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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309255
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl12
Name: chemokine (C-C motif) ligand 12
Acc ID: CHEBI:10112
Term: zileuton
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.
Chemical ID: MESH:C063449
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13194986480464CTDzileuton inhibits the reaction [CCL12 protein results in increased abundance of Leukotriene B4], zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL12 mRNA]

PMID:12388339, PMID:12794006
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.