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Gene: Pdgfra (platelet derived growth factor receptor alpha) Rattus norvegicus
Symbol: Pdgfra
Name: platelet derived growth factor receptor alpha
Description: Exhibits phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor alpha-receptor activity. Involved in several processes, including animal organ development; cellular response to interleukin-1; and response to estradiol. Localizes to several cellular components, including axon; nucleus; and plasma membrane. Used to study middle cerebral artery infarction. Biomarker of chronic ulcer of skin; hypertension; oligohydramnios; pulmonary fibrosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypereosinophilic syndrome; and pancreatic cancer. Orthologous to human PDGFRA (platelet derived growth factor receptor alpha); PARTICIPATES IN platelet-derived growth factor signaling pathway; calcium/calcium-mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha platelet-derived growth factor receptor; alpha-type platelet-derived growth factor receptor; APDGFR; CD140 antigen-like family member A; PDGF-R-alpha; PDGFACE; PDGFR-alpha; platelet derived growth factor receptor, alpha polypeptide; platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor alpha
Homo sapiens (human) : PDGFRA (platelet derived growth factor receptor alpha)  HGNC  Alliance
Mus musculus (house mouse) : Pdgfra (platelet derived growth factor receptor, alpha polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfra (platelet derived growth factor receptor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFRA (platelet derived growth factor receptor alpha)
Canis lupus familiaris (dog) : PDGFRA (platelet derived growth factor receptor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfra (platelet derived growth factor receptor alpha)
Sus scrofa (pig) : PDGFRA (platelet derived growth factor receptor alpha)
Chlorocebus sabaeus (African green monkey) : PDGFRA (platelet derived growth factor receptor alpha)
Heterocephalus glaber (naked mole-rat) : Pdgfra (platelet derived growth factor receptor alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01435,527,926 - 35,581,130 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1435,527,927 - 35,581,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01435,356,434 - 35,409,311 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41435,369,422 - 35,418,126 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11435,369,672 - 35,418,126 (-)NCBI
Celera1432,273,077 - 32,324,887 (-)NCBICelera
Cytogenetic Map14p11NCBI
RH 3.4 Map14432.47RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pdgfra
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3284
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.