Aopep (aminopeptidase O) - Rat Genome Database
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Gene: Aopep (aminopeptidase O) Rattus norvegicus
Analyze
Symbol: Aopep
Name: aminopeptidase O
RGD ID: 1309592
Description: Predicted to have metalloaminopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to localize to nucleolus. Orthologous to human AOPEP (aminopeptidase O (putative)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AP-O; Apo; LOC290963; Npepo; RGD1309592; similar to hypothetical protein FLJ14675
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2171,811,922 - 2,127,316 (-)NCBI
Rnor_6.0 Ensembl17507,377 - 821,582 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.017507,389 - 825,062 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.017550,168 - 550,965 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.017568,777 - 814,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,353,426 - 7,624,936 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1177,353,425 - 7,624,936 (-)NCBI
Celera17446,696 - 707,342 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component
nucleolus  (IBA,IEA,ISO,ISS)

Molecular Function

References

Additional References at PubMed
PMID:17803194  


Genomics

Comparative Map Data
Aopep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2171,811,922 - 2,127,316 (-)NCBI
Rnor_6.0 Ensembl17507,377 - 821,582 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.017507,389 - 825,062 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.017550,168 - 550,965 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.017568,777 - 814,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,353,426 - 7,624,936 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1177,353,425 - 7,624,936 (-)NCBI
Celera17446,696 - 707,342 (+)NCBICelera
Cytogenetic Map17p14NCBI
AOPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl994,726,604 - 95,087,159 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl994,726,701 - 95,087,218 (+)EnsemblGRCh38hg38GRCh38
GRCh38994,726,669 - 95,148,264 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37997,488,981 - 97,849,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,528,815 - 96,889,262 (+)NCBINCBI36hg18NCBI36
Build 34994,568,548 - 94,928,995NCBI
Celera967,929,905 - 68,290,531 (+)NCBI
Cytogenetic Map9q22.32NCBI
HuRef967,097,489 - 67,459,053 (+)NCBIHuRef
CHM1_1997,635,390 - 97,995,978 (+)NCBICHM1_1
Aopep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391363,112,707 - 63,473,910 (+)NCBIGRCm39mm39
GRCm39 Ensembl1363,112,707 - 63,473,910 (+)Ensembl
GRCm381362,964,893 - 63,326,096 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1362,964,893 - 63,326,096 (+)EnsemblGRCm38mm10GRCm38
MGSCv371363,116,294 - 63,400,964 (+)NCBIGRCm37mm9NCBIm37
MGSCv361362,974,516 - 63,309,939 (+)NCBImm8
Celera1364,682,940 - 64,953,836 (+)NCBICelera
Cytogenetic Map13B3NCBI
Aopep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542221,680,488 - 22,020,935 (+)NCBIChiLan1.0ChiLan1.0
AOPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1993,953,844 - 94,315,510 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl993,986,951 - 94,311,201 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0965,825,138 - 66,188,001 (+)NCBIMhudiblu_PPA_v0panPan3
C1H9orf3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl171,677,068 - 72,009,395 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1171,770,687 - 72,009,374 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Aopep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366263,704,474 - 3,973,913 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AOPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,078,113 - 27,472,310 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,078,115 - 27,472,347 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,342,998 - 31,670,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AOPEP
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112108,007,895 - 108,360,361 (-)NCBI
ChlSab1.1 Ensembl12108,171,743 - 108,360,041 (-)Ensembl
Aopep
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475316,188,323 - 16,588,989 (+)NCBI

Position Markers
D17Got1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.017677,347 - 677,567NCBIRnor6.0
Rnor_5.017671,509 - 671,729UniSTSRnor5.0
RGSC_v3.4177,505,126 - 7,505,347RGDRGSC3.4
RGSC_v3.4177,505,127 - 7,505,347UniSTSRGSC3.4
RGSC_v3.1177,505,127 - 7,505,347RGD
Celera17565,615 - 565,835UniSTS
RH 3.4 Map170.0UniSTS
RH 3.4 Map170.0RGD
Cytogenetic Map17p14UniSTS
RH133549  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.017805,275 - 805,454NCBIRnor6.0
Rnor_5.017798,088 - 798,267UniSTSRnor5.0
RGSC_v3.4177,369,552 - 7,369,731UniSTSRGSC3.4
Celera17691,037 - 691,216UniSTS
RH 3.4 Map1721.3UniSTS
Cytogenetic Map17p14UniSTS
BF399621  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.017623,260 - 623,389NCBIRnor6.0
Rnor_5.017617,422 - 617,551UniSTSRnor5.0
RGSC_v3.4177,559,715 - 7,559,844UniSTSRGSC3.4
Celera17511,519 - 511,648UniSTS
RH 3.4 Map1716.0UniSTS
Cytogenetic Map17p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17124787908Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17132230361Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17133303755Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138243814Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17163676140Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17173413148Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17173413148Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1751977023422380Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1751977036283402Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:87
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000023638
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 23 7 16 7 4 4 12 8 11 10 4
Low 3 38 34 34 3 34 4 7 62 27 30 1 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005495243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ810421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023638   ⟹   ENSRNOP00000023638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl17507,377 - 821,582 (+)Ensembl
RefSeq Acc Id: NM_001012346   ⟹   NP_001012346
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,815,405 - 2,077,176 (-)NCBI
Rnor_6.017558,184 - 821,580 (+)NCBI
Rnor_5.017550,168 - 550,965 (+)NCBI
Rnor_5.017568,777 - 814,393 (+)NCBI
RGSC_v3.4177,353,426 - 7,624,936 (-)RGD
Celera17446,696 - 707,342 (+)RGD
Sequence:
RefSeq Acc Id: XM_008771429   ⟹   XP_008769651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,127,306 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771430   ⟹   XP_008769652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,127,306 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771431   ⟹   XP_008769653
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,127,315 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771432   ⟹   XP_008769654
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,127,316 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600471   ⟹   XP_017455960
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,127,314 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600472   ⟹   XP_017455961
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,127,306 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600473   ⟹   XP_017455962
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,077,548 (-)NCBI
Rnor_6.017556,489 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095440   ⟹   XP_038951368
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,127,306 (-)NCBI
RefSeq Acc Id: XM_039095441   ⟹   XP_038951369
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,127,306 (-)NCBI
RefSeq Acc Id: XM_039095442   ⟹   XP_038951370
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,883,415 - 2,127,306 (-)NCBI
RefSeq Acc Id: XM_039095443   ⟹   XP_038951371
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,957,884 - 2,127,306 (-)NCBI
RefSeq Acc Id: XM_039095444   ⟹   XP_038951372
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,811,922 - 2,033,489 (-)NCBI
RefSeq Acc Id: XR_005495243
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2171,815,506 - 2,127,306 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001012346   ⟸   NM_001012346
- UniProtKB: P69527 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008769651   ⟸   XM_008771429
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008769652   ⟸   XM_008771430
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008769653   ⟸   XM_008771431
- Peptide Label: isoform X2
- UniProtKB: F1LRV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769654   ⟸   XM_008771432
- Peptide Label: isoform X2
- UniProtKB: F1LRV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455961   ⟸   XM_017600472
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455960   ⟸   XM_017600471
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455962   ⟸   XM_017600473
- Peptide Label: isoform X2
- UniProtKB: F1LRV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023638   ⟸   ENSRNOT00000023638
RefSeq Acc Id: XP_038951368   ⟸   XM_039095440
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038951369   ⟸   XM_039095441
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038951372   ⟸   XM_039095444
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038951370   ⟸   XM_039095442
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038951371   ⟸   XM_039095443
- Peptide Label: isoform X6
Protein Domains
Leuk-A4-hydro_C

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700258
Promoter ID:EPDNEW_R10781
Type:multiple initiation site
Name:Npepo_1
Description:aminopeptidase O
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.017507,410 - 507,470EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 718559 718560 G A snv COP/CrCrl (MCW & UW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
17 7456438 7456439 C T snv COP/CrCrl (MCW & UW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309592 AgrOrtholog
Ensembl Genes ENSRNOG00000017505 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023638 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023638 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AOPep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_LTA-4_hydro/amino_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_LTA4H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290963 UniProtKB/Swiss-Prot
NCBI Gene 290963 ENTREZGENE
PANTHER PTHR46627 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Leuk-A4-hydro_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aopep PhenoGen
SMART Leuk-A4-hydro_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AMPO_RAT UniProtKB/Swiss-Prot
  F1LRV1 ENTREZGENE, UniProtKB/TrEMBL
  P69527 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Aopep  aminopeptidase O  Npepo  aminopeptidase O  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-11 Npepo  aminopeptidase O  RGD1309592  similar to hypothetical protein FLJ14675  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309592  similar to hypothetical protein FLJ14675  RGD1309592_predicted  similar to hypothetical protein FLJ14675 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309592_predicted  similar to hypothetical protein FLJ14675 (predicted)  LOC290963_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290963_predicted  similar to hypothetical protein FLJ14675 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL