Gfra2 (GDNF family receptor alpha 2) - Rat Genome Database

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Gene: Gfra2 (GDNF family receptor alpha 2) Rattus norvegicus
Analyze
Symbol: Gfra2
Name: GDNF family receptor alpha 2
RGD ID: 61809
Description: Enables glial cell-derived neurotrophic factor receptor activity. Involved in negative regulation of protein autophosphorylation. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Biomarker of Parkinsonism. Orthologous to human GFRA2 (GDNF family receptor alpha 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GDNF family receptor alpha-2; glial cell line derived neurotrophic factor family receptor alpha 2; Retl2; tyrosine kinase receptor ligand 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,941,841 - 46,033,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,941,828 - 46,033,714 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1550,060,277 - 50,151,514 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01551,171,823 - 51,263,077 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01548,031,115 - 48,122,368 (+)NCBIRnor_WKY
Rnor_6.01552,557,004 - 52,648,984 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,557,607 - 52,648,972 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01556,280,942 - 56,372,308 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41551,279,770 - 51,371,053 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11551,295,549 - 51,386,832 (+)NCBI
Celera1545,618,968 - 45,709,881 (+)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
diazinon  (EXP)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
hydralazine  (ISO)
ionomycin  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (EXP)
naproxen  (EXP)
nickel sulfate  (ISO)
paraquat  (EXP)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sumatriptan  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thalidomide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Developmental expression of glial cell-line derived neurotrophic factor, neurturin, and their receptor mRNA in the rat urinary bladder. Kawakami T, etal., Neurourol Urodyn 2003;22(1):83-8.
4. GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection. Lindqvist N, etal., Exp Neurol. 2004 Jun;187(2):487-99.
5. Regulation of c-Ret, GFRalpha1, and GFRalpha2 in the substantia nigra pars compacta in a rat model of Parkinson's disease. Marco S, etal., J Neurobiol. 2002 Sep 15;52(4):343-51.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Sanicola M, etal., Proc Natl Acad Sci U S A 1997 Jun 10;94(12):6238-43.
12. Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. Suvanto P, etal., Hum Mol Genet 1997 Aug;6(8):1267-73.
13. Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Trupp M, etal., Mol Cell Neurosci 1998 May;11(1-2):47-63.
Additional References at PubMed
PMID:9576965   PMID:11069590   PMID:14757528   PMID:15019945   PMID:17275188   PMID:17640046   PMID:18085594   PMID:18184180   PMID:21723942   PMID:22266674   PMID:23872421  


Genomics

Comparative Map Data
Gfra2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,941,841 - 46,033,715 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,941,828 - 46,033,714 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1550,060,277 - 50,151,514 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01551,171,823 - 51,263,077 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01548,031,115 - 48,122,368 (+)NCBIRnor_WKY
Rnor_6.01552,557,004 - 52,648,984 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,557,607 - 52,648,972 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01556,280,942 - 56,372,308 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41551,279,770 - 51,371,053 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11551,295,549 - 51,386,832 (+)NCBI
Celera1545,618,968 - 45,709,881 (+)NCBICelera
Cytogenetic Map15p11NCBI
GFRA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38821,690,398 - 21,812,345 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl821,690,398 - 21,812,357 (-)EnsemblGRCh38hg38GRCh38
GRCh37821,547,910 - 21,646,387 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36821,688,430 - 21,702,292 (-)NCBINCBI36Build 36hg18NCBI36
Build 36821,593,810 - 21,652,734 (-)NCBINCBI36Build 36hg18NCBI36
Build 34821,688,428 - 21,702,292NCBI
Celera820,513,992 - 20,608,606 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,169,214 - 20,189,376 (-)NCBIHuRef
HuRef820,092,831 - 20,150,935 (-)NCBIHuRef
CHM1_1821,751,217 - 21,848,063 (-)NCBICHM1_1
T2T-CHM13v2.0821,961,568 - 22,062,705 (-)NCBIT2T-CHM13v2.0
Gfra2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391471,127,547 - 71,217,280 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1471,127,560 - 71,217,278 (+)EnsemblGRCm39 Ensembl
GRCm381470,890,107 - 70,979,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,890,120 - 70,979,838 (+)EnsemblGRCm38mm10GRCm38
MGSCv371471,289,937 - 71,379,645 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361469,625,210 - 69,714,918 (+)NCBIMGSCv36mm8
Celera1468,438,452 - 68,531,031 (+)NCBICelera
Cytogenetic Map14D2NCBI
Gfra2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,235,119 - 45,324,946 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,235,161 - 45,324,825 (-)NCBIChiLan1.0ChiLan1.0
GFRA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1817,876,843 - 17,974,457 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl817,878,102 - 17,974,457 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0820,935,512 - 21,033,571 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GFRA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12535,436,790 - 35,521,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,436,317 - 35,520,365 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2536,025,500 - 36,109,252 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02535,653,939 - 35,732,615 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2535,647,199 - 35,732,629 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12535,593,224 - 35,677,046 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02535,447,108 - 35,531,948 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02535,603,029 - 35,686,767 (+)NCBIUU_Cfam_GSD_1.0
Gfra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,916,616 - 12,996,744 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365555,573,720 - 5,653,509 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365555,573,765 - 5,653,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GFRA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl145,743,584 - 5,837,454 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1145,743,583 - 5,837,470 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,064,432 - 6,135,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GFRA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1819,767,027 - 19,866,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl819,766,917 - 19,866,965 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605222,371,628 - 22,473,608 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gfra2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,330,020 - 17,417,572 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,330,401 - 17,417,435 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gfra2
125 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:121
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000019222
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

Markers in Region
D15Wox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21546,032,467 - 46,032,688 (+)MAPPERmRatBN7.2
Rnor_6.01552,647,726 - 52,647,946NCBIRnor6.0
Rnor_5.01556,371,061 - 56,371,281UniSTSRnor5.0
RGSC_v3.41551,369,806 - 51,370,026UniSTSRGSC3.4
RGSC_v3.41551,369,805 - 51,370,026RGDRGSC3.4
Celera1545,708,638 - 45,708,854UniSTS
Cytogenetic Map15p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 2 2 11 2 38 21 22 11
Low 3 37 41 25 8 25 8 11 36 14 19 8
Below cutoff 14 14 14

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019222   ⟹   ENSRNOP00000019222
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,942,451 - 46,033,714 (+)Ensembl
Rnor_6.0 Ensembl1552,557,607 - 52,648,972 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094535   ⟹   ENSRNOP00000088757
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,941,828 - 46,033,714 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096485   ⟹   ENSRNOP00000095959
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,947,422 - 46,033,714 (+)Ensembl
RefSeq Acc Id: NM_012750   ⟹   NP_036882
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,942,451 - 46,033,715 (+)NCBI
Rnor_6.01552,557,607 - 52,648,973 (+)NCBI
Rnor_5.01556,280,942 - 56,372,308 (+)NCBI
RGSC_v3.41551,279,770 - 51,371,053 (+)RGD
Celera1545,618,968 - 45,709,881 (+)RGD
Sequence:
RefSeq Acc Id: XM_017599582   ⟹   XP_017455071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,941,841 - 46,033,715 (+)NCBI
Rnor_6.01552,557,004 - 52,648,984 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599583   ⟹   XP_017455072
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21545,941,841 - 46,033,715 (+)NCBI
Rnor_6.01552,557,004 - 52,648,984 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036882   ⟸   NM_012750
- Peptide Label: precursor
- UniProtKB: O35977 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455071   ⟸   XM_017599582
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455072   ⟸   XM_017599583
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A8G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019222   ⟸   ENSRNOT00000019222
RefSeq Acc Id: ENSRNOP00000095959   ⟸   ENSRNOT00000096485
RefSeq Acc Id: ENSRNOP00000088757   ⟸   ENSRNOT00000094535
Protein Domains
GDNF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35977-F1-model_v2 AlphaFold O35977 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61809 AgrOrtholog
BioCyc Gene G2FUF-13202 BioCyc
Ensembl Genes ENSRNOG00000014010 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019222 ENTREZGENE
  ENSRNOP00000019222.2 UniProtKB/TrEMBL
  ENSRNOP00000088757 ENTREZGENE
  ENSRNOP00000088757.1 UniProtKB/TrEMBL
  ENSRNOP00000095959.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019222 ENTREZGENE
  ENSRNOT00000019222.4 UniProtKB/TrEMBL
  ENSRNOT00000094535 ENTREZGENE
  ENSRNOT00000094535.1 UniProtKB/TrEMBL
  ENSRNOT00000096485.1 UniProtKB/TrEMBL
InterPro GDNF/GAS1 UniProtKB/TrEMBL
  GDNF_alpha UniProtKB/TrEMBL
  GDNF_rcpt UniProtKB/TrEMBL
  GDNF_rcpt_a2 UniProtKB/TrEMBL
  Glial_neurotroph_fac_rcpt_a1/2 UniProtKB/TrEMBL
KEGG Report rno:25136 UniProtKB/TrEMBL
NCBI Gene 25136 ENTREZGENE
PANTHER PTHR10269 UniProtKB/TrEMBL
Pfam GDNF UniProtKB/TrEMBL
PhenoGen Gfra2 PhenoGen
PIRSF GDNF_family_receptor_alpha UniProtKB/TrEMBL
PRINTS GDNFRALPHA2 UniProtKB/TrEMBL
  GDNFRECEPTOR UniProtKB/TrEMBL
SMART GDNF UniProtKB/TrEMBL
Superfamily-SCOP SSF110035 UniProtKB/TrEMBL
UniProt A0A8I6A8G6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B3J9_RAT UniProtKB/TrEMBL
  O35977 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Gfra2  GDNF family receptor alpha 2  Gfra2  glial cell line derived neurotrophic factor family receptor alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gfra2  glial cell line derived neurotrophic factor family receptor alpha 2      Name updated 70584 APPROVED
2001-06-12 Retl2  Tyrosine kinase receptor ligand 2      Symbol withdrawn, duplicate of Gfra2 (RGD:61809) 67953 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_drugs mRNA expression is highly induced on stimulation with kainic acid 632689
gene_expression expressed in the rat brain in a dynamic pattern 632689
gene_process maintain distinct neuronal circuits in the central and peripheral nervous systems by regulating the c-Ret activity 632689