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Gene: Atxn3 (ataxin 3) Rattus norvegicus
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Symbol: Atxn3
Name: ataxin 3
Description: Exhibits RNA polymerase II regulatory region DNA binding activity. Contributes to histone deacetylase activity. Involved in histone H3 deacetylation. Localizes to the nucleus. Predicted to colocalize with the endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to several human genes including ATXN3 (ataxin 3); PARTICIPATES IN mitochondrial autophagy pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17beta-estradiol; 4,4'-diaminodiphenylmethane; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ataxin-3; machado-Joseph disease protein 1 homolog; MJD1; Rsca3
Orthologs:
Homo sapiens (human) : ATXN3 (ataxin 3)  HGNC  Alliance
Mus musculus (house mouse) : Atxn3 (ataxin 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atxn3 (ataxin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ATXN3 (ataxin 3)
Canis lupus familiaris (dog) : ATXN3 (ataxin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atxn3 (ataxin 3)
Sus scrofa (pig) : ATXN3 (ataxin 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06125,817,420 - 125,853,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06135,029,278 - 135,065,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,196,043 - 126,229,844 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16126,199,789 - 126,233,591 (-)NCBI
Celera6118,571,601 - 118,605,060 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Atxn3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621567
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.