Tcp1 (t-complex 1) - Rat Genome Database

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Gene: Tcp1 (t-complex 1) Rattus norvegicus
Analyze
Symbol: Tcp1
Name: t-complex 1
RGD ID: 3832
Description: Predicted to enable protein folding chaperone; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including positive regulation of protein localization; positive regulation of telomerase RNA localization to Cajal body; and positive regulation of telomere maintenance via telomerase. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Part of heterochromatin. Orthologous to human TCP1 (t-complex 1); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CCT-alpha; CCTalpha; t-complex protein 1; T-complex protein 1 subunit alpha; Tcp-1; TCP-1-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Tcp1-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,376,848 - 50,384,527 (-)NCBIGRCr8
mRatBN7.2147,829,061 - 47,836,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,828,652 - 47,836,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,520,703 - 48,528,382 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,506,599 - 54,514,346 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,596,232 - 48,603,911 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,025,664 - 48,033,343 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,025,663 - 48,033,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,719,055 - 51,726,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,103,543 - 42,111,222 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,106,487 - 42,114,167 (-)NCBI
Celera143,629,524 - 43,637,203 (-)NCBICelera
RH 3.4 Map1537.31RGD
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bleomycin A5  (ISO)
bufalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
elemental selenium  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenofibrate  (EXP)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lovastatin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
Nonylphenol  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
quartz  (ISO)
raloxifene  (EXP)
selenium atom  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
T-2 toxin  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (EXP)
warfarin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels. Ishibashi K, etal., Biochem Biophys Res Commun 2000 Apr 13;270(2):370-6.
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Cloning of cDNA encoding rat TCP-1. Morita T, etal., Biochim Biophys Acta 1991 Dec 2;1129(1):96-9.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. The cytosolic chaperonin CCT associates to cytoplasmic microtubular structures during mammalian spermiogenesis and to heterochromatin in germline and somatic cells. Soues S, etal., Exp Cell Res 2003 Aug 15;288(2):363-73.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1495973   PMID:1937024   PMID:2655925   PMID:7828721   PMID:7953530   PMID:17110338   PMID:17634366   PMID:18694933   PMID:19056867   PMID:19684306   PMID:20080638   PMID:20131911  
PMID:20193073   PMID:20458337   PMID:21525035   PMID:21753002   PMID:21880732   PMID:22681889   PMID:22871113   PMID:23011926   PMID:23533145   PMID:23716698   PMID:23904609   PMID:24625528  
PMID:25002582   PMID:25467444   PMID:30053369  


Genomics

Comparative Map Data
Tcp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,376,848 - 50,384,527 (-)NCBIGRCr8
mRatBN7.2147,829,061 - 47,836,809 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,828,652 - 47,836,839 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,520,703 - 48,528,382 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,506,599 - 54,514,346 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,596,232 - 48,603,911 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,025,664 - 48,033,343 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,025,663 - 48,033,396 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,719,055 - 51,726,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,103,543 - 42,111,222 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,106,487 - 42,114,167 (-)NCBI
Celera143,629,524 - 43,637,203 (-)NCBICelera
RH 3.4 Map1537.31RGD
Cytogenetic Map1q11NCBI
TCP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386159,778,498 - 159,789,602 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,778,498 - 159,789,703 (-)EnsemblGRCh38hg38GRCh38
GRCh376160,199,530 - 160,210,634 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,119,520 - 160,130,725 (-)NCBINCBI36Build 36hg18NCBI36
Build 346160,169,941 - 160,181,146NCBI
Celera6160,845,607 - 160,856,819 (-)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,669,773 - 157,680,978 (-)NCBIHuRef
CHM1_16160,461,821 - 160,473,042 (-)NCBICHM1_1
T2T-CHM13v2.06161,024,115 - 161,035,234 (-)NCBIT2T-CHM13v2.0
Tcp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391713,135,216 - 13,143,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1713,134,588 - 13,143,954 (+)EnsemblGRCm39 Ensembl
GRCm381712,916,329 - 12,925,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,915,701 - 12,925,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv371713,109,331 - 13,117,933 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,759,446 - 12,767,497 (+)NCBIMGSCv36mm8
Celera1712,948,013 - 12,956,616 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.72NCBI
Tcp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543921,114,038 - 21,124,379 (+)NCBIChiLan1.0ChiLan1.0
TCP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25179,877,363 - 179,888,668 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,781,864 - 177,793,622 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,661,409 - 157,672,581 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,673,050 - 162,684,261 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,673,596 - 162,683,985 (-)Ensemblpanpan1.1panPan2
TCP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,029,260 - 49,038,023 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,029,282 - 49,038,020 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,871,249 - 49,879,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,213,974 - 49,222,681 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,213,961 - 49,222,697 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,096,311 - 49,105,058 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0148,967,408 - 48,976,160 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,582,581 - 49,591,336 (-)NCBIUU_Cfam_GSD_1.0
Tcp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,021,338 - 144,030,784 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648911,273,335 - 11,282,811 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl17,590,140 - 7,601,795 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,590,140 - 7,600,709 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,389,098 - 9,399,667 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TCP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11387,377,452 - 87,388,692 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,377,996 - 87,388,568 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,776,464 - 59,787,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248553,121,274 - 3,133,640 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tcp1
58 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000019531
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat

Markers in Region
AI528772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,829,186 - 47,829,332 (+)MAPPERmRatBN7.2
mRatBN7.24120,706,024 - 120,706,170 (+)MAPPERmRatBN7.2
Rnor_6.0148,025,789 - 48,025,934NCBIRnor6.0
Rnor_6.04120,180,744 - 120,180,889NCBIRnor6.0
Rnor_5.04185,422,198 - 185,422,343UniSTSRnor5.0
RGSC_v3.44122,326,785 - 122,326,930UniSTSRGSC3.4
RGSC_v3.4142,103,668 - 42,103,813UniSTSRGSC3.4
Celera143,629,649 - 43,629,794UniSTS
Celera4109,662,385 - 109,662,530UniSTS
Cytogenetic Map4q34UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map1q12UniSTS
RH94518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,829,061 - 47,829,145 (+)MAPPERmRatBN7.2
Rnor_6.0148,025,664 - 48,025,747NCBIRnor6.0
Rnor_5.0151,726,651 - 51,726,734UniSTSRnor5.0
RGSC_v3.4142,103,543 - 42,103,626UniSTSRGSC3.4
Celera143,629,524 - 43,629,607UniSTS
RH 3.4 Map1537.31UniSTS
Cytogenetic Map1q11UniSTS
Cytogenetic Map1q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000019531   ⟹   ENSRNOP00000019531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,828,652 - 47,836,839 (-)Ensembl
Rnor_6.0 Ensembl148,025,663 - 48,033,343 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076422   ⟹   ENSRNOP00000068050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,829,077 - 47,836,752 (-)Ensembl
Rnor_6.0 Ensembl148,025,667 - 48,033,396 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl148,027,007 - 48,030,554 (-)Ensembl
RefSeq Acc Id: NM_012670   ⟹   NP_036802
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,376,848 - 50,384,527 (-)NCBI
mRatBN7.2147,829,062 - 47,836,744 (-)NCBI
Rnor_6.0148,025,664 - 48,033,343 (-)NCBI
Rnor_5.0151,719,055 - 51,726,734 (+)NCBI
RGSC_v3.4142,103,543 - 42,111,222 (-)RGD
Celera143,629,524 - 43,637,203 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036802 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA14357 (Get FASTA)   NCBI Sequence Viewer  
  EDL83041 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019531
  ENSRNOP00000019531.1
  ENSRNOP00000068050.2
  ENSRNOP00055039282
  ENSRNOP00060012679
  ENSRNOP00065041236
GenBank Protein P28480 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036802   ⟸   NM_012670
- UniProtKB: P28480 (UniProtKB/Swiss-Prot),   A6KJV3 (UniProtKB/TrEMBL),   A0A096MJA0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019531   ⟸   ENSRNOT00000019531
RefSeq Acc Id: ENSRNOP00000068050   ⟸   ENSRNOT00000076422

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28480-F1-model_v2 AlphaFold P28480 1-556 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689615
Promoter ID:EPDNEW_R139
Type:initiation region
Name:Tcp1_1
Description:t-complex 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,033,371 - 48,033,431EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3832 AgrOrtholog
BioCyc Gene G2FUF-61585 BioCyc
Ensembl Genes ENSRNOG00000014160 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055027559 UniProtKB/Swiss-Prot
  ENSRNOG00060009583 UniProtKB/Swiss-Prot
  ENSRNOG00065029039 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019531 ENTREZGENE
  ENSRNOT00000019531.5 UniProtKB/Swiss-Prot
  ENSRNOT00000076422.2 UniProtKB/TrEMBL
  ENSRNOT00055047737 UniProtKB/Swiss-Prot
  ENSRNOT00060016223 UniProtKB/Swiss-Prot
  ENSRNOT00065050203 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.260.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.7.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chap_CCT_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chaperone_TCP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chaperonin_TCP-1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cpn60/TCP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroEL-like_apical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GROEL-like_equatorial_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCP-1-like_intermed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24818 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24818 ENTREZGENE
PANTHER PTHR11353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-COMPLEX PROTEIN 1 SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cpn60_TCP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tcp1 PhenoGen
PRINTS TCOMPLEXTCP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TCP1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCP1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TCP1_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014160 RatGTEx
  ENSRNOG00055027559 RatGTEx
  ENSRNOG00060009583 RatGTEx
  ENSRNOG00065029039 RatGTEx
Superfamily-SCOP SSF48592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52029 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54849 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204340
UniProt A0A096MJA0 ENTREZGENE, UniProtKB/TrEMBL
  A6KJV3 ENTREZGENE, UniProtKB/TrEMBL
  A6KJV4_RAT UniProtKB/TrEMBL
  P28480 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tcp1  t-complex 1  Tcp1  t-complex protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Tcp1  T-complex 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference