KLRK1 (killer cell lectin like receptor K1) - Rat Genome Database

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Gene: KLRK1 (killer cell lectin like receptor K1) Sus scrofa
Analyze
Symbol: KLRK1
Name: killer cell lectin like receptor K1
RGD ID: 14136065
Description: ENCODES a protein that exhibits kinase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to Gram-positive bacterium (ortholog); natural killer cell activation (ortholog); ASSOCIATED WITH Adenoviridae Infections (ortholog); AIDS-Related Complex (ortholog); anogenital venereal wart (ortholog); FOUND IN cell surface (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: killer cell lectin-like receptor subfamily K, member 1; NK cell receptor D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl561,647,043 - 61,656,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1561,646,691 - 61,655,386 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,370,029 - 64,378,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:11398969   PMID:25063224   PMID:28494934   PMID:30032202  


Genomics

Comparative Map Data
KLRK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl561,647,043 - 61,656,192 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1561,646,691 - 61,655,386 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,370,029 - 64,378,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q25NCBI
KLRK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,372,353 - 10,390,041 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,372,353 - 10,391,874 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,524,952 - 10,542,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,416,219 - 10,451,632 (-)NCBINCBI36Build 36hg18NCBI36
Build 341210,416,219 - 10,451,632NCBI
Celera1215,686,800 - 15,704,498 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1210,267,379 - 10,285,074 (-)NCBIHuRef
CHM1_11210,494,385 - 10,512,080 (-)NCBICHM1_1
T2T-CHM13v2.01210,259,174 - 10,276,858 (-)NCBIT2T-CHM13v2.0
Klrk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,587,286 - 129,600,863 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6129,587,286 - 129,600,827 (-)EnsemblGRCm39 Ensembl
GRCm386129,610,323 - 129,623,903 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,610,323 - 129,623,864 (-)EnsemblGRCm38mm10GRCm38
MGSCv376129,560,339 - 129,573,859 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366129,560,174 - 129,588,327 (-)NCBIMGSCv36mm8
Celera6131,334,935 - 131,348,842 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.44NCBI
Klrk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,767,377 - 164,778,453 (-)NCBIGRCr8
mRatBN7.24163,079,887 - 163,092,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4163,081,927 - 163,092,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4169,316,732 - 169,327,172 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04165,099,689 - 165,110,129 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,733,737 - 163,744,177 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,392,652 - 163,403,735 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,393,217 - 163,403,653 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04212,035,683 - 212,046,724 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,914,786 - 166,922,659 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14167,159,723 - 167,167,595 (-)NCBI
Celera4151,761,022 - 151,771,458 (-)NCBICelera
RH 3.4 Map41013.4RGD
Cytogenetic Map4q42NCBI
KLRK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12735,634,938 - 35,658,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2735,639,280 - 35,658,882 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,971,898 - 10,995,916 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02735,980,734 - 36,004,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2735,980,514 - 36,004,659 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12735,862,915 - 35,886,819 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02735,891,407 - 35,915,433 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02710,500,576 - 10,524,567 (-)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in KLRK1
258 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 8 2 1 3 1 2 3
Below cutoff 2 2 2 2 12 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000000691   ⟹   ENSSSCP00000000676
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl561,647,045 - 61,655,285 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000058167   ⟹   ENSSSCP00000034632
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl561,647,043 - 61,656,192 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000084543   ⟹   ENSSSCP00000065408
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl561,649,178 - 61,656,192 (+)Ensembl
RefSeq Acc Id: NM_213813   ⟹   NP_998978
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1561,648,237 - 61,655,122 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005655674   ⟹   XP_005655731
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1561,646,691 - 61,655,386 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091111   ⟹   XP_020946770
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1561,646,996 - 61,655,386 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005655731   ⟸   XM_005655674
- Peptide Label: isoform X1
- UniProtKB: A0A286ZSM5 (UniProtKB/TrEMBL),   A0A4X1UZL1 (UniProtKB/TrEMBL),   A0A8D0Y088 (UniProtKB/TrEMBL),   A0A8D1E7E4 (UniProtKB/TrEMBL),   A0A8D1L606 (UniProtKB/TrEMBL),   A0A8D1MUQ2 (UniProtKB/TrEMBL),   A0A8D0LX82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020946770   ⟸   XM_021091111
- Peptide Label: isoform X2
- UniProtKB: A0A8D0Y088 (UniProtKB/TrEMBL),   A0A8D1E7E4 (UniProtKB/TrEMBL),   A0A8D1L606 (UniProtKB/TrEMBL),   A0A8D1MUQ2 (UniProtKB/TrEMBL),   A0A8D0LX82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_998978   ⟸   NM_213813
- UniProtKB: Q9GL58 (UniProtKB/Swiss-Prot),   Q9GLF5 (UniProtKB/Swiss-Prot),   A0A8D0Y088 (UniProtKB/TrEMBL),   A0A8D1E7E4 (UniProtKB/TrEMBL),   A0A8D1L606 (UniProtKB/TrEMBL),   A0A8D1MUQ2 (UniProtKB/TrEMBL),   A0A8D0LX82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000000676   ⟸   ENSSSCT00000000691
RefSeq Acc Id: ENSSSCP00000034632   ⟸   ENSSSCT00000058167
RefSeq Acc Id: ENSSSCP00000065408   ⟸   ENSSSCT00000084543
Protein Domains
C-type lectin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040465 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005040994 UniProtKB/TrEMBL
  ENSSSCG00015080476 UniProtKB/TrEMBL
  ENSSSCG00025002803 UniProtKB/TrEMBL
  ENSSSCG00030066548 UniProtKB/TrEMBL
  ENSSSCG00035000670 UniProtKB/TrEMBL
  ENSSSCG00040029922 UniProtKB/TrEMBL
  ENSSSCG00045031223 UniProtKB/TrEMBL
  ENSSSCG00050047811 UniProtKB/TrEMBL
  ENSSSCG00055013402 UniProtKB/TrEMBL
  ENSSSCG00060006275 UniProtKB/TrEMBL
  ENSSSCG00065069053 UniProtKB/TrEMBL
  ENSSSCG00070021418 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000691.5 UniProtKB/TrEMBL
  ENSSSCT00000058167 ENTREZGENE
  ENSSSCT00000058167.3 UniProtKB/TrEMBL
  ENSSSCT00000084543.2 UniProtKB/TrEMBL
  ENSSSCT00005065655.1 UniProtKB/TrEMBL
  ENSSSCT00015109421.1 UniProtKB/TrEMBL
  ENSSSCT00015109427.1 UniProtKB/TrEMBL
  ENSSSCT00025003707.1 UniProtKB/TrEMBL
  ENSSSCT00025003724.1 UniProtKB/TrEMBL
  ENSSSCT00030092973.1 UniProtKB/TrEMBL
  ENSSSCT00035000757.1 UniProtKB/TrEMBL
  ENSSSCT00040040216.1 UniProtKB/TrEMBL
  ENSSSCT00045053206.1 UniProtKB/TrEMBL
  ENSSSCT00050065147.1 UniProtKB/TrEMBL
  ENSSSCT00055026372.1 UniProtKB/TrEMBL
  ENSSSCT00060007954.1 UniProtKB/TrEMBL
  ENSSSCT00065094795.1 UniProtKB/TrEMBL
  ENSSSCT00070042594.1 UniProtKB/TrEMBL
  ENSSSCT00070042601.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKG2D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396737 UniProtKB/Swiss-Prot
NCBI Gene KLRK1 ENTREZGENE
PANTHER NKG2-D TYPE II INTEGRAL MEMBRANE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZSM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UZL1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UZL6_PIG UniProtKB/TrEMBL
  A0A5G2QMY4_PIG UniProtKB/TrEMBL
  A0A8D0LX82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Y088 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1E7E4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1L606 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1MUQ2 ENTREZGENE, UniProtKB/TrEMBL
  F1SQ26_PIG UniProtKB/TrEMBL
  NKG2D_PIG UniProtKB/Swiss-Prot
  Q9GL58 ENTREZGENE
  Q9GLF5 ENTREZGENE
UniProt Secondary Q9GL58 UniProtKB/Swiss-Prot
VGNC ID VGNC:89549 ENTREZGENE