Sgk3 (serum/glucocorticoid regulated kinase family, member 3) - Rat Genome Database

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Gene: Sgk3 (serum/glucocorticoid regulated kinase family, member 3) Rattus norvegicus
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Symbol: Sgk3
Name: serum/glucocorticoid regulated kinase family, member 3
RGD ID: 620242
Description: Predicted to enable molecular adaptor activity; potassium channel regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; localization; and peptidyl-serine phosphorylation. Predicted to act upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in cytoplasmic vesicle and nucleoplasm. Orthologous to several human genes including SGK3 (serum/glucocorticoid regulated kinase family member 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cisk; cytokine-independent survival kinase; LOC103692278; serine/threonine protein kinase CISK; serine/threonine-protein kinase Sgk3; serum/glucocorticoid regulated kinase 3; serum/glucocorticoid regulated kinase-like; serum/glucocorticoid-regulated kinase 3; serum/glucocorticoid-regulated kinase-like; Sgkl; uncharacterized LOC103692278
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.259,345,761 - 9,472,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl59,346,040 - 9,415,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,502,631 - 11,568,922 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0513,132,573 - 13,200,616 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0512,837,301 - 12,903,595 (-)NCBIRnor_WKY
Rnor_6.059,046,889 - 9,094,740 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl59,048,614 - 9,094,616 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,847,906 - 13,941,451 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera58,858,341 - 8,925,021 (-)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
barium(0)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
estrone  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hexestrol  (ISO)
L-methionine  (ISO)
mercury dibromide  (ISO)
mestranol  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
nickel dichloride  (EXP)
ouabain  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
testosterone enanthate  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. Dai F, etal., Genomics 1999 Nov 15;62(1):95-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:11050396   PMID:15057822   PMID:23589291   PMID:26823753  


Genomics

Comparative Map Data
Sgk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.259,345,761 - 9,472,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl59,346,040 - 9,415,476 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,502,631 - 11,568,922 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0513,132,573 - 13,200,616 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0512,837,301 - 12,903,595 (-)NCBIRnor_WKY
Rnor_6.059,046,889 - 9,094,740 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl59,048,614 - 9,094,616 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,847,906 - 13,941,451 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera58,858,341 - 8,925,021 (-)NCBICelera
Cytogenetic Map5q11NCBI
SGK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,712,781 - 66,862,022 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl866,712,734 - 66,862,022 (+)EnsemblGRCh38hg38GRCh38
GRCh37867,625,016 - 67,774,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,787,445 - 67,936,811 (+)NCBINCBI36Build 36hg18NCBI36
Build 34867,850,015 - 67,936,809NCBI
Celera863,617,793 - 63,767,751 (+)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef863,116,616 - 63,266,844 (+)NCBIHuRef
CHM1_1867,679,569 - 67,829,231 (+)NCBICHM1_1
T2T-CHM13v2.0867,138,550 - 67,288,509 (+)NCBIT2T-CHM13v2.0
Sgk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3919,868,355 - 9,972,795 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl19,868,332 - 9,971,070 (+)EnsemblGRCm39 Ensembl
GRCm3819,798,130 - 9,902,570 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl19,798,107 - 9,900,845 (+)EnsemblGRCm38mm10GRCm38
MGSCv3719,788,211 - 9,892,651 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3619,783,344 - 9,887,784 (+)NCBIMGSCv36mm8
Celera19,770,220 - 9,875,393 (+)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.08NCBI
Sgk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544412,385,747 - 12,445,740 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544412,385,747 - 12,501,589 (-)NCBIChiLan1.0ChiLan1.0
LOC100987089
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1864,982,973 - 65,067,296 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,982,973 - 65,067,296 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0863,210,279 - 63,403,991 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SGK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12916,236,197 - 16,418,225 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2916,274,352 - 16,415,598 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,661,140 - 16,731,156 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02916,355,030 - 16,498,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2916,355,068 - 16,506,875 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12916,457,800 - 16,527,880 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,557,222 - 16,627,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02916,813,736 - 16,884,005 (+)NCBIUU_Cfam_GSD_1.0
Sgk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,520,278 - 67,588,541 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,195,777 - 7,265,186 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364967,196,936 - 7,287,367 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Sgk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474424,476,626 - 24,539,480 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474424,476,880 - 24,613,442 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sgk3
979 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:73
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000072210
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat

Markers in Region
D5Rat215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.259,359,693 - 9,359,791 (+)MAPPERmRatBN7.2
Rnor_6.059,060,224 - 9,060,321NCBIRnor6.0
Rnor_5.0513,861,050 - 13,861,147UniSTSRnor5.0
Celera58,869,263 - 8,869,360UniSTS
RH 3.4 Map555.5UniSTS
RH 3.4 Map555.5RGD
RH 2.0 Map573.6RGD
SHRSP x BN Map54.56RGD


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 21 5 19 5 14 35 28 11
Low 2 43 36 36 36 8 10 60 13 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072210   ⟹   ENSRNOP00000064540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl59,346,040 - 9,415,476 (-)Ensembl
Rnor_6.0 Ensembl59,048,614 - 9,094,616 (-)Ensembl
RefSeq Acc Id: NM_001376043   ⟹   NP_001362972
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.259,346,040 - 9,415,476 (-)NCBI
RefSeq Acc Id: XM_039109231   ⟹   XP_038965159
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.259,345,761 - 9,472,237 (-)NCBI
RefSeq Acc Id: XM_039109232   ⟹   XP_038965160
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.259,345,761 - 9,472,237 (-)NCBI
RefSeq Acc Id: XM_039109233   ⟹   XP_038965161
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.259,345,761 - 9,472,243 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001362972 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965159 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965160 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965161 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL91350 (Get FASTA)   NCBI Sequence Viewer  
  Q8R4V0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000064540   ⟸   ENSRNOT00000072210
RefSeq Acc Id: XP_038965161   ⟸   XM_039109233
- Peptide Label: isoform X1
- UniProtKB: M0R582 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965160   ⟸   XM_039109232
- Peptide Label: isoform X1
- UniProtKB: M0R582 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965159   ⟸   XM_039109231
- Peptide Label: isoform X1
- UniProtKB: M0R582 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001362972   ⟸   NM_001376043
- UniProtKB: M0R582 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   Protein kinase   PX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R4V0-F1-model_v2 AlphaFold Q8R4V0 1-496 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620242 AgrOrtholog
BioCyc Gene G2FUF-42200 BioCyc
Ensembl Genes ENSRNOG00000049052 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064540 ENTREZGENE
  ENSRNOP00000064540.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072210 ENTREZGENE
  ENSRNOT00000072210.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CISK_PX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SGK3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171498 ENTREZGENE
Pfam PF00787 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sgk3 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50195 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00312 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF64268 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt M0R582 ENTREZGENE, UniProtKB/TrEMBL
  Q8R4V0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Sgk3  serum/glucocorticoid regulated kinase family, member 3  LOC103692278  uncharacterized LOC103692278  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103692278  uncharacterized LOC103692278      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-08-02 Sgk3  serum/glucocorticoid regulated kinase family, member 3  Sgk3  serum/glucocorticoid regulated kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Sgk3  serum/glucocorticoid regulated kinase 3  Sgk3  serum/glucocorticoid regulated kinase family, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Sgk3  serum/glucocorticoid regulated kinase family, member 3  Sgkl  serum/glucocorticoid regulated kinase-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Sgkl  serum/glucocorticoid regulated kinase-like    serine/threonine protein kinase CISK  Name updated 1299863 APPROVED
2002-08-07 Sgkl  serine/threonine protein kinase CISK      Symbol and Name status set to provisional 70820 PROVISIONAL