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Gene: Edn3 (endothelin 3) Rattus norvegicus
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Symbol: Edn3
Name: endothelin 3
Description: Predicted to have endothelin B receptor binding activity and hormone activity. Involved in negative regulation of hormone secretion and regulation of neurotransmitter secretion. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome type 4B; Waardenburg's syndrome; and congenital central hypoventilation syndrome. Orthologous to human EDN3 (endothelin 3); PARTICIPATES IN endothelin signaling pathway; INTERACTS WITH (R)-noradrenaline; 3',5'-cyclic GMP; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: edn3_mapped; endothelin 3 (mapped); endothelin-3; ET-3; Et3; LOC502697; PPET3; preproendothelin-3; preproET-3; RGD1564825; similar to prepro-endothelin-3
Orthologs:
Homo sapiens (human) : EDN3 (endothelin 3)  HGNC  Alliance
Mus musculus (house mouse) : Edn3 (endothelin 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Edn3 (endothelin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : EDN3 (endothelin 3)
Canis lupus familiaris (dog) : EDN3 (endothelin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Edn3 (endothelin 3)
Sus scrofa (pig) : EDN3 (endothelin 3)
more info ...
Is Marker For: Strains:   SS.SR-(D3Mco19-D3Mco5)/Jr  
QTLs:   Cm14   Bp167  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03172,856,730 - 172,879,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03178,903,017 - 178,925,563 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43166,491,368 - 166,514,051 (+)NCBIRGSC3.4rn4RGSC3.4
Celera3162,730,251 - 162,752,801 (+)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Edn3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2534
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.