Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Shisa2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SHISA2 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of SHISA2 mRNA | CTD | PMID:19167446 | 17beta-estradiol | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of SHISA2 mRNA | CTD | PMID:21185374 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Shisa2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SHISA2 mRNA | CTD | PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SHISA2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SHISA2 mRNA | CTD | PMID:36370075 | 2,6-di-tert-butyl-4-methylphenol | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Butylated Hydroxytoluene results in decreased expression of SHISA2 mRNA | CTD | PMID:19925653 | 2-palmitoylglycerol | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of SHISA2 mRNA | CTD | PMID:37199045 | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in increased expression of SHISA2 mRNA | CTD | PMID:33476716 | 4,4'-sulfonyldiphenol | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | bisphenol S results in decreased expression of SHISA2 mRNA | CTD | PMID:25912373 | 4,4'-sulfonyldiphenol | increases expression | ISO | Shisa2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of SHISA2 mRNA | CTD | PMID:30951980 | 5-aza-2'-deoxycytidine | affects expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Decitabine affects the expression of SHISA2 mRNA | CTD | PMID:23300844 | acrylamide | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Acrylamide results in decreased expression of SHISA2 mRNA | CTD | PMID:30807115 | all-trans-retinoic acid | affects expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Tretinoin affects the expression of SHISA2 mRNA | CTD | PMID:31600526 | aristolochic acid A | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of SHISA2 mRNA | CTD | PMID:33212167 | arsane | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of SHISA2 mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of SHISA2 mRNA | CTD | PMID:32525701 | arsenite(3-) | increases methylation | ISO | SHISA2 (Homo sapiens) | 6480464 | arsenite results in increased methylation of SHISA2 promoter | CTD | PMID:23974009 | arsenous acid | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of SHISA2 mRNA | CTD | PMID:24356939 | benzo[a]pyrene | multiple interactions | ISO | Shisa2 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to SHISA2 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SHISA2 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | SHISA2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SHISA2 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | SHISA2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SHISA2 exon and Benzo(a)pyrene affects the methylation of SHISA2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SHISA2 mRNA | CTD | PMID:21569818 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SHISA2 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SHISA2 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Shisa2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SHISA2 mRNA | CTD | PMID:30951980 and PMID:32156529 | bisphenol A | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SHISA2 mRNA | CTD | PMID:25912373 and PMID:29718440 | bisphenol F | increases expression | ISO | Shisa2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of SHISA2 mRNA | CTD | PMID:30951980 | carbamazepine | affects expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SHISA2 mRNA | CTD | PMID:25979313 | carbon nanotube | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Nanotubes and Carbon results in decreased expression of SHISA2 mRNA | CTD | PMID:24389112 | carbon nanotube | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chloroethene | increases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Vinyl Chloride results in increased expression of SHISA2 mRNA | CTD | PMID:18579281 | chloroprene | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Chloroprene results in decreased expression of SHISA2 mRNA | CTD | PMID:23125180 | chlorpyrifos | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SHISA2 mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Shisa2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SHISA2 mRNA | CTD | PMID:20938992 | chrysene | increases expression | ISO | Shisa2 (Mus musculus) | 6480464 | chrysene results in increased expression of SHISA2 mRNA | CTD | PMID:26377693 | cisplatin | affects expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Cisplatin affects the expression of SHISA2 mRNA | CTD | PMID:23300844 | copper atom | multiple interactions | EXP | | 6480464 | [Copper co-treated with Dietary Sucrose] results in increased expression of SHISA2 mRNA | CTD | PMID:26033743 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of SHISA2 mRNA | CTD | PMID:26033743 | copper(0) | multiple interactions | EXP | | 6480464 | [Copper co-treated with Dietary Sucrose] results in increased expression of SHISA2 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of SHISA2 mRNA | CTD | PMID:26033743 | coumestrol | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SHISA2 mRNA | CTD | PMID:19167446 | diarsenic trioxide | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of SHISA2 mRNA | CTD | PMID:24356939 | dibutyl phthalate | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of SHISA2 mRNA | CTD | PMID:21266533 | dioxygen | multiple interactions | ISO | Shisa2 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SHISA2 mRNA | CTD | PMID:30529165 | dorsomorphin | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SHISA2 mRNA | CTD | PMID:29803840 | Enterolactone | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SHISA2 mRNA | CTD | PMID:19167446 | entinostat | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | entinostat results in decreased expression of SHISA2 mRNA | CTD | PMID:26272509 | folic acid | multiple interactions | ISO | Shisa2 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | hydralazine | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SHISA2 mRNA | CTD | PMID:17183730 | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SHISA2 mRNA | CTD | PMID:22129741 | iron dichloride | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | ferrous chloride results in increased expression of SHISA2 mRNA | CTD | PMID:35984750 | L-methionine | multiple interactions | ISO | Shisa2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SHISA2 mRNA | CTD | PMID:20938992 | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of SHISA2 mRNA | CTD | PMID:28801915 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of SHISA2 mRNA | CTD | PMID:28341135 | methylmercury chloride | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of SHISA2 mRNA | CTD | PMID:28001369 | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SHISA2 mRNA | CTD | PMID:22129741 | N-methyl-4-phenylpyridinium | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SHISA2 mRNA | CTD | PMID:24810058 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SHISA2 mRNA | CTD | PMID:28801915 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of SHISA2 mRNA | CTD | PMID:22129741 | ochratoxin A | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | ochratoxin A metabolite results in decreased expression of SHISA2 mRNA and ochratoxin A results in decreased expression of SHISA2 mRNA | CTD | PMID:24356939 | ozone | multiple interactions | ISO | Shisa2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of SHISA2 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of SHISA2 mRNA | CTD | PMID:27106289 and PMID:34911549 | panobinostat | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHISA2 mRNA | CTD | PMID:27188386 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SHISA2 mRNA | CTD | PMID:33387578 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of SHISA2 mRNA | CTD | PMID:32680482 | phenylmercury acetate | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of SHISA2 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHISA2 mRNA | CTD | PMID:27188386 | potassium chromate | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SHISA2 mRNA | CTD | PMID:22714537 | progesterone | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Progesterone results in decreased expression of SHISA2 mRNA | CTD | PMID:22238285 | raloxifene | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of SHISA2 mRNA | CTD | PMID:21185374 | SB 431542 | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silver atom | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Silver results in decreased expression of SHISA2 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Silver results in decreased expression of SHISA2 mRNA | CTD | PMID:27131904 | sirolimus | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Sirolimus results in increased expression of SHISA2 mRNA | CTD | PMID:24356939 | sodium arsenate | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of SHISA2 mRNA | CTD | PMID:32525701 | sodium arsenite | affects methylation | ISO | SHISA2 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of SHISA2 gene | CTD | PMID:28589171 | tamoxifen | increases expression | ISO | Shisa2 (Mus musculus) | 6480464 | Tamoxifen results in increased expression of SHISA2 mRNA | CTD | PMID:25123088 | temozolomide | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of SHISA2 mRNA | CTD | PMID:31758290 | tetrachloromethane | affects expression | ISO | Shisa2 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of SHISA2 mRNA | CTD | PMID:17484886 | tetraphene | increases expression | ISO | Shisa2 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of SHISA2 mRNA | CTD | PMID:26377693 | thapsigargin | increases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of SHISA2 mRNA | CTD | PMID:29453283 | Tributyltin oxide | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | bis(tri-n-butyltin)oxide results in decreased expression of SHISA2 mRNA | CTD | PMID:24356939 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SHISA2 mRNA | CTD | PMID:33387578 | trichostatin A | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of SHISA2 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHISA2 mRNA | CTD | PMID:27188386 | triptonide | increases expression | ISO | Shisa2 (Mus musculus) | 6480464 | triptonide results in increased expression of SHISA2 mRNA | CTD | PMID:33045310 | valproic acid | multiple interactions | ISO | SHISA2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of SHISA2 mRNA more ... | CTD | PMID:17183730 and PMID:27188386 | valproic acid | increases methylation | ISO | SHISA2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SHISA2 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SHISA2 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | SHISA2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SHISA2 mRNA | CTD | PMID:23179753 more ... | 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