO | RGD:730930 | 6480464 | [Piroxicam co-treated with Cisplatin] results in increased expression of GPC1 mRNA | CTD | PMID:21858171 | quercetin | increases expression | ISO | RGD:730930 | 6480464 | Quercetin results in increased expression of GPC1 mRNA | CTD | PMID:21632981 | raloxifene | affects expression | ISO | RGD:730930 | 6480464 | Raloxifene Hydrochloride affects the expression of GPC1 mRNA | CTD | PMID:14699072 | resveratrol | decreases expression | ISO | RGD:62145 | 6480464 | resveratrol results in decreased expression of GPC1 protein | CTD | PMID:25505154 | silicon dioxide | affects secretion | ISO | RGD:730930 | 6480464 | Silicon Dioxide analog affects the secretion of GPC1 protein | CTD | PMID:25895662 | sodium arsenate | decreases expression | ISO | RGD:62145 | 6480464 | sodium arsenate results in decreased expression of GPC1 mRNA | CTD | PMID:21795629 | streptozocin | multiple interactions | ISO | RGD:62145 | 6480464 | [Streptozocin co-treated with Dietary Fats] results in increased expression of GPC1 mRNA | CTD | PMID:29127188 | sulforaphane | increases expression | ISO | RGD:730930 | 6480464 | sulforafan results in increased expression of GPC1 mRNA | CTD | PMID:31838189 | sunitinib | decreases expression | ISO | RGD:730930 | 6480464 | Sunitinib results in decreased expression of GPC1 mRNA | CTD | PMID:31533062 | tamoxifen | increases expression | ISO | RGD:62145 | 6480464 | Tamoxifen results in increased expression of GPC1 mRNA | CTD | PMID:25123088 | tamoxifen | affects expression | ISO | RGD:730930 | 6480464 | Tamoxifen affects the expression of GPC1 mRNA | CTD | PMID:14699072 | tert-butyl hydroperoxide | increases expression | ISO | RGD:62145 | 6480464 | tert-Butylhydroperoxide results in increased expression of GPC1 mRNA | CTD | PMID:15003993 | testosterone | affects expression | ISO | RGD:62145 | 6480464 | Testosterone affects the expression of GPC1 mRNA | CTD | PMID:20403060 | testosterone enanthate | affects expression | ISO | RGD:730930 | 6480464 | testosterone enanthate affects the expression of GPC1 mRNA | CTD | PMID:17440010 | tetrachloromethane | affects expression | ISO | RGD:62145 | 6480464 | Carbon Tetrachloride affects the expression of GPC1 mRNA | CTD | PMID:17484886 | titanium dioxide | decreases expression | ISO | RGD:62145 | 6480464 | titanium dioxide results in decreased expression of GPC1 mRNA | CTD | PMID:23557971 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of GPC1 mRNA | CTD | PMID:25729387 | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of GPC1 mRNA | CTD | PMID:25729387 | valproic acid | affects expression | ISO | RGD:62145 | 6480464 | Valproic Acid affects the expression of GPC1 mRNA | CTD | PMID:17963808 | valproic acid | increases methylation | ISO | RGD:730930 | 6480464 | Valproic Acid results in increased methylation of GPC1 gene | CTD | PMID:29154799 | vorinostat | decreases expression | ISO | RGD:730930 | 6480464 | vorinostat results in decreased expression of GPC1 mRNA | CTD | PMID:27188386 | zinc atom | multiple interactions | ISO | RGD:62145 | 6480464 | [APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form more ... | CTD | PMID:12732622, PMID:15677459 | zinc(0) | multiple interactions | ISO | RGD:62145 | 6480464 | [APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form more ... | CTD | PMID:12732622, PMID:15677459 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations
