Cpb2 (carboxypeptidase B2) - Rat Genome Database
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Gene: Cpb2 (carboxypeptidase B2) Rattus norvegicus
Analyze
Symbol: Cpb2
Name: carboxypeptidase B2
RGD ID: 71035
Description: Exhibits carboxypeptidase activity. Involved in several processes, including liver regeneration; negative regulation of hepatocyte proliferation; and regulation of blood coagulation. Localizes to extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPB2 (carboxypeptidase B2); PARTICIPATES IN fibrinolysis pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: carboxypeptidase B2 (plasma); carboxypeptidase R; carboxypeptidase U; CPR; CPU; LOC684726; similar to carboxypeptidase B2 (plasma); TAFI; thrombin-activable fibrinolysis inhibitor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21550,557,722 - 50,606,569 (+)NCBI
Rnor_6.0 Ensembl1557,290,849 - 57,339,760 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01557,290,849 - 57,339,762 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01561,001,889 - 61,050,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41556,104,920 - 56,154,321 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11556,120,686 - 56,170,027 (+)NCBI
Celera1550,189,675 - 50,237,544 (+)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Aso Y, etal., Diabetes Care. 2005 Sep;28(9):2211-6.
2. Atkinson JM, etal., Matrix Biol. 2013 Jan 29. pii: S0945-053X(13)00007-3. doi: 10.1016/j.matbio.2013.01.006.
3. Bruno NE, etal., J Thromb Haemost. 2008 Jan;6(1):139-46. Epub 2007 Nov 5.
4. Bruno NE, etal., Thromb Haemost. 2008 Jul;100(1):90-100. doi: 10.1160/TH08-02-0092.
5. Donmez A, etal., Thromb Res. 2005;115(4):287-92.
6. Eichinger S, etal., Blood. 2004 May 15;103(10):3773-6. Epub 2004 Jan 22.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Hashimoto M, etal., Thromb Haemost 2002 Jan;87(1):110-3.
9. Hillmayer K, etal., J Thromb Haemost. 2006 Nov;4(11):2470-7. Epub 2006 Sep 21.
10. Hori Y, etal., J Clin Endocrinol Metab. 2002 Feb;87(2):660-5.
11. Kaftan O, etal., Clin Appl Thromb Hemost. 2005 Oct;11(4):449-54.
12. Kato T, etal., Microbiol Immunol 2000;44(8):719-28.
13. Kremer Hovinga JA, etal., J Thromb Haemost. 2004 Jan;2(1):54-7.
14. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
15. Malyszko J, etal., Blood Coagul Fibrinolysis. 2002 Oct;13(7):615-21.
16. Malyszko J, etal., Thromb Haemost. 2004 Mar;91(3):480-6.
17. MGD Curation, June 12, 2002
18. MGD data from the GO Consortium
19. Morange PE, etal., Thromb Haemost. 2003 Mar;89(3):554-60.
20. Muto Y, etal., Crit Care Med. 2009 May;37(5):1744-9. doi: 10.1097/CCM.0b013e31819ffc14.
21. NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Okumura N, etal., J Biol Chem. 2009 Jun 12;284(24):16553-61. doi: 10.1074/jbc.M109.011452. Epub 2009 Apr 22.
23. Pipeline to import KEGG annotations from KEGG into RGD
24. Ravindranath TM, etal., Clin Appl Thromb Hemost. 2004 Oct;10(4):379-85.
25. Ravindranath TM, etal., Clin Appl Thromb Hemost. 2007 Oct;13(4):362-8.
26. RGD automated data pipeline
27. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. RGD automated import pipeline for gene-chemical interactions
29. Stoop MP, etal., J Proteome Res. 2012 Aug 3;11(8):4315-25. doi: 10.1021/pr300428e. Epub 2012 Jul 25.
30. Sucker C, etal., Nephrol Dial Transplant. 2007 May;22(5):1347-50. Epub 2007 Feb 27.
31. Xu CW, etal., J Endocrinol Invest. 2012 Jul;35(7):620-4.
32. Yano Y, etal., J Clin Endocrinol Metab. 2003 Feb;88(2):736-41.
33. Yoshida T, etal., Genomics. 2009 Mar;93(3):221-6. doi: 10.1016/j.ygeno.2008.11.001. Epub 2008 Dec 6.
Additional References at PubMed
PMID:10739389   PMID:12477932   PMID:12958609   PMID:18513211   PMID:23533145   PMID:24188431   PMID:28289017  


Genomics

Comparative Map Data
Cpb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21550,557,722 - 50,606,569 (+)NCBI
Rnor_6.0 Ensembl1557,290,849 - 57,339,760 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01557,290,849 - 57,339,762 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01561,001,889 - 61,050,732 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41556,104,920 - 56,154,321 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11556,120,686 - 56,170,027 (+)NCBI
Celera1550,189,675 - 50,237,544 (+)NCBICelera
Cytogenetic Map15q11NCBI
CPB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1346,053,186 - 46,105,033 (-)EnsemblGRCh38hg38GRCh38
GRCh381346,053,066 - 46,105,033 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371346,627,321 - 46,679,168 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361345,525,323 - 45,577,212 (-)NCBINCBI36hg18NCBI36
Build 341345,525,322 - 45,577,169NCBI
Celera1327,682,037 - 27,734,241 (-)NCBI
Cytogenetic Map13q14.13NCBI
HuRef1327,424,287 - 27,477,016 (-)NCBIHuRef
CHM1_11346,596,461 - 46,648,341 (-)NCBICHM1_1
Cpb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391475,479,727 - 75,520,995 (+)NCBIGRCm39mm39
GRCm39 Ensembl1475,479,727 - 75,520,995 (+)Ensembl
GRCm381475,242,287 - 75,283,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1475,242,287 - 75,283,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv371475,642,094 - 75,683,362 (+)NCBIGRCm37mm9NCBIm37
MGSCv361473,976,443 - 74,017,701 (+)NCBImm8
Celera1472,744,408 - 72,785,554 (+)NCBICelera
Cytogenetic Map14D3NCBI
Cpb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555183,740,348 - 3,803,539 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555183,740,348 - 3,803,540 (-)NCBIChiLan1.0ChiLan1.0
CPB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01326,926,788 - 26,979,767 (+)NCBIMhudiblu_PPA_v0panPan3
CPB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1225,074,805 - 5,126,635 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl225,074,816 - 5,126,170 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha225,060,946 - 5,113,389 (+)NCBI
ROS_Cfam_1.0225,190,115 - 5,242,228 (+)NCBI
UMICH_Zoey_3.1224,972,456 - 5,024,301 (+)NCBI
UNSW_CanFamBas_1.0225,035,678 - 5,087,765 (+)NCBI
UU_Cfam_GSD_1.0225,040,873 - 5,092,730 (+)NCBI
Cpb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945156,155,086 - 156,203,983 (-)NCBI
SpeTri2.0NW_004936857577,067 - 609,855 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,234,447 - 21,298,244 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,234,447 - 21,298,250 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21121,696,077 - 21,757,686 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPB2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1324,108,854 - 24,161,669 (-)NCBI
ChlSab1.1 Ensembl324,109,416 - 24,161,408 (-)Ensembl
Cpb2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247488,850,128 - 8,927,986 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
9590272Scort14Serum corticosterone level QTL 142.780.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)151698090761980907Rat
8694427Bw163Body weight QTL 1634.820.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)151698090761980907Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151724964162249641Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151809320881255430Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1526381041106550657Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1526381041106550657Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1526381041106550657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152870974173709741Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)153321910189640841Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)153321910189640841Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)153321910189640841Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)153948079762596410Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153974955779033707Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153974955779033707Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154106809486068094Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1543097470106550657Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:106
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000014909
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 41 41 1
Low 3 3 9 6 2 2 4 3 14 9 2
Below cutoff 6 7 12 6 7 28 23 20 1 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014909   ⟹   ENSRNOP00000014909
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1557,290,849 - 57,339,760 (+)Ensembl
RefSeq Acc Id: NM_053617   ⟹   NP_446069
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21550,557,722 - 50,606,563 (+)NCBI
Rnor_6.01557,290,849 - 57,339,762 (+)NCBI
Rnor_5.01561,001,889 - 61,050,732 (+)NCBI
RGSC_v3.41556,104,920 - 56,154,321 (+)RGD
Celera1550,189,675 - 50,237,544 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092945   ⟹   XP_038948873
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21550,557,737 - 50,606,569 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446069   ⟸   NM_053617
- Peptide Label: precursor
- UniProtKB: Q9EQV9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014909   ⟸   ENSRNOT00000014909
RefSeq Acc Id: XP_038948873   ⟸   XM_039092945
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699831
Promoter ID:EPDNEW_R10353
Type:initiation region
Name:Cpb2_1
Description:carboxypeptidase B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01557,290,838 - 57,290,898EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71035 AgrOrtholog
Ensembl Genes ENSRNOG00000010935 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000014909 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014909 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.340 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7323668 IMAGE-MGC_LOAD
  IMAGE:7323735 IMAGE-MGC_LOAD
InterPro CPB2 UniProtKB/Swiss-Prot
  M14A-like_propep UniProtKB/Swiss-Prot
  M14A_act_pep UniProtKB/Swiss-Prot
  Peptidase_M14 UniProtKB/Swiss-Prot
KEGG Report rno:113936 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108633 IMAGE-MGC_LOAD
  MGC:124950 IMAGE-MGC_LOAD
NCBI Gene 113936 ENTREZGENE
Pfam Peptidase_M14 UniProtKB/Swiss-Prot
  Propep_M14 UniProtKB/Swiss-Prot
PhenoGen Cpb2 PhenoGen
PRINTS CRBOXYPTASEA UniProtKB/Swiss-Prot
SMART Zn_pept UniProtKB/Swiss-Prot
UniProt CBPB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3B7V3 UniProtKB/Swiss-Prot
  Q5BKB8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Cpb2  carboxypeptidase B2  Cpb2  carboxypeptidase B2 (plasma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Cpb2  carboxypeptidase B2 (plasma)  LOC684726  similar to carboxypeptidase B2 (plasma)  Data Merged 737654 PROVISIONAL
2006-11-19 LOC684726  similar to carboxypeptidase B2 (plasma)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-07-09 Cpb2  carboxypeptidase B2 (plasma)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference