Flnb (filamin B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Flnb (filamin B) Rattus norvegicus
Analyze
Symbol: Flnb
Name: filamin B
RGD ID: 1311915
Description: Predicted to enable identical protein binding activity. Predicted to act upstream of or within several processes, including cellular response to type II interferon; epithelial cell development; and skeletal muscle tissue development. Located in neuronal cell body. Human ortholog(s) of this gene implicated in Larsen syndrome; bone development disease (multiple); cleft palate; and spinal disease (multiple). Orthologous to human FLNB (filamin B); PARTICIPATES IN integrin mediated signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: filamin B, beta; filamin, beta; filamin-B; filamin-B-like; LOC100911261; LOC306204
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,392,212 - 19,525,278 (-)NCBIGRCr8
mRatBN7.21516,961,999 - 17,095,059 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,962,003 - 17,095,006 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1519,136,669 - 19,269,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01520,095,144 - 20,228,215 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,350,059 - 18,483,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,750,152 - 18,883,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,750,118 - 18,883,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,716,606 - 22,849,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,949,027 - 19,082,504 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,950,017 - 19,108,490 (-)NCBI
Celera1516,918,384 - 17,051,016 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dicrotophos  (ISO)
dimethylselenide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in FLNB cause boomerang dysplasia. Bicknell LS, etal., J Med Genet. 2005 Jul;42(7):e43.
2. A molecular and clinical study of Larsen syndrome caused by mutations in FLNB. Bicknell LS, etal., J Med Genet. 2007 Feb;44(2):89-98. Epub 2006 Jun 26.
3. Integrin inactivators: balancing cellular functions in vitro and in vivo. Bouvard D, etal., Nat Rev Mol Cell Biol. 2013 Jul;14(7):430-42. doi: 10.1038/nrm3599. Epub 2013 May 30.
4. Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome. Farrington-Rock C, etal., Hum Mol Genet. 2008 Mar 1;17(5):631-41. Epub 2007 Jul 17.
5. Mutations in two regions of FLNB result in atelosteogenesis I and III. Farrington-Rock C, etal., Hum Mutat. 2006 Jul;27(7):705-10.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, etal., PLoS One. 2010 Jul 9;5(7):e11493. doi: 10.1371/journal.pone.0011493.
8. Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Krakow D, etal., Nat Genet. 2004 Apr;36(4):405-10. Epub 2004 Feb 29.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Sheen VL, etal., Hum Mol Genet. 2002 Nov 1;11(23):2845-54.
16. Three novel missense mutations in the filamin B gene are associated with isolated congenital talipes equinovarus. Yang H, etal., Hum Genet. 2016 Oct;135(10):1181-9. doi: 10.1007/s00439-016-1701-7. Epub 2016 Jul 9.
Additional References at PubMed
PMID:11807098   PMID:16791210   PMID:19056867   PMID:19144319   PMID:21423176   PMID:22114352   PMID:22681889   PMID:23533145   PMID:23979707   PMID:24012369   PMID:25468996  


Genomics

Comparative Map Data
Flnb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,392,212 - 19,525,278 (-)NCBIGRCr8
mRatBN7.21516,961,999 - 17,095,059 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,962,003 - 17,095,006 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1519,136,669 - 19,269,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01520,095,144 - 20,228,215 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,350,059 - 18,483,132 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,750,152 - 18,883,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,750,118 - 18,883,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,716,606 - 22,849,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,949,027 - 19,082,504 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,950,017 - 19,108,490 (-)NCBI
Celera1516,918,384 - 17,051,016 (-)NCBICelera
Cytogenetic Map15p14NCBI
FLNB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38358,008,422 - 58,172,251 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl358,008,398 - 58,172,251 (+)EnsemblGRCh38hg38GRCh38
GRCh37357,994,149 - 58,157,978 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,969,167 - 58,133,018 (+)NCBINCBI36Build 36hg18NCBI36
Build 34357,969,200 - 58,133,015NCBI
Celera358,008,139 - 58,172,548 (+)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef358,091,507 - 58,255,398 (+)NCBIHuRef
CHM1_1357,944,271 - 58,108,169 (+)NCBICHM1_1
T2T-CHM13v2.0358,048,835 - 58,212,708 (+)NCBIT2T-CHM13v2.0
Flnb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,518,185 - 14,651,852 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,518,185 - 14,651,816 (-)EnsemblGRCm39 Ensembl
GRCm38147,817,921 - 7,951,588 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl147,817,957 - 7,951,588 (+)EnsemblGRCm38mm10GRCm38
MGSCv37148,650,471 - 8,784,102 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36146,608,366 - 6,743,464 (+)NCBIMGSCv36mm8
Celera143,438,528 - 3,574,962 (+)NCBICelera
Cytogenetic Map14A1NCBI
cM Map144.59NCBI
Flnb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554307,680,394 - 7,832,124 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554307,680,394 - 7,832,124 (+)NCBIChiLan1.0ChiLan1.0
FLNB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2257,978,724 - 58,142,635 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1357,983,508 - 58,147,409 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0357,943,263 - 58,107,115 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1359,359,234 - 59,521,989 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl359,359,234 - 59,521,989 (+)Ensemblpanpan1.1panPan2
FLNB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,394,755 - 32,533,440 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,396,165 - 32,533,275 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,324,259 - 32,462,636 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02032,668,416 - 32,806,815 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,668,423 - 32,806,776 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,123,648 - 32,261,938 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,480,340 - 32,618,596 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,652,257 - 32,790,526 (-)NCBIUU_Cfam_GSD_1.0
Flnb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118175,129,741 - 175,274,947 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364738,268,496 - 8,411,975 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364738,268,326 - 8,413,955 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLNB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,789,739 - 39,938,746 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,789,259 - 39,938,751 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21343,752,537 - 43,820,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLNB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12219,304,822 - 19,468,037 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2219,304,781 - 19,468,036 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041147,393,314 - 147,556,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flnb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624821691,272 - 836,322 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624821691,291 - 835,244 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flnb
789 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:200
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000066546
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat

Markers in Region
RH127642  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21516,962,035 - 16,962,218 (+)MAPPERmRatBN7.2
Rnor_6.01518,750,189 - 18,750,371NCBIRnor6.0
Rnor_6.01517,958,825 - 17,959,007NCBIRnor6.0
Rnor_5.01522,716,643 - 22,716,825UniSTSRnor5.0
Rnor_5.01521,939,082 - 21,939,264UniSTSRnor5.0
RGSC_v3.41518,949,060 - 18,949,242UniSTSRGSC3.4
Celera1516,918,417 - 16,918,599UniSTS
RH 3.4 Map15144.4UniSTS
Cytogenetic Map15p14UniSTS
BE121117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21517,086,598 - 17,086,749 (+)MAPPERmRatBN7.2
Rnor_6.01518,874,552 - 18,874,702NCBIRnor6.0
Rnor_5.01522,840,956 - 22,841,106UniSTSRnor5.0
RGSC_v3.41519,074,097 - 19,074,247UniSTSRGSC3.4
Celera1517,042,619 - 17,042,769UniSTS
RH 3.4 Map15139.7UniSTS
Cytogenetic Map15p14UniSTS
RH135239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21517,073,737 - 17,073,917 (+)MAPPERmRatBN7.2
Rnor_6.01518,861,693 - 18,861,872NCBIRnor6.0
Rnor_5.01522,828,097 - 22,828,276UniSTSRnor5.0
RGSC_v3.41519,061,238 - 19,061,417UniSTSRGSC3.4
Celera1517,029,738 - 17,029,917UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000066546   ⟹   ENSRNOP00000061198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,962,003 - 17,095,006 (-)Ensembl
Rnor_6.0 Ensembl1518,750,156 - 18,882,959 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088264   ⟹   ENSRNOP00000070399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,962,003 - 17,095,006 (-)Ensembl
Rnor_6.0 Ensembl1518,750,118 - 18,883,005 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106091   ⟹   ENSRNOP00000092630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,962,003 - 17,095,006 (-)Ensembl
RefSeq Acc Id: NM_001107288   ⟹   NP_001100758
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,392,216 - 19,525,209 (-)NCBI
mRatBN7.21516,962,003 - 17,095,006 (-)NCBI
Rnor_6.01518,750,156 - 18,882,959 (-)NCBI
Rnor_5.01522,716,606 - 22,849,401 (-)NCBI
RGSC_v3.41518,949,027 - 19,082,504 (-)RGD
Celera1516,918,384 - 17,051,016 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251780   ⟹   XP_006251842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,392,212 - 19,525,278 (-)NCBI
mRatBN7.21516,961,999 - 17,095,059 (-)NCBI
Rnor_6.01518,750,152 - 18,883,019 (-)NCBI
Rnor_5.01522,716,606 - 22,849,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251781   ⟹   XP_006251843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,392,212 - 19,525,272 (-)NCBI
mRatBN7.21516,961,999 - 17,095,059 (-)NCBI
Rnor_6.01518,750,152 - 18,883,019 (-)NCBI
Rnor_5.01522,716,606 - 22,849,401 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001100758   ⟸   NM_001107288
- UniProtKB: D4A8D5 (UniProtKB/TrEMBL),   A6K0C4 (UniProtKB/TrEMBL),   A0A8I6GK95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251843   ⟸   XM_006251781
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GK95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251842   ⟸   XM_006251780
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JXT8 (UniProtKB/TrEMBL),   A0A8I6GK95 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061198   ⟸   ENSRNOT00000066546
Ensembl Acc Id: ENSRNOP00000070399   ⟸   ENSRNOT00000088264
Ensembl Acc Id: ENSRNOP00000092630   ⟸   ENSRNOT00000106091
Protein Domains
Calponin-homology (CH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXT8-F1-model_v2 AlphaFold A0A0G2JXT8 1-2602 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699594
Promoter ID:EPDNEW_R10117
Type:initiation region
Name:Flnb_1
Description:filamin B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01518,882,974 - 18,883,034EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311915 AgrOrtholog
BioCyc Gene G2FUF-14278 BioCyc
Ensembl Genes ENSRNOG00000009470 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066546.2 UniProtKB/TrEMBL
  ENSRNOT00000088264.2 UniProtKB/TrEMBL
  ENSRNOT00000106091.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  Calponin_act-bd UniProtKB/TrEMBL
  Filamin UniProtKB/TrEMBL
  Filamin UniProtKB/TrEMBL
  Filamin/ABP280_repeat-like UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
KEGG Report rno:306204 UniProtKB/TrEMBL
NCBI Gene 306204 ENTREZGENE
PANTHER FILAMIN-B UniProtKB/TrEMBL
  JITTERBUG, ISOFORM N UniProtKB/TrEMBL
  PTHR38537 UniProtKB/TrEMBL
Pfam Filamin UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
PhenoGen Flnb PhenoGen
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  FILAMIN_REPEAT UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009470 RatGTEx
SMART IG_FLMN UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
UniProt A0A0G2JXT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GK95 ENTREZGENE, UniProtKB/TrEMBL
  A6K0C4 ENTREZGENE, UniProtKB/TrEMBL
  D4A8D5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Flnb  filamin B  LOC100911261  filamin-B-like  Data merged from RGD:6493869 737654 PROVISIONAL
2016-01-11 Flnb  filamin B  Flnb  filamin B, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911261  filamin-B-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-01-17 Flnb  filamin B, beta  Flnb  filamin, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Flnb  filamin, beta   Flnb_predicted  filamin, beta (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Flnb_predicted  filamin, beta (predicted)      Symbol and Name status set to approved 70820 APPROVED