Otud5 (OTU deubiquitinase 5) - Rat Genome Database

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Gene: Otud5 (OTU deubiquitinase 5) Rattus norvegicus
Analyze
Symbol: Otud5
Name: OTU deubiquitinase 5 (Ensembl:OTU domain containing 5)
RGD ID: 1563027
Description: Predicted to enable K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including positive regulation of TOR signaling; protein deubiquitination; and response to lipopolysaccharide. Predicted to act upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Predicted to be located in nucleus. Orthologous to human OTUD5 (OTU deubiquitinase 5); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deubiquinating enzyme A; deubiquitinating enzyme A; DUBA; OTU domain containing 5; OTU domain-containing protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X14,626,173 - 14,659,331 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,626,164 - 14,659,573 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,439,719 - 19,472,216 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X20,610,895 - 20,643,392 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X16,876,064 - 16,908,562 (+)NCBIRnor_WKY
Rnor_6.0X15,471,212 - 15,504,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,471,211 - 15,504,165 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,252,447 - 16,285,771 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,660,722 - 26,693,208 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,710,922 - 14,743,382 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15057822   PMID:15489334   PMID:17991829   PMID:22245969   PMID:23827681   PMID:25470037  


Genomics

Comparative Map Data
Otud5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X14,626,173 - 14,659,331 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,626,164 - 14,659,573 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,439,719 - 19,472,216 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X20,610,895 - 20,643,392 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X16,876,064 - 16,908,562 (+)NCBIRnor_WKY
Rnor_6.0X15,471,212 - 15,504,372 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,471,211 - 15,504,165 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,252,447 - 16,285,771 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,660,722 - 26,693,208 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,710,922 - 14,743,382 (-)NCBICelera
Cytogenetic MapXq12NCBI
OTUD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,922,024 - 48,958,381 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX48,922,024 - 48,958,386 (-)EnsemblGRCh38hg38GRCh38
GRCh37X48,779,301 - 48,815,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,664,432 - 48,699,837 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX52,847,869 - 52,884,227 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,435,456 - 46,472,247 (-)NCBIHuRef
CHM1_1X48,810,457 - 48,846,938 (-)NCBICHM1_1
T2T-CHM13v2.0X48,332,501 - 48,368,844 (-)NCBIT2T-CHM13v2.0
Otud5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,705,852 - 7,742,865 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,707,603 - 7,742,865 (+)EnsemblGRCm39 Ensembl
GRCm38X7,839,613 - 7,876,626 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,841,364 - 7,876,626 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,418,957 - 7,451,986 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,998,790 - 7,031,819 (+)NCBIMGSCv36mm8
CeleraX3,595,012 - 3,628,228 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.54NCBI
Otud5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543452,121 - 484,560 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955543452,172 - 484,564 (-)NCBIChiLan1.0ChiLan1.0
OTUD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X49,077,807 - 49,112,128 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0X41,219,536 - 41,256,219 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
OTUD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,079,396 - 42,109,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,081,561 - 42,108,612 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,454,836 - 16,484,611 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,215,589 - 42,245,392 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,217,333 - 42,245,108 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,201,829 - 42,231,594 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,190,077 - 42,219,859 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,284,322 - 42,314,095 (-)NCBIUU_Cfam_GSD_1.0
Otud5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,606,971 - 34,636,523 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721848,324 - 877,068 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936721847,360 - 876,912 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTUD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,000,231 - 43,029,468 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,001,491 - 43,029,471 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,784,223 - 47,812,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OTUD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,041,348 - 46,077,195 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607611,526,666 - 11,563,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otud5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624893702,895 - 736,623 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Otud5
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:601
Count of miRNA genes:214
Interacting mature miRNAs:268
Transcripts:ENSRNOT00000006233, ENSRNOT00000044743
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
Slc25a39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,648,551 - 14,649,326 (+)MAPPERmRatBN7.2
Rnor_6.0X15,493,588 - 15,494,362NCBIRnor6.0
Rnor_5.0X16,274,823 - 16,275,597UniSTSRnor5.0
CeleraX14,733,272 - 14,734,046UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 6 9 74 35 41 11 6
Low 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006233   ⟹   ENSRNOP00000006233
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,626,174 - 14,659,501 (-)Ensembl
Rnor_6.0 EnsemblX15,471,211 - 15,504,165 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112857   ⟹   ENSRNOP00000090218
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,626,164 - 14,659,573 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113203   ⟹   ENSRNOP00000080452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,626,174 - 14,659,573 (-)Ensembl
RefSeq Acc Id: NM_001037496   ⟹   NP_001032585
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,626,173 - 14,658,662 (-)NCBI
Rnor_6.0X15,471,212 - 15,503,698 (-)NCBI
Rnor_5.0X16,252,447 - 16,285,771 (-)NCBI
RGSC_v3.4X26,660,722 - 26,693,208 (-)RGD
CeleraX14,710,922 - 14,743,382 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256737   ⟹   XP_006256799
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,626,173 - 14,659,329 (-)NCBI
Rnor_6.0X15,471,212 - 15,504,372 (-)NCBI
Rnor_5.0X16,252,447 - 16,285,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256738   ⟹   XP_006256800
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,626,173 - 14,659,328 (-)NCBI
Rnor_6.0X15,471,212 - 15,504,372 (-)NCBI
Rnor_5.0X16,252,447 - 16,285,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256740   ⟹   XP_006256802
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,626,173 - 14,659,328 (-)NCBI
Rnor_6.0X15,471,212 - 15,504,371 (-)NCBI
Rnor_5.0X16,252,447 - 16,285,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256741   ⟹   XP_006256803
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,626,173 - 14,659,327 (-)NCBI
Rnor_6.0X15,471,212 - 15,504,371 (-)NCBI
Rnor_5.0X16,252,447 - 16,285,771 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602103   ⟹   XP_017457592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,626,173 - 14,659,329 (-)NCBI
Rnor_6.0X15,471,212 - 15,504,372 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099870   ⟹   XP_038955798
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,628,689 - 14,659,331 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001032585   ⟸   NM_001037496
- UniProtKB: Q2YDU3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256799   ⟸   XM_006256737
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AAB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256800   ⟸   XM_006256738
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006256802   ⟸   XM_006256740
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006256803   ⟸   XM_006256741
- Peptide Label: isoform X4
- UniProtKB: A0A0H2UHD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457592   ⟸   XM_017602103
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000006233   ⟸   ENSRNOT00000006233
RefSeq Acc Id: XP_038955798   ⟸   XM_039099870
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000080452   ⟸   ENSRNOT00000113203
RefSeq Acc Id: ENSRNOP00000090218   ⟸   ENSRNOT00000112857
Protein Domains
OTU

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2YDU3-F1-model_v2 AlphaFold Q2YDU3 1-566 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563027 AgrOrtholog
BioCyc Gene G2FUF-2925 BioCyc
Ensembl Genes ENSRNOG00000008764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006233 ENTREZGENE
  ENSRNOP00000006233.6 UniProtKB/TrEMBL
  ENSRNOP00000080452 ENTREZGENE
  ENSRNOP00000080452.1 UniProtKB/TrEMBL
  ENSRNOP00000090218 ENTREZGENE
  ENSRNOP00000090218.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006233 ENTREZGENE
  ENSRNOT00000006233.8 UniProtKB/TrEMBL
  ENSRNOT00000112857 ENTREZGENE
  ENSRNOT00000112857.1 UniProtKB/TrEMBL
  ENSRNOT00000113203 ENTREZGENE
  ENSRNOT00000113203.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7446041 IMAGE-MGC_LOAD
InterPro OTU5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OTU_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:363452 UniProtKB/Swiss-Prot
MGC_CLONE MGC:125088 IMAGE-MGC_LOAD
NCBI Gene 363452 ENTREZGENE
PANTHER PTHR12419:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam OTU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Otud5 PhenoGen
PROSITE OTU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZQ70_RAT UniProtKB/TrEMBL
  A0A8I6AAB2 ENTREZGENE, UniProtKB/TrEMBL
  OTUD5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Otud5  OTU deubiquitinase 5  Otud5  OTU domain containing 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Otud5  OTU domain containing 5      Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Otud5  OTU domain containing 5      Symbol and Name status set to provisional 70820 PROVISIONAL