RGD Reference Report - Interleukin-15 mediates protection against experimental tuberculosis: a role for NKG2D-dependent effector mechanisms of CD8+ T cells. - Rat Genome Database

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Interleukin-15 mediates protection against experimental tuberculosis: a role for NKG2D-dependent effector mechanisms of CD8+ T cells.

Authors: Rausch, Alexandra  Hessmann, Manuela  Hölscher, Alexandra  Schreiber, Tanja  Bulfone-Paus, Silvia  Ehlers, Stefan  Hölscher, Christoph 
Citation: Rausch A, etal., Eur J Immunol. 2006 May;36(5):1156-67. doi: 10.1002/eji.200535290.
RGD ID: 39018558
Pubmed: PMID:16619285   (View Abstract at PubMed)
DOI: DOI:10.1002/eji.200535290   (Journal Full-text)

CD8+ T cells are involved in protection against Mycobacterium tuberculosis infection and represent a promising target for new vaccine strategies. Because IL-15 is important for the homeostasis of CD8+ T cells, we studied the immune response in IL-15-deficient mice during tuberculosis. In the absence of IL-15, CD8+ T cells failed to efficiently accumulate in draining lymph nodes and at the site of infection. The expression of antigen-specific effector functions, such as the production of interferon-gamma and cytotoxicity, were impaired in CD8+ T cells, but not CD4+ T cells, from IL-15-deficient mice. This defect was associated with an increased mortality of IL-15-deficient mice during the chronic phase of infection. The lectin-like stimulatory receptor natural killer group 2D (NKG2D) was up-regulated on CD8+ T cells only from wild-type mice, but not from IL-15-deficient mice. Mechanistically, blocking NKG2D function with an mAb inhibited M. tuberculosis-directed CD8+ T cell responses in vitro. We conclude that in addition to regulating the expansion of CD8+ T cells, IL-15 is also necessary for inducing effector mechanisms in CD8+ T cells that depend on NKG2D expression. Hence, our results implicate IL-15 and NKG2D as promising targets for modulating CD8+ T cell-mediated protection against tuberculosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
tuberculosis  ISOKlrk1 (Mus musculus)39018558; 39018558 RGD 
tuberculosis  IMP 39018558 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Klrk1  (killer cell lectin like receptor K1)

Genes (Mus musculus)
Klrk1  (killer cell lectin-like receptor subfamily K, member 1)

Genes (Homo sapiens)
KLRK1  (killer cell lectin like receptor K1)


Additional Information