Symbol:
Dram1
Name:
DNA-damage regulated autophagy modulator 1
Description:
Predicted to be involved in regulation of autophagy. Predicted to localize to the lysosome. Orthologous to human DRAM1 (DNA damage regulated autophagy modulator 1); INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-diaminodiphenylmethane; all-trans-retinoic acid.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
damage-regulated autophagy modulator; DNA damage-regulated autophagy modulator protein 1; Dram; LOC679937; MGC187403; similar to CG4025-PA
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DRAM1 (DNA damage regulated autophagy modulator 1) HGNC
EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Dram1 (DNA-damage regulated autophagy modulator 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Dram1 (DNA damage regulated autophagy modulator 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DRAM1 (DNA damage regulated autophagy modulator 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
DRAM1 (DNA damage regulated autophagy modulator 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Dram1 (DNA damage regulated autophagy modulator 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
DRAM1 (DNA damage regulated autophagy modulator 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
DRAM1 (DNA damage regulated autophagy modulator 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Dram1 (DNA-damage regulated autophagy modulator 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
dram1 (DNA-damage regulated autophagy modulator 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
C33A11.2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
CG4025
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
F11E6.6
Alliance
DIOPT (OrthoFinder, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 28,898,647 - 28,932,641 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 28,898,649 - 28,932,641 (-) Ensembl Rnor_5.0 7 29,007,043 - 29,040,879 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 25,024,991 - 25,060,230 (-) NCBI RGSC3.4 rn4 RGSC3.4 Celera 7 19,903,485 - 19,937,259 (-) NCBI Celera Cytogenetic Map 7 q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(-)-demecolcine increases expression ISO RGD:1605066 6480464 Demecolcine results in increased expression of DRAM1 mRNA CTD PMID:23649840 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1605066 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DRAM1 mRNA CTD PMID:22079256 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of DRAM1 mRNA CTD PMID:25380136 17beta-estradiol decreases expression ISO RGD:1605066 6480464 Estradiol results in decreased expression of DRAM1 mRNA CTD PMID:19619570 , PMID:21185374 17beta-estradiol multiple interactions ISO RGD:1605066 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DRAM1 mRNA, Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of DRAM1 mRNA] CTD PMID:19619570 , PMID:21185374 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1605066 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DRAM1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1605066 6480464 Tetrachlorodibenzodioxin results in decreased expression of DRAM1 mRNA CTD PMID:19619570 more ... 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1622283 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of DRAM1 mRNA CTD PMID:20188158 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of DRAM1 mRNA CTD PMID:25380136 5-aza-2'-deoxycytidine affects expression ISO RGD:1605066 6480464 Decitabine affects the expression of DRAM1 mRNA CTD PMID:23300844 5-fluorouracil multiple interactions ISO RGD:1605066 6480464 TP53 protein promotes the reaction [Fluorouracil results in increased expression of DRAM1 mRNA] CTD PMID:17982676 5-fluorouracil increases expression ISO RGD:1605066 6480464 Fluorouracil results in increased expression of DRAM1 mRNA CTD PMID:17982676 aflatoxin B1 affects expression ISO RGD:1605066 6480464 Aflatoxin B1 affects the expression of DRAM1 protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:1605066 6480464 Aflatoxin B1 results in increased expression of DRAM1 mRNA CTD PMID:21632981 more ... all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of DRAM1 mRNA CTD PMID:20488242 all-trans-retinoic acid increases expression ISO RGD:1605066 6480464 Tretinoin results in increased expression of DRAM1 mRNA CTD PMID:21934132 more ... antirheumatic drug decreases expression ISO RGD:1605066 6480464 Antirheumatic Agents results in decreased expression of DRAM1 mRNA CTD PMID:24449571 benzo[a]pyrene increases expression ISO RGD:1605066 6480464 Benzo(a)pyrene results in increased expression of DRAM1 mRNA CTD PMID:20106945 more ... benzo[a]pyrene diol epoxide I increases expression ISO RGD:1605066 6480464 7 more ... CTD PMID:26238291 bis(2-ethylhexyl) phthalate increases expression ISO RGD:1605066 6480464 Diethylhexyl Phthalate results in increased expression of DRAM1 mRNA CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of DRAM1 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1622283 6480464 bisphenol A results in decreased expression of DRAM1 mRNA CTD PMID:30951980 bisphenol A decreases expression ISO RGD:1605066 6480464 bisphenol A results in decreased expression of DRAM1 mRNA CTD PMID:29275510 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of DRAM1 mRNA CTD PMID:22110744 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of DRAM1 mRNA CTD PMID:25993096 carbamazepine affects expression ISO RGD:1605066 6480464 Carbamazepine affects the expression of DRAM1 mRNA CTD PMID:25979313 carbon nanotube increases expression ISO RGD:1605066 6480464 Nanotubes, Carbon results in increased expression of DRAM1, Nanotubes, Carbon results in increased expression of DRAM1 mRNA CTD PMID:24389112 cisplatin increases expression ISO RGD:1605066 6480464 Cisplatin results in increased expression of DRAM1 mRNA CTD PMID:25450742 , PMID:27392435 cisplatin affects expression ISO RGD:1605066 6480464 Cisplatin affects the expression of DRAM1 mRNA CTD PMID:23300844 cobalt dichloride decreases expression ISO RGD:1605066 6480464 cobaltous chloride results in decreased expression of DRAM1 mRNA CTD PMID:19320972 copper atom multiple interactions ISO RGD:1605066 6480464 [Disulfiram binds to Copper] which results in increased expression of DRAM1 mRNA CTD PMID:24690739 copper(0) multiple interactions ISO RGD:1605066 6480464 [Disulfiram binds to Copper] which results in increased expression of DRAM1 mRNA CTD PMID:24690739 crocidolite asbestos affects expression ISO RGD:1605066 6480464 Asbestos, Crocidolite affects the expression of DRAM1 mRNA CTD PMID:25757056 curcumin increases expression ISO RGD:1605066 6480464 Curcumin results in increased expression of DRAM1 mRNA CTD PMID:21594647 cyclosporin A increases expression ISO RGD:1605066 6480464 Cyclosporine results in increased expression of DRAM1 mRNA CTD PMID:20106945 dioxygen multiple interactions ISO RGD:1622283 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of DRAM1 mRNA CTD PMID:30529165 disodium selenite decreases expression ISO RGD:1605066 6480464 Sodium Selenite results in decreased expression of DRAM1 mRNA CTD PMID:18175754 disulfiram multiple interactions ISO RGD:1605066 6480464 [Disulfiram binds to Copper] which results in increased expression of DRAM1 mRNA CTD PMID:24690739 diuron increases expression EXP 6480464 Diuron results in increased expression of DRAM1 mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:1605066 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin affects response to substance ISO RGD:1605066 6480464 DRAM1 protein affects the susceptibility to Doxorubicin CTD PMID:16217747 doxorubicin increases expression ISO RGD:1605066 6480464 Doxorubicin results in increased expression of DRAM1 mRNA CTD PMID:30031762 entinostat multiple interactions ISO RGD:1605066 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DRAM1 mRNA CTD PMID:27188386 entinostat increases expression ISO RGD:1605066 6480464 entinostat results in increased expression of DRAM1 mRNA CTD PMID:26272509 , PMID:27188386 ethyl methanesulfonate increases expression ISO RGD:1605066 6480464 Ethyl Methanesulfonate results in increased expression of DRAM1 mRNA CTD PMID:23649840 formaldehyde increases expression ISO RGD:1605066 6480464 Formaldehyde results in increased expression of DRAM1 mRNA CTD PMID:23649840 lipopolysaccharide increases expression ISO RGD:1622283 6480464 Lipopolysaccharides results in increased expression of DRAM1 mRNA CTD PMID:27339419 methotrexate increases expression ISO RGD:1605066 6480464 Methotrexate results in increased expression of DRAM1 mRNA CTD PMID:21678067 methyl methanesulfonate increases expression ISO RGD:1605066 6480464 Methyl Methanesulfonate results in increased expression of DRAM1 mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:1605066 6480464 methylmercuric chloride results in increased expression of DRAM1 mRNA CTD PMID:28001369 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of DRAM1 mRNA CTD PMID:25380136 nickel sulfate increases expression ISO RGD:1605066 6480464 nickel sulfate results in increased expression of DRAM1 mRNA CTD PMID:22714537 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of DRAM1 mRNA CTD PMID:23665939 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of DRAM1 mRNA CTD PMID:25729387 paracetamol increases expression ISO RGD:1605066 6480464 Acetaminophen results in increased expression of DRAM1 mRNA CTD PMID:22230336 paracetamol decreases expression ISO RGD:1605066 6480464 Acetaminophen results in decreased expression of DRAM1 mRNA CTD PMID:21420995 phenylmercury acetate increases expression ISO RGD:1605066 6480464 Phenylmercuric Acetate results in increased expression of DRAM1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1605066 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DRAM1 mRNA CTD PMID:27188386 potassium chromate decreases expression ISO RGD:1605066 6480464 potassium chromate(VI) results in decreased expression of DRAM1 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1605066 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DRAM1 mRNA CTD PMID:22079256 quercetin increases expression ISO RGD:1605066 6480464 Quercetin results in increased expression of DRAM1 mRNA CTD PMID:21632981 quinolin-8-ol increases expression ISO RGD:1605066 6480464 Oxyquinoline results in increased expression of DRAM1 mRNA CTD PMID:21632981 raloxifene multiple interactions ISO RGD:1605066 6480464 Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of DRAM1 mRNA] CTD PMID:21185374 resveratrol increases expression ISO RGD:1605066 6480464 resveratrol results in increased expression of DRAM1 mRNA CTD PMID:23750556 SB 431542 multiple interactions ISO RGD:1605066 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1605066 6480464 Silicon Dioxide results in increased expression of DRAM1 mRNA CTD PMID:25351596 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of DRAM1 mRNA CTD PMID:25993096 Soman increases expression EXP 6480464 Soman results in increased expression of DRAM1 mRNA CTD PMID:19281266 tetrachloromethane increases expression ISO RGD:1622283 6480464 Carbon Tetrachloride results in increased expression of DRAM1 mRNA CTD PMID:27339419 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of DRAM1 mRNA CTD PMID:30723492 topotecan increases expression EXP 6480464 Topotecan results in increased expression of DRAM1 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of DRAM1 mRNA CTD PMID:25729387 trichostatin A increases expression ISO RGD:1605066 6480464 trichostatin A results in increased expression of DRAM1 mRNA CTD PMID:24935251 tris(2-butoxyethyl) phosphate affects expression ISO RGD:1605066 6480464 tris(2-butoxyethyl) phosphate affects the expression of DRAM1 mRNA CTD PMID:29024780 valproic acid increases methylation ISO RGD:1605066 6480464 Valproic Acid results in increased methylation of DRAM1 gene CTD PMID:29154799 valproic acid increases expression ISO RGD:1605066 6480464 Valproic Acid results in increased expression of DRAM1 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1605066 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DRAM1 mRNA CTD PMID:27188386 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of DRAM1 mRNA CTD PMID:19015723 vincristine increases expression ISO RGD:1605066 6480464 Vincristine results in increased expression of DRAM1 mRNA CTD PMID:23649840 vorinostat increases expression ISO RGD:1605066 6480464 vorinostat results in increased expression of DRAM1 mRNA CTD PMID:27188386 
Gene-Chemical Interaction Annotations
