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Gene: Npr2 (natriuretic peptide receptor 2) Rattus norvegicus
Symbol: Npr2
Name: natriuretic peptide receptor 2
Description: Exhibits peptide hormone binding activity. Involved in cGMP-mediated signaling and positive regulation of cGMP-mediated signaling. Localizes to plasma membrane. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2); PARTICIPATES IN C-type natriuretic peptide signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonia; ammonium chloride.
Type: protein-coding
Also known as: ANP-B; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor B; atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); natriuretic peptide receptor-B; NPR-B
Homo sapiens (human) : NPR2 (natriuretic peptide receptor 2)  HGNC  Alliance
Mus musculus (house mouse) : Npr2 (natriuretic peptide receptor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr2 (natriuretic peptide receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR2 (natriuretic peptide receptor 2)
Canis lupus familiaris (dog) : NPR2 (natriuretic peptide receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr2 (natriuretic peptide receptor 2)
Sus scrofa (pig) : NPR2 (natriuretic peptide receptor 2)
Chlorocebus sabaeus (African green monkey) : NPR2 (natriuretic peptide receptor 2)
Heterocephalus glaber (naked mole-rat) : Npr2 (natriuretic peptide receptor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0559,128,186 - 59,147,321 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,128,315 - 59,147,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,652,957 - 63,672,114 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,107,563 - 60,127,960 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1560,107,741 - 60,128,139 (+)NCBI
Celera556,463,705 - 56,482,048 (+)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Npr2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620851
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.