RGD Reference Report - Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. - Rat Genome Database

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Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection.

Authors: Nabekura, Tsukasa  Gotthardt, Dagmar  Niizuma, Kouta  Trsan, Tihana  Jenus, Tina  Jonjic, Stipan  Lanier, Lewis L 
Citation: Nabekura T, etal., J Immunol. 2017 Sep 1;199(5):1567-1571. doi: 10.4049/jimmunol.1700799. Epub 2017 Jul 31.
RGD ID: 39018560
Pubmed: PMID:28760883   (View Abstract at PubMed)
PMCID: PMC5567695   (View Article at PubMed Central)
DOI: DOI:10.4049/jimmunol.1700799   (Journal Full-text)

NK cells play a critical role in host defense against viruses. In this study, we investigated the role of NKG2D in the expansion of NK cells after mouse CMV (MCMV) infection. Wild-type and NKG2D-deficient (Klrk1-/- ) Ly49H+ NK cells proliferated robustly when infected with MCMV strains engineered to allow expression of NKG2D ligands, which enhanced the response of wild-type NK cells. Naive NK cells exclusively express NKG2D-L, which pairs only with DAP10, whereas NKG2D-S expressed by activated NK cells pairs with DAP10 and DAP12, similar to Ly49H. However, NKG2D alone was unable to drive robust expansion of Ly49H- NK cells when mice were infected with these MCMV strains, likely because NKG2D-S was only transiently expressed postinfection. These findings demonstrate that NKG2D augments Ly49H-dependent proliferation of NK cells; however, NKG2D signaling alone is inadequate for expansion of NK cells, likely due to only transient expression of the NKG2D-DAP12 complex.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
KLRK1HumanCytomegalovirus Infections  ISOKlrk1 (Mus musculus) RGD 
Klrk1RatCytomegalovirus Infections  ISOKlrk1 (Mus musculus) RGD 
Klrk1MouseCytomegalovirus Infections  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Klrk1  (killer cell lectin like receptor K1)

Genes (Mus musculus)
Klrk1  (killer cell lectin-like receptor subfamily K, member 1)

Genes (Homo sapiens)
KLRK1  (killer cell lectin like receptor K1)


Additional Information