Golga5 (golgin A5) - Rat Genome Database

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Gene: Golga5 (golgin A5) Rattus norvegicus
Analyze
Symbol: Golga5
Name: golgin A5
RGD ID: 1308163
Description: Enables protein-macromolecule adaptor activity and small GTPase binding activity. Involved in Golgi organization and retrograde transport, vesicle recycling within Golgi. Located in COPI-coated vesicle membrane and Golgi apparatus. Orthologous to human GOLGA5 (golgin A5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; flutamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: golgi autoantigen, golgin subfamily a, 5; golgin subfamily A member 5; golgin-84; Ret-II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26121,612,389 - 121,640,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,612,529 - 121,640,413 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,751,246 - 121,779,125 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.06122,046,504 - 122,074,379 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.06121,382,568 - 121,410,729 (+)NCBIRnor_WKY
Rnor_6.06126,350,572 - 126,378,735 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,353,223 - 126,378,610 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,561,133 - 135,589,807 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,740,320 - 126,765,513 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,744,066 - 126,769,260 (+)NCBI
Celera6119,103,910 - 119,128,964 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Detection of a novel type of RET rearrangement (PTC5) in thyroid carcinomas after Chernobyl and analysis of the involved RET-fused gene RFG5. Klugbauer S, etal., Cancer Res. 1998 Jan 15;58(2):198-203.
4. Golgin tethers define subpopulations of COPI vesicles. Malsam J, etal., Science. 2005 Feb 18;307(5712):1095-8.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Golgin-84 is a rab1 binding partner involved in Golgi structure. Satoh A, etal., Traffic. 2003 Mar;4(3):153-61.
Additional References at PubMed
PMID:9915833   PMID:12538640   PMID:15047867   PMID:19946888   PMID:27502188  


Genomics

Comparative Map Data
Golga5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26121,612,389 - 121,640,552 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,612,529 - 121,640,413 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,751,246 - 121,779,125 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.06122,046,504 - 122,074,379 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.06121,382,568 - 121,410,729 (+)NCBIRnor_WKY
Rnor_6.06126,350,572 - 126,378,735 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,353,223 - 126,378,610 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,561,133 - 135,589,807 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,740,320 - 126,765,513 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,744,066 - 126,769,260 (+)NCBI
Celera6119,103,910 - 119,128,964 (+)NCBICelera
Cytogenetic Map6q32NCBI
GOLGA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,794,305 - 92,839,947 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1492,794,305 - 92,839,947 (+)EnsemblGRCh38hg38GRCh38
GRCh371493,260,650 - 93,306,292 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361492,330,403 - 92,376,057 (+)NCBINCBI36Build 36hg18NCBI36
Build 341492,330,402 - 92,376,057NCBI
Celera1473,314,759 - 73,360,445 (+)NCBICelera
Cytogenetic Map14q32.12ENTREZGENE
HuRef1473,443,587 - 73,489,353 (+)NCBIHuRef
CHM1_11493,198,767 - 93,244,558 (+)NCBICHM1_1
T2T-CHM13v2.01487,026,063 - 87,071,707 (+)NCBIT2T-CHM13v2.0
Golga5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,435,372 - 102,464,274 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,435,394 - 102,464,166 (+)EnsemblGRCm39 Ensembl
GRCm3812102,469,109 - 102,498,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,469,135 - 102,497,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712103,708,120 - 103,736,117 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,870,242 - 102,898,957 (+)NCBIMGSCv36mm8
Celera12103,681,112 - 103,708,985 (+)NCBICelera
Cytogenetic Map12ENCBI
Golga5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,992,710 - 15,035,136 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543814,992,710 - 15,031,297 (+)NCBIChiLan1.0ChiLan1.0
GOLGA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11492,770,342 - 92,815,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,770,342 - 92,815,444 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01473,430,700 - 73,475,979 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GOLGA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,874,716 - 1,907,251 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,874,833 - 1,907,403 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,898,418 - 1,931,308 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,930,507 - 1,963,631 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,930,452 - 1,963,631 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,866,438 - 1,899,688 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,816,771 - 1,849,647 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,943,874 - 1,976,991 (+)NCBIUU_Cfam_GSD_1.0
Golga5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864012,599,965 - 12,635,665 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733831,076 - 867,207 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936733831,247 - 867,207 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GOLGA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7114,237,145 - 114,273,915 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17114,237,059 - 114,273,916 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,849,075 - 120,882,783 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GOLGA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12470,544,246 - 70,590,195 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2470,544,237 - 70,590,312 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605357,792,637 - 57,838,832 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Golga5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247349,292,714 - 9,340,905 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247349,288,953 - 9,339,573 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Golga5
101 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:86
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000010385
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat

Markers in Region
RH132984  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26121,640,151 - 121,640,349 (+)MAPPERmRatBN7.2
Rnor_6.06126,378,335 - 126,378,532NCBIRnor6.0
Rnor_5.06135,589,407 - 135,589,604UniSTSRnor5.0
RGSC_v3.46126,765,591 - 126,765,788UniSTSRGSC3.4
Celera6119,129,042 - 119,129,239UniSTS
RH 3.4 Map6849.0UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 10 74 35 41 11 8
Low 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010385   ⟹   ENSRNOP00000010385
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,612,529 - 121,640,413 (+)Ensembl
Rnor_6.0 Ensembl6126,353,223 - 126,378,610 (+)Ensembl
RefSeq Acc Id: NM_001033065   ⟹   NP_001028237
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26121,612,389 - 121,640,552 (+)NCBI
Rnor_6.06126,353,252 - 126,378,257 (+)NCBI
Rnor_5.06135,561,133 - 135,589,807 (+)NCBI
RGSC_v3.46126,740,320 - 126,765,513 (+)RGD
Celera6119,103,910 - 119,128,964 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001028237 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAN17671 (Get FASTA)   NCBI Sequence Viewer  
  EDL81746 (Get FASTA)   NCBI Sequence Viewer  
  EDL81747 (Get FASTA)   NCBI Sequence Viewer  
  Q3ZU82 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001028237   ⟸   NM_001033065
- UniProtKB: G3V6Z7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010385   ⟸   ENSRNOT00000010385

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3ZU82-F1-model_v2 AlphaFold Q3ZU82 1-728 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308163 AgrOrtholog
BioCyc Gene G2FUF-36449 BioCyc
Ensembl Genes ENSRNOG00000007699 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010385 ENTREZGENE
  ENSRNOP00000010385.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010385 ENTREZGENE
  ENSRNOT00000010385.6 UniProtKB/TrEMBL
InterPro Golgin_subfamily_A_member_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299258 UniProtKB/Swiss-Prot
NCBI Gene 299258 ENTREZGENE
PANTHER PTHR13815 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Golgin_A5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Golga5 PhenoGen
UniProt G3V6Z7 ENTREZGENE, UniProtKB/TrEMBL
  GOGA5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Golga5  golgin A5  Golga5  golgi autoantigen, golgin subfamily a, 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Golga5  golgi autoantigen, golgin subfamily a, 5  Golga5_predicted  golgi autoantigen, golgin subfamily a, 5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Golga5_predicted  golgi autoantigen, golgin subfamily a, 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED