Tars1 (threonyl-tRNA synthetase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Tars1 (threonyl-tRNA synthetase 1) Rattus norvegicus
Analyze
Symbol: Tars1
Name: threonyl-tRNA synthetase 1
RGD ID: 1359527
Description: Predicted to enable several functions, including ATP binding activity; threonine-tRNA ligase activity; and zinc ion binding activity. Predicted to be involved in threonyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 7. Orthologous to human TARS1 (threonyl-tRNA synthetase 1); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC95288; Tars; threonine--tRNA ligase; threonine--tRNA ligase 1, cytoplasmic; threonine--tRNA ligase, cytoplasmic; threonyl-tRNA synthetase; threonyl-tRNA synthetase, cytoplasmic; thrRS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2260,368,251 - 60,387,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl260,367,796 - 60,387,717 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx267,486,539 - 67,505,360 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0265,608,075 - 65,626,896 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0260,609,454 - 60,628,275 (-)NCBIRnor_WKY
Rnor_6.0261,394,632 - 61,414,115 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,394,770 - 61,414,102 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0283,279,708 - 83,299,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4260,765,899 - 60,784,665 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1260,694,140 - 60,712,898 (-)NCBI
Celera258,303,445 - 58,322,211 (+)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ampicillin  (EXP)
aristolochic acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
borrelidin  (ISO)
buspirone  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenofibrate  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
lithium chloride  (ISO)
mercury dichloride  (EXP)
methylmercury chloride  (ISO)
metronidazole  (EXP)
neomycin  (EXP)
ochratoxin A  (ISO)
oxycodone  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
threonyl-tRNA aminoacylation  (IBA,IEA,ISO,ISS)

Cellular Component
cytoplasm  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nucleotide and deduced amino acid sequence of human threonyl-tRNA synthetase reveals extensive homology to the Escherichia coli and yeast enzymes. Cruzen ME and Arfin SM, J Biol Chem 1991 May 25;266(15):9919-23.
2. Threonyl-tRNA synthetase. Freist W and Gauss DH, Biol Chem Hoppe Seyler. 1995 Apr;376(4):213-24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Presence of role of the 5SrRNA-L5 protein complex (5SRNP) in the threonyl- and histidyl-tRNA synthetase complex in rat liver cytosol. Ogata K, etal., Biochim Biophys Acta 1994 Aug 2;1218(3):388-400.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12060739   PMID:15489334   PMID:20458337   PMID:22082260   PMID:25824639   PMID:29579307  


Genomics

Comparative Map Data
Tars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2260,368,251 - 60,387,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl260,367,796 - 60,387,717 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx267,486,539 - 67,505,360 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0265,608,075 - 65,626,896 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0260,609,454 - 60,628,275 (-)NCBIRnor_WKY
Rnor_6.0261,394,632 - 61,414,115 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl261,394,770 - 61,414,102 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0283,279,708 - 83,299,254 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4260,765,899 - 60,784,665 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1260,694,140 - 60,712,898 (-)NCBI
Celera258,303,445 - 58,322,211 (+)NCBICelera
Cytogenetic Map2q16NCBI
TARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38533,440,696 - 33,468,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl533,440,696 - 33,468,091 (+)EnsemblGRCh38hg38GRCh38
GRCh37533,440,802 - 33,468,196 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36533,476,655 - 33,503,953 (+)NCBINCBI36Build 36hg18NCBI36
Build 34533,476,654 - 33,503,953NCBI
Celera533,321,918 - 33,349,216 (+)NCBICelera
Cytogenetic Map5p13.3NCBI
HuRef533,409,576 - 33,436,969 (+)NCBIHuRef
CHM1_1533,442,410 - 33,469,806 (+)NCBICHM1_1
T2T-CHM13v2.0533,555,295 - 33,582,692 (+)NCBIT2T-CHM13v2.0
Tars
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391511,383,749 - 11,399,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1511,382,387 - 11,399,751 (-)EnsemblGRCm39 Ensembl
GRCm381511,383,663 - 11,399,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1511,382,301 - 11,399,665 (-)EnsemblGRCm38mm10GRCm38
MGSCv371511,313,418 - 11,329,413 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361511,328,388 - 11,344,383 (-)NCBIMGSCv36mm8
Celera1511,167,393 - 11,183,912 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.6NCBI
Tars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542619,087,389 - 19,110,609 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542619,086,817 - 19,110,609 (+)NCBIChiLan1.0ChiLan1.0
TARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1582,258,960 - 82,286,179 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl582,256,706 - 82,286,179 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0576,874,096 - 76,901,208 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1474,213,475 - 74,239,056 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl474,213,772 - 74,238,971 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha473,838,693 - 73,864,242 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0474,724,661 - 74,750,271 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl474,724,664 - 74,750,266 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1474,470,041 - 74,495,641 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0474,598,119 - 74,623,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0475,128,157 - 75,153,735 (-)NCBIUU_Cfam_GSD_1.0
Tars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213223,835,129 - 223,859,335 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365187,512,854 - 7,533,189 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365187,512,498 - 7,536,854 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1619,455,092 - 19,486,732 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11619,455,294 - 19,486,735 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21620,336,784 - 20,350,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1432,670,020 - 32,697,608 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl432,670,203 - 32,699,168 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607122,947,080 - 22,976,025 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475921,132,116 - 21,154,620 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475921,132,104 - 21,154,533 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tars1
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:37
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000051910
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25666087974786777Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25760561276539510Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 39 57 41 19 41 8 11 74 35 41 11 8
Low 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051910   ⟹   ENSRNOP00000044467
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl260,368,904 - 60,387,657 (-)Ensembl
Rnor_6.0 Ensembl261,395,285 - 61,414,038 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000088202   ⟹   ENSRNOP00000075146
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl260,367,796 - 60,387,717 (-)Ensembl
Rnor_6.0 Ensembl261,394,770 - 61,414,102 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113724   ⟹   ENSRNOP00000084087
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl260,367,796 - 60,386,513 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118066   ⟹   ENSRNOP00000096069
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl260,367,796 - 60,382,956 (-)Ensembl
RefSeq Acc Id: NM_001006976   ⟹   NP_001006977
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2260,368,893 - 60,387,657 (-)NCBI
Rnor_6.0261,395,274 - 61,414,038 (-)NCBI
Rnor_5.0283,279,708 - 83,299,254 (+)NCBI
RGSC_v3.4260,765,899 - 60,784,665 (-)RGD
Celera258,303,445 - 58,322,211 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232068   ⟹   XP_006232130
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2260,368,251 - 60,387,733 (-)NCBI
Rnor_6.0261,394,632 - 61,414,115 (-)NCBI
Rnor_5.0283,279,708 - 83,299,254 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001006977   ⟸   NM_001006976
- UniProtKB: Q5XHY5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232130   ⟸   XM_006232068
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9V6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044467   ⟸   ENSRNOT00000051910
RefSeq Acc Id: ENSRNOP00000075146   ⟸   ENSRNOT00000088202
RefSeq Acc Id: ENSRNOP00000096069   ⟸   ENSRNOT00000118066
RefSeq Acc Id: ENSRNOP00000084087   ⟸   ENSRNOT00000113724
Protein Domains
AA_TRNA_LIGASE_II   TGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XHY5-F1-model_v2 AlphaFold Q5XHY5 1-695 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691191
Promoter ID:EPDNEW_R1715
Type:initiation region
Name:Tars_1
Description:threonyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0261,414,074 - 61,414,134EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359527 AgrOrtholog
BioCyc Gene G2FUF-54060 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
Ensembl Genes ENSRNOG00000019023 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000044467 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000075146 ENTREZGENE
  ENSRNOP00000075146.1 UniProtKB/TrEMBL
  ENSRNOP00000084087.1 UniProtKB/TrEMBL
  ENSRNOP00000096069.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051910 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000088202 ENTREZGENE
  ENSRNOT00000088202.2 UniProtKB/TrEMBL
  ENSRNOT00000113724.1 UniProtKB/TrEMBL
  ENSRNOT00000118066.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.930.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134406 IMAGE-MGC_LOAD
InterPro aa-tRNA-synt_IIb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  aa-tRNA-synth_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anticodon-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anticodon-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thr-tRNA-ligase_IIa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thr/Ala-tRNA-synth_IIc_edit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ThrRS_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA_SAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294810 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95288 IMAGE-MGC_LOAD
NCBI Gene 294810 ENTREZGENE
PANTHER PTHR11451 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HGTP_anticodon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA-synt_2b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA_SAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tars1 PhenoGen
PRINTS TRNASYNTHTHR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART tRNA_SAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55186 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55681 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs thrS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9V6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZX23_RAT UniProtKB/TrEMBL
  A0A8I6AQ83_RAT UniProtKB/TrEMBL
  Q5XHY5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Tars1  threonyl-tRNA synthetase 1  Tars  threonyl-tRNA synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tars  threonyl-tRNA synthetase      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Tars  threonyl-tRNA synthetase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction complex formation with ribosomal protein L5 appears to enhance the activity of Tars 1556518
gene_protein both monomer and dimer forms are active 1556518