Klrk1 (killer cell lectin like receptor K1) - Rat Genome Database

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Gene: Klrk1 (killer cell lectin like receptor K1) Rattus norvegicus
Analyze
Symbol: Klrk1
Name: killer cell lectin like receptor K1
RGD ID: 3180
Description: Predicted to enable several functions, including MHC class I protein binding activity; MHC class Ib receptor activity; and identical protein binding activity. Involved in positive regulation of apoptotic process; positive regulation of myeloid dendritic cell activation; and positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target. Located in cell surface. Used to study histiocytoma. Human ortholog(s) of this gene implicated in HTLV-1-associated myelopathy/tropical spastic paraparesis. Orthologous to several human genes including KLRK1 (killer cell lectin like receptor K1); PARTICIPATES IN malaria pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: killer cell lectin-like receptor subfamily K, member 1; NK cell receptor D; NK lectin-like receptor; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D; NKLLR; NKR-P2, ortholog of human NKG2D; Nkrp2
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,767,377 - 164,778,453 (-)NCBIGRCr8
mRatBN7.24163,079,887 - 163,092,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4163,081,927 - 163,092,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4169,316,732 - 169,327,172 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04165,099,689 - 165,110,129 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,733,737 - 163,744,177 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,392,652 - 163,403,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,393,217 - 163,403,653 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04212,035,683 - 212,046,724 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,914,786 - 166,922,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14167,159,723 - 167,167,595 (-)NCBI
Celera4151,761,022 - 151,771,458 (-)NCBICelera
RH 3.4 Map41013.4RGD
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Killing of avian and Swine influenza virus by natural killer cells. Achdout H, etal., J Virol. 2010 Apr;84(8):3993-4001. doi: 10.1128/JVI.02289-09. Epub 2010 Feb 3.
2. Involvement of NKR-P2/NKG2D in DC-mediated killing of tumor targets: indicative of a common, innate, target-recognition paradigm? Alli R, etal., Eur J Immunol. 2004 Apr;34(4):1119-26.
3. Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance. Alter G, etal., J Hepatol. 2011 Aug;55(2):278-88. doi: 10.1016/j.jhep.2010.11.030. Epub 2010 Dec 17.
4. Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. Berg SF, etal., Int Immunol 1998 Apr;10(4):379-85.
5. Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype. Bhardwaj S, etal., Virol J. 2016 Apr 18;13:67. doi: 10.1186/s12985-016-0507-5.
6. Genotype-Associated Differential NKG2D Expression on CD56+CD3+ Lymphocytes Predicts Response to Pegylated-Interferon/Ribavirin Therapy in Chronic Hepatitis C. Chu PS, etal., PLoS One. 2015 May 12;10(5):e0125664. doi: 10.1371/journal.pone.0125664. eCollection 2015.
7. Chronic HCV infection affects the NK cell phenotype in the blood more than in the liver. Cosgrove C, etal., PLoS One. 2014 Aug 22;9(8):e105950. doi: 10.1371/journal.pone.0105950. eCollection 2014.
8. Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. Crosby EJ, etal., J Immunol. 2015 Oct 1;195(7):3301-10. doi: 10.4049/jimmunol.1500855. Epub 2015 Aug 19.
9. Contradicting roles of miR-182 in both NK cells and their host target hepatocytes in HCV. El Sobky SA, etal., Immunol Lett. 2016 Jan;169:52-60. doi: 10.1016/j.imlet.2015.10.013. Epub 2015 Oct 27.
10. A role for NKG2D in NK cell-mediated resistance to poxvirus disease. Fang M, etal., PLoS Pathog. 2008 Feb 8;4(2):e30. doi: 10.1371/journal.ppat.0040030.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Modulation of NKG2D expression in human CD8(+) T cells corresponding with tuberculosis drug cure. Hassan SS, etal., PLoS One. 2013 Jul 26;8(7):e70063. doi: 10.1371/journal.pone.0070063. Print 2013.
13. Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin. Hayakawa Y, etal., J Immunol 2002 Nov 15;169(10):5377-81.
14. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
15. NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers. Lecuroux C, etal., J Acquir Immune Defic Syndr. 2013 Jan 1;62(1):17-20. doi: 10.1097/QAI.0b013e318274579f.
16. NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection. Lenartić M, etal., J Immunol. 2017 Feb 15;198(4):1531-1542. doi: 10.4049/jimmunol.1600461. Epub 2017 Jan 13.
17. Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese population. Ma J, etal., J Med Virol. 2010 Sep;82(9):1501-7. doi: 10.1002/jmv.21855.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. Nabekura T, etal., J Immunol. 2017 Sep 1;199(5):1567-1571. doi: 10.4049/jimmunol.1700799. Epub 2017 Jul 31.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. NKG2D gene variation and susceptibility to viral bronchiolitis in childhood. Pasanen A, etal., Pediatr Res. 2018 Sep;84(3):451-457. doi: 10.1038/s41390-018-0086-9. Epub 2018 Jun 9.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Bone Marrow-Derived Mesenchymal Stem Cells Attenuate Immune-Mediated Liver Injury and Compromise Virus Control During Acute Hepatitis B Virus Infection in Mice. Qu M, etal., Stem Cells Dev. 2017 Jun 1;26(11):818-827. doi: 10.1089/scd.2016.0348. Epub 2017 Feb 2.
24. Interleukin-15 mediates protection against experimental tuberculosis: a role for NKG2D-dependent effector mechanisms of CD8+ T cells. Rausch A, etal., Eur J Immunol. 2006 May;36(5):1156-67. doi: 10.1002/eji.200535290.
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. A transmembrane-anchored rat RAE-1-like transcript as a ligand for NKR-P2, the rat ortholog of human and mouse NKG2D. Savithri B and Khar A, Eur J Immunol. 2006 Jan;36(1):107-17.
28. NKG2D blockade significantly attenuates ischemia-reperfusion injury in a cardiac transplantation model. Shen B, etal., Transplant Proc. 2013 Jul-Aug;45(6):2513-6. doi: 10.1016/j.transproceed.2013.02.126.
29. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
30. Cross-linking a mAb to NKR-P2/NKG2D on dendritic cells induces their activation and maturation leading to enhanced anti-tumor immune response. Srivastava RM, etal., Int Immunol. 2007 May;19(5):591-607. Epub 2007 Mar 15.
31. Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. Talledo M, etal., J Med Virol. 2012 Feb;84(2):319-26. doi: 10.1002/jmv.22255.
32. A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease. Taniguchi R, etal., Infection. 2015 Jun;43(3):353-9. doi: 10.1007/s15010-015-0774-x. Epub 2015 Apr 10.
33. NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes. Van Belle TL, etal., J Autoimmun. 2013 Feb;40:66-73. doi: 10.1016/j.jaut.2012.08.001. Epub 2012 Sep 1.
34. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Vilarinho S, etal., Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18187-92. doi: 10.1073/pnas.0708968104. Epub 2007 Nov 8.
35. Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease. Walsh KB, etal., J Virol. 2008 Mar;82(6):3021-30. doi: 10.1128/JVI.02032-07. Epub 2007 Dec 19.
36. NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis. Walsh KB, etal., J Virol. 2008 Mar;82(6):3031-44. doi: 10.1128/JVI.02033-07. Epub 2007 Dec 26.
37. NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection. Wesselkamper SC, etal., J Immunol. 2008 Oct 15;181(8):5481-9. doi: 10.4049/jimmunol.181.8.5481.
38. Decreased NKp46 and NKG2D and elevated PD-1 are associated with altered NK-cell function in pediatric transplant patients with PTLD. Wiesmayr S, etal., Eur J Immunol. 2012 Feb;42(2):541-50. doi: 10.1002/eji.201141832. Epub 2011 Dec 16.
39. TGF-β1 improving abnormal pregnancy outcomes induced by Toxoplasma gondii infection: Regulating NKG2D/DAP10 and killer subset of decidual NK cells. Xu X, etal., Cell Immunol. 2017 Jul;317:9-17. doi: 10.1016/j.cellimm.2017.04.004. Epub 2017 Apr 18.
40. NKG2D is required for NK cell activation and function in response to E1-deleted adenovirus. Zhu J, etal., J Immunol. 2010 Dec 15;185(12):7480-6. doi: 10.4049/jimmunol.1002771. Epub 2010 Nov 12.
41. Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection. Zhuo M, etal., Eur J Immunol. 2010 Jun;40(6):1748-57. doi: 10.1002/eji.200939779.
Additional References at PubMed
PMID:2341409   PMID:10426994   PMID:11567106   PMID:12426565   PMID:12645935   PMID:14707119   PMID:14764662   PMID:15065764   PMID:15294961   PMID:16339517   PMID:16973387   PMID:17562706  
PMID:18178852   PMID:18209064   PMID:18292522   PMID:19304755   PMID:21106845   PMID:22585739   PMID:23610400   PMID:24586170  


Genomics

Comparative Map Data
Klrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,767,377 - 164,778,453 (-)NCBIGRCr8
mRatBN7.24163,079,887 - 163,092,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4163,081,927 - 163,092,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4169,316,732 - 169,327,172 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04165,099,689 - 165,110,129 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,733,737 - 163,744,177 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,392,652 - 163,403,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,393,217 - 163,403,653 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04212,035,683 - 212,046,724 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,914,786 - 166,922,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14167,159,723 - 167,167,595 (-)NCBI
Celera4151,761,022 - 151,771,458 (-)NCBICelera
RH 3.4 Map41013.4RGD
Cytogenetic Map4q42NCBI
KLRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,372,353 - 10,390,041 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,372,353 - 10,391,874 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,524,952 - 10,542,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,416,219 - 10,451,632 (-)NCBINCBI36Build 36hg18NCBI36
Build 341210,416,219 - 10,451,632NCBI
Celera1215,686,800 - 15,704,498 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1210,267,379 - 10,285,074 (-)NCBIHuRef
CHM1_11210,494,385 - 10,512,080 (-)NCBICHM1_1
T2T-CHM13v2.01210,259,174 - 10,276,858 (-)NCBIT2T-CHM13v2.0
Klrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,587,286 - 129,600,863 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6129,587,286 - 129,600,827 (-)EnsemblGRCm39 Ensembl
GRCm386129,610,323 - 129,623,903 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,610,323 - 129,623,864 (-)EnsemblGRCm38mm10GRCm38
MGSCv376129,560,339 - 129,573,859 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366129,560,174 - 129,588,327 (-)NCBIMGSCv36mm8
Celera6131,334,935 - 131,348,842 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.44NCBI
KLRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12735,634,938 - 35,658,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2735,639,280 - 35,658,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,971,898 - 10,995,916 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02735,980,734 - 36,004,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2735,980,514 - 36,004,659 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12735,862,915 - 35,886,819 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02735,891,407 - 35,915,433 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02710,500,576 - 10,524,567 (-)NCBIUU_Cfam_GSD_1.0
KLRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl561,647,043 - 61,656,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1561,646,691 - 61,655,386 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,370,029 - 64,378,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q25NCBI

Variants

.
Variants in Klrk1
252 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:42
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000012886
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
RH142207  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24163,082,108 - 163,082,299 (+)MAPPERmRatBN7.2
Rnor_6.04163,393,399 - 163,393,589NCBIRnor6.0
Rnor_5.04212,036,430 - 212,036,620UniSTSRnor5.0
RGSC_v3.44166,914,968 - 166,915,158UniSTSRGSC3.4
Celera4151,761,204 - 151,761,394UniSTS
RH 3.4 Map41013.4UniSTS
Cytogenetic Map4q42UniSTS
D6H12S2489E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24163,084,236 - 163,084,954 (+)MAPPERmRatBN7.2
Rnor_6.04163,395,527 - 163,396,244NCBIRnor6.0
Rnor_5.04212,038,558 - 212,039,275UniSTSRnor5.0
RGSC_v3.44166,917,096 - 166,917,813UniSTSRGSC3.4
Celera4151,763,332 - 151,764,049UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 37 67 87 86 55 25 55 6 200 85 47 43 52 31

Sequence


Ensembl Acc Id: ENSRNOT00000088151   ⟹   ENSRNOP00000074391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4163,081,927 - 163,092,363 (-)Ensembl
Rnor_6.0 Ensembl4163,393,217 - 163,403,653 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091890   ⟹   ENSRNOP00000071035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4163,081,927 - 163,092,459 (-)Ensembl
Rnor_6.0 Ensembl4163,393,435 - 163,402,561 (-)Ensembl
RefSeq Acc Id: NM_133512   ⟹   NP_598196
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,767,946 - 164,778,382 (-)NCBI
mRatBN7.24163,081,927 - 163,092,363 (-)NCBI
Rnor_6.04163,393,217 - 163,403,653 (-)NCBI
Rnor_5.04212,035,683 - 212,046,724 (-)NCBI
RGSC_v3.44166,914,786 - 166,922,659 (-)RGD
Celera4151,761,022 - 151,771,458 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237073   ⟹   XP_006237135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,767,377 - 164,778,316 (-)NCBI
mRatBN7.24163,081,362 - 163,092,299 (-)NCBI
Rnor_6.04163,392,652 - 163,403,597 (-)NCBI
Rnor_5.04212,035,683 - 212,046,724 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237074   ⟹   XP_006237136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,767,377 - 164,778,313 (-)NCBI
mRatBN7.24163,081,362 - 163,092,297 (-)NCBI
Rnor_6.04163,392,652 - 163,403,597 (-)NCBI
Rnor_5.04212,035,683 - 212,046,724 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237075   ⟹   XP_006237137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,767,377 - 164,778,416 (-)NCBI
mRatBN7.24163,081,362 - 163,092,397 (-)NCBI
Rnor_6.04163,392,652 - 163,403,735 (-)NCBI
Rnor_5.04212,035,683 - 212,046,724 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237076   ⟹   XP_006237138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,767,377 - 164,778,314 (-)NCBI
mRatBN7.24163,081,362 - 163,092,297 (-)NCBI
Rnor_6.04163,392,652 - 163,403,597 (-)NCBI
Rnor_5.04212,035,683 - 212,046,724 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237077   ⟹   XP_006237139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,767,377 - 164,778,443 (-)NCBI
mRatBN7.24163,081,362 - 163,092,424 (-)NCBI
Rnor_6.04163,392,652 - 163,403,735 (-)NCBI
Rnor_5.04212,035,683 - 212,046,724 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107081   ⟹   XP_038963009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84164,767,377 - 164,778,453 (-)NCBI
mRatBN7.24163,081,362 - 163,092,434 (-)NCBI
RefSeq Acc Id: NP_598196   ⟸   NM_133512
- UniProtKB: O70215 (UniProtKB/Swiss-Prot),   A6IM72 (UniProtKB/TrEMBL),   A0A8L2URA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237139   ⟸   XM_006237077
- Peptide Label: isoform X3
- UniProtKB: O70215 (UniProtKB/Swiss-Prot),   A6IM72 (UniProtKB/TrEMBL),   A0A8L2URA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237137   ⟸   XM_006237075
- Peptide Label: isoform X2
- UniProtKB: A6IM70 (UniProtKB/TrEMBL),   A0A8L2URA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237135   ⟸   XM_006237073
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JZG3 (UniProtKB/TrEMBL),   A6IM69 (UniProtKB/TrEMBL),   A0A8L2URA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237138   ⟸   XM_006237076
- Peptide Label: isoform X2
- UniProtKB: A6IM70 (UniProtKB/TrEMBL),   A0A8L2URA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237136   ⟸   XM_006237074
- Peptide Label: isoform X2
- UniProtKB: A6IM70 (UniProtKB/TrEMBL),   A0A8L2URA6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071035   ⟸   ENSRNOT00000091890
Ensembl Acc Id: ENSRNOP00000074391   ⟸   ENSRNOT00000088151
RefSeq Acc Id: XP_038963009   ⟸   XM_039107081
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JZG3 (UniProtKB/TrEMBL),   A6IM69 (UniProtKB/TrEMBL),   A0A8L2URA6 (UniProtKB/TrEMBL)
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70215-F1-model_v2 AlphaFold O70215 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693440
Promoter ID:EPDNEW_R3964
Type:single initiation site
Name:Klrk1_1
Description:killer cell lectin like receptor K1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04163,403,653 - 163,403,713EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3180 AgrOrtholog
BioCyc Gene G2FUF-42770 BioCyc
Ensembl Genes ENSRNOG00000061739 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088151.2 UniProtKB/TrEMBL
  ENSRNOT00000091890 ENTREZGENE
  ENSRNOT00000091890.2 UniProtKB/TrEMBL
  ENSRNOT00000146938 ENTREZGENE
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKG2D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24934 ENTREZGENE
PANTHER NKG2-D TYPE II INTEGRAL MEMBRANE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klrk1 PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061739 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZG3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2URA6 ENTREZGENE, UniProtKB/TrEMBL
  A6IM68_RAT UniProtKB/TrEMBL
  A6IM69 ENTREZGENE, UniProtKB/TrEMBL
  A6IM70 ENTREZGENE, UniProtKB/TrEMBL
  A6IM71_RAT UniProtKB/TrEMBL
  A6IM72 ENTREZGENE, UniProtKB/TrEMBL
  A6IM73_RAT UniProtKB/TrEMBL
  NKG2D_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Klrk1  killer cell lectin like receptor K1  Klrk1  killer cell lectin-like receptor subfamily K, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Klrk1  killer cell lectin-like receptor subfamily K, member 1  Nkrp2  NKR-P2, ortholog of human NKG2D  Symbol and Name updated 1299863 APPROVED
2002-06-10 Nkrp2  NKR-P2, ortholog of human NKG2D      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed by NK cells, and resting thoracic duct CD4+ and CD8+ T cells 633359