Aopep (aminopeptidase O) - Rat Genome Database

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Gene: Aopep (aminopeptidase O) Rattus norvegicus
Analyze
Symbol: Aopep
Name: aminopeptidase O
RGD ID: 1309592
Description: Predicted to enable metalloaminopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in dystonia. Orthologous to human AOPEP (aminopeptidase O (putative)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AP-O; Apo; LOC290963; Npepo; RGD1309592; similar to hypothetical protein FLJ14675
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8171,817,001 - 2,133,008 (-)NCBIGRCr8
mRatBN7.2171,811,281 - 2,127,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,811,980 - 2,127,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,829,980 - 2,145,965 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0173,372,578 - 3,688,561 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0171,827,430 - 2,143,418 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.017507,389 - 825,062 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17507,377 - 821,582 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017550,168 - 550,965 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.017568,777 - 814,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,353,426 - 7,624,936 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,353,425 - 7,624,936 (-)NCBI
Celera17446,696 - 707,342 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
manganese(II) chloride  (EXP)
methapyrilene  (EXP,ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
permethrin  (EXP)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component
nucleolus  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase. Diaz-Perales A, etal., J Biol Chem. 2005 Apr 8;280(14):14310-7. Epub 2005 Feb 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17803194  


Genomics

Comparative Map Data
Aopep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8171,817,001 - 2,133,008 (-)NCBIGRCr8
mRatBN7.2171,811,281 - 2,127,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl171,811,980 - 2,127,331 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,829,980 - 2,145,965 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0173,372,578 - 3,688,561 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0171,827,430 - 2,143,418 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.017507,389 - 825,062 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl17507,377 - 821,582 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.017550,168 - 550,965 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.017568,777 - 814,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,353,426 - 7,624,936 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1177,353,425 - 7,624,936 (-)NCBI
Celera17446,696 - 707,342 (+)NCBICelera
Cytogenetic Map17p14NCBI
AOPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38994,726,699 - 95,150,224 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl994,726,604 - 95,151,793 (+)EnsemblGRCh38hg38GRCh38
GRCh37997,488,981 - 97,849,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,528,815 - 96,889,262 (+)NCBINCBI36Build 36hg18NCBI36
Build 34994,568,548 - 94,928,995NCBI
Celera967,929,905 - 68,290,531 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef967,097,489 - 67,459,053 (+)NCBIHuRef
CHM1_1997,635,390 - 97,995,978 (+)NCBICHM1_1
T2T-CHM13v2.09106,896,013 - 107,317,676 (+)NCBIT2T-CHM13v2.0
Aopep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391363,112,707 - 63,473,910 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1363,112,707 - 63,473,910 (+)EnsemblGRCm39 Ensembl
GRCm381362,964,893 - 63,326,096 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1362,964,893 - 63,326,096 (+)EnsemblGRCm38mm10GRCm38
MGSCv371363,116,294 - 63,400,964 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361362,974,516 - 63,309,939 (+)NCBIMGSCv36mm8
Celera1364,682,940 - 64,953,836 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1332.8NCBI
Aopep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542221,680,488 - 22,020,935 (+)NCBIChiLan1.0ChiLan1.0
AOPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21144,299,187 - 44,728,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1944,301,567 - 44,730,736 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0965,825,138 - 66,188,001 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1993,953,844 - 94,315,510 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl993,986,951 - 94,311,201 (+)Ensemblpanpan1.1panPan2
AOPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1171,770,687 - 72,009,374 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl171,677,068 - 72,009,395 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha172,438,651 - 72,771,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0171,981,049 - 72,313,890 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl171,981,051 - 72,313,868 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1171,792,454 - 72,124,878 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0171,556,523 - 71,890,575 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0172,262,807 - 72,595,715 (-)NCBIUU_Cfam_GSD_1.0
Aopep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049444,466,607 - 4,745,317 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366263,667,123 - 3,970,433 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366263,704,474 - 3,973,913 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AOPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1027,078,113 - 27,472,310 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11027,078,115 - 27,472,347 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21031,342,998 - 31,670,377 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AOPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112108,007,895 - 108,360,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12108,171,743 - 108,360,041 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603896,390,611 - 96,723,601 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aopep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475316,188,323 - 16,588,989 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aopep
258 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:87
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000023638
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat

Markers in Region
D17Got1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2171,957,814 - 1,958,035 (-)MAPPERmRatBN7.2
Rnor_6.017677,347 - 677,567NCBIRnor6.0
Rnor_5.017671,509 - 671,729UniSTSRnor5.0
RGSC_v3.4177,505,126 - 7,505,347RGDRGSC3.4
RGSC_v3.4177,505,127 - 7,505,347UniSTSRGSC3.4
RGSC_v3.1177,505,127 - 7,505,347RGD
Celera17565,615 - 565,835UniSTS
RH 3.4 Map170.0RGD
RH 3.4 Map170.0UniSTS
Cytogenetic Map17p14UniSTS
RH133549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2171,831,529 - 1,831,709 (-)MAPPERmRatBN7.2
Rnor_6.017805,275 - 805,454NCBIRnor6.0
Rnor_5.017798,088 - 798,267UniSTSRnor5.0
RGSC_v3.4177,369,552 - 7,369,731UniSTSRGSC3.4
Celera17691,037 - 691,216UniSTS
RH 3.4 Map1721.3UniSTS
Cytogenetic Map17p14UniSTS
BF399621  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2172,011,959 - 2,012,089 (-)MAPPERmRatBN7.2
Rnor_6.017623,260 - 623,389NCBIRnor6.0
Rnor_5.017617,422 - 617,551UniSTSRnor5.0
RGSC_v3.4177,559,715 - 7,559,844UniSTSRGSC3.4
Celera17511,519 - 511,648UniSTS
RH 3.4 Map1716.0UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 23 7 16 7 4 4 12 8 11 10 4
Low 3 38 34 34 3 34 4 7 62 27 30 1 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ810421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000023638   ⟹   ENSRNOP00000023638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl171,811,980 - 2,127,331 (-)Ensembl
Rnor_6.0 Ensembl17507,377 - 821,582 (+)Ensembl
RefSeq Acc Id: NM_001012346   ⟹   NP_001012346
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,001 - 2,132,979 (-)NCBI
mRatBN7.2171,811,281 - 2,127,286 (-)NCBI
Rnor_6.017558,184 - 821,580 (+)NCBI
Rnor_5.017550,168 - 550,965 (+)NCBI
Rnor_5.017568,777 - 814,393 (+)NCBI
RGSC_v3.4177,353,426 - 7,624,936 (-)RGD
Celera17446,696 - 707,342 (+)RGD
Sequence:
RefSeq Acc Id: XM_008771429   ⟹   XP_008769651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,002 (-)NCBI
mRatBN7.2171,811,922 - 2,127,306 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771431   ⟹   XP_008769653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,007 (-)NCBI
mRatBN7.2171,811,922 - 2,127,315 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771432   ⟹   XP_008769654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,006 (-)NCBI
mRatBN7.2171,811,922 - 2,127,316 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600471   ⟹   XP_017455960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
mRatBN7.2171,811,922 - 2,127,314 (-)NCBI
Rnor_6.017507,389 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600473   ⟹   XP_017455962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,083,259 (-)NCBI
mRatBN7.2171,811,922 - 2,077,548 (-)NCBI
Rnor_6.017556,489 - 825,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063276125   ⟹   XP_063132195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276126   ⟹   XP_063132196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276127   ⟹   XP_063132197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,132,803 (-)NCBI
RefSeq Acc Id: XM_063276129   ⟹   XP_063132199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276130   ⟹   XP_063132200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276131   ⟹   XP_063132201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,889,130 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276132   ⟹   XP_063132202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,963,589 - 2,133,008 (-)NCBI
RefSeq Acc Id: XM_063276133   ⟹   XP_063132203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,817,637 - 2,035,545 (-)NCBI
RefSeq Acc Id: XR_010058813
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,821,246 - 2,133,008 (-)NCBI
RefSeq Acc Id: XR_010058814
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,947,406 - 2,133,008 (-)NCBI
RefSeq Acc Id: XR_010058815
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,923,488 - 2,133,008 (-)NCBI
RefSeq Acc Id: XR_010058816
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8171,966,904 - 2,133,008 (-)NCBI
RefSeq Acc Id: NP_001012346   ⟸   NM_001012346
- UniProtKB: P69527 (UniProtKB/Swiss-Prot),   F1LRV1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008769651   ⟸   XM_008771429
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QC72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769653   ⟸   XM_008771431
- Peptide Label: isoform X2
- UniProtKB: P69527 (UniProtKB/Swiss-Prot),   F1LRV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769654   ⟸   XM_008771432
- Peptide Label: isoform X2
- UniProtKB: P69527 (UniProtKB/Swiss-Prot),   F1LRV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455960   ⟸   XM_017600471
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QC72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455962   ⟸   XM_017600473
- Peptide Label: isoform X2
- UniProtKB: P69527 (UniProtKB/Swiss-Prot),   F1LRV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023638   ⟸   ENSRNOT00000023638
RefSeq Acc Id: XP_063132199   ⟸   XM_063276129
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132200   ⟸   XM_063276130
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132195   ⟸   XM_063276125
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132196   ⟸   XM_063276126
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132197   ⟸   XM_063276127
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132203   ⟸   XM_063276133
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063132201   ⟸   XM_063276131
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063132202   ⟸   XM_063276132
- Peptide Label: isoform X6
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P69527-F1-model_v2 AlphaFold P69527 1-822 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700258
Promoter ID:EPDNEW_R10781
Type:multiple initiation site
Name:Npepo_1
Description:aminopeptidase O
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.017507,410 - 507,470EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309592 AgrOrtholog
BioCyc Gene G2FUF-10526 BioCyc
Ensembl Genes ENSRNOG00000017505 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055023304 UniProtKB/Swiss-Prot
  ENSRNOG00060017408 UniProtKB/Swiss-Prot
  ENSRNOG00065023363 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023638.7 UniProtKB/TrEMBL
  ENSRNOT00055040036 UniProtKB/Swiss-Prot
  ENSRNOT00060029756 UniProtKB/Swiss-Prot
  ENSRNOT00065039930 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.2010.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AOPep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M1_LTA-4_hydro/amino_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290963 UniProtKB/Swiss-Prot
NCBI Gene 290963 ENTREZGENE
PANTHER AMINOPEPTIDASE O UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46627 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Leuk-A4-hydro_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aopep PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017505 RatGTEx
  ENSRNOG00055023304 RatGTEx
  ENSRNOG00060017408 RatGTEx
  ENSRNOG00065023363 RatGTEx
SMART Leuk-A4-hydro_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QC72 ENTREZGENE, UniProtKB/TrEMBL
  AMPO_RAT UniProtKB/Swiss-Prot
  F1LRV1 ENTREZGENE
  P69527 ENTREZGENE
UniProt Secondary F1LRV1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Aopep  aminopeptidase O  Npepo  aminopeptidase O  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-11 Npepo  aminopeptidase O  RGD1309592  similar to hypothetical protein FLJ14675  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309592  similar to hypothetical protein FLJ14675  RGD1309592_predicted  similar to hypothetical protein FLJ14675 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309592_predicted  similar to hypothetical protein FLJ14675 (predicted)  LOC290963_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290963_predicted  similar to hypothetical protein FLJ14675 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL