Npr2 (natriuretic peptide receptor 2) - Rat Genome Database

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Gene: Npr2 (natriuretic peptide receptor 2) Rattus norvegicus
Analyze
Symbol: Npr2
Name: natriuretic peptide receptor 2
RGD ID: 620851
Description: Enables peptide hormone binding activity. Involved in cGMP-mediated signaling; positive regulation of signal transduction; and wound healing. Predicted to be located in synapse. Predicted to be active in several cellular components, including cilium; neuron projection; and nucleus. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2); PARTICIPATES IN C-type natriuretic peptide signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ANP-B; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor B; atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); natriuretic peptide receptor-B; NPR-B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,678,197 - 62,697,360 (+)NCBIGRCr8
mRatBN7.2557,883,171 - 57,901,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,883,171 - 57,901,580 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,863,179 - 59,881,665 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,681,991 - 61,700,479 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,653,242 - 61,671,683 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,128,186 - 59,147,321 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,128,315 - 59,147,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,652,957 - 63,672,114 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,107,563 - 60,127,960 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,107,741 - 60,128,139 (+)NCBI
Celera556,463,705 - 56,482,048 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Npr2Ratachondroplasia  ISONpr2 (Mus musculus)1580771DNA:missense mutation:cds:p.L885R (mouse)RGD 
Npr2Ratessential hypertension  ISONPR2 (Homo sapiens)1580772DNA:repeat:intron:IVS2+150(GT)10-11 (human)RGD 
Npr2RatIntimal Hyperplasia amelioratesIMP 11528696 RGD 
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Npr2Ratacromesomelic dysplasia  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Acromesomelic dysplasiaClinVarPMID:28492532
Npr2Ratacromesomelic dysplasia, Maroteaux type  ISONPR2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15146390 more ...
Npr2Ratanauxetic dysplasia  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Anauxetic dysplasiaClinVarPMID:28492532
Npr2Ratautosomal recessive distal hereditary motor neuronopathy 2  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive distal spinal muscular atrophy 2ClinVarPMID:28492532
Npr2RatCraniosynostosis Syndrome, Autosomal Recessive  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Craniosynostosis syndromeClinVar 
Npr2Ratdistal arthrogryposis type 1A  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Arthrogryposis more ...ClinVarPMID:28492532
Npr2RatDwarfism  ISONPR2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:35741827
Npr2Ratfamilial focal epilepsy with variable foci 2  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:25387261 more ...
Npr2Ratfrontotemporal dementia and/or amyotrophic lateral sclerosis 6  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Frontotemporal dementia and/or amyotrophic lateral sclerosis 6ClinVarPMID:28492532
Npr2Ratgalactosemia  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferaseClinVarPMID:28492532
Npr2Ratgenetic disease  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:15146390 more ...
Npr2Rathyperphosphatasia with impaired intellectual development syndrome 2  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 6ClinVarPMID:22683086 more ...
Npr2Ratintellectual disability  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868
Npr2RatMiura type epiphyseal chondrodysplasia  ISONPR2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15146390 more ...
Npr2Ratparaplegia  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:23332916 more ...
Npr2Ratprimary ciliary dyskinesia  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:28492532
Npr2RatShort Stature with Nonspecific Skeletal Abnormalities 1  ISONPR2 (Homo sapiens)8554872ClinVar Annotator: match by term: SHORT STATURE WITH NONSPECIFIC SKELETAL ABNORMALITIES 1ClinVarPMID:15146390 more ...
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Original Reference(s)
Npr2Ratacromesomelic dysplasia, Maroteaux type  ISONPR2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Npr2Ratachondroplasia  ISSNpr2 (Mus musculus)13592920OMIM:100800MouseDO 
Npr2Ratacromesomelic dysplasia, Maroteaux type  ISSNpr2 (Mus musculus)13592920OMIM:602875MouseDO 
Npr2Ratbone development disease  ISSNpr2 (Mus musculus)13592920 MouseDO 

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Npr2Rat(1->4)-beta-D-glucan multiple interactionsISONpr2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of NPR2 mRNACTDPMID:36331819
Npr2Rat1,1-dichloroethene decreases expressionISONpr2 (Mus musculus)6480464vinylidene chloride results in decreased expression of NPR2 mRNACTDPMID:26682919
Npr2Rat1,2-dimethylhydrazine increases expressionISONpr2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of NPR2 mRNACTDPMID:22206623
Npr2Rat17beta-estradiol affects expressionISONPR2 (Homo sapiens)6480464Estradiol affects the expression of NPR2 mRNACTDPMID:14699072
Npr2Rat17beta-estradiol decreases expressionISONpr2 (Mus musculus)6480464Estradiol results in decreased expression of NPR2 mRNACTDPMID:39298647
Npr2Rat17beta-estradiol multiple interactionsISONPR2 (Homo sapiens)6480464[Estradiol binds to ESR2 protein] which results in increased expression of NPR2 mRNA more ...CTDPMID:20404318 and PMID:30165855
Npr2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of NPR2 mRNACTDPMID:22298810
Npr2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONpr2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of NPR2 mRNACTDPMID:21570461 and PMID:26377647
Npr2Rat2-hydroxypropanoic acid decreases expressionISONPR2 (Homo sapiens)6480464Lactic Acid results in decreased expression of NPR2 mRNACTDPMID:30851411
Npr2Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISONpr2 (Mus musculus)64804643 more ...CTDPMID:19467301
Npr2Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISONPR2 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NPR2 mRNACTDPMID:28628672
Npr2Rat4,4'-sulfonyldiphenol decreases methylationISONpr2 (Mus musculus)6480464bisphenol S results in decreased methylation of NPR2 exonCTDPMID:33297965
Npr2Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of NPR2 mRNACTDPMID:36041667
Npr2Rat4,4'-sulfonyldiphenol affects methylationISONpr2 (Mus musculus)6480464bisphenol S affects the methylation of NPR2 geneCTDPMID:31683443
Npr2Rat4,4'-sulfonyldiphenol increases methylationISONPR2 (Homo sapiens)6480464bisphenol S results in increased methylation of NPR2 geneCTDPMID:31601247
Npr2Rat4,4'-sulfonyldiphenol decreases expressionISONpr2 (Mus musculus)6480464bisphenol S results in decreased expression of NPR2 mRNACTDPMID:39298647
Npr2Rat4-hydroxyphenyl retinamide decreases expressionISONpr2 (Mus musculus)6480464Fenretinide results in decreased expression of NPR2 mRNACTDPMID:28973697
Npr2Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of NPR2 mRNACTDPMID:30047161
Npr2Ratacrolein multiple interactionsISONPR2 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased expression of NPR2 mRNACTDPMID:32845096
Npr2Ratafimoxifene decreases response to substanceISONPR2 (Homo sapiens)6480464NPR2 results in decreased susceptibility to afimoxifeneCTDPMID:21233418

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Biological Process
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Npr2Ratactivation of meiosis involved in egg activation involved_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratactivation of meiosis involved in egg activation involved_inISONpr2 (Mus musculus)1624291MGI:1856702 more ...RGDPMID:22987720 more ...
Npr2Rataxonogenesis involved_inISONpr2 (Mus musculus)1624291MGI:1856702 more ...RGDPMID:17954614 and PMID:30249793
Npr2Rataxonogenesis involved_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Rataxonogenesis involved in innervation involved_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Rataxonogenesis involved in innervation involved_inISONpr2 (Mus musculus)1624291MGI:1856702 PMID:25473838RGDPMID:25473838
Npr2Ratblood circulation involved_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratblood circulation involved_inISONpr2 (Mus musculus)1624291MGI:3774275 PMID:32901096RGDPMID:32901096
Npr2Ratblood vessel development involved_inISONpr2 (Mus musculus)1624291MGI:3774275 PMID:32901096RGDPMID:32901096
Npr2Ratblood vessel development involved_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratblood vessel remodeling involved_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratblood vessel remodeling involved_inISONpr2 (Mus musculus)1624291MGI:3522129 PMID:32394795RGDPMID:32394795
Npr2Ratbone development acts_upstream_of_or_withinISONpr2 (Mus musculus)1624291MGI:1856702 PMID:624676RGDPMID:624676
Npr2Ratbone development acts_upstream_of_or_withinIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratbone growth involved_inISONpr2 (Mus musculus)1624291MGI:4358115 more ...RGDPMID:23065701 more ...
Npr2Ratbone growth involved_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratc-di-GMP signaling involved_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratc-di-GMP signaling involved_inISONpr2 (Mus musculus)1624291MGI:3774275 PMID:20616347 and PMID:23127564RGDPMID:20616347 and PMID:23127564
Npr2Ratcartilage development involved_inISONpr2 (Mus musculus)1624291MGI:1856702 more ...RGDPMID:15722353 and PMID:17728275
Npr2Ratcartilage development involved_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Npr2Ratcilium is_active_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratcilium is_active_inISONpr2 (Mus musculus)1624291 PMID:28054671RGDPMID:28054671
Npr2Ratcytoplasm is_active_inISONpr2 (Mus musculus)1624291 PMID:23127564RGDPMID:23127564
Npr2Ratcytoplasm is_active_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Npr2Ratmembrane located_inIEAInterPro:IPR0011701600115GO_REF:0000002InterProGO_REF:0000002
Npr2Ratneuron projection is_active_inISONpr2 (Mus musculus)1624291 PMID:23127564RGDPMID:23127564
Npr2Ratneuron projection is_active_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratnucleus is_active_inIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratnucleus is_active_inISONpr2 (Mus musculus)1624291 PMID:23127564RGDPMID:23127564
Npr2Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Npr2Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Npr2Ratplasma membrane is_active_inIBAFB:FBgn0266136 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Npr2Ratplasma membrane located_inISONPR2 (Homo sapiens)1624291 PMID:24001744 more ...RGDPMID:24001744 more ...
Npr2Ratplasma membrane located_inIEAUniProtKB:P20594 and ensembl:ENSP000003410831600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratplasma membrane located_inISSUniProtKB:P205941600115GO_REF:0000024UniProtGO_REF:0000024
Npr2Ratsynapse located_inIEAGO:00072681600115GO_REF:0000108GOCGO_REF:0000108
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Molecular Function
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Npr2RatATP binding enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
Npr2RatGTP binding enablesIEAUniProtKB-KW:KW-03421600115GO_REF:0000043UniProtGO_REF:0000043
Npr2Ratguanylate cyclase activity enablesISONPR2 (Homo sapiens)1624291 PMID:1672777 and PMID:26980729RGDPMID:1672777 and PMID:26980729
Npr2Ratguanylate cyclase activity enablesISONpr2 (Mus musculus)1624291 PMID:14514678 more ...RGDPMID:14514678 more ...
Npr2Ratguanylate cyclase activity enablesIEAEC:4.6.1.21600115GO_REF:0000003UniProtGO_REF:0000003
Npr2Ratguanylate cyclase activity enablesIBAFB:FBgn0266136 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Npr2Ratguanylate cyclase activity enablesIEARHEA:136651600115GO_REF:0000116RHEAGO_REF:0000116
Npr2Ratguanylate cyclase activity enablesIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratguanylate cyclase activity enablesIEAUniProtKB:P20594 and ensembl:ENSP000003410831600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Rathormone binding enablesISONPR2 (Homo sapiens)1624291UniProtKB:P23582 and PMID:1672777RGDPMID:1672777
Npr2Rathormone binding enablesIEAUniProtKB:P20594 and ensembl:ENSP000003410831600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratidentical protein binding enablesIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratidentical protein binding enablesISONpr2 (Mus musculus)1624291PR:Q6VVW5 PMID:14514678RGDPMID:14514678
Npr2Ratlyase activity enablesIEAUniProtKB-KW:KW-04561600115GO_REF:0000043UniProtGO_REF:0000043
Npr2Ratnatriuretic peptide receptor activity enablesISONPR2 (Homo sapiens)1624291 PMID:1660465 more ...RGDPMID:1660465 more ...
Npr2Ratnatriuretic peptide receptor activity enablesISONpr2 (Mus musculus)1624291 PMID:14514678RGDPMID:14514678
Npr2Ratnatriuretic peptide receptor activity enablesIBAMGI:97372 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Npr2Ratnatriuretic peptide receptor activity enablesIEAUniProtKB:Q6VVW5 and ensembl:ENSMUSP000000301911600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratnatriuretic peptide receptor activity enablesIEAUniProtKB:P20594 and ensembl:ENSP000003410831600115GO_REF:0000107EnsemblGO_REF:0000107
Npr2Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  
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Npr2RatC-type natriuretic peptide signaling pathway  IMP 1601488 RGD 

Imported Annotations - KEGG (archival)

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Npr2Ratpurine metabolic pathway  IEA 6907045 KEGGrno:00230
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Npr2Ratcardiac hypertrophy  IAGP 1601488 RGD 

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Reference Title
Reference Citation
1. Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population. Doyle DD, etal., Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2117-23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Forced homodimerization by site-directed mutagenesis alters guanylyl cyclase activity of natriuretic peptide receptor B. Langenickel T, etal., Hypertension. 2004 Feb;43(2):460-5. Epub 2003 Dec 22.
6. Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B. Langenickel TH, etal., Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4735-40. Epub 2006 Mar 14.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury. Pellet-Many C, etal., Cardiovasc Res. 2015 Nov 1;108(2):288-98. doi: 10.1093/cvr/cvv229. Epub 2015 Sep 25.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Rahmutula D and Gardner DG, Endocrinology. 2005 Nov;146(11):4968-74. Epub 2005 Aug 18.
13. Structure of the type B human natriuretic peptide receptor gene and association of a novel microsatellite polymorphism with essential hypertension. Rehemudula D, etal., Circ Res. 1999 Mar 19;84(5):605-10.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family. Schulz S, etal., Cell 1989 Sep 22;58(6):1155-62.
18. Detection of membrane-bound guanylate cyclase activity in rat C6 glioma cells at different growth states following activation by natriuretic peptides. Sorci G, etal., Brain Res. 1995 Jun 12;683(1):51-8.
19. A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse. Tsuji T and Kunieda T, J Biol Chem. 2005 Apr 8;280(14):14288-92. Epub 2005 Feb 18.
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PMID:624676   PMID:1660465   PMID:1672777   PMID:9624142   PMID:14514678   PMID:14687666   PMID:15371450   PMID:16272201   PMID:17629948   PMID:19837875   PMID:19969282   PMID:20079378  
PMID:20304036   PMID:20880010   PMID:20947764   PMID:20977274   PMID:24001744   PMID:24333928   PMID:24352806   PMID:24471569   PMID:25183874   PMID:26980729   PMID:27496871   PMID:27557795  
PMID:28743500   PMID:28964968   PMID:37774352  



Npr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,678,197 - 62,697,360 (+)NCBIGRCr8
mRatBN7.2557,883,171 - 57,901,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,883,171 - 57,901,580 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,863,179 - 59,881,665 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,681,991 - 61,700,479 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,653,242 - 61,671,683 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,128,186 - 59,147,321 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,128,315 - 59,147,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,652,957 - 63,672,114 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,107,563 - 60,127,960 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,107,741 - 60,128,139 (+)NCBI
Celera556,463,705 - 56,482,048 (+)NCBICelera
Cytogenetic Map5q22NCBI
NPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,791,591 - 35,809,731 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,791,003 - 35,809,732 (+)EnsemblGRCh38hg38GRCh38
GRCh37935,791,588 - 35,809,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,782,406 - 35,799,728 (+)NCBINCBI36Build 36hg18NCBI36
Build 34935,782,405 - 35,799,709NCBI
Celera935,725,947 - 35,743,260 (+)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,748,436 - 35,765,752 (+)NCBIHuRef
CHM1_1935,792,795 - 35,810,116 (+)NCBICHM1_1
T2T-CHM13v2.0935,777,317 - 35,830,398 (+)NCBIT2T-CHM13v2.0
Npr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,629,015 - 43,651,437 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,631,935 - 43,651,244 (+)EnsemblGRCm39 Ensembl
GRCm38443,629,015 - 43,651,437 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,631,935 - 43,651,244 (+)EnsemblGRCm38mm10GRCm38
MGSCv37443,644,807 - 43,664,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,653,035 - 43,672,344 (+)NCBIMGSCv36mm8
Celera443,666,379 - 43,685,849 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Npr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472506,351 - 523,316 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955472506,351 - 523,647 (-)NCBIChiLan1.0ChiLan1.0
NPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,779,098 - 88,796,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,785,250 - 88,802,729 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,642,534 - 35,660,210 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,445,576 - 36,462,637 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,445,576 - 36,462,637 (+)Ensemblpanpan1.1panPan2
NPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,283,680 - 52,339,247 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,321,590 - 52,339,249 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,888,024 - 50,906,818 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,385,429 - 53,404,264 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,386,145 - 53,450,659 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,929,955 - 51,948,772 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,913,486 - 51,932,996 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,615,631 - 52,634,454 (+)NCBIUU_Cfam_GSD_1.0
Npr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,231,815 - 167,250,482 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,779,392 - 3,798,501 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,779,398 - 3,798,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,508,998 - 236,529,128 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,508,994 - 236,529,172 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,233,393 - 264,254,186 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,795,822 - 44,844,464 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,793,253 - 44,813,671 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,900,466 - 41,949,193 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,974,810 - 4,993,817 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,974,690 - 4,993,886 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Npr2
49 total Variants

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:34
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000021802
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat

1 to 10 of 34 rows
BE097058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,896,526 - 57,896,687 (+)MAPPERmRatBN7.2
Rnor_6.0559,142,258 - 59,142,418NCBIRnor6.0
Rnor_5.0563,667,050 - 63,667,210UniSTSRnor5.0
RGSC_v3.4560,122,907 - 60,123,067UniSTSRGSC3.4
Celera556,476,995 - 56,477,155UniSTS
RH 3.4 Map5394.5UniSTS
Cytogenetic Map5q22UniSTS
RH141203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,901,764 - 57,901,982 (+)MAPPERmRatBN7.2
Rnor_6.0559,147,496 - 59,147,713NCBIRnor6.0
Rnor_5.0563,672,288 - 63,672,505UniSTSRnor5.0
RGSC_v3.4560,128,145 - 60,128,362UniSTSRGSC3.4
Celera556,482,233 - 56,482,450UniSTS
RH 3.4 Map5395.0UniSTS
Cytogenetic Map5q22UniSTS
RH141379  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2557,901,334 - 57,901,535 (+)MAPPERmRatBN7.2
Rnor_6.0559,147,066 - 59,147,266NCBIRnor6.0
Rnor_5.0563,671,858 - 63,672,058UniSTSRnor5.0
RGSC_v3.4560,127,715 - 60,127,915UniSTSRGSC3.4
Celera556,481,803 - 56,482,003UniSTS
RH 3.4 Map5395.6UniSTS
Cytogenetic Map5q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000021802   ⟹   ENSRNOP00000021802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,883,171 - 57,901,580 (+)Ensembl
Rnor_6.0 Ensembl559,128,315 - 59,147,255 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112447   ⟹   ENSRNOP00000086809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl557,883,171 - 57,901,580 (+)Ensembl
RefSeq Acc Id: NM_053838   ⟹   NP_446290
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,678,942 - 62,697,350 (+)NCBI
mRatBN7.2557,883,171 - 57,901,580 (+)NCBI
Rnor_6.0559,128,903 - 59,147,311 (+)NCBI
Rnor_5.0563,652,957 - 63,672,114 (+)NCBI
RGSC_v3.4560,107,563 - 60,127,960 (+)RGD
Celera556,463,705 - 56,482,048 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238010   ⟹   XP_006238072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,678,197 - 62,697,360 (+)NCBI
mRatBN7.2557,883,207 - 57,901,590 (+)NCBI
Rnor_6.0559,128,186 - 59,147,321 (+)NCBI
Rnor_5.0563,652,957 - 63,672,114 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063287066   ⟹   XP_063143136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8562,687,999 - 62,697,360 (+)NCBI
Protein RefSeqs NP_446290 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238072 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143136 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41205 (Get FASTA)   NCBI Sequence Viewer  
  EDL98761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021802
  ENSRNOP00000086809
GenBank Protein P16067 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446290   ⟸   NM_053838
- Peptide Label: precursor
- UniProtKB: P16067 (UniProtKB/Swiss-Prot),   A6IJ41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238072   ⟸   XM_006238010
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UJL6 (UniProtKB/TrEMBL),   A6IJ41 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021802   ⟸   ENSRNOT00000021802
Ensembl Acc Id: ENSRNOP00000086809   ⟸   ENSRNOT00000112447
RefSeq Acc Id: XP_063143136   ⟸   XM_063287066
- Peptide Label: isoform X2
Guanylate cyclase   Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P16067-F1-model_v2 AlphaFold P16067 1-1047 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-41499 BioCyc
Ensembl Genes ENSRNOG00000015991 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021802 ENTREZGENE
  ENSRNOT00000112447 ENTREZGENE
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  A/G_cyclase_CS UniProtKB/Swiss-Prot
  ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  ANPR/GUC UniProtKB/Swiss-Prot
  Cyclic_nucleotide_synthase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:116564 UniProtKB/Swiss-Prot
NCBI Gene 116564 ENTREZGENE
PANTHER ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2 UniProtKB/Swiss-Prot
  GUANYLYL CYCLASE UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Guanylate_cyc UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PharmGKB NPR2 RGD
PhenoGen Npr2 PhenoGen
PRINTS NATPEPTIDER UniProtKB/Swiss-Prot
PROSITE ANF_RECEPTORS UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015991 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6GEF8_RAT UniProtKB/TrEMBL
  A0A8L2UJL6 ENTREZGENE, UniProtKB/TrEMBL
  A6IJ41 ENTREZGENE, UniProtKB/TrEMBL
  ANPRB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-07 Npr2  natriuretic peptide receptor 2  Npr2  natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Npr2  natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)  Npr2  natriuretic peptide receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Npr2  natriuretic peptide receptor 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Npr2  natriuretic peptide receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_homology has 78% identity to npr1 receptor 728952