Abhd5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase) - Rat Genome Database

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Gene: Abhd5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase) Rattus norvegicus
Analyze
Symbol: Abhd5
Name: abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
RGD ID: 1303237
Description: Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity; carboxylic ester hydrolase activity; and lipase activator activity. Acts upstream of or within lipid metabolic process. Located in lipid droplet. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to human ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; abhydrolase domain containing 5; abhydrolase domain-containing protein 5; CGI-58; CGI-58-like protein; lipid droplet-binding protein CGI-58; LOC316122
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88130,877,834 - 130,903,947 (+)NCBIGRCr8
mRatBN7.28122,000,241 - 122,026,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,000,389 - 122,026,447 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8127,595,594 - 127,619,764 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08125,794,662 - 125,818,828 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08123,620,818 - 123,645,005 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08130,973,222 - 131,001,448 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8130,973,201 - 131,001,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08130,136,551 - 130,164,777 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48122,148,937 - 122,173,147 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18122,168,673 - 122,192,884 (+)NCBI
Celera8121,121,379 - 121,145,558 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
levonorgestrel  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
testosterone undecanoate  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO,ISS)
intracellular membrane-bounded organelle  (ISO)
lipid droplet  (IBA,IDA,IEA,ISO,ISS)
mitochondrion  (IBA)
nucleoplasm  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. PNPLA3/adiponutrin functions in lipid droplet formation. Chamoun Z, etal., Biol Cell. 2013 May;105(5):219-33. doi: 10.1111/boc.201200036. Epub 2013 Apr 17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome. Lefevre C, etal., Am J Hum Genet. 2001 Nov;69(5):1002-12. Epub 2001 Oct 2.
4. Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction. MacPherson RE, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Apr 15;304(8):R644-50. doi: 10.1152/ajpregu.00418.2012. Epub 2013 Feb 13.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield. Ou J, etal., Nat Commun. 2019 Mar 6;10(1):1078. doi: 10.1038/s41467-019-08902-x.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. Yamaguchi T, etal., J Biol Chem 2004 Jul 16;279(29):30490-7. Epub 2004 May 10.
Additional References at PubMed
PMID:12477932   PMID:16679289   PMID:17074755   PMID:17308334   PMID:18606822   PMID:21148142   PMID:21498505   PMID:22383684   PMID:27590244  


Genomics

Comparative Map Data
Abhd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88130,877,834 - 130,903,947 (+)NCBIGRCr8
mRatBN7.28122,000,241 - 122,026,447 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8122,000,389 - 122,026,447 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8127,595,594 - 127,619,764 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08125,794,662 - 125,818,828 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08123,620,818 - 123,645,005 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08130,973,222 - 131,001,448 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8130,973,201 - 131,001,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08130,136,551 - 130,164,777 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48122,148,937 - 122,173,147 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18122,168,673 - 122,192,884 (+)NCBI
Celera8121,121,379 - 121,145,558 (+)NCBICelera
Cytogenetic Map8q32NCBI
ABHD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38343,690,870 - 43,734,371 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl343,690,108 - 43,734,371 (+)EnsemblGRCh38hg38GRCh38
GRCh37343,732,362 - 43,775,863 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36343,707,379 - 43,735,296 (+)NCBINCBI36Build 36hg18NCBI36
Build 34343,707,378 - 43,735,295NCBI
Celera343,670,699 - 43,702,531 (+)NCBICelera
Cytogenetic Map3p21.33NCBI
HuRef343,775,563 - 43,807,394 (+)NCBIHuRef
CHM1_1343,682,530 - 43,714,373 (+)NCBICHM1_1
T2T-CHM13v2.0343,706,458 - 43,749,966 (+)NCBIT2T-CHM13v2.0
Abhd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399122,180,681 - 122,210,589 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9122,180,673 - 122,210,589 (+)EnsemblGRCm39 Ensembl
GRCm389122,351,616 - 122,381,524 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9122,351,608 - 122,381,524 (+)EnsemblGRCm38mm10GRCm38
MGSCv379122,260,734 - 122,290,641 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369122,200,314 - 122,230,221 (+)NCBIMGSCv36mm8
Celera9122,816,005 - 122,845,910 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map973.03NCBI
Abhd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542027,482,709 - 27,508,360 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542027,484,500 - 27,508,360 (-)NCBIChiLan1.0ChiLan1.0
ABHD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2243,637,759 - 43,677,319 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1343,642,524 - 43,672,420 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0343,580,752 - 43,612,637 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1344,640,215 - 44,669,885 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl344,640,215 - 44,669,885 (+)Ensemblpanpan1.1panPan2
ABHD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1232,584,813 - 2,619,204 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl232,586,678 - 2,737,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,622,390 - 2,656,835 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0232,837,297 - 2,871,778 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl232,837,304 - 2,871,784 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1232,673,959 - 2,708,185 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0232,804,668 - 2,839,064 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0232,772,747 - 2,807,406 (-)NCBIUU_Cfam_GSD_1.0
Abhd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118199,292,423 - 199,319,725 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366951,644,581 - 1,672,117 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366951,644,758 - 1,672,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABHD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1327,006,208 - 27,056,744 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11327,006,331 - 27,053,760 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21329,834,219 - 29,881,698 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q12-q22NCBI
ABHD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1225,109,699 - 5,139,021 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl225,109,765 - 5,137,673 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041162,051,858 - 162,081,174 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abhd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473076,414,626 - 76,436,156 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473076,414,732 - 76,436,177 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abhd5
93 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:29
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000000239
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
RH129832  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28122,024,595 - 122,024,792 (+)MAPPERmRatBN7.2
Rnor_6.08130,999,597 - 130,999,793NCBIRnor6.0
Rnor_5.08130,162,926 - 130,163,122UniSTSRnor5.0
RGSC_v3.48122,173,190 - 122,173,386UniSTSRGSC3.4
Celera8121,145,601 - 121,145,797UniSTS
RH 3.4 Map81262.9UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 56 41 18 41 4 5 72 35 39 11 4
Low 6 1 1 4 6 2 2 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000000239   ⟹   ENSRNOP00000000239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8122,000,389 - 122,026,447 (+)Ensembl
Rnor_6.0 Ensembl8130,973,201 - 131,001,458 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110511   ⟹   ENSRNOP00000077546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8122,000,409 - 122,026,447 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116075   ⟹   ENSRNOP00000077694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8122,012,901 - 122,026,447 (+)Ensembl
RefSeq Acc Id: NM_212524   ⟹   NP_997689
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,872 - 130,902,053 (+)NCBI
mRatBN7.28122,000,369 - 122,024,553 (+)NCBI
Rnor_6.08130,973,222 - 130,999,554 (+)NCBI
Rnor_5.08130,136,551 - 130,164,777 (+)NCBI
RGSC_v3.48122,148,937 - 122,173,147 (+)RGD
Celera8121,121,379 - 121,145,558 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244107   ⟹   XP_006244169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,926 - 130,903,947 (+)NCBI
mRatBN7.28122,000,332 - 122,026,447 (+)NCBI
Rnor_6.08130,973,231 - 131,001,448 (+)NCBI
Rnor_5.08130,136,551 - 130,164,777 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006244108   ⟹   XP_006244170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,878,156 - 130,903,947 (+)NCBI
mRatBN7.28122,000,568 - 122,026,447 (+)NCBI
Rnor_6.08130,973,814 - 131,001,448 (+)NCBI
Rnor_5.08130,136,551 - 130,164,777 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595704   ⟹   XP_017451193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,848 - 130,903,947 (+)NCBI
mRatBN7.28122,000,339 - 122,026,447 (+)NCBI
Rnor_6.08130,973,240 - 131,001,448 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081671   ⟹   XP_038937599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,927 - 130,903,947 (+)NCBI
mRatBN7.28122,000,343 - 122,026,447 (+)NCBI
RefSeq Acc Id: XM_039081672   ⟹   XP_038937600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,878,156 - 130,903,947 (+)NCBI
mRatBN7.28122,000,568 - 122,026,447 (+)NCBI
RefSeq Acc Id: XR_005487859
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88130,877,834 - 130,898,415 (+)NCBI
mRatBN7.28122,000,241 - 122,020,914 (+)NCBI
RefSeq Acc Id: NP_997689   ⟸   NM_212524
- UniProtKB: Q6QA69 (UniProtKB/Swiss-Prot),   A6I477 (UniProtKB/TrEMBL),   A0A8L2PZE5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244169   ⟸   XM_006244107
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244170   ⟸   XM_006244108
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451193   ⟸   XM_017595704
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000239   ⟸   ENSRNOT00000000239
RefSeq Acc Id: XP_038937599   ⟸   XM_039081671
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937600   ⟸   XM_039081672
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y666 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077546   ⟸   ENSRNOT00000110511
RefSeq Acc Id: ENSRNOP00000077694   ⟸   ENSRNOT00000116075
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QA69-F1-model_v2 AlphaFold Q6QA69 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696396
Promoter ID:EPDNEW_R6921
Type:initiation region
Name:Abhd5_1
Description:abhydrolase domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08130,973,207 - 130,973,267EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303237 AgrOrtholog
BioCyc Gene G2FUF-28652 BioCyc
Ensembl Genes ENSRNOG00000000221 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055002210 UniProtKB/Swiss-Prot
  ENSRNOG00060017885 UniProtKB/Swiss-Prot
  ENSRNOG00065000577 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000239.6 UniProtKB/TrEMBL
  ENSRNOT00000110511.1 UniProtKB/TrEMBL
  ENSRNOT00000116075.1 UniProtKB/TrEMBL
  ENSRNOT00055003514 UniProtKB/Swiss-Prot
  ENSRNOT00060030757 UniProtKB/Swiss-Prot
  ENSRNOT00065000815 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132142 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:316122 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156550 IMAGE-MGC_LOAD
NCBI Gene 316122 ENTREZGENE
PANTHER 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ABHD5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RE40534P-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abhd5 PhenoGen
PRINTS ABHYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000221 RatGTEx
  ENSRNOG00055002210 RatGTEx
  ENSRNOG00060017885 RatGTEx
  ENSRNOG00065000577 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y666 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y7N9_RAT UniProtKB/TrEMBL
  A0A8L2PZE5 ENTREZGENE, UniProtKB/TrEMBL
  A0JPK5_RAT UniProtKB/TrEMBL
  A6I477 ENTREZGENE, UniProtKB/TrEMBL
  ABHD5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-13 Abhd5  abhydrolase domain containing 5, lysophosphatidic acid acyltransferase  Abhd5  abhydrolase domain containing 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-09 Abhd5  abhydrolase domain containing 5  LOC316122  CGI-58-like protein  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-07-14 LOC316122  CGI-58-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mislocalization may be involved in pathogenesis of Chanarin-Dorfman syndrome in humans 1303992
gene_physical_interaction directly interacts with perilipin in lipid droplets; also binds to ADRP 1303992