Usp19 (ubiquitin specific peptidase 19) - Rat Genome Database

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Gene: Usp19 (ubiquitin specific peptidase 19) Rattus norvegicus
Analyze
Symbol: Usp19
Name: ubiquitin specific peptidase 19
RGD ID: 1303276
Description: Predicted to enable Hsp90 protein binding activity; deubiquitinase activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of cell cycle process; protein deubiquitination; and regulation of protein stability. Predicted to be located in cytosol and endoplasmic reticulum membrane. Orthologous to human USP19 (ubiquitin specific peptidase 19); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deubiquitinating enzyme 19; ubiquitin carboxyl-terminal hydrolase 19; ubiquitin specific protease 19; ubiquitin thioesterase 19; ubiquitin thiolesterase 19; ubiquitin-specific-processing protease 19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28109,190,727 - 109,201,761 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,190,724 - 109,201,741 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08117,280,690 - 117,291,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,280,705 - 117,291,351 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,625,419 - 116,636,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,488,932 - 108,497,573 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states. Combaret L, etal., Am J Physiol Endocrinol Metab. 2005 Apr;288(4):E693-700. Epub 2004 Nov 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Lu Y, etal., Mol Cell Biol. 2009 Jan;29(2):547-58. doi: 10.1128/MCB.00329-08. Epub 2008 Nov 17.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19465887   PMID:19773579   PMID:21971047   PMID:22128162   PMID:24356957   PMID:25088257   PMID:25568336   PMID:27156111   PMID:32798288  


Genomics

Comparative Map Data
Usp19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28109,190,727 - 109,201,761 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,190,724 - 109,201,741 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08117,280,690 - 117,291,729 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,280,705 - 117,291,351 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,625,419 - 116,636,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,488,932 - 108,497,573 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
USP19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,108,050 - 49,120,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl349,108,046 - 49,120,938 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,145,483 - 49,158,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,121,112 - 49,133,217 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,121,111 - 49,133,217NCBI
Celera349,103,060 - 49,115,165 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,204,015 - 49,216,907 (-)NCBIHuRef
CHM1_1349,098,226 - 49,111,118 (-)NCBICHM1_1
T2T-CHM13v2.0349,136,122 - 49,148,895 (-)NCBIT2T-CHM13v2.0
Usp19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,367,806 - 108,379,536 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,367,801 - 108,379,536 (+)EnsemblGRCm39 Ensembl
GRCm389108,490,607 - 108,502,337 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,490,602 - 108,502,337 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,393,007 - 108,404,668 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,348,851 - 108,359,802 (+)NCBIMGSCv36mm8
Celera9108,100,140 - 108,111,769 (+)NCBICelera
Cytogenetic Map9F2NCBI
Usp19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,104,591 - 1,113,567 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,104,212 - 1,115,267 (-)NCBIChiLan1.0ChiLan1.0
USP19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,112,271 - 50,125,114 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,100,216 - 50,125,112 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0349,032,373 - 49,045,238 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
USP19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,062,802 - 40,074,221 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,064,599 - 40,074,082 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,980,975 - 39,992,470 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,419,685 - 40,431,184 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,419,711 - 40,431,178 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,786,538 - 39,798,032 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,190,048 - 40,201,538 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,470,345 - 40,481,844 (+)NCBIUU_Cfam_GSD_1.0
Usp19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,054,119 - 64,065,492 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936529814,649 - 826,008 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,726,672 - 31,737,981 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,726,668 - 31,738,135 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,958,907 - 34,968,638 (-)NCBISscrofa10.2Sscrofa10.2susScr3
USP19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,510,554 - 10,523,576 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,510,423 - 10,523,487 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,558,381 - 156,571,234 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,133,595 - 3,146,221 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,134,419 - 3,145,512 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
BI274871  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,201,365 - 109,201,557 (+)MAPPERmRatBN7.2
Rnor_6.08117,291,331 - 117,291,522NCBIRnor6.0
Rnor_5.08116,636,034 - 116,636,225UniSTSRnor5.0
Celera8108,497,873 - 108,498,064UniSTS
RH 3.4 Map81116.09UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:38
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000074772
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001001516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039081692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005487861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY605065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000074772   ⟹   ENSRNOP00000067744
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,190,868 - 109,201,123 (+)Ensembl
Rnor_6.0 Ensembl8117,282,390 - 117,291,031 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085038   ⟹   ENSRNOP00000069554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,190,724 - 109,201,741 (+)Ensembl
Rnor_6.0 Ensembl8117,280,705 - 117,291,351 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094044   ⟹   ENSRNOP00000090860
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,190,724 - 109,201,123 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099172   ⟹   ENSRNOP00000097405
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,190,724 - 109,201,124 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119213   ⟹   ENSRNOP00000078495
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,190,868 - 109,201,741 (+)Ensembl
RefSeq Acc Id: NM_001001516   ⟹   NP_001001516
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,192,425 - 109,201,066 (+)NCBI
Rnor_6.08117,282,390 - 117,291,031 (+)NCBI
Rnor_5.08116,625,419 - 116,636,432 (+)NCBI
Celera8108,488,932 - 108,497,573 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006243793   ⟹   XP_006243855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,728 - 109,201,125 (+)NCBI
Rnor_6.08117,280,691 - 117,291,090 (+)NCBI
Rnor_5.08116,625,419 - 116,636,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243794   ⟹   XP_006243856
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,728 - 109,201,125 (+)NCBI
Rnor_6.08117,280,690 - 117,291,090 (+)NCBI
Rnor_5.08116,625,419 - 116,636,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243795   ⟹   XP_006243857
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,728 - 109,201,125 (+)NCBI
Rnor_6.08117,280,691 - 117,291,090 (+)NCBI
Rnor_5.08116,625,419 - 116,636,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243796   ⟹   XP_006243858
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,728 - 109,201,125 (+)NCBI
Rnor_6.08117,280,691 - 117,291,090 (+)NCBI
Rnor_5.08116,625,419 - 116,636,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243797   ⟹   XP_006243859
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,729 - 109,201,761 (+)NCBI
Rnor_6.08117,280,691 - 117,291,729 (+)NCBI
Rnor_5.08116,625,419 - 116,636,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243798   ⟹   XP_006243860
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,729 - 109,201,761 (+)NCBI
Rnor_6.08117,280,691 - 117,291,729 (+)NCBI
Rnor_5.08116,625,419 - 116,636,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243799   ⟹   XP_006243861
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,729 - 109,201,761 (+)NCBI
Rnor_6.08117,280,691 - 117,291,729 (+)NCBI
Rnor_5.08116,625,419 - 116,636,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081691   ⟹   XP_038937619
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,727 - 109,201,125 (+)NCBI
RefSeq Acc Id: XM_039081692   ⟹   XP_038937620
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,728 - 109,201,761 (+)NCBI
RefSeq Acc Id: XR_005487861
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28109,190,728 - 109,201,402 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001001516   ⟸   NM_001001516
- UniProtKB: Q6J1Y9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243856   ⟸   XM_006243794
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006243860   ⟸   XM_006243798
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006243855   ⟸   XM_006243793
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006243857   ⟸   XM_006243795
- Peptide Label: isoform X3
- UniProtKB: M0RDN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243858   ⟸   XM_006243796
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006243859   ⟸   XM_006243797
- Peptide Label: isoform X6
- UniProtKB: A0A0G2JVN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243861   ⟸   XM_006243799
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: ENSRNOP00000069554   ⟸   ENSRNOT00000085038
RefSeq Acc Id: ENSRNOP00000067744   ⟸   ENSRNOT00000074772
RefSeq Acc Id: XP_038937619   ⟸   XM_039081691
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038937620   ⟸   XM_039081692
- Peptide Label: isoform X9
RefSeq Acc Id: ENSRNOP00000097405   ⟸   ENSRNOT00000099172
RefSeq Acc Id: ENSRNOP00000090860   ⟸   ENSRNOT00000094044
RefSeq Acc Id: ENSRNOP00000078495   ⟸   ENSRNOT00000119213
Protein Domains
CS   MYND-type   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6J1Y9-F1-model_v2 AlphaFold Q6J1Y9 1-1357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696315
Promoter ID:EPDNEW_R6828
Type:initiation region
Name:Usp19_1
Description:ubiquitin specific peptidase 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6829  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,280,692 - 117,280,752EPDNEW
RGD ID:13696304
Promoter ID:EPDNEW_R6829
Type:multiple initiation site
Name:Usp19_2
Description:ubiquitin specific peptidase 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6828  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08117,280,813 - 117,280,873EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 117289662 117289663 C A snv F344/NCrl (RGD), F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), LEXF10A/StmMcwi (2020), LEXF11/Stm (2020), LEXF1A/Stm (2019), LEXF1C/Stm (2019), LEXF2B/Stm (2019), FXLE18/Stm (2020)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 116633348 116633349 A G snv SR/JrHsd (MCW)
8 116634365 116634366 C A snv F344/NCrl (KNAW), F344/Jcl (KyushuU), F344/NRrrc (Illumina) (KNAW), F344/DuCrlCrlj (KyushuU), F344/Stm (KyushuU), F344/NRrrc (SOLiD) (KNAW), F344/NHsd (KNAW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 109199697 109199698 C A snv F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), LEXF10A/StmMcwi (2020), LEXF11/Stm (2020), LEXF1A/Stm (2019), LEXF1C/Stm (2019), LEXF2B/Stm (2019), FXLE18/Stm (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303276 AgrOrtholog
BioCyc Gene G2FUF-29138 BioCyc
Ensembl Genes ENSRNOG00000049531 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067744 ENTREZGENE
  ENSRNOP00000067744.2 UniProtKB/TrEMBL
  ENSRNOP00000069554 ENTREZGENE
  ENSRNOP00000069554.2 UniProtKB/TrEMBL
  ENSRNOP00000078495 ENTREZGENE
  ENSRNOP00000078495.1 UniProtKB/TrEMBL
  ENSRNOP00000090860 ENTREZGENE
  ENSRNOP00000090860.1 UniProtKB/TrEMBL
  ENSRNOP00000097405.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074772 ENTREZGENE
  ENSRNOT00000074772.3 UniProtKB/TrEMBL
  ENSRNOT00000085038 ENTREZGENE
  ENSRNOT00000085038.2 UniProtKB/TrEMBL
  ENSRNOT00000094044 ENTREZGENE
  ENSRNOT00000094044.1 UniProtKB/TrEMBL
  ENSRNOT00000099172.1 UniProtKB/TrEMBL
  ENSRNOT00000119213 ENTREZGENE
  ENSRNOT00000119213.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP20-like_chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C19_UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_MYND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361190 UniProtKB/Swiss-Prot
NCBI Gene 361190 ENTREZGENE
Pfam PF04969 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-MYND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Usp19 PhenoGen
PROSITE PS51203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  USP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_MYND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_MYND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49764 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMS3_RAT UniProtKB/TrEMBL
  A0A8I6AF46_RAT UniProtKB/TrEMBL
  A0A8I6B5Q8_RAT UniProtKB/TrEMBL
  M0RDN9 ENTREZGENE, UniProtKB/TrEMBL
  Q5BK03_RAT UniProtKB/TrEMBL
  Q6J1Y9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Usp19  ubiquitin specific peptidase 19  Usp19  ubiquitin specific protease 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Usp19        Symbol and Name status set to provisional 70820 PROVISIONAL