EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	*EC 1.2.1. (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor**	go back to main search page
Accession:	CHEBI:76852	browse the term
Definition:	An EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor that interferes with the action of any such enzyme using NAD(+) or NADP(+) as acceptor (EC 1.2.1.*).
Synonyms:	related_synonym:	EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitors; EC 1.2.1.* inhibitor; EC 1.2.1.* inhibitors

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Genes (1047)

4-(diethylamino)benzaldehyde

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 1 family, member A1

decreases activity
multiple interactions
increases oxidation

4-(diethylamino)benzaldehyde results in decreased activity of ALDH1A1 protein
4-(diethylamino)benzaldehyde inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to mafosfamide]
ALDH1A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde

PMID:8662658 PMID:16316642 PMID:25512087

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A2

multiple interactions

4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH1A2 protein

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

aldehyde dehydrogenase 2 family member

multiple interactions

4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH2 protein

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A1

increases oxidation

ALDH3A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

cyanamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

multiple interactions

Cyanamide promotes the reaction [[ADH1 protein co-treated with Ethanol] results in increased abundance of Acetaldehyde]; Cyanamide promotes the reaction [[ADH1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde]

PMID:7646056 PMID:11981770

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

aldehyde dehydrogenase 2 family member

multiple interactions
decreases activity

[Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin
Cyanamide affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of ALDH2 protein]]; Cyanamide affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of ALDH2 protein]; Cyanamide affects the reaction [Ethanol affects the expression of ALDH2 protein]

PMID:14690875 PMID:18272654 PMID:19576883 PMID:31550440

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

arginine vasopressin

multiple interactions
increases expression

[Ethanol co-treated with Cyanamide] results in increased expression of AVP mRNA
Cyanamide increases expression of Avp mRNA in the paraventricular nucleus of hypothalamus
Cyanamide results in increased expression of AVP mRNA

CTD
RGD

PMID:10718921 PMID:10978654 PMID:11139417 PMID:10718921

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

BCL2 associated X, apoptosis regulator

increases expression

Cyanamide results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[Ethanol co-treated with Cyanamide] results in increased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone morphogenetic protein 7

multiple interactions

Cyanamide inhibits the reaction [CGA protein results in increased expression of BMP7 mRNA]

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

cyclin D2

multiple interactions

Cyanamide inhibits the reaction [CGA protein results in increased expression of CCND2 mRNA]

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[Ethanol co-treated with Cyanamide] results in decreased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

glycoprotein hormones, alpha polypeptide

multiple interactions

Cyanamide inhibits the reaction [CGA protein results in increased expression of BMP7 mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of CCND2 mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of CYP17A1 mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of FSHR mRNA]; Cyanamide inhibits the reaction [CGA protein results in increased expression of LHCGR mRNA]

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

choline O-acetyltransferase

multiple interactions

Cyanamide affects the reaction [Ethanol results in decreased expression of CHAT mRNA]; Cyanamide affects the reaction [Ethanol results in decreased expression of CHAT protein]

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

corticotropin releasing hormone

multiple interactions
increases expression

[Cyanamide co-treated with Ethanol] results in increased expression of CRH mRNA; [Ethanol co-treated with Cyanamide] results in increased expression of CRH mRNA
Cyanamide results in increased expression of CRH mRNA

PMID:10718921 PMID:10978654 PMID:11139417 PMID:12217933 PMID:16375214

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cathepsin K

multiple interactions

Cyanamide analog binds to and results in decreased activity of CTSK protein

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

Cyanamide inhibits the reaction [CGA protein results in increased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

Cyanamide inhibits the reaction [CGA protein results in increased expression of CYP19A1 mRNA]

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

Cyanamide inhibits the reaction [Ethanol results in decreased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[Acetaldehyde co-treated with Cyanamide] results in increased expression of FOS protein; Acetaldehyde promotes the reaction [Cyanamide results in increased expression of FOS protein]; candesartan inhibits the reaction [[Acetaldehyde co-treated with Cyanamide] results in increased expression of FOS protein]; candesartan inhibits the reaction [Acetaldehyde promotes the reaction [Cyanamide results in increased expression of FOS protein]]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

follicle stimulating hormone receptor

multiple interactions

Cyanamide inhibits the reaction [CGA protein results in increased expression of FSHR mRNA]

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

insulin-like growth factor binding protein 1

multiple interactions

Cyanamide inhibits the reaction [Ethanol results in increased expression of IGFBP1 mRNA]

NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions

Cyanamide inhibits the reaction [CGA protein results in increased expression of LHCGR mRNA]

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases lipidation

Cyanamide promotes the reaction [Acetaldehyde results in increased lipidation of MAP1LC3B protein]
Cyanamide results in increased lipidation of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

melanocyte inducing transcription factor

decreases expression

Cyanamide results in decreased expression of MITF mRNA

NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

[Cyanamide co-treated with Ethanol] results in increased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

N-acetyltransferase 1

multiple interactions
decreases activity

Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

natriuretic peptide A

multiple interactions

[Ethanol co-treated with Cyanamide] results in increased expression of NPPA mRNA

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

proopiomelanocortin

multiple interactions
increases expression

[Cyanamide co-treated with Ethanol] results in increased expression of POMC mRNA; [Ethanol co-treated with Cyanamide] results in decreased expression of POMC mRNA; [Ethanol co-treated with Cyanamide] results in increased expression of POMC mRNA
Cyanamide results in increased expression of POMC mRNA

PMID:10978654 PMID:11139417 PMID:16375214

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

peroxisome proliferator activated receptor alpha

multiple interactions

Cyanamide promotes the reaction [Ethanol results in decreased activity of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Cyanamide inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

renin

multiple interactions

[Acetaldehyde co-treated with Cyanamide] results in increased activity of REN protein

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

tumor protein p53

multiple interactions

[Ethanol co-treated with Cyanamide] results in increased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tyrosinase

decreases expression

Cyanamide results in decreased expression of TYR mRNA

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

disulfiram

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of AARS1 mRNA

NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147

G

4-aminobutyrate aminotransferase

multiple interactions

[Ethanol co-treated with Disulfiram] results in decreased activity of ABAT protein; [Ethanol co-treated with Disulfiram] results in decreased expression of ABAT mRNA

NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835

G

ATP binding cassette subfamily A member 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily A member 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ABCA3 mRNA

NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745

G

ATP binding cassette subfamily B member 11

decreases activity
multiple interactions

Disulfiram results in decreased activity of ABCB11 protein
Disulfiram inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity

Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCB1 protein]; Disulfiram inhibits the reaction [azidopine binds to ABCB1 protein]; Disulfiram inhibits the reaction [azidoprazosin binds to ABCB1 protein]
Disulfiram metabolite results in decreased activity of ABCB1 protein; Disulfiram results in decreased activity of ABCB1 protein

PMID:10841824 PMID:14978246 PMID:16028354

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

decreases activity
multiple interactions

Disulfiram results in decreased activity of ABCC1 protein
Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC1 protein]

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 4

multiple interactions

Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC4 protein]; Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

acyl-CoA dehydrogenase family, member 11

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ACAD11 mRNA

NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560

G

angiotensin converting enzyme 2

decreases expression

Disulfiram results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

acetylcholinesterase

decreases expression

Disulfiram results in decreased expression of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA synthetase short-chain family member 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

G

actin alpha 2, smooth muscle

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ACTA2 mRNA

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

ADAM metallopeptidase domain 9

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ADAM9 mRNA

NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ADAMTS1 mRNA

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

adenosine deaminase, RNA-specific, B1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ADARB1 mRNA

NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852

G

adenylate cyclase 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ADCY3 mRNA

NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686

G

adhesion G protein-coupled receptor E5

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ADGRE5 mRNA

NCBI chr19:24,397,972...24,418,648
Ensembl chr19:24,398,689...24,418,638

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

decreases activity

Disulfiram results in decreased activity of ADH1 protein

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

adrenomedullin

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

actin filament associated protein 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of AFAP1 mRNA

NCBI chr14:74,743,322...74,856,300
Ensembl chr14:74,743,320...74,856,263

G

alanine--glyoxylate aminotransferase

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of AGXT mRNA

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336

G

alanine-glyoxylate aminotransferase 2

multiple interactions

[Ethanol co-treated with Disulfiram] results in decreased activity of AGXT2 protein

NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926

G

activator of Hsp90 ATPase activity 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of AHSA1 mRNA

NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345

G

aldo-keto reductase family 1 member B1

increases expression

Disulfiram results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

increases expression

Disulfiram results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C1

increases expression

Disulfiram results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C3

increases expression

Disulfiram results in increased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

AKT serine/threonine kinase 1

decreases phosphorylation

Disulfiram results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

multiple interactions

[Disulfiram co-treated with Lead] results in decreased activity of ALAD protein

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

aldehyde dehydrogenase 1 family, member A1

decreases activity
decreases expression
multiple interactions

Disulfiram results in decreased activity of ALDH1A1 protein
Disulfiram results in decreased expression of ALDH1A1 mRNA; Disulfiram results in decreased expression of ALDH1A1 protein
Disulfiram inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to maphosphamide]

PMID:8562935 PMID:10998257 PMID:21035945 PMID:34242567

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A2

decreases activity

Disulfiram results in decreased activity of ALDH1A2 protein

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

aldehyde dehydrogenase 2 family member

decreases activity
decreases expression
multiple interactions

Disulfiram metabolite results in decreased activity of ALDH2 protein; Disulfiram results in decreased activity of ALDH2 protein
Disulfiram results in decreased expression of ALDH2 mRNA
[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to hydroxypyruvic acid; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde

PMID:9585485 PMID:10513990 PMID:11142365 PMID:21334317 PMID:21376711 More...

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A1

increases metabolic processing

ALDH3A1 protein results in increased metabolism of Disulfiram

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

angiopoietin-like 4

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

anoctamin 6

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ANO6 mRNA

NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589

G

apoptotic peptidase activating factor 1

increases expression

Disulfiram results in increased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

amyloid beta precursor protein binding family B member 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of APBB3 mRNA

NCBI chr18:28,273,168...28,280,347
Ensembl chr18:28,270,545...28,280,094

G

APC down-regulated 1 like

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of APCDD1L mRNA

NCBI chr 3:162,587,484...162,658,362
Ensembl chr 3:162,582,252...162,658,073

G

amyloid beta precursor protein

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

androgen receptor

multiple interactions

[Disulfiram co-treated with cupric chloride] results in decreased expression of AR protein; Disulfiram inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

PMID:19789329 PMID:33049310

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

activity-regulated cytoskeleton-associated protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ARC mRNA

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

asialoglycoprotein receptor 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ASGR1 mRNA

NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631

G

acetylserotonin O-methyltransferase-like

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ASMTL mRNA

NCBI chr12:16,315,335...16,318,083
Ensembl chr12:16,315,414...16,318,080

G

asparagine synthetase (glutamine-hydrolyzing)

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 1

multiple interactions

[Disulfiram co-treated with Copper] results in decreased activity of ATF1 protein; Copper promotes the reaction [Disulfiram results in decreased activity of ATF1 protein]

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

activating transcription factor 2

multiple interactions

[Disulfiram co-treated with Copper] results in decreased activity of ATF2 protein; Copper promotes the reaction [Disulfiram results in decreased activity of ATF2 protein]

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

activating transcription factor 3

multiple interactions
increases expression

[Disulfiram binds to Copper] which results in decreased expression of ATF3 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of ATF3 mRNA]

PMID:24690739 PMID:32661532

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

autophagy related 101

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ATG101 mRNA

NCBI chr 7:132,398,477...132,407,643
Ensembl chr 7:132,398,483...132,407,633

G

ATPase plasma membrane Ca2+ transporting 1

decreases expression

Disulfiram results in decreased expression of ATP2B1 mRNA

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

ATP synthase membrane subunit K

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ATP5MK mRNA

NCBI chr 1:245,973,910...245,980,702
Ensembl chr 1:245,973,914...245,980,761
Ensembl chr10:245,973,914...245,980,761

G

ATPase H+ transporting V0 subunit D1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ATP6V0D1 mRNA

NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450

G

ATPase H+ transporting V1 subunit G1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ATP6V1G1 mRNA

NCBI chr 5:76,961,462...76,967,642
Ensembl chr 5:76,961,499...76,969,463

G

ataxin 1 like

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ATXN1L mRNA

NCBI chr19:37,700,341...37,711,529
Ensembl chr19:37,700,106...37,711,538

G

ataxin 3

affects localization
increases response to substance

Disulfiram affects the localization of ATXN3 protein alternative form
ATXN3 protein alternative form results in increased susceptibility to Disulfiram

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

BCL2-associated agonist of cell death

increases expression

Disulfiram results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAG cochaperone 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BCL2-antagonist/killer 1

multiple interactions

[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Disulfiram results in increased expression of BAX mRNA; Disulfiram results in increased expression of BAX protein
[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in increased expression of BAX protein; [Copper co-treated with Disulfiram] results in increased expression of BAX protein

PMID:17079463 PMID:23033007 PMID:24126434 PMID:34182011

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

Disulfiram results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

Bardet-Biedl syndrome 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of BBS2 mRNA

NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993

G

BRCA2 and CDKN1A interacting protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of BCCIP mRNA

NCBI chr 1:188,512,544...188,524,957
Ensembl chr 1:188,512,367...188,524,958

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Arsenic Trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Copper co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Disulfiram co-treated with cupric chloride] results in decreased expression of BCL2 protein
Disulfiram results in decreased expression of BCL2 mRNA

PMID:21911303 PMID:23033007 PMID:24126434 PMID:34182011

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

Disulfiram results in decreased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

increases expression

Disulfiram results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

brain-derived neurotrophic factor

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

increases expression

Disulfiram results in increased expression of BECN1 mRNA

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

increases expression

Disulfiram results in increased expression of BGLAP mRNA

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

baculoviral IAP repeat-containing 5

increases expression

Disulfiram results in increased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 7

multiple interactions

Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

BCL2 interacting protein 3

increases expression

Disulfiram results in increased expression of BNIP3 mRNA

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BRF2 general transcription factor 3B subunit

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of BRF2 mRNA

NCBI chr16:64,928,334...64,933,057
Ensembl chr16:64,928,300...64,933,059

G

Bruton tyrosine kinase

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of BTK mRNA

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

G

similar to human chromosome 3 open reading frame 52

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of C3ORF52 mRNA

NCBI chr11:55,166,986...55,192,273
Ensembl chr11:55,166,678...55,192,292

G

complement C1r

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of C1R mRNA

NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484

G

complement C1s

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of C1S mRNA

NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303

G

similar to human chromosome 11 open reading frame 96

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of C11ORF96 mRNA

NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523

G

similar to human chromosome 2 open reading frame 42

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of C2ORF42 mRNA

NCBI chr 4:118,887,688...118,916,808
Ensembl chr 4:118,888,112...118,916,936

G

similar to human chromosome 2 open reading frame 49

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of C2ORF49 mRNA

NCBI chr 9:45,371,396...45,382,123
Ensembl chr 9:45,371,430...45,382,120

G

calcyclin binding protein

multiple interactions
increases expression

[Disulfiram binds to Copper] which results in decreased expression of CACYBP mRNA
Disulfiram results in increased expression of CACYBP mRNA; Disulfiram results in increased expression of CACYBP protein

PMID:24690739 PMID:34182011

NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177

G

calcitonin-related polypeptide, beta

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CALCB mRNA

NCBI chr 1:168,965,383...168,970,259
Ensembl chr 1:168,966,465...168,970,125

G

caldesmon 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CALD1 mRNA

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calmodulin 1

decreases expression

Disulfiram results in decreased expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calmodulin 2

increases expression

Disulfiram results in increased expression of CALM2 mRNA

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287

G

calmodulin 3

decreases expression

Disulfiram results in decreased expression of CALM3 mRNA

NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207

G

carbonic anhydrase 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CA2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 7

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CA7 mRNA

NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467

G

caspase 3

multiple interactions
increases activity

[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein]
[Disulfiram binds to Copper] which results in increased activity of CASP3 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of CASP3 protein]
Disulfiram results in increased activity of CASP3 protein

PMID:11239917 PMID:17026967 PMID:17079463 PMID:24193513 PMID:24690739

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity

Disulfiram results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

multiple interactions
increases expression

[Disulfiram binds to Copper] which results in increased activity of CASP9 protein
Disulfiram results in increased expression of CASP9 mRNA

PMID:24690739 PMID:34182011

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases expression
multiple interactions
decreases expression

Disulfiram results in increased expression of CAT mRNA
Zinc Sulfate inhibits the reaction [Disulfiram results in decreased expression of CAT mRNA]

PMID:20566472 PMID:32712770 PMID:34182011

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cell division cycle and apoptosis regulator 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CCAR1 protein

NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526

G

coiled-coil domain containing 59

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CCDC59 mRNA

NCBI chr 7:41,142,760...41,149,143
Ensembl chr 7:41,142,760...41,149,143

G

coiled-coil domain containing 92

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CCDC92 mRNA

NCBI chr12:31,796,102...31,823,333
Ensembl chr12:31,796,684...31,823,337

G

cholecystokinin

decreases expression
multiple interactions

Disulfiram results in decreased expression of CCK protein alternative form
[Disulfiram binds to Copper] which results in decreased expression of CCK mRNA

PMID:8246921 PMID:24690739

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

C-C motif chemokine ligand 2

multiple interactions
decreases secretion

[Disulfiram binds to Copper] which results in increased expression of CCL2 mRNA; [Zinc Sulfate co-treated with Disulfiram] inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; Disulfiram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Disulfiram results in decreased secretion of CCL2 protein

PMID:24690739 PMID:32712770

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 26

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CCL26 mRNA

NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335

G

C-C motif chemokine ligand 5

multiple interactions

Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein]
[Disulfiram binds to Copper] which results in increased expression of CCL5 mRNA

PMID:19016906 PMID:24690739

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin A2

multiple interactions
decreases expression

[Disulfiram co-treated with Copper] results in decreased expression of CCNA2 protein
Disulfiram results in decreased expression of CCNA2 mRNA

PMID:15367699 PMID:34182011

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

decreases expression

Disulfiram results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

multiple interactions

Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin K

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CCNK mRNA

NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191

G

cell cycle progression 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CCPG1 mRNA

NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430

G

C-C motif chemokine receptor 2

increases expression

Disulfiram results in increased expression of CCR2 protein

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

C-C motif chemokine receptor 5

multiple interactions

Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein]

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

CD163 molecule

multiple interactions
decreases expression

[Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD163 mRNA
Disulfiram results in decreased expression of CD163 mRNA

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

CD36 molecule

multiple interactions
decreases expression

[Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD36 mRNA
Disulfiram results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD46 molecule

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CD46 mRNA

NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445

G

Cd47 molecule

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

CD9 molecule

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CD9 mRNA

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

G

CDC42 effector protein 5

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CDC42EP5 mRNA

NCBI chr 1:70,035,921...70,038,990

G

cadherin 11

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CDH11 mRNA

NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272

G

cadherin 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CDH2 mRNA

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cyclin dependent kinase 2

decreases expression

Disulfiram results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

decreases expression

Disulfiram results in decreased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 5 regulatory subunit 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

G

CDK5 regulatory subunit associated protein 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CDK5RAP3 mRNA

NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590

G

cyclin-dependent kinase 6

decreases expression

Disulfiram results in decreased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

increases expression

Disulfiram results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions

Disulfiram results in increased expression of CDKN1B mRNA; Disulfiram results in increased expression of CDKN1B protein
[Disulfiram binds to Copper] which results in increased expression of CDKN1B protein

PMID:17079463 PMID:24690739 PMID:34182011

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 1C

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

CDKN2A interacting protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CDKN2AIP mRNA

NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033

G

cyclin-dependent kinase inhibitor 2B

increases expression

Disulfiram results in increased expression of CDKN2B mRNA

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cell migration inducing hyaluronidase 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CEMIP mRNA

NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415

G

centromere protein W

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CENPW mRNA

NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464

G

cilia and flagella associated protein 53

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CFAP53 mRNA

NCBI chr18:67,884,651...67,955,873
Ensembl chr18:67,869,855...67,952,318

G

complement factor B

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CFB mRNA

NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505

G

cofilin 1

increases expression

Disulfiram results in increased expression of CFL1 protein

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

chromogranin A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CHGA mRNA

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

G

charged multivesicular body protein 1B

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CHMP1B mRNA

NCBI chr18:60,740,349...60,742,879

G

cysteine and histidine rich domain containing 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CHORDC1 mRNA

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

cartilage intermediate layer protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CILP mRNA

NCBI chr 8:65,777,281...65,792,251
Ensembl chr 8:65,777,281...65,792,251

G

cold inducible RNA binding protein

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CIRBP mRNA

NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818

G

cytoskeleton-associated protein 4

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CKAP4 mRNA

NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914

G

claudin 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CLDN1 mRNA

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

C-type lectin domain containing 7A

increases expression

Disulfiram results in increased expression of CLEC7A protein

NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897

G

cleavage factor polyribonucleotide kinase subunit 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CLP1 mRNA

NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421

G

clathrin, light chain A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CLTA mRNA

NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472

G

chemerin chemokine-like receptor 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CMKLR2 mRNA

NCBI chr 9:64,583,310...64,617,883
Ensembl chr 9:64,585,594...64,586,655

G

contactin associated protein 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CNTNAP1 mRNA

NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611

G

collagen type XII alpha 1 chain

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

collagen type I alpha 1 chain

decreases expression

Disulfiram results in decreased expression of COL1A1 protein

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type V alpha 1 chain

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

COMM domain containing 9

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of COMMD9 mRNA

NCBI chr 3:88,175,909...88,190,427
Ensembl chr 3:88,175,987...88,190,439

G

cellular retinoic acid binding protein 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CRABP2 mRNA

NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379

G

cAMP responsive element binding protein 1

multiple interactions

[Disulfiram co-treated with Copper] results in decreased activity of CREB1 protein; Copper promotes the reaction [Disulfiram results in decreased activity of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cysteine-rich with EGF-like domains 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CRELD2 mRNA

NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543

G

cysteine rich transmembrane BMP regulator 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CRIM1 mRNA

NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259

G

CXXC repeat containing interactor of PDZ3 domain

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CRIPT mRNA

NCBI chr 6:7,581,428...7,589,384
Ensembl chr 6:7,580,703...7,589,399

G

cysteine-rich secretory protein LCCL domain containing 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CRISPLD2 mRNA

NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465

G

crystallin, alpha B

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

chromosome segregation 1 like

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CSE1L mRNA

NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865

G

casein kinase 1, epsilon

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CSNK1E mRNA

NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794

G

cysteine and serine rich nuclear protein 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of AXUD1 mRNA

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

cysteine and glycine-rich protein 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CSRP2 mRNA

NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745

G

cystatin E/M

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CST6 mRNA

NCBI chr 1:202,655,322...202,657,030
Ensembl chr 1:202,655,322...202,657,030

G

cystathionine gamma-lyase

increases expression

Disulfiram results in increased expression of CTH protein

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

CWC25 spliceosome-associated protein homolog

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CWC25 mRNA

NCBI chr10:82,735,698...82,760,373
Ensembl chr10:82,736,995...82,760,354

G

C-X-C motif chemokine receptor 4

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

Disulfiram results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Disulfiram results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
increases expression

GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B1 mRNA]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
multiple interactions

Disulfiram results in increased expression of CYP2B2 mRNA
GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B2 mRNA]

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, subfamily 2, polypeptide 11

decreases activity
decreases expression

Disulfiram results in decreased activity of CYP2C11 protein
Disulfiram results in decreased expression of CYP2C11 protein

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity
decreases expression

[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane]
Disulfiram results in decreased expression of CYP2E1 mRNA; Disulfiram results in decreased expression of CYP2E1 protein
Disulfiram binds to and results in decreased activity of CYP2E1 protein

PMID:1664256 PMID:8637342 PMID:9393675 PMID:10805064 PMID:18754103 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily r, polypeptide 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CYP2R1 mRNA

NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression
increases response to substance
decreases activity

Disulfiram results in decreased expression of CYP3A2 mRNA
CYP3A4 protein results in increased susceptibility to Disulfiram
Disulfiram results in decreased activity of CYP3A2 protein

PMID:9393675 PMID:21540358

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dystroglycan 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of DAG1 mRNA

NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325

G

dopamine beta-hydroxylase

decreases activity
affects response to substance

Disulfiram results in decreased activity of DBH protein
DBH gene SNP affects the susceptibility to Disulfiram
DBH gene polymorphism affects the susceptibility to Disulfiram

PMID:90468 PMID:16163519 PMID:19462300

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

DDB1 and CUL4 associated factor 13

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DCAF13 mRNA

NCBI chr 7:70,160,983...70,196,142
Ensembl chr 7:70,160,941...70,196,142

G

dicarbonyl and L-xylulose reductase

multiple interactions

[Disulfiram co-treated with NADP] binds to DCXR protein

NCBI chr10:106,006,404...106,008,293

G

DNA-damage inducible transcript 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DExD-box helicase 39A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DDX39A mRNA

NCBI chr19:24,418,743...24,427,422
Ensembl chr19:24,418,114...24,426,954

G

DEXD/H-box helicase 60

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of DDX60 mRNA

NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526

G

death effector domain containing 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DEDD2 mRNA

NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714

G

dihydrodiol dehydrogenase

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DHDH mRNA

NCBI chr 1:95,954,361...95,965,262
Ensembl chr 1:95,953,092...95,965,197

G

dehydrogenase/reductase 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DHRS2 mRNA

NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644

G

dehydrogenase/reductase 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

dickkopf WNT signaling pathway inhibitor 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of DKK3 mRNA

NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590

G

delta like canonical Notch ligand 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DLL1 mRNA

NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179

G

DnaJ heat shock protein family (Hsp40) member A1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member A4

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DNAJA4 mRNA

NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B6

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member C3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DNAJC3 mRNA

NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181

G

diphthamide biosynthesis 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DPH3 mRNA

NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265

G

DNA-damage regulated autophagy modulator 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of DRAM1 mRNA

NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765

G

dermatan sulfate epimerase

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of DSE mRNA

NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992

G

dual specificity phosphatase 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DUSP2 mRNA

NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499

G

dual specificity phosphatase 5

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

dynein light chain LC8-type 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of DYNLL2 mRNA

NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805

G

ELL associated factor 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of EAF1 mRNA

NCBI chr16:6,698,322...6,713,071
Ensembl chr16:6,698,322...6,713,071

G

EGF like repeats and discoidin domains 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

G

embryonic ectoderm development

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of EED mRNA

NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974

G

EGF containing fibulin extracellular matrix protein 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

early growth response 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 4A3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of EIF4A3 mRNA

NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057

G

elongation factor for RNA polymerase II 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ELL2 mRNA

NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781

G

elongation factor 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ELOF1 mRNA

NCBI chr 8:20,645,336...20,650,888
Ensembl chr 8:20,645,336...20,650,579

G

estrogen receptor 1

multiple interactions

Disulfiram binds to and results in decreased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

ETS proto-oncogene 1, transcription factor

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ETS1 mRNA

NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010

G

coagulation factor XII

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of F12 mRNA

NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530

G

family with sequence similarity 210, member A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FAM210A mRNA

NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171

G

family with sequence similarity 234, member A

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of FAM234A mRNA

NCBI chr10:15,232,267...15,263,529
Ensembl chr10:15,232,278...15,263,488

G

family with sequence similarity 32, member A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FAM32A mRNA

NCBI chr16:17,603,054...17,607,376
Ensembl chr16:17,603,946...17,607,398

G

Fas ligand

increases expression

Disulfiram results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

ferrochelatase

increases expression

Disulfiram results in increased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

FKBP prolyl isomerase 1A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FKBP1A mRNA

NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743

G

folliculin

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FLCN mRNA

NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769

G

fibronectin type III domain containing 11

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FNDC11 mRNA

NCBI chr 3:168,330,607...168,333,111
Ensembl chr 3:168,330,602...168,334,617

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

forkhead box A3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FOXA3 mRNA

NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155

G

forkhead box J1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FOXJ1 mRNA

NCBI chr10:101,566,299...101,570,370
Ensembl chr10:101,566,304...101,570,237

G

forkhead box O1

increases expression

Disulfiram results in increased expression of FOXO1 mRNA

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

increases expression

Disulfiram results in increased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box O4

increases expression

Disulfiram results in increased expression of FOXO4 mRNA

NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115

G

FSHD region gene 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FRG1 mRNA

NCBI chr16:50,925,783...50,946,661
Ensembl chr16:50,925,803...50,946,661

G

follicle stimulating hormone subunit beta

multiple interactions

Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follicle stimulating hormone receptor

multiple interactions

Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

follistatin-like 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of FSTL1 mRNA

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

formimidoyltransferase cyclodeaminase

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of FTCD mRNA

NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735

G

ferritin light chain 1

increases expression

Disulfiram results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

glucose-6-phosphate dehydrogenase

increases expression

Disulfiram results in increased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Disulfiram results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

growth arrest and DNA-damage-inducible, beta

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

polypeptide N-acetylgalactosaminyltransferase 10

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of GALNT10 mRNA

NCBI chr10:41,821,216...41,967,618
Ensembl chr10:41,820,158...41,967,013

G

growth arrest specific 6

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of GAS6 mRNA

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

GATA binding protein 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GATA2 mRNA

NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761

G

guanylate binding protein 4

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of GBP4 mRNA

NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879

G

GRIP and coiled-coil domain containing 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GCC1 mRNA

NCBI chr 4:57,030,817...57,042,682
Ensembl chr 4:57,032,314...57,042,663

G

glucagon receptor

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GCGR mRNA

NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640

G

glutamate-cysteine ligase, catalytic subunit

increases expression

Disulfiram results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

Disulfiram results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

GTP binding protein overexpressed in skeletal muscle

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GEM mRNA

NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222

G

gem (nuclear organelle) associated protein 6

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GEMIN6 mRNA

NCBI chr 6:14,786,090...14,790,617
Ensembl chr 6:14,786,070...14,790,612

G

growth hormone 1

multiple interactions

GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B1 mRNA]; GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B2 mRNA]

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

golgi glycoprotein 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of GLG1 mRNA

NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178

G

glutaredoxin 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GLRX2 mRNA

NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831

G

golgi SNAP receptor complex member 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GOSR2 mRNA

NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625

G

G-protein signaling modulator 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of GPSM1 mRNA

NCBI chr 3:9,140,816...9,167,828
Ensembl chr 3:9,128,636...9,167,827

G

glutamic--pyruvic transaminase 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione peroxidase 3

increases expression

Disulfiram results in increased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

GRAM domain containing 1A

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of GRAMD1A mRNA

NCBI chr 1:86,367,001...86,393,348
Ensembl chr 1:86,367,001...86,393,336

G

GRAM domain containing 2B

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of GRAMD2B mRNA

NCBI chr18:49,884,014...49,981,955
Ensembl chr18:49,884,014...49,981,953

G

glutamate-rich WD repeat containing 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GRWD1 mRNA

NCBI chr 1:96,301,260...96,306,962
Ensembl chr 1:96,301,261...96,307,201

G

gasdermin D

decreases cleavage
multiple interactions

Disulfiram results in decreased cleavage of GSDMD protein
Disulfiram binds to and results in decreased activity of GSDMD protein; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein]

PMID:32367036 PMID:33851234

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

gasdermin E

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of GSDME mRNA

NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806

G

glutathione-disulfide reductase

increases expression

Disulfiram results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

general transcription factor IIB

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of GTF2B mRNA

NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651

G

H2A clustered histone 20

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of H2AC20 mRNA

NCBI chr 2:183,779,879...183,780,357

G

H2A.X variant histone

multiple interactions
increases expression

Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein]; Disulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein]; Disulfiram inhibits the reaction [Trichloroethylene results in increased phosphorylation of H2AX protein]
Disulfiram results in increased expression of H2AX protein

PMID:28300663 PMID:29722447 PMID:34830855 PMID:35279910

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

H2B clustered histone 12

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of H2BC12 mRNA

NCBI chr17:42,485,699...42,486,162

G

H2B clustered histone 8

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of H2BC8 mRNA

NCBI chr17:42,708,658...42,709,408

G

H3.4 histone, cluster member

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of H3-4 mRNA

NCBI chr10:43,740,702...43,741,262

G

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of H6PD mRNA

NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171

G

hemoglobin alpha, adult chain 2

multiple interactions
increases expression

[Disulfiram binds to Copper] which results in decreased expression of HBA1 mRNA
Disulfiram results in increased expression of HBA1 protein

PMID:24690739 PMID:34182011

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392

G

heparin-binding EGF-like growth factor

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HBEGF mRNA

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

hes family bHLH transcription factor 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HES1 mRNA

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes family bHLH transcription factor 6

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HES6 mRNA

NCBI chr 9:92,001,849...92,003,562
Ensembl chr 9:92,001,841...92,003,559

G

heme oxygenase 1

increases expression
multiple interactions

Disulfiram results in increased expression of HMOX1 mRNA
[Disulfiram binds to Copper] which results in decreased expression of HMOX1 mRNA; [Disulfiram co-treated with Zinc Sulfate] results in increased expression of HMOX1 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of HMOX1 mRNA]

PMID:20566472 PMID:24690739 PMID:32661532 PMID:32712770

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein A2/B1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of HNRNPA2B1 mRNA

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

homeobox A1

multiple interactions

Disulfiram inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]

NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504

G

homeo box D1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HOXD1 mRNA

NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769

G

harakiri, BCL2 interacting protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HRK mRNA

NCBI chr12:38,387,484...38,409,652

G

heparan sulfate-glucosamine 3-sulfotransferase 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HS3ST2 mRNA

NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399

G

hydroxysteroid 11-beta dehydrogenase 1

multiple interactions

[Disulfiram co-treated with NAD] binds to HSD11B1 protein

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Disulfiram results in decreased activity of HSD11B2 protein

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein 90 alpha family class B member 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

increases expression
multiple interactions

Disulfiram results in increased expression of HSPA1B mRNA
[Disulfiram binds to Copper] which results in decreased expression of HSPA1B mRNA

PMID:20566472 PMID:24690739

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 4

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family A (Hsp70) member 8

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family B (small) member 8

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

heat shock protein family H (Hsp110) member 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

5-hydroxytryptamine receptor 2B

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of HTR2B mRNA

NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108

G

inhibitor of DNA binding 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

immediate early response 5

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of IER5 mRNA

NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227

G

interferon-induced protein with tetratricopeptide repeats 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon-induced protein with tetratricopeptide repeats 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon gamma receptor 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of IFNGR2 mRNA

NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005

G

insulin-like growth factor 2 receptor

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of IGF2R mRNA

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

insulin-like growth factor binding protein 7

multiple interactions
increases expression

[Disulfiram binds to Copper] which results in increased expression of IGFBP7 mRNA; [Disulfiram binds to Copper] which results in increased expression of IGFBP7 protein
[Disulfiram cotreated with copper(+2)] increases expression of IGFBP7 mRNA in malignant pleural mesothelioma cells

CTD
RGD

PMID:24690739 PMID:24690739

NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314

G

interleukin 18

multiple interactions

[Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]

PMID:33579316 PMID:33851234

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of IL1B mRNA; [Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [Nigericin results in increased secretion of IL1B protein]
Disulfiram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:24690739 PMID:32367036 PMID:32712770 PMID:33579316 PMID:33851234

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of IL6 mRNA; [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein]

PMID:24690739 PMID:32712770 PMID:33851234

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin induced gene 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

interferon regulatory factor 8

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of IRF8 mRNA

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

G

ISY1 splicing factor homolog

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ISY1 mRNA

NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188

G

integrin subunit alpha 11

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ITGA11 mRNA

NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407

G

integrin subunit alpha 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ITGA3 mRNA

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit alpha M

increases expression

Disulfiram results in increased expression of ITGAM protein

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit alpha V

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ITGAV mRNA

NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639

G

integrin subunit beta 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 5

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ITGB5 mRNA

NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472

G

jagged canonical Notch ligand 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of JAG2 mRNA

NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein; [Copper co-treated with Disulfiram] results in increased expression of and results in increased phosphorylation of JUN protein; [Disulfiram co-treated with cupric chloride co-treated with Doxorubicin] results in increased expression of and results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [[Copper co-treated with Disulfiram] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Disulfiram co-treated with Copper co-treated with Doxorubicin] results in increased phosphorylation of and results in increased expression of JUN protein]

PMID:21911303 PMID:23033007

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel modifier subfamily G member 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of KCNG1 mRNA

NCBI chr 3:156,960,717...156,992,877
Ensembl chr 3:156,973,156...156,992,635

G

KH RNA binding domain containing, signal transduction associated 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of KHDRBS3 mRNA

NCBI chr 7:100,837,707...100,995,644
Ensembl chr 7:100,837,934...100,988,460

G

KLF transcription factor 10

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of KLF10 mRNA

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

G

kelch-like family member 22

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of KLHL22 mRNA

NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770

G

kelch-like family member 5

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of KLHL5 mRNA

NCBI chr14:43,144,254...43,206,192
Ensembl chr14:43,144,257...43,184,238

G

keratin 1

increases expression

Disulfiram results in increased expression of KRT1 mRNA; Disulfiram results in increased expression of KRT1 protein

NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844

G

keratin 75

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of KRT75 mRNA

NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345

G

laminin subunit gamma 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of LAMC1 mRNA

NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492

G

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of LAMTOR3 mRNA

NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607

G

LEM domain nuclear envelope protein 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of LEMD2 mRNA

NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626

G

luteinizing hormone subunit beta

multiple interactions

Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions

Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

LIM and calponin homology domains 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of LIMCH1 mRNA

NCBI chr14:41,112,579...41,425,001
Ensembl chr14:41,114,803...41,425,191

G

lipoyltransferase 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of LIPT1 mRNA

NCBI chr 9:40,107,938...40,118,268
Ensembl chr 9:40,098,615...40,113,565

G

LIM and cysteine-rich domains 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of LMCD1 mRNA

NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046

G

lemur tyrosine kinase 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of LMTK2 mRNA

NCBI chr12:10,426,772...10,508,750
Ensembl chr12:10,426,777...10,508,750

G

loricrin cornified envelope precursor protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of LORICRIN mRNA

NCBI chr 2:177,558,062...177,560,960
Ensembl chr 2:177,558,252...177,559,807

G

LRAT domain containing 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of LRATD2 mRNA

NCBI chr 7:92,376,713...92,387,045
Ensembl chr 7:92,362,194...92,388,189

G

LDL receptor related protein 8

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of LRP8 mRNA

NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352

G

leucine-rich single-pass membrane protein 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of LSMEM1 mRNA

NCBI chr 6:57,251,720...57,261,590
Ensembl chr 6:57,252,056...57,261,653

G

leukotriene B4 receptor

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of LTB4R mRNA

NCBI chr15:29,263,199...29,265,716

G

LUC7-like 3 pre-mRNA splicing factor

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of CROP mRNA

NCBI chr10:79,240,050...79,276,555
Ensembl chr10:79,240,563...79,276,538

G

microtubule-actin crosslinking factor 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of MACF1 mRNA

NCBI chr 5:135,623,734...135,949,097
Ensembl chr 5:135,623,742...135,945,905

G

MAD2L1 binding protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MAD2L1BP mRNA

NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447

G

MAF bZIP transcription factor B

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MAFB mRNA

NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031

G

MAF bZIP transcription factor F

increases expression

Disulfiram results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAF bZIP transcription factor G

increases expression

Disulfiram results in increased expression of MAFG mRNA

NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026

G

MAF bZIP transcription factor K

increases expression

Disulfiram results in increased expression of MAFK mRNA

NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048

G

mago homolog, exon junction complex subunit

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MAGOH mRNA

NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617

G

mannosidase, alpha, class 1B, member 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of MAN1B1 mRNA

NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006

G

monoamine oxidase A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases expression

[Disulfiram binds to Copper] which results in decreased expression of MAP1LC3B mRNA
Disulfiram results in increased expression of MAP1LC3B mRNA

PMID:24690739 PMID:34182011

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MAP2K3 mRNA

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen-activated protein kinase kinase kinase 13

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MAP3K13 mRNA

NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181

G

mitogen-activated protein kinase kinase kinase 20

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of MAP3K20 mRNA

NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626

G

mitogen activated protein kinase 1

multiple interactions

[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK1 protein; [Copper co-treated with Disulfiram] results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK3 protein; [Copper co-treated with Disulfiram] results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein]
[Disulfiram binds to Copper] which results in increased phosphorylation of MAPK8 protein

PMID:11239917 PMID:24690739

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

[Disulfiram binds to Copper] which results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein, RP/EB family, member 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MAPRE2 mRNA

NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044

G

minichromosome maintenance complex component 2

multiple interactions
decreases expression

cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM2 mRNA]

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 5

multiple interactions
decreases expression

cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM5 mRNA]

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

malic enzyme 1

increases expression

Disulfiram results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

major facilitator superfamily domain containing 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of MFSD3 mRNA

NCBI chr 7:108,419,644...108,423,469
Ensembl chr 7:108,421,350...108,423,461

G

O-6-methylguanine-DNA methyltransferase

multiple interactions
decreases activity
increases degradation

[Disulfiram binds to Copper] which results in decreased expression of and results in decreased activity of MGMT protein; [Disulfiram co-treated with cupric chloride] affects the expression of and affects the activity of MGMT protein; bortezomib inhibits the reaction [Disulfiram results in increased degradation of MGMT protein]; Disulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]; Disulfiram results in decreased expression of and results in decreased activity of MGMT protein
Disulfiram results in decreased activity of MGMT protein

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microsomal glutathione S-transferase 1

increases expression

Disulfiram results in increased expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

midnolin

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MIDN mRNA

NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752

G

macrophage migration inhibitory factor

increases expression

Disulfiram results in increased expression of MIF protein

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

mitochondrial matrix import factor 23

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MIX23 mRNA

NCBI chr11:64,660,711...64,681,000
Ensembl chr11:64,660,711...64,681,000

G

matrix metallopeptidase 10

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 2

decreases expression

Disulfiram results in decreased expression of MMP2

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

decreases expression

Disulfiram results in decreased expression of MMP9

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

metallophosphoesterase 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of MPPE1 mRNA

NCBI chr18:60,763,418...60,781,553
Ensembl chr18:60,763,419...60,781,553

G

mitochondrial ribosomal protein L10

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MRPL10 mRNA

NCBI chr10:82,026,031...82,034,451
Ensembl chr10:82,026,031...82,034,443

G

mitochondrial ribosomal protein L18

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MRPL18 mRNA

NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987

G

mitochondrial ribosomal protein L45

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MRPL45 mRNA

NCBI chr10:82,308,650...82,320,474
Ensembl chr10:82,308,427...82,320,474

G

macrophage stimulating 1

increases expression

Disulfiram results in increased expression of MST1 mRNA

NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416

G

mitochondrially encoded cytochrome c oxidase I

affects activity
affects expression

Disulfiram affects the activity of COX1 protein
Disulfiram affects the expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

metallothionein 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2A

increases expression
multiple interactions

Disulfiram results in increased expression of MT2A mRNA
cupric chloride promotes the reaction [Disulfiram results in increased expression of MT2A mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT2A mRNA]

PMID:19789329 PMID:32661532

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metallothionein 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MT3 mRNA

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

metal-regulatory transcription factor 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MTF1 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of ATF3 mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of HMOX1 mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT1M mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT2A mRNA]

PMID:24690739 PMID:32661532

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

MX dynamin like GTPase 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

Disulfiram results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin regulatory light chain interacting protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of MYLIP mRNA

NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295

G

myosin light chain kinase

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of MYLK mRNA

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

N-acetyltransferase 14

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NAT14 mRNA

NCBI chr 1:68,910,599...68,913,452
Ensembl chr 1:68,910,601...68,912,733

G

neutral cholesterol ester hydrolase 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NCEH1 mRNA

NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588

G

nuclear receptor coactivator 7

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NCOA7 mRNA

NCBI chr 1:26,856,228...27,016,950
Ensembl chr 1:26,856,530...27,015,871

G

nicastrin

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NCSTN mRNA

NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454

G

neurofilament heavy chain

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

NFE2 like bZIP transcription factor 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NFE2L3 mRNA

NCBI chr 4:80,506,756...80,534,629
Ensembl chr 4:80,506,756...80,534,629

G

nuclear factor kappa B subunit 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

decreases degradation
multiple interactions

Disulfiram results in decreased degradation of NFKBIA protein
[Disulfiram binds to Copper] which results in increased expression of NFKBIA protein

PMID:10418820 PMID:24690739

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor beta

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NFKBIB protein

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

neuroguidin

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NGDN mRNA

NCBI chr15:28,489,950...28,497,286
Ensembl chr15:28,490,040...28,519,654

G

niban apoptosis regulator 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NIBAN1 mRNA

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729

G

nucleolar protein 12

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NOL12 mRNA

NCBI chr 7:110,493,294...110,498,908
Ensembl chr 7:110,493,246...110,498,907

G

nitric oxide synthase 2

affects expression

Disulfiram affects the expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase interacting protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NOSIP mRNA

NCBI chr 1:95,543,329...95,559,101
Ensembl chr 1:95,543,360...95,558,650

G

aminopeptidase-like 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NPEPL1 mRNA

NCBI chr 3:162,893,932...162,906,491
Ensembl chr 3:162,893,943...162,906,492

G

natriuretic peptide B

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

neuronal pentraxin 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NPTX2 mRNA

NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345

G

NAD(P)H quinone dehydrogenase 1

increases expression
increases activity

Disulfiram results in increased expression of NQO1 mRNA
Disulfiram results in increased activity of NQO1 protein

PMID:16045903 PMID:20566472

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Disulfiram binds to and affects the activity of NR1I2 protein
Disulfiram binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

Notch-regulated ankyrin repeat protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NRARP mRNA

NCBI chr 3:7,992,582...7,995,136
Ensembl chr 3:7,992,552...7,995,133

G

NRAS proto-oncogene, GTPase

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NRAS mRNA

NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626

G

neuropilin 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NRP1 mRNA

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

G

5' nucleotidase, ecto

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of NT5E mRNA

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

NUBP iron-sulfur cluster assembly factor 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NUBP1 mRNA

NCBI chr10:5,259,328...5,270,848

G

nuclear RNA export factor 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NXF1 mRNA

NCBI chr 1:205,655,442...205,668,637
Ensembl chr 1:205,655,375...205,668,636

G

nuclear transport factor 2-like export factor 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of NXT2 mRNA

NCBI chr X:105,855,616...105,862,902
Ensembl chr X:105,855,608...105,862,899

G

2'-5'-oligoadenylate synthetase-like

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of OASL mRNA

NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641

G

oncostatin M receptor

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of OSMR mRNA

NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262

G

prolyl 3-hydroxylase 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of P3H3 mRNA

NCBI chr 4:157,646,242...157,662,035
Ensembl chr 4:157,646,243...157,662,035

G

prolyl 3-hydroxylase family member 4

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of P3H4 mRNA

NCBI chr10:85,338,158...85,345,108
Ensembl chr10:85,338,161...85,345,093

G

peptidylglycine alpha-amidating monooxygenase

increases activity

Disulfiram results in increased activity of PAM protein

PMID:8246921 PMID:10347250

NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[Copper co-treated with Disulfiram] results in increased cleavage of PARP1 protein; [Disulfiram binds to Copper] which results in increased cleavage of PARP1 protein; [Disulfiram co-treated with cupric chloride] results in increased cleavage of PARP1 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of PARP1 protein]
Disulfiram results in increased cleavage of PARP1 protein

PMID:17079463 PMID:19789329 PMID:23033007 PMID:24193513 PMID:24690739 More...

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PCK2 mRNA

NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283

G

pecanex 4

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PCNX4 mRNA

NCBI chr 6:91,125,063...91,170,423
Ensembl chr 6:91,125,063...91,170,439

G

phosphodiesterase 5A

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PDE5A mRNA

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

platelet derived growth factor receptor beta

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

PDZ and LIM domain 5

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PDLIM5 mRNA

NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275

G

podoplanin

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PDPN protein
[Disulfiram binds to Copper] which results in increased expression of and results in increased phosphorylation of and results in increased ubiquitination of PDPN protein

NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656

G

p53 and DNA damage regulated 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PDRG1 mRNA

NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858
Ensembl chr 3:141,476,501...141,483,858

G

phosphogluconate dehydrogenase

increases expression

Disulfiram results in increased expression of PGD mRNA

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

pleckstrin homology-like domain, family A, member 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PHLDA2 mRNA

NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836

G

pleckstrin homology-like domain, family B, member 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PHLDB2 mRNA

NCBI chr11:54,859,173...55,078,212
Ensembl chr11:54,859,135...55,078,467

G

phosphatidylinositol glycan anchor biosynthesis, class Q

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PIGQ mRNA

NCBI chr10:14,942,571...14,958,584
Ensembl chr10:14,942,577...14,958,584

G

phosphoinositide-3-kinase interacting protein 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PIK3IP1 mRNA

NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608

G

phosphatidylinositol-5-phosphate 4-kinase type 2 alpha

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PIP4K2A mRNA

NCBI chr17:81,496,669...81,668,180
Ensembl chr17:81,496,670...81,668,029

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PLOD2 mRNA

NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255

G

pyridoxal phosphate binding protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PLPBP mRNA

NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886

G

phospholipid scramblase 4

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PLSCR4 mRNA

NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049

G

plexin B2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PLXNB2 mRNA

NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Disulfiram results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

PARN like ribonuclease domain containing exonuclease 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PNLDC1 mRNA

NCBI chr 1:47,843,224...47,861,675
Ensembl chr 1:47,843,224...47,861,674

G

PNMA family member 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PNMA2 mRNA

NCBI chr15:41,111,942...41,119,649
Ensembl chr15:41,112,009...41,121,427

G

RNA polymerase II subunit C

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of POLR2C mRNA

NCBI chr19:10,158,153...10,164,935
Ensembl chr19:10,157,823...10,164,945

G

RNA polymerase II subunit M

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of POLR2M mRNA

NCBI chr 8:72,131,992...72,139,423
Ensembl chr 8:72,131,530...72,243,036

G

proopiomelanocortin

decreases expression

Disulfiram results in decreased expression of POMC protein alternative form

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

POP4 homolog, ribonuclease P/MRP subunit

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of POP4 mRNA

NCBI chr 1:90,960,026...90,968,360
Ensembl chr 1:90,960,022...90,968,443

G

periostin

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of POSTN mRNA

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

peroxisome proliferator-activated receptor gamma

affects expression
multiple interactions

Disulfiram affects the expression of PPARG mRNA
Disulfiram binds to and results in increased activity of PPARG protein

PMID:32712770 PMID:33049310

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

peptidylprolyl isomerase A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PPIA mRNA

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

protein phosphatase 1, regulatory subunit 15A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory subunit 3C

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

protein phosphatase 2, regulatory subunit B, beta

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PPP2R2B mRNA

NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025

G

peroxiredoxin 1

increases expression

Disulfiram results in increased expression of PRDX1 mRNA; Disulfiram results in increased expression of PRDX1 protein

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

prokineticin 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PROK2 mRNA

NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385

G

serine protease 8

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PRSS8 mRNA

NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815

G

phosphoserine aminotransferase 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

proteasome 26S subunit, ATPase 4

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PSMC4 mRNA

NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494

G

persephin

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PSPN mRNA

NCBI chr 9:1,840,906...1,841,748
Ensembl chr 9:1,840,896...1,854,327

G

phosphatase and tensin homolog

multiple interactions
increases expression

[Copper co-treated with Disulfiram] results in decreased expression of PTEN protein
Disulfiram results in increased expression of PTEN mRNA

PMID:20424113 PMID:34182011

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E synthase 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PTGES3 mRNA

NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084

G

prostaglandin reductase 1

increases expression

Disulfiram results in increased expression of PTGR1 mRNA

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

prostaglandin-endoperoxide synthase 2

decreases expression

Disulfiram results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

prothymosin alpha

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of PTMA mRNA

NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333

G

pentraxin 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of PTX3 mRNA

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

RAB5C, member RAS oncogene family

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RAB5C mRNA

NCBI chr10:85,642,553...85,666,142
Ensembl chr10:85,642,809...85,666,103

G

Rac family small GTPase 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RAC1 mRNA

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

retinoic acid induced 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RAI2 mRNA

NCBI chr X:32,948,656...33,011,222
Ensembl chr X:32,948,656...33,011,264

G

RNA guanine-7 methyltransferase activating subunit

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RAMAC mRNA

NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151

G

RAS p21 protein activator 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of RASA1 mRNA

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

ras related dexamethasone induced 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RASD1 mRNA

NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186

G

RAS-like family 11 member B

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RASL11B mRNA

NCBI chr14:34,014,924...34,019,146
Ensembl chr14:34,014,509...34,019,152

G

ribosomal biogenesis factor

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RBIS mRNA

NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:86,991,315...87,041,339

G

RNA binding motif protein 18

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RBM18 mRNA

NCBI chr 3:19,467,333...19,487,171
Ensembl chr 3:19,467,335...19,487,178

G

RNA binding motif protein 48

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RBM48 mRNA

NCBI chr 4:30,559,063...30,569,409
Ensembl chr 4:30,559,087...30,569,406

G

RAB15 effector protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of REP15 mRNA

NCBI chr 4:179,951,935...179,953,008
Ensembl chr 4:179,951,935...179,953,008

G

raftlin lipid raft linker 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of RFTN1 mRNA

NCBI chr 9:10,804,611...11,002,084
Ensembl chr 9:10,804,611...11,002,084

G

raftlin family member 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RFTN2 mRNA

NCBI chr 9:56,651,617...56,707,830
Ensembl chr 9:56,630,460...56,707,810

G

regulator of cell cycle

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RGCC mRNA

NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141

G

regulator of G-protein signaling 11

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of RGS11 mRNA

NCBI chr10:15,222,804...15,231,062
Ensembl chr10:15,222,803...15,231,060

G

regulator of G-protein signaling 16

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

regulator of G-protein signaling 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RGS2 mRNA

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

rhomboid 5 homolog 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of RHBDF1 mRNA

NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763

G

rhomboid 5 homolog 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of RHBDF2 mRNA

NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283

G

ras homolog family member B

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RHOB mRNA

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

ring finger protein 207

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of RNF207 mRNA

NCBI chr 5:162,815,351...162,828,325
Ensembl chr 5:162,815,357...162,828,375

G

ribosomal protein L23

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RPL23 mRNA

NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870

G

ribosomal protein L29

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RPL29 mRNA

NCBI chr 8:107,068,929...107,070,963
Ensembl chr 8:107,068,480...107,070,914
Ensembl chr12:107,068,480...107,070,914

G

ribosomal protein L38

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RPL38 mRNA

NCBI chr10:99,701,330...99,705,004
Ensembl chr10:99,701,362...99,705,004
Ensembl chr14:99,701,362...99,705,004
Ensembl chr 3:99,701,362...99,705,004
Ensembl chr 2:99,701,362...99,705,004
Ensembl chr16:99,701,362...99,705,004

G

ribosomal protein lateral stalk subunit P1

increases expression

Disulfiram results in increased expression of RPLP1 protein

NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339

G

ribosomal protein S15

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RPS15 mRNA

NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450

G

ribosomal protein S7

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RPS7 mRNA

NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
Ensembl chr 5:45,223,980...45,271,145

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RRAD mRNA

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

Ras-related GTP binding D

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RRAGD mRNA

NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356

G

RAS related

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of RRAS mRNA

NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357

G

radical S-adenosyl methionine domain containing 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

RT1 class I, locus CE5

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of HLA-F mRNA

NCBI chr20:3,403,418...3,479,476

G

RUNX family transcription factor 2

increases expression

Disulfiram results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

RING1 and YY1 binding protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of RYBP mRNA

NCBI chr 4:132,876,260...132,928,328
Ensembl chr 4:132,876,361...132,928,316

G

Sin3A associated protein 18

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SAP18 mRNA

NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038
Ensembl chr10:31,943,230...31,950,038

G

secretion associated, Ras related GTPase 1B

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SAR1B mRNA

NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066

G

spermidine/spermine N1-acetyl transferase 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

Sbds, ribosome maturation factor

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SBDS mRNA

NCBI chr12:26,420,410...26,429,650
Ensembl chr12:26,420,414...26,429,649

G

scavenger receptor class F, member 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SCARF2 mRNA

NCBI chr11:83,175,956...83,187,415
Ensembl chr11:83,175,963...83,187,348

G

SEC61 translocon subunit beta

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SEC61B mRNA

NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804

G

SEL1L family member 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SEL1L3 mRNA

NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644

G

SEM1 26S proteasome subunit

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SEM1 mRNA

NCBI chr 4:34,671,848...34,692,005
Ensembl chr 4:34,671,848...34,692,005

G

SERTA domain containing 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SERTAD1 mRNA

NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091

G

splicing factor 3B subunit 4

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SF3B4 mRNA

NCBI chr 2:183,732,791...183,737,545
Ensembl chr 2:183,732,754...183,737,959

G

small glutamine rich tetratricopeptide repeat co-chaperone alpha

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SGTA mRNA

NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458

G

SH3 and PX domains 2A

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SH3PXD2A mRNA

NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166

G

salt-inducible kinase 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

sirtuin 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 6

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SIRT6 mRNA

NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914

G

Ski proto-oncogene

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SKI mRNA

NCBI chr 5:165,713,525...165,782,134
Ensembl chr 5:165,714,093...165,782,733

G

SKI-like proto-oncogene

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SKIL mRNA

NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080

G

solute carrier family 16 member 10

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SLC16A10 mRNA

NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839

G

solute carrier family 25 member 37

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SLC25A37 mRNA

NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199

G

solute carrier family 30 member 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SLC30A1 mRNA

NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 44 member 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SLC44A1 mRNA

NCBI chr 5:68,061,941...68,241,912
Ensembl chr 5:68,063,618...68,241,909

G

solute carrier family 44 member 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SLC44A2 mRNA

NCBI chr 8:19,870,867...19,905,345
Ensembl chr 8:19,870,888...19,905,342

G

solute carrier family 6 member 9

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SLC6A9 mRNA

NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728

G

solute carrier family 7 member 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SLC7A1 mRNA

NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849

G

solute carrier family 7, member 6 opposite strand

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SLC7A6OS mRNA

NCBI chr19:34,101,978...34,110,666
Ensembl chr19:34,101,982...34,110,651

G

schlafen family member 9

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SLFN11 mRNA

NCBI chr10:67,909,105...67,955,912
Ensembl chr10:67,909,106...67,925,383

G

SLU7 homolog, splicing factor

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SLU7 mRNA

NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349

G

SMAD family member 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

spermine oxidase

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SMOX mRNA

NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710
Ensembl chr X:118,731,900...118,765,710

G

snail family transcriptional repressor 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SNAI1 mRNA

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

Smad nuclear interacting protein 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SNIP1 mRNA

NCBI chr 5:137,328,371...137,335,846
Ensembl chr 5:137,328,371...137,335,845

G

small nuclear ribonucleoprotein polypeptide B2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SNRPB2 mRNA

NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812

G

superoxide dismutase 1

increases expression
decreases activity

Disulfiram results in increased expression of SOD1 mRNA
Disulfiram results in decreased activity of SOD1 protein

PMID:19016906 PMID:20566472

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression
multiple interactions

Disulfiram results in increased expression of SOD2 mRNA
[Disulfiram co-treated with Zinc Sulfate] results in increased expression of SOD2 mRNA

PMID:20566472 PMID:32712770 PMID:34182011

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

increases expression

Disulfiram results in increased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

SRY-box transcription factor 8

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SOX8 mRNA

NCBI chr10:14,584,829...14,589,818
Ensembl chr10:14,584,829...14,589,818

G

sperm acrosome developmental regulator

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SPACDR mRNA

NCBI chr12:18,930,608...18,936,787
Ensembl chr12:18,914,398...18,952,008

G

spermatogenesis associated 20

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SPATA20 mRNA

NCBI chr10:79,427,525...79,435,472
Ensembl chr10:79,427,528...79,434,368

G

spire-type actin nucleation factor 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SPIRE1 mRNA

NCBI chr18:61,041,914...61,171,670
Ensembl chr18:61,041,290...61,171,899

G

splA/ryanodine receptor domain and SOCS box containing 1

increases expression

Disulfiram results in increased expression of SPSB1 mRNA

NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468

G

spectrin, beta, non-erythrocytic 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SPTBN1 mRNA

NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507

G

SPT2 chromatin protein domain containing 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SPTY2D1 mRNA

NCBI chr 1:97,531,495...97,549,616
Ensembl chr 1:97,531,508...97,549,581

G

sequestosome 1

decreases expression

Disulfiram results in decreased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sulfiredoxin 1

increases expression

Disulfiram results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

stanniocalcin 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

STING1 ER exit protein 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of STEEP1 mRNA

NCBI chr X:116,087,626...116,114,159
Ensembl chr X:116,060,929...116,114,159

G

syntaxin 3

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of STX3 mRNA

NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805

G

sulfatase 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SULF1 mRNA; [Disulfiram binds to Copper] which results in increased expression of SULF1 protein

NCBI chr 5:6,362,894...6,526,174
Ensembl chr 5:6,362,911...6,525,584

G

small ubiquitin-like modifier 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SUMO2 mRNA

NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513
Ensembl chr 5:100,686,797...100,784,513

G

Sad1 and UNC84 domain containing 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SUN1 mRNA

NCBI chr12:15,396,378...15,441,277
Ensembl chr12:15,396,381...15,441,571

G

Sad1 and UNC84 domain containing 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of SUN2 mRNA

NCBI chr 7:111,275,374...111,292,565
Ensembl chr 7:111,275,380...111,292,553

G

SPT4 homolog, DSIF elongation factor subunit

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SUPT4H1 mRNA

NCBI chr10:72,539,323...72,545,582
Ensembl chr10:72,539,382...72,545,831

G

synaptojanin 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SYNJ1 mRNA

NCBI chr11:30,192,629...30,269,447
Ensembl chr11:30,192,629...30,269,220

G

SUZ RNA binding domain containing 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of SZRD1 mRNA

NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252

G

TATA-box binding protein associated factor 13

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TAF13 mRNA

NCBI chr 2:196,205,219...196,215,882
Ensembl chr 2:196,205,243...196,215,878

G

TATA-box binding protein associated factor 7

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TAF7 mRNA

NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134

G

trafficking regulator and scaffold protein tamalin

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TAMALIN mRNA

NCBI chr 7:132,338,900...132,359,519
Ensembl chr 7:132,338,900...132,346,666

G

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TANC1 mRNA

NCBI chr 3:44,099,387...44,335,478
Ensembl chr 3:44,134,016...44,331,627

G

transporter 2, ATP binding cassette subfamily B member

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TAP2 mRNA

NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407

G

TAP binding protein

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TAPBP mRNA

NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181

G

tyrosine aminotransferase

multiple interactions

[Ethanol co-treated with Disulfiram] results in increased activity of TAT protein

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

transcription elongation factor A2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TCEA2 mRNA

NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116

G

t-complex 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TCP1 mRNA

NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839

G

terminal nucleotidyltransferase 5B

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TENT5B mRNA

NCBI chr 5:145,695,358...145,702,668
Ensembl chr 5:145,695,362...145,706,073
Ensembl chr11:145,695,362...145,706,073

G

terminal nucleotidyltransferase 5C

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TENT5C mRNA

NCBI chr 2:187,853,026...187,875,260
Ensembl chr 2:187,853,024...187,894,744

G

tuftelin interacting protein 11

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TFIP11 mRNA

NCBI chr12:44,299,619...44,311,851
Ensembl chr12:44,299,622...44,311,855

G

transforming growth factor, beta 1

decreases activity

Disulfiram results in decreased activity of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

THAP domain containing 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of THAP1 mRNA

NCBI chr16:65,905,348...65,909,942
Ensembl chr16:65,904,230...65,909,942

G

thioesterase superfamily member 6

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of THEM6 mRNA

NCBI chr 7:106,606,570...106,609,747
Ensembl chr 7:106,606,570...106,609,746

G

thyroid hormone receptor alpha

multiple interactions

Disulfiram binds to and results in increased activity of THRA protein

NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936

G

TIR domain containing adaptor molecule 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TICAM2 mRNA

NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462

G

transmembrane protein 167A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TMEM167A mRNA

NCBI chr 2:21,197,799...21,216,746
Ensembl chr 2:21,197,786...21,212,099

G

transmembrane protein 175

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TMEM175 mRNA

NCBI chr14:1,073,410...1,089,764
Ensembl chr14:1,073,523...1,089,819

G

transmembrane protein 208

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TMEM208 mRNA

NCBI chr19:33,203,587...33,206,287
Ensembl chr19:33,203,587...33,212,183

G

transmembrane protein 35B

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TMEM35B mRNA

NCBI chr 5:139,446,317...139,449,947
Ensembl chr 5:139,444,399...139,449,947

G

transmembrane protein 42

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TMEM42 mRNA

NCBI chr 8:122,674,793...122,677,290
Ensembl chr 8:122,674,070...122,677,276

G

transmembrane protein 43

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TMEM43 mRNA

NCBI chr 4:123,977,680...123,992,823
Ensembl chr 4:123,977,625...123,992,825

G

transmembrane protein 44

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TMEM44 mRNA

NCBI chr11:70,181,120...70,216,958
Ensembl chr11:70,181,345...70,216,958

G

tumor necrosis factor

decreases expression
increases secretion
multiple interactions

Disulfiram results in decreased expression of TNF mRNA
Disulfiram results in increased secretion of TNF protein
[Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; Disulfiram promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein]

PMID:10418820 PMID:19016906 PMID:32712770 PMID:33851234

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

increases expression

Disulfiram results in increased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNFAIP3 interacting protein 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TNIP1 protein

NCBI chr10:39,037,048...39,084,328
Ensembl chr10:39,037,058...39,077,625

G

TNFAIP3 interacting protein 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TNIP2 protein

NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265

G

tensin 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TNS3 mRNA

NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998

G

Tp53rk binding protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TPRKB mRNA

NCBI chr 4:118,342,910...118,357,908
Ensembl chr 4:118,342,945...118,357,901

G

tryptase alpha/beta 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TPSAB1 mRNA

NCBI chr10:14,360,396...14,362,811
Ensembl chr10:14,360,396...14,362,811

G

transformer 2 beta

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TRA2B mRNA

NCBI chr11:78,788,880...78,807,252
Ensembl chr11:78,788,884...78,807,249

G

TraB domain containing

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TRABD mRNA

NCBI chr 7:120,155,042...120,166,015
Ensembl chr 7:120,155,042...120,166,015

G

thyrotropin releasing hormone

multiple interactions
increases expression
decreases expression

Dexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein]
Disulfiram results in increased expression of TRH mRNA alternative form

NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637

G

thyroid stimulating hormone subunit beta

multiple interactions
decreases secretion

Dexamethasone promotes the reaction [Disulfiram results in decreased secretion of TSHB protein]

NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559

G

TSPY-like 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TSPYL2 mRNA

NCBI chr X:21,439,478...21,445,208
Ensembl chr X:21,439,478...21,445,089

G

tetratricopeptide repeat domain 13

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of TTC13 mRNA

NCBI chr19:52,637,599...52,692,196
Ensembl chr19:52,637,431...52,692,198

G

transcription termination factor 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TTF1 mRNA

NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257

G

tubulin, alpha 4A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TUBA4A mRNA

NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918

G

tubulin, beta 2A class IIa

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TUBB2A mRNA

NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714

G

tubulin, beta 2B class IIb

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TUBB2B mRNA

NCBI chr17:30,747,734...30,750,781
Ensembl chr17:30,747,734...30,750,638

G

tubulin, beta 3 class III

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TUBB3 mRNA

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

G

thioredoxin 2

increases expression

Disulfiram results in increased expression of TXN2 mRNA

NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359

G

thioredoxin-like 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of TXNL1 mRNA

NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266

G

thioredoxin reductase 1

increases expression

Disulfiram results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

increases expression

Disulfiram results in increased expression of TXNRD2 mRNA

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

G

ubiquitin family domain containing 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of UBFD1 mRNA

NCBI chr 1:176,626,003...176,640,993
Ensembl chr 1:176,625,657...176,640,993

G

UDP glucuronosyltransferase family 1 member A6

increases expression

Disulfiram results in increased expression of UGT1A6 mRNA

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

unc-51 like autophagy activating kinase 1

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ULK1 mRNA

NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966

G

ubiquinol-cytochrome c reductase complex assembly factor 4

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of UQCC4 mRNA

NCBI chr10:14,202,217...14,203,519
Ensembl chr10:14,202,243...14,204,029

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of UQCRB mRNA

NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150

G

ubiquinol-cytochrome c reductase hinge protein

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of UQCRH mRNA

NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242

G

ubiquitin specific peptidase like 1

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of USPL1 mRNA

NCBI chr12:5,823,460...5,850,470
Ensembl chr12:5,823,359...5,850,366

G

UTP11, small subunit processome component

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of UTP11 mRNA

NCBI chr 5:136,931,279...136,946,164
Ensembl chr 5:136,931,008...136,946,191

G

UTP3, small subunit processome component

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of UTP3 mRNA

NCBI chr14:19,515,716...19,517,370
Ensembl chr14:19,515,669...19,517,396

G

versican

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of VCAN mRNA

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637

G

vinculin

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of VCL mRNA

NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606

G

voltage-dependent anion channel 1

multiple interactions

VDAC1 protein results in increased susceptibility to [arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram]

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

vascular endothelial growth factor C

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of VEGFC mRNA

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

G

VGF nerve growth factor inducible

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of VGF mRNA

NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341

G

vimentin

multiple interactions

[Disulfiram binds to Copper] which results in increased cleavage of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

VPS37B subunit of ESCRT-I

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of VPS37B mRNA

NCBI chr12:32,560,047...32,589,015
Ensembl chr12:32,560,047...32,589,014

G

WD repeat domain 20

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of WDR20 mRNA

NCBI chr 6:129,751,952...129,821,464
Ensembl chr 6:129,752,014...129,847,339

G

xylosyltransferase 2

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of XYLT2 mRNA

NCBI chr10:79,605,910...79,619,482
Ensembl chr10:79,606,007...79,619,391

G

YJU2 splicing factor

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of YJU2 mRNA

NCBI chr 9:789,603...799,505
Ensembl chr 9:789,606...799,496

G

zinc finger and BTB domain containing 43

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZBTB43 mRNA

NCBI chr 3:16,744,535...16,763,854
Ensembl chr 3:16,744,535...16,763,909

G

zinc finger AN1-type containing 2A

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZFAND2A mRNA

NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677

G

zinc finger protein 105

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZNF35 mRNA

NCBI chr 8:122,567,229...122,578,696
Ensembl chr 8:122,567,214...122,578,692

G

zinc finger protein 143

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZNF143 mRNA

NCBI chr 1:164,109,041...164,144,902
Ensembl chr 1:164,109,116...164,144,902

G

zinc finger protein 217

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ZNF217 mRNA

NCBI chr 3:158,890,464...158,931,148
Ensembl chr 3:158,892,265...158,913,040

G

zinc finger protein 26

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZNF778 mRNA

NCBI chr 8:18,959,656...18,985,647
Ensembl chr 8:18,965,271...18,988,325

G

zinc finger protein 34

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZNF34 mRNA

NCBI chr 5:157,509,762...157,513,970
Ensembl chr 5:157,509,451...157,599,926

G

zinc finger protein 36

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 622

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZNF622 mRNA

NCBI chr 2:76,479,605...76,494,405
Ensembl chr 2:76,335,609...76,493,898

G

zinc finger protein 77

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZNF77 mRNA

NCBI chr 7:7,269,879...7,316,286
Ensembl chr 7:7,269,927...7,286,051

G

zinc fingers and homeoboxes 3

multiple interactions

[Disulfiram binds to Copper] which results in increased expression of ZHX3 mRNA

NCBI chr 3:149,417,787...149,548,671
Ensembl chr 3:149,417,818...149,527,079

G

zinc finger with KRAB and SCAN domains 5

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZKSCAN5 mRNA

NCBI chr12:9,384,561...9,405,763
Ensembl chr12:9,384,571...9,405,881

G

zinc finger, matrin type 2

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZMAT2 mRNA

NCBI chr18:28,409,606...28,414,241
Ensembl chr18:28,398,795...28,414,747

G

zinc finger, matrin type 5

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZMAT5 mRNA

NCBI chr14:79,568,644...79,599,595
Ensembl chr14:79,568,758...79,599,594

G

zinc finger protein 408

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZNF408 mRNA

NCBI chr 3:77,615,595...77,621,325
Ensembl chr 3:77,616,808...77,621,055

G

zinc finger and SCAN domain containing 26

multiple interactions

[Disulfiram binds to Copper] which results in decreased expression of ZSCAN26 mRNA

NCBI chr17:43,148,063...43,168,070
Ensembl chr17:43,148,079...43,168,070

L-cystine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

kynurenine aminotransferase 1

increases amination

KYAT1 protein results in increased amination of Cystine

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

mitogen activated protein kinase 1

multiple interactions

Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

solute carrier family 3 member 1

increases uptake
multiple interactions

SLC3A1 protein results in increased uptake of Cystine
[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine

PMID:14978168 PMID:18845132

NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907

G

solute carrier family 3 member 2

multiple interactions

[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine

PMID:19576933 PMID:22216172

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 7 member 11

multiple interactions

[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine

PMID:19576933 PMID:22216172

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 7 member 9

multiple interactions

[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine

NCBI chr 1:88,109,517...88,132,653
Ensembl chr 1:88,110,644...88,132,641

melamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

melamine results in increased expression of A2M

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

albumin

multiple interactions

[melamine co-treated with cyanuric acid] results in increased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

BCL2-associated agonist of cell death

multiple interactions
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of BAD protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of BAD protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions
decreases expression
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of BAX protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of BAX protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAX protein]
melamine results in decreased expression of BAX protein

PMID:22915474 PMID:29254411

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
increases expression

melamine results in decreased expression of BCL2 protein
melamine results in increased expression of BCL2 protein

PMID:22915474 PMID:29254411

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

melamine results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

caspase 3

multiple interactions
decreases expression
increases cleavage

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased cleavage of CASP3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased cleavage of CASP3 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP3 protein]
melamine results in decreased expression of CASP3 protein

PMID:22915474 PMID:29254411

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions
increases cleavage

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased cleavage of CASP9 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased cleavage of CASP9 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of CCL2 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

CD44 molecule

increases expression

melamine results in increased expression of CD44; melamine results in increased expression of CD44 protein

PMID:23052191 PMID:33211169

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

clusterin

multiple interactions
increases expression

[cyanuric acid co-treated with melamine] results in increased expression of CLU mRNA; [melamine co-treated with cyanuric acid] results in increased expression of CLU mRNA; [melamine co-treated with cyanuric acid] results in increased expression of CLU protein
melamine results in increased expression of CLU

PMID:21784140 PMID:22610612 PMID:23022069 PMID:23052191

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases activity

melamine results in increased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

fibronectin 1

multiple interactions
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of FN1 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of FN1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of FN1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of FN1 protein]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 mRNA]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 protein]
melamine results in increased expression of FN1 mRNA; melamine results in increased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

glycoprotein nmb

increases expression

melamine results in increased expression of GPNMB

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression

melamine results in decreased expression of GRIN1 protein

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

melamine results in decreased expression of GRIN2B protein

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

hepatitis A virus cellular receptor 1

increases expression
multiple interactions

melamine results in increased expression of HAVCR1
[cyanuric acid co-treated with melamine] results in increased expression of HAVCR1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of HAVCR1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of HAVCR1 protein

PMID:21784140 PMID:22610612 PMID:23022069 PMID:23052191

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

interleukin 6

multiple interactions
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of IL6 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [melamine results in increased expression of IL6 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of IL6 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of IL6 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

keratin 14

increases expression

melamine results in increased expression of KRT14 protein

NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799

G

lipocalin 2

multiple interactions
increases expression

[cyanuric acid co-treated with melamine] results in increased expression of LCN2 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of LCN2 mRNA
melamine results in increased expression of LCN2

PMID:21784140 PMID:23022069 PMID:23052191

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

lactate dehydrogenase A

decreases activity

melamine results in decreased activity of LDHA protein

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

mitogen activated protein kinase 1

increases phosphorylation

melamine results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

increases expression

melamine results in increased expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

increases phosphorylation
increases expression

melamine results in increased phosphorylation of MAPK3 protein
melamine results in increased expression of MAPK3 mRNA

PMID:22915474 PMID:34842327

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 9

increases expression

melamine results in increased expression of MAPK9 mRNA

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

NFKB inhibitor alpha

increases phosphorylation

melamine results in increased phosphorylation of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation

melamine results in increased phosphorylation of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

superoxide dismutase 1

decreases activity

melamine results in decreased activity of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

sorbitol dehydrogenase

decreases activity

melamine results in decreased activity of SORD protein

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

secreted phosphoprotein 1

multiple interactions

[cyanuric acid co-treated with melamine] results in increased expression of SPP1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of SPP1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of SPP1 protein

PMID:21784140 PMID:22610612 PMID:23022069

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

trefoil factor 3

decreases expression

melamine results in decreased expression of TFF3

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

transforming growth factor, beta 1

multiple interactions
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of TGFB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of TGFB1 protein]; SN50 peptide inhibits the reaction [melamine results in increased expression of TGFB1 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of TGFB1 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP3 protein]; TGFB1 protein affects the reaction [melamine results in increased cleavage of CASP9 protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAD protein]; TGFB1 protein affects the reaction [melamine results in increased expression of BAX protein]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 mRNA]; TGFB1 protein affects the reaction [melamine results in increased expression of FN1 protein]
melamine results in increased expression of TGFB1 mRNA; melamine results in increased expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

multiple interactions

[cyanuric acid co-treated with melamine] results in increased expression of TIMP1 mRNA; [melamine co-treated with cyanuric acid] results in increased expression of TIMP1 mRNA

PMID:21784140 PMID:23022069

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TNF receptor superfamily member 12A

increases expression

melamine results in increased expression of TNFRSF12A

NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045

G

vascular cell adhesion molecule 1

multiple interactions
increases expression

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; SB 203580 inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]; SN50 peptide inhibits the reaction [melamine results in increased expression of VCAM1 mRNA]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

phenethyl isothiocyanate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 6430548M08 gene like

increases expression

phenethyl isothiocyanate results in increased expression of KIAA0513 mRNA

NCBI chr19:48,168,651...48,216,571
Ensembl chr19:48,198,209...48,216,575

G

ATP binding cassette subfamily C member 2

affects export
multiple interactions

ABCC2 protein affects the export of phenethyl isothiocyanate
Glutathione promotes the reaction [ABCC2 protein affects the export of phenethyl isothiocyanate]

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

acetyl-CoA acetyltransferase 2

decreases expression

phenethyl isothiocyanate results in decreased expression of ACAT2 mRNA

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

actin alpha 2, smooth muscle

affects binding
increases expression

ACTA2 protein binds to phenethyl isothiocyanate
phenethyl isothiocyanate results in increased expression of ACTA2 mRNA

PMID:21838287 PMID:26678675

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, beta

affects binding

ACTB protein binds to phenethyl isothiocyanate

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

ADAM metallopeptidase domain 7

affects binding

ADAM7 protein binds to phenethyl isothiocyanate

NCBI chr15:42,833,796...42,882,201
Ensembl chr15:42,833,796...42,882,201

G

aldo-keto reductase family 7 member A3

increases expression
increases activity

phenethyl isothiocyanate results in increased expression of AKR7A3 mRNA
phenethyl isothiocyanate results in increased activity of AKR7A3 protein

PMID:9328168 PMID:17616710

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

aldehyde dehydrogenase 1 family, member A1

increases expression

phenethyl isothiocyanate results in increased expression of ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

anaphase promoting complex subunit 15

decreases expression

phenethyl isothiocyanate results in decreased expression of ANAPC15 mRNA

NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145

G

anaphase promoting complex subunit 4

decreases expression

phenethyl isothiocyanate results in decreased expression of ANAPC4 mRNA

NCBI chr14:58,125,995...58,159,253
Ensembl chr14:58,125,995...58,157,770

G

annexin A2, pseudogene1

decreases expression

phenethyl isothiocyanate results in decreased expression of ANXA2-PS1 mRNA

NCBI chr15:39,787,844...39,789,055

G

apoptotic peptidase activating factor 1

increases expression

phenethyl isothiocyanate results in increased expression of APAF1 protein

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

Rho GTPase activating protein 11A

decreases expression

phenethyl isothiocyanate results in decreased expression of ARHGAP11A mRNA

NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559

G

Rho GDP dissociation inhibitor beta

decreases expression

phenethyl isothiocyanate results in decreased expression of ARHGDIB mRNA

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

G

assembly factor for spindle microtubules

decreases expression

phenethyl isothiocyanate results in decreased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

ATPase family, AAA domain containing 5

decreases expression

phenethyl isothiocyanate results in decreased expression of ATAD5 mRNA

NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845

G

ATPase phospholipid transporting 10D (putative)

increases expression

phenethyl isothiocyanate results in increased expression of ATP10D mRNA

NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564

G

ATP synthase F1 subunit beta

affects binding

ATP5F1B protein binds to phenethyl isothiocyanate

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase membrane subunit e

affects binding

ATP5ME protein binds to phenethyl isothiocyanate

NCBI chr14:1,319,868...1,320,996
Ensembl chr14:1,319,868...1,321,013

G

ATP synthase membrane subunit G

affects binding

ATP5MG protein binds to phenethyl isothiocyanate

NCBI chr 8:45,225,680...45,233,630
Ensembl chr 8:45,225,686...45,233,559

G

ATRX, chromatin remodeler

decreases expression

phenethyl isothiocyanate results in decreased expression of ATRX mRNA

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

aurora kinase A

decreases expression

phenethyl isothiocyanate results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

increases expression

phenethyl isothiocyanate results in increased expression of AURKB protein

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [phenethyl isothiocyanate results in increased expression of BAX protein]; Vitamin E inhibits the reaction [phenethyl isothiocyanate results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bromodomain adjacent to zinc finger domain, 1B

decreases expression

phenethyl isothiocyanate results in decreased expression of BAZ1B mRNA

NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426

G

BCL2, apoptosis regulator

decreases expression

phenethyl isothiocyanate results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

phenethyl isothiocyanate results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

3-hydroxybutyrate dehydrogenase 1

decreases expression

phenethyl isothiocyanate results in decreased expression of BDH1 mRNA

NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671

G

BICD family like cargo adaptor 1

increases expression

phenethyl isothiocyanate results in increased expression of BICDL1 mRNA

NCBI chr12:40,878,190...41,001,152
Ensembl chr12:40,876,884...40,966,130

G

BH3 interacting domain death agonist

multiple interactions

phenethyl isothiocyanate results in increased expression of and results in increased cleavage of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

BLM RecQ like helicase

decreases expression

phenethyl isothiocyanate results in decreased expression of BLM mRNA

NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312

G

biliverdin reductase B

increases expression

phenethyl isothiocyanate results in increased expression of BLVRB mRNA

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

biorientation of chromosomes in cell division 1-like 1

decreases expression

phenethyl isothiocyanate results in decreased expression of BOD1L1 mRNA

NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490

G

BRCA2, DNA repair associated

decreases expression

phenethyl isothiocyanate results in decreased expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

BRCA1 interacting DNA helicase 1

decreases expression

phenethyl isothiocyanate results in decreased expression of BRIP1 mRNA

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

BTG anti-proliferation factor 2

increases expression

phenethyl isothiocyanate results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BUB1 mitotic checkpoint serine/threonine kinase B

decreases expression

phenethyl isothiocyanate results in decreased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

similar to human chromosome 4 open reading frame 46

decreases expression

phenethyl isothiocyanate results in decreased expression of C4ORF46 mRNA

NCBI chr 2:164,762,994...164,766,126
Ensembl chr 2:164,762,960...164,766,128

G

similar to human chromosome 1 open reading frame 210

increases expression

phenethyl isothiocyanate results in increased expression of C5H1ORF210 mRNA

NCBI chr 5:132,048,755...132,051,913
Ensembl chr 5:132,048,773...132,051,925

G

calcium binding protein 39-like

increases expression

phenethyl isothiocyanate results in increased expression of CAB39L mRNA

NCBI chr15:33,606,588...33,710,518
Ensembl chr15:33,606,694...33,743,545

G

calcium binding and coiled coil domain 1

increases expression

phenethyl isothiocyanate results in increased expression of CALCOCO1 mRNA

NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422

G

calpain 2

decreases expression

phenethyl isothiocyanate results in decreased expression of CAPN2 mRNA

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

caspase 3

multiple interactions
increases activity

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [phenethyl isothiocyanate results in increased activity of CASP3 protein]; Vitamin E inhibits the reaction [phenethyl isothiocyanate results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

phenethyl isothiocyanate results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

phenethyl isothiocyanate results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases activity

phenethyl isothiocyanate results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

decreases expression

phenethyl isothiocyanate results in decreased expression of CAV1 mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

chromobox 5

decreases expression

phenethyl isothiocyanate results in decreased expression of CBX5 mRNA

NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022

G

C-C motif chemokine ligand 2

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]

PMID:20423518 PMID:23724058

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin A2

decreases expression

phenethyl isothiocyanate results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

decreases expression

phenethyl isothiocyanate results in decreased expression of CCNB1 mRNA; phenethyl isothiocyanate results in decreased expression of CCNB1 protein

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

increases expression

phenethyl isothiocyanate results in increased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

decreases expression

phenethyl isothiocyanate results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin F

decreases expression

phenethyl isothiocyanate results in decreased expression of CCNF mRNA

NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101

G

cell cycle progression 1

increases expression

phenethyl isothiocyanate results in increased expression of CCPG1 mRNA

NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430

G

chaperonin containing TCP1 subunit 4

decreases expression

phenethyl isothiocyanate results in decreased expression of CCT4 mRNA

NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267

G

CD40 molecule

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]

PMID:20423518 PMID:23724058

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD44 molecule

increases expression

phenethyl isothiocyanate results in increased expression of CD44 protein

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

Cd82 molecule

increases expression

phenethyl isothiocyanate results in increased expression of CD82 mRNA

NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809

G

cell division cycle 20

decreases expression

phenethyl isothiocyanate results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25C

decreases expression

phenethyl isothiocyanate results in decreased expression of CDC25C protein

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 45

decreases expression

phenethyl isothiocyanate results in decreased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle 6

decreases expression

phenethyl isothiocyanate results in decreased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle associated 3

decreases expression

phenethyl isothiocyanate results in decreased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cell division cycle associated 7

decreases expression

phenethyl isothiocyanate results in decreased expression of CDCA7 mRNA

NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353

G

cyclin-dependent kinase 1

increases expression

phenethyl isothiocyanate results in increased expression of CDK1 protein

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases expression

phenethyl isothiocyanate results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression

phenethyl isothiocyanate results in increased expression of CDKN1A mRNA; phenethyl isothiocyanate results in increased expression of CDKN1A protein

PMID:17937621 PMID:26678675

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 3

decreases expression

phenethyl isothiocyanate results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

chromatin licensing and DNA replication factor 1

decreases expression

phenethyl isothiocyanate results in decreased expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

G

centromere protein C

decreases expression

phenethyl isothiocyanate results in decreased expression of CENPC1 mRNA

NCBI chr14:21,988,067...22,046,732
Ensembl chr14:21,988,144...22,055,476

G

centromere protein F

decreases expression

phenethyl isothiocyanate results in decreased expression of CENPF mRNA

PMID:17616710 PMID:26678675

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

centromere protein I

decreases expression

phenethyl isothiocyanate results in decreased expression of CENPI mRNA

NCBI chr X:97,515,919...97,567,671
Ensembl chr X:97,515,972...97,567,657

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

phenethyl isothiocyanate results in increased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

chromatin assembly factor 1 subunit B

decreases expression

phenethyl isothiocyanate results in decreased expression of CHAF1B mRNA

NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070

G

claudin 1

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Irinotecan results in decreased expression of CLDN1 protein]

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

C-type lectin domain containing 14A

increases expression

phenethyl isothiocyanate results in increased expression of CLEC14A mRNA

NCBI chr 6:75,881,470...75,884,612
Ensembl chr 6:75,881,473...75,884,612

G

claspin

decreases expression

phenethyl isothiocyanate results in decreased expression of CLSPN mRNA

NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034

G

clusterin

increases expression

phenethyl isothiocyanate results in increased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

collagen type IV alpha 2 chain

decreases expression

phenethyl isothiocyanate results in decreased expression of COL4A2 mRNA

NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839

G

coenzyme Q2, polyprenyltransferase

decreases expression

phenethyl isothiocyanate results in decreased expression of COQ2 mRNA

NCBI chr14:8,941,429...8,961,418
Ensembl chr14:8,941,461...8,960,891

G

carboxypeptidase A6

increases expression

phenethyl isothiocyanate results in increased expression of CPA6 mRNA

NCBI chr 5:8,526,708...8,888,492
Ensembl chr 5:8,526,741...8,888,485

G

cysteine-rich secretory protein 1

increases expression

phenethyl isothiocyanate results in increased expression of CRISP1 mRNA

NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796

G

colony stimulating factor 2

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]

PMID:20423518 PMID:23724058

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 mRNA]

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

casein kinase 2 beta

increases expression

phenethyl isothiocyanate results in increased expression of CSNK2B mRNA

NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133

G

cathepsin O

increases expression

phenethyl isothiocyanate results in increased expression of CTSO mRNA

NCBI chr 2:167,230,407...167,254,761
Ensembl chr 2:167,230,330...167,253,702

G

C-X-C motif chemokine ligand 10

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]

PMID:20423518 PMID:23724058

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

cytochrome b5 type B

affects binding

CYB5B protein binds to phenethyl isothiocyanate

NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249

G

cytochrome c, somatic

multiple interactions
affects localization

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [phenethyl isothiocyanate affects the localization of CYCS protein]; Vitamin E inhibits the reaction [phenethyl isothiocyanate affects the localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity
multiple interactions

phenethyl isothiocyanate results in increased expression of CYP1A1 mRNA
phenethyl isothiocyanate results in decreased activity of CYP1A1 protein
phenethyl isothiocyanate results in increased activity of [CYP1A1 protein co-treated with CYP1A2 protein]
phenethyl isothiocyanate results in increased expression of CYP1A1 mRNA; phenethyl isothiocyanate results in increased expression of CYP1A1 protein

PMID:15672752 PMID:17582584 PMID:20025923 PMID:20442190 PMID:22664424

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
increases expression
multiple interactions
decreases expression

phenethyl isothiocyanate results in decreased activity of CYP1A2 mRNA
phenethyl isothiocyanate results in increased expression of CYP1A2 mRNA
phenethyl isothiocyanate results in increased activity of [CYP1A1 protein co-treated with CYP1A2 protein]
phenethyl isothiocyanate results in decreased expression of CYP1A2 protein

PMID:15672752 PMID:20025923 PMID:20442190 PMID:22664424

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity
decreases expression

phenethyl isothiocyanate inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde]; phenethyl isothiocyanate inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; phenethyl isothiocyanate inhibits the reaction [CYP2E1 protein results in increased metabolism of Carbon Tetrachloride]; phenethyl isothiocyanate inhibits the reaction [Ethanol results in increased expression of CYP2E1 mRNA]; phenethyl isothiocyanate inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]
phenethyl isothiocyanate results in decreased activity of CYP2E1 protein
phenethyl isothiocyanate results in decreased expression of CYP2E1 protein

PMID:7562599 PMID:7601153 PMID:10616189 PMID:17582584

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression
decreases activity
increases expression

phenethyl isothiocyanate results in decreased expression of CYP3A2 mRNA
phenethyl isothiocyanate results in decreased activity of CYP3A4 mRNA
phenethyl isothiocyanate results in decreased expression of CYP3A4 mRNA
phenethyl isothiocyanate results in increased expression of CYP3A4 protein
phenethyl isothiocyanate results in decreased activity of CYP3A2 protein

PMID:20025923 PMID:20442190 PMID:22664424

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases expression

phenethyl isothiocyanate results in decreased expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

DNA-damage inducible transcript 3

increases expression

phenethyl isothiocyanate results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

defensin beta 1

increases expression

phenethyl isothiocyanate results in increased expression of DEFB1 mRNA

NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604

G

7-dehydrocholesterol reductase

decreases expression

phenethyl isothiocyanate results in decreased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

diablo, IAP-binding mitochondrial protein

multiple interactions
affects binding
affects localization

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [phenethyl isothiocyanate affects the localization of DIABLO protein]; Vitamin E inhibits the reaction [phenethyl isothiocyanate affects the localization of DIABLO protein]
DIABLO protein binds to phenethyl isothiocyanate

PMID:16054126 PMID:21838287

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

iodothyronine deiodinase 2

decreases expression

phenethyl isothiocyanate results in decreased expression of DIO2 mRNA

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

dystonin

decreases expression

phenethyl isothiocyanate results in decreased expression of DST mRNA

NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615

G

DAZ interacting zinc finger protein 3

decreases expression

phenethyl isothiocyanate results in decreased expression of DZIP3 mRNA

NCBI chr11:51,823,235...51,893,353
Ensembl chr11:51,823,231...51,893,353

G

EBP, cholestenol delta-isomerase

decreases expression

phenethyl isothiocyanate results in decreased expression of EBP mRNA

NCBI chr X:14,299,427...14,305,826
Ensembl chr X:14,299,448...14,305,826

G

extracellular matrix protein 1

increases expression

phenethyl isothiocyanate results in increased expression of ECM1 mRNA

NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671

G

endothelin 1

decreases expression

phenethyl isothiocyanate results in decreased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 1 alpha 2

decreases expression

phenethyl isothiocyanate results in decreased expression of EEF1A2 mRNA

NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071

G

eukaryotic translation elongation factor 2

decreases expression

phenethyl isothiocyanate results in decreased expression of EEF2 mRNA

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

eukaryotic elongation factor-2 kinase

decreases expression

phenethyl isothiocyanate results in decreased expression of EEF2K mRNA

NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164

G

eukaryotic elongation factor 2 lysine methyltransferase

decreases expression

phenethyl isothiocyanate results in decreased expression of EEF2KMT mRNA

NCBI chr10:10,336,933...10,349,463
Ensembl chr10:10,336,974...10,347,039

G

early growth response 1

increases expression

phenethyl isothiocyanate results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

phenethyl isothiocyanate results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 3, subunit A

decreases expression

phenethyl isothiocyanate results in decreased expression of EIF3A mRNA

NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976

G

eukaryotic translation initiation factor 4 gamma 1

decreases expression

phenethyl isothiocyanate results in decreased expression of EIF4G1 mRNA

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

G

elastase, neutrophil expressed

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of ELANE mRNA]

NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100

G

ectodermal-neural cortex 1

increases expression

phenethyl isothiocyanate results in increased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

epoxide hydrolase 1

increases expression

phenethyl isothiocyanate results in increased expression of EPHX1 protein

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

epsin 3

increases expression

phenethyl isothiocyanate results in increased expression of EPN3 mRNA

NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356

G

ERCC excision repair 4, endonuclease catalytic subunit

increases expression

phenethyl isothiocyanate results in increased expression of ERCC4 mRNA

NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
Ensembl chr10:2,419,038...2,448,369

G

ERCC excision repair 5, endonuclease

increases expression

phenethyl isothiocyanate results in increased expression of ERCC5 mRNA

NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

decreases expression

phenethyl isothiocyanate results in decreased expression of ERCC6L mRNA

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

ESF1 nucleolar pre-rRNA processing protein homolog

decreases expression

phenethyl isothiocyanate results in decreased expression of ESF1 mRNA

NCBI chr 3:127,454,744...127,507,941
Ensembl chr 3:127,454,811...127,507,817

G

extra spindle pole bodies like 1, separase

decreases expression

phenethyl isothiocyanate results in decreased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

ETAA1 activator of ATR kinase

decreases expression

phenethyl isothiocyanate results in decreased expression of ETAA1 mRNA

NCBI chr14:92,298,461...92,314,044
Ensembl chr14:92,299,553...92,314,104

G

coagulation factor II (thrombin) receptor-like 2

increases expression

phenethyl isothiocyanate results in increased expression of F2RL2 mRNA

NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098

G

coagulation factor III, tissue factor

decreases expression

phenethyl isothiocyanate results in decreased expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid desaturase 2

decreases expression

phenethyl isothiocyanate results in decreased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

FA complementation group D2

decreases expression

phenethyl isothiocyanate results in decreased expression of FANCD2 mRNA

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

FA complementation group I

decreases expression

phenethyl isothiocyanate results in decreased expression of FANCI mRNA

NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640

G

F-box protein 32

increases expression

phenethyl isothiocyanate results in increased expression of FBXO32 mRNA

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

F-box protein 41

affects binding

FBXO41 protein binds to phenethyl isothiocyanate

NCBI chr 4:118,007,517...118,039,547
Ensembl chr 4:118,010,978...118,039,406

G

flap structure-specific endonuclease 1

decreases expression

phenethyl isothiocyanate results in decreased expression of FEN1 mRNA

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

FIGNL1 interacting regulator of recombination and mitosis

decreases expression

phenethyl isothiocyanate results in decreased expression of FIRRM mRNA

NCBI chr13:76,301,914...76,345,842
Ensembl chr13:76,301,918...76,345,804

G

filamin A

decreases expression

phenethyl isothiocyanate results in decreased expression of FLNA mRNA

NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box M1

decreases expression

phenethyl isothiocyanate results in decreased expression of FOXM1 mRNA

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

follistatin

decreases expression

phenethyl isothiocyanate results in decreased expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

ferritin light chain 1

increases expression

phenethyl isothiocyanate results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

FMR1 autosomal homolog 1

decreases expression

phenethyl isothiocyanate results in decreased expression of FXR1 mRNA

NCBI chr 2:116,884,167...116,937,590
Ensembl chr 2:116,884,248...116,937,590

G

GABA type A receptor associated protein like 1

increases expression

phenethyl isothiocyanate results in increased expression of GABARAPL1 mRNA

NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450

G

growth arrest and DNA-damage-inducible, alpha

increases expression

phenethyl isothiocyanate results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glutamate-cysteine ligase, catalytic subunit

increases expression

phenethyl isothiocyanate results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

gamma-glutamyl hydrolase

increases expression

phenethyl isothiocyanate results in increased expression of GGH mRNA

NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787

G

GINS complex subunit 2

decreases expression

phenethyl isothiocyanate results in decreased expression of GINS2 mRNA

NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339

G

gonadotropin inducible ovarian transcription factor 1

decreases expression

phenethyl isothiocyanate results in decreased expression of GIOT1 mRNA

NCBI chr 7:10,215,602...10,236,423
Ensembl chr 7:10,202,982...10,237,099

G

gap junction protein, alpha 1

multiple interactions
increases expression

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of GJA1 mRNA]
phenethyl isothiocyanate results in increased expression of GJA1 mRNA

PMID:17616710 PMID:20423518

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gastrokine 1

decreases expression

phenethyl isothiocyanate results in decreased expression of GKN1 mRNA

NCBI chr 4:119,790,101...119,795,389
Ensembl chr 4:119,790,101...119,795,389

G

GLE1 RNA export mediator, pseudogene 1

decreases expression

phenethyl isothiocyanate results in decreased expression of GLE1-PS1 mRNA

NCBI chr 6:107,124,892...107,127,024
Ensembl chr 6:107,124,892...107,127,024
Ensembl chr 6:107,124,892...107,127,024

G

G protein subunit gamma 5

increases expression

phenethyl isothiocyanate results in increased expression of GNG5 mRNA

NCBI chr 2:235,394,680...235,403,177
Ensembl chr 1:77,292,043...77,292,513
Ensembl chr11:77,292,043...77,292,513

G

glutamic--pyruvic transaminase

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

increases expression

phenethyl isothiocyanate results in increased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione-disulfide reductase

decreases activity
increases activity

phenethyl isothiocyanate results in decreased activity of GSR protein
phenethyl isothiocyanate results in increased activity of GSR protein

PMID:17937621 PMID:22664424

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 2

increases expression

phenethyl isothiocyanate results in increased expression of GSTA2 mRNA

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

increases expression

phenethyl isothiocyanate results in increased expression of GSTA3 mRNA

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 5

increases activity

phenethyl isothiocyanate results in increased activity of GSTA5 protein

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

affects metabolic processing

GSTM1 protein affects the metabolism of phenethyl isothiocyanate

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

affects metabolic processing
increases expression
multiple interactions

GSTP1 protein affects the metabolism of phenethyl isothiocyanate
phenethyl isothiocyanate results in increased expression of GSTP1 mRNA
[indole-3-carbinol co-treated with phenethyl isothiocyanate] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 protein

PMID:7826396 PMID:32070777

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

increases expression

phenethyl isothiocyanate results in increased expression of GSTT1 protein

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

G-2 and S-phase expressed 1

decreases expression

phenethyl isothiocyanate results in decreased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

H2A clustered histone 12

decreases expression

phenethyl isothiocyanate results in decreased expression of H2AC12 mRNA

NCBI chr17:42,486,415...42,486,880
Ensembl chr17:42,486,415...42,486,941

G

H2A clustered histone 4

decreases expression

phenethyl isothiocyanate results in decreased expression of H2AC4 mRNA

NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381

G

H2B clustered histone 9

decreases expression

phenethyl isothiocyanate results in decreased expression of H2BC9 mRNA

NCBI chr17:42,470,593...42,478,590

G

H3 clustered histone 1

decreases expression

phenethyl isothiocyanate results in decreased expression of H3C1 mRNA

NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856

G

H4 clustered histone 14

decreases expression

phenethyl isothiocyanate results in decreased expression of H4C2 mRNA

NCBI chr 2:183,831,601...183,831,996
Ensembl chr 2:183,825,994...183,832,048

G

hemoglobin alpha, adult chain 2

increases expression

phenethyl isothiocyanate results in increased expression of HBA-A2 mRNA

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392

G

histone deacetylase 1

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Freund's Adjuvant results in increased expression of HDAC1 protein]

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

high density lipoprotein binding protein

decreases expression

phenethyl isothiocyanate results in decreased expression of HDLBP mRNA

NCBI chr 9:93,948,099...94,018,040
Ensembl chr 9:93,949,913...94,018,048

G

helicase, lymphoid specific

decreases expression

phenethyl isothiocyanate results in decreased expression of HELLS mRNA

NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844

G

histone cluster 1 H2B family member Q

decreases expression

phenethyl isothiocyanate results in decreased expression of H2BC7 mRNA

NCBI chr17:41,432,100...41,441,487
Ensembl chr17:41,429,164...41,442,153
Ensembl chr17:41,429,164...41,442,153
Ensembl chr17:41,429,164...41,442,153

G

heme oxygenase 1

increases expression
multiple interactions
increases activity

phenethyl isothiocyanate results in increased expression of HMOX1 mRNA
phenethyl isothiocyanate results in increased expression of HMOX1 mRNA; phenethyl isothiocyanate results in increased expression of HMOX1 protein
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; 2,2'-Dipyridyl inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; 2,2'-Dipyridyl inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; acetovanillone inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; diphenyleneiodonium inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]
NFE2L2 gene mutant form affects the reaction [phenethyl isothiocyanate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; phenethyl isothiocyanate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; phenethyl isothiocyanate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]
phenethyl isothiocyanate results in increased activity of HMOX1 protein

PMID:20402460 PMID:22664424 PMID:25246272 PMID:25387343 PMID:26945724

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein F

affects binding

HNRNPF protein binds to phenethyl isothiocyanate

NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038

G

heterogeneous nuclear ribonucleoprotein K

affects binding

HNRNPK protein binds to phenethyl isothiocyanate

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

heterogeneous nuclear ribonucleoprotein R

decreases expression

phenethyl isothiocyanate results in decreased expression of HNRNPR mRNA

NCBI chr 5:148,542,999...148,574,888
Ensembl chr 5:148,543,044...148,574,867

G

heat shock protein 90 alpha family class A member 1

decreases expression

phenethyl isothiocyanate results in decreased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 4

affects binding

HSPA4 protein binds to phenethyl isothiocyanate

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family B (small) member 1

increases expression
affects binding

phenethyl isothiocyanate results in increased expression of HSPB1 mRNA
HSPB1 protein binds to phenethyl isothiocyanate

PMID:17616710 PMID:21838287

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family E (Hsp10) member 1

affects binding

HSPE1 protein binds to phenethyl isothiocyanate

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

heat shock protein family H (Hsp110) member 1

affects binding

HSPH1 protein binds to phenethyl isothiocyanate

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

interleukin 10

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
decreases expression

phenethyl isothiocyanate inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of IL1B mRNA]; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
phenethyl isothiocyanate results in decreased expression of IL1B mRNA

PMID:16373530 PMID:20423518 PMID:38341106

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
decreases expression

NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]]; phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
phenethyl isothiocyanate results in decreased expression of IL6 mRNA

PMID:20423518 PMID:25387343 PMID:26678675

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

IQ motif containing GTPase activating protein 3

decreases expression

phenethyl isothiocyanate results in decreased expression of IQGAP3 mRNA

NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956

G

jade family PHD finger 2

decreases expression

phenethyl isothiocyanate results in decreased expression of JADE2 mRNA

NCBI chr10:36,075,239...36,124,210
Ensembl chr10:36,078,917...36,116,984

G

jagged canonical Notch ligand 1

increases expression

phenethyl isothiocyanate results in increased expression of JAG1 mRNA

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

jagged canonical Notch ligand 2

increases expression

phenethyl isothiocyanate results in increased expression of JAG2 mRNA

NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818

G

Janus kinase 1

decreases expression

phenethyl isothiocyanate results in decreased expression of JAK1 mRNA

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

phenethyl isothiocyanate results in increased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

potassium inwardly-rectifying channel, subfamily J, member 12

increases expression

phenethyl isothiocyanate results in increased expression of KCNJ12 mRNA

NCBI chr10:45,696,621...45,745,528
Ensembl chr10:45,696,849...45,745,492

G

kinesin family member 18B

decreases expression

phenethyl isothiocyanate results in decreased expression of KIF18B mRNA

NCBI chr10:87,870,424...87,889,895
Ensembl chr10:87,870,428...87,889,850

G

kinesin family member 20A

decreases expression

phenethyl isothiocyanate results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 23

decreases expression

phenethyl isothiocyanate results in decreased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

keratin 10

increases expression

phenethyl isothiocyanate results in increased expression of KRT10 mRNA

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

G

keratin 14

increases expression

phenethyl isothiocyanate results in increased expression of KRT14 protein

NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799

G

keratin 16

decreases expression

phenethyl isothiocyanate results in decreased expression of KRT16 mRNA

NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799

G

keratin associated protein 14 like

increases expression

phenethyl isothiocyanate results in increased expression of KRTAP14L mRNA

NCBI chr11:28,085,729...28,086,516
Ensembl chr11:28,086,010...28,086,516

G

kinectin 1

decreases expression

phenethyl isothiocyanate results in decreased expression of KTN1 mRNA

NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578

G

leucyl-tRNA synthetase 1

decreases expression

phenethyl isothiocyanate results in decreased expression of LARS1 mRNA

NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931

G

DNA ligase 1

decreases expression

phenethyl isothiocyanate results in decreased expression of LIG1 mRNA

NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413

G

LIM domain and actin binding 1

decreases expression

phenethyl isothiocyanate results in decreased expression of LIMA1 mRNA

NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473

G

lamin B1

decreases expression

phenethyl isothiocyanate results in decreased expression of LMNB1 mRNA

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

small nucleolar RNA SNORD63

increases expression

phenethyl isothiocyanate results in increased expression of SNORD63 mRNA

NCBI chr18:26,541,469...26,541,541
Ensembl chr18:26,541,469...26,541,541

G

small nucleolar RNA SNORA14

increases expression

phenethyl isothiocyanate results in increased expression of SNORA14B mRNA

NCBI chr19:54,934,225...54,934,358
Ensembl chr19:54,934,225...54,934,358

G

leucine rich repeat protein 1

decreases expression

phenethyl isothiocyanate results in decreased expression of LRR1 mRNA

NCBI chr 6:87,643,195...87,651,894
Ensembl chr 6:87,643,217...87,651,894

G

leucine rich repeat containing 17

decreases expression

phenethyl isothiocyanate results in decreased expression of LRRC17 mRNA

NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845

G

leucine rich repeat and coiled-coil centrosomal protein 1

decreases expression

phenethyl isothiocyanate results in decreased expression of LRRCC1 mRNA

NCBI chr 2:87,025,671...87,060,313
Ensembl chr 2:87,025,598...87,060,294

G

lymphocyte antigen 6 family member K

decreases expression

phenethyl isothiocyanate results in decreased expression of LY6K mRNA

NCBI chr 7:106,683,749...106,712,802
Ensembl chr 7:106,683,753...106,686,372

G

Ly6/Plaur domain containing 3

increases expression

phenethyl isothiocyanate results in increased expression of LYPD3 mRNA

NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901

G

microtubule-associated protein 2

decreases expression

phenethyl isothiocyanate results in decreased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen-activated protein kinase kinase kinase kinase 3

decreases expression

phenethyl isothiocyanate results in decreased expression of MAP4K3 mRNA

NCBI chr 6:14,276,623...14,446,321
Ensembl chr 6:14,277,121...14,446,334

G

mitogen activated protein kinase 1

multiple interactions

phenethyl isothiocyanate results in decreased phosphorylation of and results in decreased expression of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK3 mRNA]
phenethyl isothiocyanate results in decreased phosphorylation of and results in decreased expression of MAPK3 protein

PMID:20423518 PMID:26456889

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrilin 2

decreases expression

phenethyl isothiocyanate results in decreased expression of MATN2 mRNA

NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113

G

matrin 3

decreases expression

phenethyl isothiocyanate results in decreased expression of MATR3 mRNA

NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

phenethyl isothiocyanate results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

minichromosome maintenance 10 replication initiation factor

decreases expression

phenethyl isothiocyanate results in decreased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

G

minichromosome maintenance complex component 2

decreases expression

phenethyl isothiocyanate results in decreased expression of MCM2 mRNA

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 5

decreases expression

phenethyl isothiocyanate results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 7

decreases expression

phenethyl isothiocyanate results in decreased expression of MCM7 mRNA

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

G

mucolipin TRP cation channel 1

increases expression

phenethyl isothiocyanate results in increased expression of MCOLN1 mRNA

NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252

G

mirror-image polydactyly 1

affects binding

MIPOL1 protein binds to phenethyl isothiocyanate

NCBI chr 6:74,755,293...75,090,403
Ensembl chr 6:74,755,395...75,086,811

G

marker of proliferation Ki-67

decreases expression
increases expression

phenethyl isothiocyanate results in decreased expression of MKI67 mRNA
phenethyl isothiocyanate results in increased expression of MKI67 protein

PMID:17616710 PMID:23535288

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 7

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of MMP7 mRNA]

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

meiotic nuclear divisions 1

decreases expression

phenethyl isothiocyanate results in decreased expression of MND1 mRNA

NCBI chr 2:169,433,523...169,496,081
Ensembl chr 2:169,433,540...169,496,096

G

meiosis-specific nuclear structural 1

decreases expression

phenethyl isothiocyanate results in decreased expression of MNS1 mRNA

NCBI chr 8:73,148,877...73,169,570
Ensembl chr 8:73,148,877...73,176,925

G

myeloperoxidase

multiple interactions

phenethyl isothiocyanate inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Dimethyl Sulfoxide] results in increased activity of MPO protein]
phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased activity of MPO protein]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of MPO mRNA]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

myelin protein zero-like 2

decreases expression

phenethyl isothiocyanate results in decreased expression of MPZL2 mRNA

NCBI chr 8:45,348,285...45,359,298
Ensembl chr 8:45,348,285...45,359,298

G

metal response element binding transcription factor 2

decreases expression

phenethyl isothiocyanate results in decreased expression of MTF2 mRNA

NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524

G

MYB proto-oncogene like 2

decreases expression

phenethyl isothiocyanate results in decreased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

phenethyl isothiocyanate results in decreased expression of MYC mRNA; phenethyl isothiocyanate results in decreased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin light chain 6

affects binding

MYL6 protein binds to phenethyl isothiocyanate

NCBI chr 7:910,764...914,062
Ensembl chr 7:910,774...933,791

G

myosin XIX

decreases expression

phenethyl isothiocyanate results in decreased expression of MYO19 mRNA

NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450

G

non-SMC condensin I complex, subunit G

decreases expression

phenethyl isothiocyanate results in decreased expression of NCAPG mRNA

NCBI chr14:65,403,930...65,432,902
Ensembl chr14:65,404,163...65,432,902

G

non-SMC condensin II complex, subunit G2

decreases expression

phenethyl isothiocyanate results in decreased expression of NCAPG2 mRNA

NCBI chr 6:137,342,449...137,418,083
Ensembl chr 6:137,342,943...137,415,159

G

non-SMC condensin I complex, subunit H

decreases expression

phenethyl isothiocyanate results in decreased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

nuclear receptor co-repressor 1

decreases expression

phenethyl isothiocyanate results in decreased expression of NCOR1 mRNA

NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032

G

N-myc downstream regulated 1

increases expression

phenethyl isothiocyanate results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NADH:ubiquinone oxidoreductase subunit A2

affects binding

NDUFA2 protein binds to phenethyl isothiocyanate

NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076

G

NIMA-related kinase 9

decreases expression

phenethyl isothiocyanate results in decreased expression of NEK9 mRNA

NCBI chr 6:104,944,056...104,984,538
Ensembl chr 6:104,944,056...104,984,538

G

neuroepithelial cell transforming 1

decreases expression

phenethyl isothiocyanate results in decreased expression of NET1 mRNA

NCBI chr17:66,341,251...66,370,445
Ensembl chr17:66,340,728...66,370,441

G

NFE2 like bZIP transcription factor 2

affects localization
increases activity
increases expression
multiple interactions

phenethyl isothiocyanate affects the localization of NFE2L2 protein
phenethyl isothiocyanate results in increased activity of NFE2L2 protein
phenethyl isothiocyanate results in increased expression of NFE2L2 mRNA; phenethyl isothiocyanate results in increased expression of NFE2L2 protein
[indole-3-carbinol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; [Resveratrol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of and results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of and affects the localization of NFE2L2 protein]; diphenyleneiodonium inhibits the reaction [phenethyl isothiocyanate affects the localization of NFE2L2 protein]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of and affects the localization of NFE2L2 protein]]; phenethyl isothiocyanate results in increased expression of and affects the localization of NFE2L2 protein
NFE2L2 gene mutant form affects the reaction [phenethyl isothiocyanate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]]; NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]]; NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]]; NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]]; NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]; NFE2L2 protein affects the reaction [phenethyl isothiocyanate results in increased expression of CYP2A5 mRNA]; NFE2L2 protein results in increased susceptibility to [lipopolysaccharide, Escherichia coli O111 B4 co-treated with phenethyl isothiocyanate]

PMID:20402460 PMID:22664424 PMID:25246272 PMID:25387343 PMID:26945724 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions
decreases expression

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 mRNA]
phenethyl isothiocyanate results in decreased expression of NFKB1 mRNA
[indole-3-carbinol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of and results in decreased activity of NFKB1 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 mRNA]; phenethyl isothiocyanate results in decreased expression of and results in decreased activity of NFKB1 protein

PMID:20423518 PMID:23724058 PMID:32070777

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nuclear factor kappa B subunit 2

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 mRNA]

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor alpha

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]

PMID:20423518 PMID:23724058

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

phenethyl isothiocyanate results in increased expression of NME1 mRNA

NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408

G

NOP53 ribosome biogenesis factor

decreases expression

phenethyl isothiocyanate results in decreased expression of NOP53 mRNA

NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902

G

nitric oxide synthase 2

decreases expression
multiple interactions

phenethyl isothiocyanate results in decreased expression of NOS2 mRNA
phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of NOS2 mRNA]; phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]

PMID:12628514 PMID:16373530 PMID:25387343 PMID:38341106

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 1

multiple interactions
increases expression

N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of and results in increased activity of NOTCH1 protein]; phenethyl isothiocyanate results in increased cleavage of and results in increased activity of NOTCH1 protein
phenethyl isothiocyanate results in increased expression of NOTCH1 mRNA

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

notch receptor 2

increases expression
increases response to substance
multiple interactions

phenethyl isothiocyanate results in increased expression of NOTCH2 mRNA
NOTCH2 protein results in increased susceptibility to phenethyl isothiocyanate
phenethyl isothiocyanate results in increased cleavage of and results in increased activity of and results in increased localization of NOTCH2 protein

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

NPC1 like intracellular cholesterol transporter 1

increases expression

phenethyl isothiocyanate results in increased expression of NPC1L1 mRNA

NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions
increases activity

phenethyl isothiocyanate results in increased expression of NQO1 mRNA; phenethyl isothiocyanate results in increased expression of NQO1 protein
[indole-3-carbinol co-treated with phenethyl isothiocyanate] results in increased expression of NQO1 mRNA; [phenethyl isothiocyanate co-treated with Resveratrol] results in increased expression of NQO1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NQO1 protein
phenethyl isothiocyanate results in increased activity of NQO1 protein

PMID:12628514 PMID:15672752 PMID:20442190 PMID:22664424 PMID:32070777

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 2, group F, member 2

decreases expression

phenethyl isothiocyanate results in decreased expression of NR2F2 mRNA

NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031

G

nurim

decreases expression

phenethyl isothiocyanate results in decreased expression of NRM mRNA

NCBI chr20:2,888,321...2,892,804
Ensembl chr20:2,877,567...2,891,802

G

neurturin

increases expression

phenethyl isothiocyanate results in increased expression of NRTN mRNA

NCBI chr 9:1,581,860...1,587,835
Ensembl chr 9:1,581,975...1,583,102

G

nuclear distribution C, dynein complex regulator

affects binding

NUDC protein binds to phenethyl isothiocyanate

NCBI chr 5:145,758,006...145,771,390
Ensembl chr 5:145,758,002...145,771,425

G

occludin

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Irinotecan results in decreased expression of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

ornithine decarboxylase 1

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

olfactory receptor family 1 subfamily F member 19F

decreases expression

phenethyl isothiocyanate results in decreased expression of OR1F19F mRNA

NCBI chr10:12,227,446...12,232,048
Ensembl chr10:12,231,119...12,232,048

G

olfactory receptor family 51 subfamily B member 6B

decreases expression

phenethyl isothiocyanate results in decreased expression of OR51B5 mRNA

NCBI chr 1:158,072,748...158,073,701
Ensembl chr 1:158,072,748...158,073,701

G

olfactory receptor family 52 subfamily Z member 1

increases expression

phenethyl isothiocyanate results in increased expression of OR52Z1 mRNA

NCBI chr 1:158,206,284...158,207,246

G

oxytocin receptor

decreases expression

phenethyl isothiocyanate results in decreased expression of OXTR mRNA

NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674

G

poly(A) binding protein, cytoplasmic 4

decreases expression

phenethyl isothiocyanate results in decreased expression of PABPC4 mRNA

NCBI chr 5:135,563,142...135,578,985
Ensembl chr 5:135,563,562...135,578,979

G

pappalysin

affects binding

PAPPA protein binds to phenethyl isothiocyanate

NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

poly (ADP-ribose) polymerase family, member 8

increases expression

phenethyl isothiocyanate results in increased expression of PARP8 mRNA

NCBI chr 2:48,679,405...48,848,700
Ensembl chr 2:48,679,436...48,849,253

G

PDZ binding kinase

decreases expression

phenethyl isothiocyanate results in decreased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

G

PCNA clamp associated factor

decreases expression

phenethyl isothiocyanate results in decreased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

pericentriolar material 1

decreases expression

phenethyl isothiocyanate results in decreased expression of PCM1 mRNA

NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091

G

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1

increases expression

phenethyl isothiocyanate results in increased expression of PCMTD1 mRNA

NCBI chr 5:12,284,711...12,355,680
Ensembl chr 5:12,284,711...12,354,899

G

phosducin-like 3

decreases expression

phenethyl isothiocyanate results in decreased expression of PDCL3 mRNA

NCBI chr 9:41,234,322...41,243,769
Ensembl chr 9:41,234,234...41,243,735

G

period circadian regulator 3

decreases expression

phenethyl isothiocyanate results in decreased expression of PER3 mRNA

NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607

G

PHD finger protein 19

decreases expression

phenethyl isothiocyanate results in decreased expression of PHF19 mRNA

NCBI chr 3:18,175,281...18,197,289
Ensembl chr 3:18,175,282...18,196,405

G

placenta associated 8

decreases expression

phenethyl isothiocyanate results in decreased expression of PLAC8 mRNA

NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264

G

pleckstrin homology domain containing A7

decreases expression

phenethyl isothiocyanate results in decreased expression of PLEKHA7 mRNA

NCBI chr 1:170,364,524...170,547,843
Ensembl chr 1:170,365,135...170,547,775

G

pleckstrin homology, MyTH4 and FERM domain containing H2

decreases expression

phenethyl isothiocyanate results in decreased expression of PLEKHH2 mRNA

NCBI chr 6:10,032,837...10,132,081
Ensembl chr 6:10,032,660...10,140,794

G

polo-like kinase 1

decreases expression

phenethyl isothiocyanate results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 4

decreases expression

phenethyl isothiocyanate results in decreased expression of PLK4 mRNA

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

POF1B, actin binding protein

increases expression

phenethyl isothiocyanate results in increased expression of POF1B mRNA

NCBI chr X:77,683,128...77,749,827
Ensembl chr X:77,683,128...77,749,688

G

DNA polymerase alpha 1, catalytic subunit

decreases expression

phenethyl isothiocyanate results in decreased expression of POLA1 mRNA

NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536

G

DNA polymerase alpha 2, accessory subunit

decreases expression

phenethyl isothiocyanate results in decreased expression of POLA2 mRNA

NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348

G

DNA polymerase delta 1, catalytic subunit

decreases expression

phenethyl isothiocyanate results in decreased expression of POLD1 mRNA

NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465

G

DNA polymerase epsilon, catalytic subunit

decreases expression

phenethyl isothiocyanate results in decreased expression of POLE mRNA

NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939

G

DNA polymerase epsilon 2, accessory subunit

decreases expression

phenethyl isothiocyanate results in decreased expression of POLE2 mRNA

NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305

G

peptidylprolyl isomerase H

decreases expression

phenethyl isothiocyanate results in decreased expression of PPIH mRNA

NCBI chr 5:132,906,324...132,924,341
Ensembl chr 5:132,906,328...132,924,267

G

peptidylprolyl isomerase like 4

decreases expression

phenethyl isothiocyanate results in decreased expression of PPIL4 mRNA

NCBI chr 1:2,273,582...2,305,639
Ensembl chr 1:2,273,609...2,305,632

G

protein phosphatase 1, regulatory subunit 12A

decreases expression

phenethyl isothiocyanate results in decreased expression of PPP1R12A mRNA

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

DNA primase subunit 1

decreases expression

phenethyl isothiocyanate results in decreased expression of PRIM1 mRNA

NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526

G

protein kinase AMP-activated non-catalytic subunit beta 2

increases expression

phenethyl isothiocyanate results in increased expression of PRKAB2 mRNA

NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872

G

protein kinase C, alpha

multiple interactions

phenethyl isothiocyanate results in decreased phosphorylation of and results in decreased expression of PRKCA protein

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, beta

multiple interactions

phenethyl isothiocyanate results in decreased phosphorylation of and results in decreased expression of PRKCB protein

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, zeta

multiple interactions

phenethyl isothiocyanate results in decreased phosphorylation of and results in decreased expression of PRKCZ protein

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

protein S

increases expression

phenethyl isothiocyanate results in increased expression of PROS1 mRNA

NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286

G

proteasome 20S subunit alpha 3

affects binding

PSMA3 protein binds to phenethyl isothiocyanate

NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965

G

proteasome 20S subunit beta 3

increases expression

phenethyl isothiocyanate results in increased expression of PSMB3 mRNA

NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521

G

proteasome 26S subunit, ATPase 3

affects binding

PSMC3 protein binds to phenethyl isothiocyanate

NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

phenethyl isothiocyanate results in decreased expression of PTGS2 mRNA
[phenethyl isothiocyanate co-treated with indole-3-carbinol] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 protein
NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]]; NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]]; phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]

PMID:16373530 PMID:25387343 PMID:32070777

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, E

increases expression

phenethyl isothiocyanate results in increased expression of PTPRE mRNA

NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534

G

PWWP domain containing 2A

decreases expression

phenethyl isothiocyanate results in decreased expression of PWWP2A mRNA

NCBI chr10:28,155,509...28,195,255
Ensembl chr10:28,155,605...28,194,308

G

quiescin sulfhydryl oxidase 1

increases expression

phenethyl isothiocyanate results in increased expression of QSOX1 mRNA

NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459

G

RAB11a, member RAS oncogene family

increases expression

phenethyl isothiocyanate results in increased expression of RAB11A mRNA

NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525

G

RAB15, member RAS oncogene family

affects binding

RAB15 protein binds to phenethyl isothiocyanate

NCBI chr 6:95,499,584...95,524,073
Ensembl chr 6:95,499,587...95,523,942

G

RAD51 recombinase

decreases expression

phenethyl isothiocyanate results in decreased expression of RAD51 mRNA

NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases expression

phenethyl isothiocyanate results in decreased expression of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAN binding protein 1

affects binding

RANBP1 protein binds to phenethyl isothiocyanate

NCBI chr11:82,742,603...82,750,836
Ensembl chr11:82,742,600...82,750,838

G

RAP1B, member of RAS oncogene family

increases expression

phenethyl isothiocyanate results in increased expression of RAP1B mRNA

NCBI chr 7:53,423,039...53,456,349
Ensembl chr 7:53,423,130...53,456,370

G

RAS p21 protein activator 1

decreases expression

phenethyl isothiocyanate results in decreased expression of RASA1 mRNA

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RB binding protein 6, ubiquitin ligase

decreases expression

phenethyl isothiocyanate results in decreased expression of RBBP6 mRNA

NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678

G

REC114 meiotic recombination protein

increases expression

phenethyl isothiocyanate results in increased expression of REC114 mRNA

NCBI chr 8:59,063,352...59,221,439
Ensembl chr 8:59,063,352...59,149,887

G

receptor accessory protein 5

decreases expression

phenethyl isothiocyanate results in decreased expression of REEP5 mRNA

NCBI chr18:25,945,375...25,983,271
Ensembl chr18:25,945,381...25,976,509

G

REL proto-oncogene, NF-kB subunit

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of REL mRNA]

PMID:20423518 PMID:23724058

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression

[indole-3-carbinol co-treated with phenethyl isothiocyanate] results in decreased activity of RELA protein; [indole-3-carbinol co-treated with phenethyl isothiocyanate] results in decreased expression of RELA mRNA; [phenethyl isothiocyanate co-treated with Resveratrol] results in decreased expression of RELA mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of and results in decreased activity of RELA protein; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of RELA mRNA; [Resveratrol co-treated with phenethyl isothiocyanate] results in decreased activity of RELA protein; phenethyl isothiocyanate results in decreased expression of and results in decreased activity of RELA protein
phenethyl isothiocyanate results in decreased expression of RELA mRNA

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RELB proto-oncogene, NF-kB subunit

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of RELB mRNA]

PMID:20423518 PMID:23724058

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

receptor-interacting serine-threonine kinase 2

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of RIPK2 mRNA]

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

ring finger protein 39

increases expression

phenethyl isothiocyanate results in increased expression of RNF39 mRNA

NCBI chr20:1,604,794...1,610,283
Ensembl chr20:1,604,794...1,610,283

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

phenethyl isothiocyanate results in decreased expression of ROCK1 mRNA

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

Rho-associated coiled-coil containing protein kinase 2

decreases expression

phenethyl isothiocyanate results in decreased expression of ROCK2 mRNA

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

ribosomal protein L3

decreases expression

phenethyl isothiocyanate results in decreased expression of RPL3 mRNA

NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468

G

ribosomal protein L5

decreases expression

phenethyl isothiocyanate results in decreased expression of RPL5 mRNA

NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290

G

ribosomal protein lateral stalk subunit P2

affects binding

RPLP2 protein binds to phenethyl isothiocyanate

NCBI chr 1:196,546,086...196,548,636
Ensembl chr 1:196,546,352...196,548,645

G

ribosomal protein S21, pseudogene 1

affects binding

RPS21 protein binds to phenethyl isothiocyanate

NCBI chr 5:153,387,133...153,387,476
Ensembl chr 5:153,387,176...153,387,427

G

ribosomal protein S6 kinase B1

decreases phosphorylation

phenethyl isothiocyanate results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

radial spoke head 3

increases expression

phenethyl isothiocyanate results in increased expression of RSPH3 mRNA

NCBI chr 1:47,101,961...47,155,201
Ensembl chr 1:47,101,961...47,154,232

G

rhotekin 2

decreases expression

phenethyl isothiocyanate results in decreased expression of RTKN2 mRNA

NCBI chr20:20,536,628...20,609,951
Ensembl chr20:20,525,256...20,609,951

G

S100 calcium binding protein A10

affects binding

S100A10 protein binds to phenethyl isothiocyanate

NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661

G

S100 calcium binding protein A7 like 2

increases expression

phenethyl isothiocyanate results in increased expression of S100A7L2 mRNA

NCBI chr 2:176,506,300...176,509,196
Ensembl chr 2:176,506,300...176,509,196
Ensembl chr 2:176,506,300...176,509,196

G

scaffold attachment factor B

decreases expression

phenethyl isothiocyanate results in decreased expression of SAFB mRNA

NCBI chr 9:1,417,449...1,438,408
Ensembl chr 9:1,417,525...1,438,644

G

spermidine/spermine N1-acetyl transferase 1

increases expression

phenethyl isothiocyanate results in increased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

strawberry notch homolog 1

decreases expression

phenethyl isothiocyanate results in decreased expression of SBNO1 mRNA

NCBI chr12:32,175,176...32,234,200
Ensembl chr12:32,185,485...32,230,158

G

small Cajal body-specific RNA 7

increases expression

phenethyl isothiocyanate results in increased expression of SCARNA7 mRNA

NCBI chr 2:153,336,855...153,337,181
Ensembl chr 2:153,336,855...153,337,181

G

stearoyl-CoA desaturase

decreases expression

phenethyl isothiocyanate results in decreased expression of SCD mRNA

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

succinate dehydrogenase complex assembly factor 1

decreases expression

phenethyl isothiocyanate results in decreased expression of SDHAF1 mRNA

NCBI chr 1:85,576,207...85,577,156
Ensembl chr 1:85,576,041...85,577,366
Ensembl chr 1:85,576,041...85,577,366

G

SEC16 homolog A, endoplasmic reticulum export factor

increases expression

phenethyl isothiocyanate results in increased expression of SEC16A mRNA

NCBI chr 3:9,229,687...9,264,837
Ensembl chr 3:9,229,687...9,264,273

G

selenium binding protein 1

decreases expression

phenethyl isothiocyanate results in decreased expression of SELENBP1 mRNA

NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594

G

selenophosphate synthetase 1

decreases expression

phenethyl isothiocyanate results in decreased expression of SEPHS1 mRNA

NCBI chr17:73,354,435...73,382,803
Ensembl chr17:73,356,530...73,382,593

G

serpin family B member 12

increases expression

phenethyl isothiocyanate results in increased expression of SERPINB12 mRNA

NCBI chr13:23,052,384...23,083,691
Ensembl chr13:23,052,448...23,083,691

G

serpin family E member 1

increases expression

phenethyl isothiocyanate results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family I member 1

increases expression

phenethyl isothiocyanate results in increased expression of SERPINI1 mRNA

NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135

G

splicing factor 3a, subunit 3

affects binding

SF3A3 protein binds to phenethyl isothiocyanate

NCBI chr 5:136,967,713...136,987,345
Ensembl chr 5:136,967,691...136,987,361

G

splicing factor 3b, subunit 2

decreases expression

phenethyl isothiocyanate results in decreased expression of SF3B2 mRNA

NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759

G

SHC binding and spindle associated 1

decreases expression

phenethyl isothiocyanate results in decreased expression of SHCBP1 mRNA

NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844

G

spindle and kinetochore associated complex subunit 2

decreases expression

phenethyl isothiocyanate results in decreased expression of SKA2 mRNA

NCBI chr10:71,921,474...71,939,461
Ensembl chr10:71,921,582...71,939,458

G

spindle and kinetochore associated complex subunit 3

decreases expression

phenethyl isothiocyanate results in decreased expression of SKA3 mRNA

NCBI chr15:31,951,812...31,971,010
Ensembl chr15:31,951,825...31,971,010

G

S-phase kinase associated protein 2

decreases expression

phenethyl isothiocyanate results in decreased expression of SKP2 mRNA

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

G

solute carrier family 12 member 2

decreases expression

phenethyl isothiocyanate results in decreased expression of SLC12A2 mRNA

NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440

G

solute carrier family 20 member 1

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of SLC20A1 mRNA]

NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051

G

solute carrier family 20 member 2

increases expression

phenethyl isothiocyanate results in increased expression of SLC20A2 mRNA

NCBI chr16:69,460,850...69,551,418
Ensembl chr16:69,460,462...69,521,711

G

schlafen family member 5

increases expression

phenethyl isothiocyanate results in increased expression of SLFN5 mRNA

NCBI chr10:67,881,068...67,895,013
Ensembl chr10:67,880,009...67,893,109

G

secreted Ly6/Plaur domain containing 1

increases expression

phenethyl isothiocyanate results in increased expression of SLURP1 mRNA

NCBI chr 7:106,611,949...106,613,365
Ensembl chr 7:106,611,949...106,613,365

G

SWI/SNF related BAF chromatin remodeling complex subunit E1

affects binding

SMARCE1 protein binds to phenethyl isothiocyanate

NCBI chr10:84,159,270...84,180,547
Ensembl chr10:84,159,275...84,179,989

G

structural maintenance of chromosomes 3

decreases expression

phenethyl isothiocyanate results in decreased expression of SMC3 mRNA

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

sphingomyelin phosphodiesterase 1

increases expression

phenethyl isothiocyanate results in increased expression of SMPD1 mRNA

NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794

G

SMAD specific E3 ubiquitin protein ligase 2

decreases expression

phenethyl isothiocyanate results in decreased expression of SMURF2 mRNA

NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488

G

splA/ryanodine receptor domain and SOCS box containing 3

increases expression

phenethyl isothiocyanate results in increased expression of SPSB3 mRNA

NCBI chr10:13,907,175...13,912,841
Ensembl chr10:13,907,253...13,912,841

G

serine and arginine repetitive matrix 1

decreases expression

phenethyl isothiocyanate results in decreased expression of SRRM1 mRNA

NCBI chr 5:147,559,515...147,591,895
Ensembl chr 5:147,559,514...147,591,849

G

signal transducer and activator of transcription 1

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT1 protein]; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]
phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 mRNA]; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of STAT1 protein]

PMID:20423518 PMID:23724058

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

succinate-CoA ligase GDP-forming subunit beta

affects binding

SUCLG2 protein binds to phenethyl isothiocyanate

NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170

G

SUV39H1 histone lysine methyltransferase

decreases expression

phenethyl isothiocyanate results in decreased expression of SUV39H1 mRNA

NCBI chr X:14,421,028...14,433,993
Ensembl chr X:14,421,109...14,433,982

G

SUV39H1 histone lysine methyltransferase, pseudogene 1

decreases expression

phenethyl isothiocyanate results in decreased expression of SUV39H1 mRNA

NCBI chr X:141,792,589...141,795,257

G

SWT1 RNA endoribonuclease homolog

increases expression

phenethyl isothiocyanate results in increased expression of SWT1 mRNA

NCBI chr13:63,452,494...63,509,982
Ensembl chr13:63,452,496...63,509,980

G

transgelin 3

increases expression

phenethyl isothiocyanate results in increased expression of TAGLN3 mRNA

NCBI chr11:55,099,887...55,113,457
Ensembl chr11:55,099,743...55,113,485

G

transcription factor 12

decreases expression

phenethyl isothiocyanate results in decreased expression of TCF12 mRNA

NCBI chr 8:72,490,447...72,799,265
Ensembl chr 8:72,492,567...72,799,201

G

t-complex 11 like 2

increases expression

phenethyl isothiocyanate results in increased expression of TCP11L2 mRNA

NCBI chr 7:19,150,241...19,185,135
Ensembl chr 7:19,150,252...19,185,095

G

transferrin receptor 2

decreases expression

phenethyl isothiocyanate results in decreased expression of TFR2 mRNA

NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591

G

THO complex subunit 2

decreases expression

phenethyl isothiocyanate results in decreased expression of THOC2 mRNA

NCBI chr X:120,634,966...120,749,569
Ensembl chr X:120,634,968...120,749,513

G

timeless circadian regulator

decreases expression

phenethyl isothiocyanate results in decreased expression of TIMELESS mRNA

NCBI chr 7:654,804...678,769
Ensembl chr 7:654,822...678,738

G

tight junction protein 1

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Irinotecan results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

transmembrane protein 229B

increases expression

phenethyl isothiocyanate results in increased expression of TMEM229B mRNA

NCBI chr 6:97,771,645...97,819,582
Ensembl chr 6:97,775,332...97,819,489

G

transmembrane protein 97

decreases expression

phenethyl isothiocyanate results in decreased expression of TMEM97 mRNA

NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730

G

thymopoietin

decreases expression

phenethyl isothiocyanate results in decreased expression of TMPO mRNA

NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727

G

tumor necrosis factor

multiple interactions

NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]]; NFE2L2 gene mutant form inhibits the reaction [phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; phenethyl isothiocyanate inhibits the reaction [Irinotecan results in increased expression of TNF mRNA]; phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; phenethyl isothiocyanate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
phenethyl isothiocyanate inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]

PMID:25387343 PMID:32289289 PMID:38341106

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

multiple interactions

phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of TNFAIP3 mRNA]

PMID:20423518 PMID:23724058

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

tumor protein p53

increases expression

phenethyl isothiocyanate results in increased expression of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TPD52 like 2

affects binding

TPD52L2 protein binds to phenethyl isothiocyanate

NCBI chr 3:168,598,449...168,618,201
Ensembl chr 3:168,594,609...168,619,762

G

tropomyosin 1

affects binding

TPM1 protein binds to phenethyl isothiocyanate

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

tropomyosin 3

affects binding

TPM3 protein binds to phenethyl isothiocyanate

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

tropomyosin 4

affects binding

TPM4 protein binds to phenethyl isothiocyanate

NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984

G

translocated promoter region, nuclear basket protein

decreases expression

phenethyl isothiocyanate results in decreased expression of TPR mRNA

NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496

G

thyroid hormone receptor interactor 13

decreases expression

phenethyl isothiocyanate results in decreased expression of TRIP13 mRNA

NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074

G

tetratricopeptide repeat domain 14

decreases expression

phenethyl isothiocyanate results in decreased expression of TTC14 mRNA

NCBI chr 2:116,653,543...116,665,072
Ensembl chr 2:116,653,595...116,664,158

G

tubulin, alpha 1A

affects binding

TUBA1A protein binds to phenethyl isothiocyanate

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, alpha 3B

affects binding

TUBA3D protein binds to phenethyl isothiocyanate

NCBI chr 4:178,588,779...178,594,328
Ensembl chr 4:178,588,779...178,594,326

G

tubulin, alpha 4A

increases expression
affects binding

phenethyl isothiocyanate results in increased expression of TUBA4A mRNA
TUBA4A protein binds to phenethyl isothiocyanate

PMID:17616710 PMID:21838287

NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918

G

tubulin, beta 1 class VI

affects binding

TUBB1 protein binds to phenethyl isothiocyanate

NCBI chr 3:163,247,990...163,257,460
Ensembl chr 3:163,247,967...163,256,063

G

tubulin, beta 2A class IIa

affects binding

TUBB2A protein binds to phenethyl isothiocyanate

NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714

G

tubulin, beta 3 class III

affects binding

TUBB3 protein binds to phenethyl isothiocyanate

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

G

tubulin, beta 4B class IVb

affects binding

TUBB4B protein binds to phenethyl isothiocyanate

NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296

G

thioredoxin 1

increases expression
affects binding

phenethyl isothiocyanate results in increased expression of TXN mRNA
TXN protein binds to phenethyl isothiocyanate
phenethyl isothiocyanate results in increased expression of TXN1 mRNA

PMID:17616710 PMID:20442190 PMID:21838287

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin interacting protein

increases expression

phenethyl isothiocyanate results in increased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

decreases activity
increases expression

phenethyl isothiocyanate results in decreased activity of TXNRD1 protein
phenethyl isothiocyanate results in increased expression of TXNRD1 mRNA

PMID:17616710 PMID:17937621 PMID:20442190

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

upstream binding transcription factor

decreases expression

phenethyl isothiocyanate results in decreased expression of UBTF mRNA

NCBI chr10:87,258,217...87,274,291
Ensembl chr10:87,258,217...87,272,969

G

ubiquitin C-terminal hydrolase L1

affects binding

UCHL1 protein binds to phenethyl isothiocyanate

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

UDP glucuronosyltransferase family 1 member A6

increases expression

phenethyl isothiocyanate results in increased expression of UGT1A6 protein

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

unc-5 netrin receptor B

increases expression

phenethyl isothiocyanate results in increased expression of UNC5B mRNA

NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537

G

uracil-DNA glycosylase

decreases expression

phenethyl isothiocyanate results in decreased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

ubiquitin specific peptidase 14

affects binding

USP14 protein binds to phenethyl isothiocyanate

NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519

G

ubiquitin specific peptidase 7

decreases expression

phenethyl isothiocyanate results in decreased expression of USP7 mRNA

NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355

G

valosin-containing protein

affects binding

VCP protein binds to phenethyl isothiocyanate

NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571

G

vascular endothelial zinc finger 1

decreases expression

phenethyl isothiocyanate results in decreased expression of VEZF1 mRNA

NCBI chr10:72,859,669...72,876,111
Ensembl chr10:72,859,877...72,876,111

G

vimentin

affects binding

VIM protein binds to phenethyl isothiocyanate

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

WD repeat domain 76

decreases expression

phenethyl isothiocyanate results in decreased expression of WDR76 mRNA

NCBI chr 3:108,456,784...108,491,528
Ensembl chr 3:108,456,815...108,490,840

G

X-linked inhibitor of apoptosis

multiple interactions
decreases expression

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [phenethyl isothiocyanate results in decreased expression of XIAP protein]; Vitamin E inhibits the reaction [phenethyl isothiocyanate results in decreased expression of XIAP protein]

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

yippee-like 2

increases expression

phenethyl isothiocyanate results in increased expression of YPEL2 mRNA

NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

affects binding

YWHAB protein binds to phenethyl isothiocyanate

NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

affects binding

YWHAE protein binds to phenethyl isothiocyanate

NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

affects binding

YWHAH protein binds to phenethyl isothiocyanate

NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

affects binding

YWHAQ protein binds to phenethyl isothiocyanate

NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

affects binding

YWHAZ protein binds to phenethyl isothiocyanate

NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668

G

zinc finger CCCH type containing 13

decreases expression

phenethyl isothiocyanate results in decreased expression of ZC3H13 mRNA

NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802

G

zinc finger CCCH type containing 6

increases expression

phenethyl isothiocyanate results in increased expression of ZC3H6 mRNA

NCBI chr 3:116,203,466...116,254,186
Ensembl chr 3:116,204,197...116,253,282

G

zinc finger protein 131

decreases expression

phenethyl isothiocyanate results in decreased expression of ZFP131 mRNA

NCBI chr 2:51,722,774...51,753,662
Ensembl chr 2:51,725,541...51,753,639

G

zinc finger protein 157

decreases expression

phenethyl isothiocyanate results in decreased expression of ZFP157 mRNA

NCBI chr12:16,248,230...16,279,459
Ensembl chr12:16,248,230...16,270,698

G

zinc finger protein 706

increases expression

phenethyl isothiocyanate results in increased expression of ZFP706 mRNA

NCBI chr 7:68,167,496...68,174,121
Ensembl chr 7:68,166,323...68,174,148

piperidin-2-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases abundance

CYP2E1 protein results in increased abundance of 2-piperidone

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

prunetin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 2 family member

decreases activity

prunetin results in decreased activity of ALDH2 protein

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

interleukin 1 beta

multiple interactions

prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

NFKB inhibitor alpha

multiple interactions

prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions
decreases expression

[prunetin results in decreased expression of NOS2 mRNA] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased chemical synthesis of Nitric Oxide]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

[prunetin results in decreased expression of PTGS2 mRNA] which results in decreased chemical synthesis of Dinoprostone; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

tumor necrosis factor

multiple interactions

prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; prunetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

thiacloprid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions

[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions
increases expression

[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of ABCC3 mRNA
thiacloprid results in increased expression of ABCC3 mRNA
[thiacloprid co-treated with clothianidin] results in increased expression of ABCC3 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ABCC3 mRNA

PMID:32745781 PMID:33426623

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

acetylcholinesterase

decreases activity

thiacloprid results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA oxidase 1

multiple interactions

[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

albumin

multiple interactions
decreases expression

astaxanthine inhibits the reaction [thiacloprid results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

increases expression
multiple interactions

thiacloprid results in increased expression of ALDH1A1 mRNA
[thiacloprid co-treated with clothianidin] results in increased expression of ALDH1A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of ALDH1A1 mRNA
[thiacloprid co-treated with enilconazole] results in decreased expression of ALDH1A1 mRNA

PMID:32201337 PMID:33426623

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

autophagy related 5

decreases expression

thiacloprid results in decreased expression of ATG5 mRNA; thiacloprid results in decreased expression of ATG5 protein

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

catalase

decreases activity
multiple interactions
decreases expression

thiacloprid results in decreased activity of CAT protein
astaxanthine inhibits the reaction [thiacloprid results in decreased activity of CAT protein]; Polysaccharides inhibits the reaction [thiacloprid results in decreased activity of CAT protein]; Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of CAT mRNA]

PMID:28692354 PMID:34564187

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

CD36 molecule

multiple interactions

[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

carboxylesterase 2H

multiple interactions

[clothianidin co-treated with thiacloprid] results in increased expression of CES2 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CES2 protein

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

thiacloprid results in increased activity of [NACHRA8 protein co-treated with CHRNB2 protein]; thiacloprid results in increased activity of [NACHRALPHA1 protein co-treated with CHRNB2 protein]

PMID:16981889 PMID:25459289

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

carnitine palmitoyltransferase 1A

multiple interactions

[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cAMP responsive element modulator

decreases expression

thiacloprid results in decreased expression of CREM mRNA; thiacloprid results in decreased expression of CREM protein

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

cytochrome b-245 beta chain

increases expression

thiacloprid results in increased expression of CYBB mRNA

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

thiacloprid results in decreased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases activity
affects expression
multiple interactions
increases expression

thiacloprid results in increased activity of CYP19A1 protein
thiacloprid affects the expression of CYP19A1 mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [thiacloprid affects the expression of CYP19A1 mRNA]
thiacloprid results in increased expression of CYP19A1 mRNA

PMID:26464060 PMID:28750898 PMID:29701941

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

thiacloprid results in increased expression of CYP1A1 mRNA; thiacloprid results in increased expression of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
multiple interactions

thiacloprid results in increased expression of CYP1A2 mRNA; thiacloprid results in increased expression of CYP1A2 protein
[enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP1A2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP1A2 mRNA

PMID:21784029 PMID:32201337

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression
multiple interactions

thiacloprid results in increased expression of CYP2B2 mRNA
[thiacloprid co-treated with clothianidin] results in increased expression of CYP2B2 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions
increases expression

[clothianidin co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B6 protein; [enilconazole co-treated with thiacloprid] results in increased expression of CYP2B9 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP2B6 mRNA
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2B10 mRNA; [Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2B10 mRNA
thiacloprid results in increased expression of CYP2B6 mRNA

PMID:32201337 PMID:32736067 PMID:32745781

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily c, polypeptide 24

multiple interactions

[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of CYP2C55 mRNA

NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression
multiple interactions
decreases expression

thiacloprid results in increased expression of CYP2C19 mRNA
[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of CYP2C29 mRNA
thiacloprid results in decreased expression of CYP2C19 protein

PMID:32194361 PMID:32201337 PMID:32745781

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression
multiple interactions

thiacloprid results in decreased expression of CYP2E1 mRNA
[clothianidin co-treated with thiacloprid] results in increased expression of CYP2E1 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with clothianidin] results in decreased expression of CYP2E1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions

thiacloprid results in increased expression of CYP3A4 mRNA; thiacloprid results in increased expression of CYP3A4 protein
[clothianidin co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [enilconazole co-treated with thiacloprid co-treated with clothianidin] results in increased expression of CYP3A4 mRNA; [enilconazole co-treated with thiacloprid] results in increased expression of CYP3A4 protein; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
increases expression

[thiacloprid co-treated with clothianidin] results in increased expression of CYP3A23-3A1 mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of CYP3A23-3A1 mRNA
thiacloprid results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression
multiple interactions

thiacloprid results in increased expression of CYP3A5 mRNA
[enilconazole co-treated with thiacloprid] results in increased expression of CYP3A5 protein; [thiacloprid co-treated with clothianidin] results in increased expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

thiacloprid results in decreased expression of CYP7A1 protein
thiacloprid results in decreased expression of CYP7A1 mRNA
[thiacloprid co-treated with clothianidin] results in decreased expression of CYP7A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of CYP7A1 mRNA

PMID:32194361 PMID:33426623

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DEAD-box helicase 4

decreases expression

thiacloprid results in decreased expression of DDX4 mRNA; thiacloprid results in decreased expression of DDX4 protein

NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723

G

iodothyronine deiodinase 1

multiple interactions

[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of DIO1 mRNA

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

enoyl-CoA delta isomerase 1

multiple interactions

[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061

G

elastin

multiple interactions
decreases expression

[thiacloprid co-treated with clothianidin] results in decreased expression of ELN mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of ELN mRNA
thiacloprid results in decreased expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

glial fibrillary acidic protein

multiple interactions

[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glutamic--pyruvic transaminase

increases expression
multiple interactions

thiacloprid results in increased expression of GPT protein
astaxanthine inhibits the reaction [thiacloprid results in increased expression of GPT protein]; Polysaccharides inhibits the reaction [thiacloprid results in increased expression of GPT protein]

PMID:31328355 PMID:34564187

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions
decreases expression

Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of GPX1 mRNA]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

high mobility group box 1

multiple interactions
increases expression

astaxanthine inhibits the reaction [thiacloprid results in increased expression of HMGB1 mRNA]

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions

[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

interleukin 10

increases expression
multiple interactions

thiacloprid results in increased expression of IL10 protein
astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

increases expression
multiple interactions

thiacloprid results in increased expression of IL1B protein
astaxanthine inhibits the reaction [thiacloprid results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

thiacloprid results in increased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of INS1 protein

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

kyphoscoliosis peptidase

decreases expression
multiple interactions

thiacloprid results in decreased expression of KY mRNA
[thiacloprid co-treated with clothianidin] results in decreased expression of KY mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of KY mRNA

NCBI chr 8:103,086,959...103,126,305
Ensembl chr 8:103,086,630...103,126,024

G

multiple EGF-like-domains 11

decreases expression
multiple interactions

thiacloprid results in decreased expression of MEGF11 mRNA
[thiacloprid co-treated with clothianidin] results in decreased expression of MEGF11 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of MEGF11 mRNA

NCBI chr 8:64,892,312...65,218,984
Ensembl chr 8:64,892,387...65,216,061

G

marker of proliferation Ki-67

decreases expression

thiacloprid results in decreased expression of MKI67 mRNA; thiacloprid results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

membrane metallo-endopeptidase

increases expression
multiple interactions

thiacloprid results in increased expression of MME mRNA
[thiacloprid co-treated with clothianidin] results in increased expression of MME mRNA; [thiacloprid co-treated with enilconazole] results in increased expression of MME mRNA

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

nitric oxide synthase 2

increases expression
multiple interactions

thiacloprid results in increased expression of NOS2 mRNA
astaxanthine inhibits the reaction [thiacloprid results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

NR1I3 protein affects the susceptibility to [2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with Thiophanate co-treated with thiacloprid co-treated with Ziram]

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

platelet derived growth factor receptor beta

multiple interactions

[Ziram co-treated with Thiophanate co-treated with Captan co-treated with Chlorpyrifos co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with thiacloprid] results in increased expression of PDGFRB protein

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

cytochrome p450 oxidoreductase

increases expression

thiacloprid results in increased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

serpin family E member 1

multiple interactions

[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 16 member 2

multiple interactions

[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SLC16A2 mRNA

NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771

G

solute carrier family 22 member 1

increases activity

thiacloprid metabolite results in increased activity of SLC22A1 protein; thiacloprid results in increased activity of SLC22A1 protein

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

decreases activity

thiacloprid metabolite results in decreased activity of SLC22A2 protein; thiacloprid results in decreased activity of SLC22A2 protein

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 8

decreases activity

thiacloprid metabolite results in decreased activity of SLC22A8 protein; thiacloprid results in decreased activity of SLC22A8 protein

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 6 member 1

decreases expression
multiple interactions

thiacloprid results in decreased expression of SLC6A1 mRNA
[thiacloprid co-treated with clothianidin] results in decreased expression of SLC6A1 mRNA; [thiacloprid co-treated with enilconazole] results in decreased expression of SLC6A1 mRNA

NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293

G

superoxide dismutase 1

multiple interactions
decreases expression

Polysaccharides inhibits the reaction [thiacloprid results in decreased expression of SOD1 mRNA]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

steroidogenic acute regulatory protein

decreases expression

thiacloprid results in decreased expression of STAR mRNA

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

sulfotransferase family 1B member 1

multiple interactions

[Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of SULT1B1 mRNA

NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483

G

synaptonemal complex protein 3

decreases expression

thiacloprid results in decreased expression of SYCP3 mRNA; thiacloprid results in decreased expression of SYCP3 protein

NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511

G

thyroid hormone responsive

multiple interactions

[2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA; [Dietary Fats co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in decreased expression of THRSP mRNA; Dietary Fats inhibits the reaction [[2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Captan co-treated with Chlorpyrifos co-treated with thiacloprid co-treated with Thiophanate co-treated with Ziram] results in increased expression of THRSP mRNA]

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

WIN 18446

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 1 family, member A2

decreases activity

N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine results in decreased activity of ALDH1A2 protein

PMID:12547725 PMID:30958995

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

HOP homeobox

multiple interactions

[nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in decreased expression of HOPX mRNA; [nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in decreased expression of HOPX protein

NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909

G

homeobox A1

multiple interactions

N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA]

NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504

G

inhibitor of DNA binding 2

multiple interactions

[nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

podoplanin

multiple interactions

[nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in decreased expression of PDPN mRNA; [nitrofen co-treated with N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine] results in decreased expression of PDPN protein

NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19901
role	19871
biological role	19869
biochemical role	19576
enzyme inhibitor	18778
EC 1.* (oxidoreductase) inhibitor	17561
EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor	11767
EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor	1047
EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitor +	7
EC 1.2.1.12 [glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)] inhibitor +	0
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor +	1042
EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor +	1

paths to the root