Rgs11 (regulator of G-protein signaling 11) - Rat Genome Database

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Gene: Rgs11 (regulator of G-protein signaling 11) Rattus norvegicus
Analyze
Symbol: Rgs11
Name: regulator of G-protein signaling 11
RGD ID: 3563
Description: Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be located in dendrite terminus. Predicted to be part of protein-containing complex. Orthologous to human RGS11 (regulator of G protein signaling 11); INTERACTS WITH 2,4,6-trinitrotoluene; 4-amino-2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: VALIDATED
Previously known as: LOC360501
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21015,222,803 - 15,231,060 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,222,803 - 15,231,060 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,962,573 - 19,970,833 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01019,451,452 - 19,459,712 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01014,950,732 - 14,958,986 (+)NCBIRnor_WKY
Rnor_5.01015,383,438 - 15,391,694 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,469,922 - 15,478,157 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,476,071 - 15,476,346 (+)NCBI
Celera1014,890,608 - 14,898,855 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. Gold SJ, etal., J Neurosci 1997 Oct 15;17(20):8024-37.
3. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12606627   PMID:18468998   PMID:22689652  


Genomics

Comparative Map Data
Rgs11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21015,222,803 - 15,231,060 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,222,803 - 15,231,060 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,962,573 - 19,970,833 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01019,451,452 - 19,459,712 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01014,950,732 - 14,958,986 (+)NCBIRnor_WKY
Rnor_5.01015,383,438 - 15,391,694 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,469,922 - 15,478,157 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,476,071 - 15,476,346 (+)NCBI
Celera1014,890,608 - 14,898,855 (+)NCBICelera
Cytogenetic Map10q12NCBI
RGS11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816268,307 - 275,944 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl16268,301 - 275,980 (-)EnsemblGRCh38hg38GRCh38
GRCh3716318,306 - 325,944 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616258,311 - 265,915 (-)NCBINCBI36Build 36hg18NCBI36
Build 3416258,310 - 265,915NCBI
Celera16518,212 - 525,816 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16236,516 - 243,705 (-)NCBIHuRef
CHM1_116318,250 - 325,856 (-)NCBICHM1_1
T2T-CHM13v2.016263,137 - 270,775 (-)NCBIT2T-CHM13v2.0
Rgs11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391726,421,500 - 26,430,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1726,421,925 - 26,430,298 (+)EnsemblGRCm39 Ensembl
GRCm381726,202,527 - 26,211,324 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1726,202,951 - 26,211,324 (+)EnsemblGRCm38mm10GRCm38
MGSCv371726,339,907 - 26,348,269 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,930,541 - 25,938,925 (+)NCBIMGSCv36mm8
Celera1726,736,772 - 26,745,093 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
Rgs11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,905,982 - 16,914,772 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,905,982 - 16,914,772 (+)NCBIChiLan1.0ChiLan1.0
RGS11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1164,279,752 - 4,286,846 (-)NCBINHGRI_mPanPan1
PanPan1.116259,143 - 266,526 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16259,143 - 266,520 (-)Ensemblpanpan1.1panPan2
RGS11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,225,910 - 40,233,942 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,225,506 - 40,233,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,489,642 - 41,497,658 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,568,394 - 40,576,437 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,568,469 - 40,576,429 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,256,636 - 40,264,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,217,686 - 40,225,659 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,696,163 - 40,704,193 (+)NCBIUU_Cfam_GSD_1.0
Rgs11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,541,691 - 112,549,960 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501641,391 - 651,098 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936501641,339 - 647,833 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,402,316 - 41,410,868 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,402,345 - 41,410,813 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,025,834 - 41,030,124 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGS11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15214,626 - 222,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5214,964 - 223,167 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606830,956,062 - 30,964,390 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,122,704 - 1,130,869 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,121,987 - 1,132,313 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rgs11
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:158
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000027763
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000100171
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1015,222,803 - 15,231,060 (+)Ensembl
RefSeq Acc Id: NM_019338   ⟹   NP_062211
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21015,222,803 - 15,231,060 (+)NCBI
Rnor_5.01015,383,438 - 15,391,694 (+)NCBI
Celera1014,890,608 - 14,898,855 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062211 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52375 (Get FASTA)   NCBI Sequence Viewer  
  P49807 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062211   ⟸   NM_019338
- Sequence:
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49807-F1-model_v2 AlphaFold P49807 1-66 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3563 AgrOrtholog
BioCyc Gene G2FUF-25722 BioCyc
Ensembl Genes ENSRNOG00000066310 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000100171 ENTREZGENE
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
InterPro RGS UniProtKB/Swiss-Prot
  RGS6/7/9/11 UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
NCBI Gene 54291 ENTREZGENE
PANTHER LP21163P UniProtKB/Swiss-Prot
  REGULATOR OF G-PROTEIN SIGNALING 11 UniProtKB/Swiss-Prot
Pfam RGS UniProtKB/Swiss-Prot
PhenoGen Rgs11 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
UniProt P49807 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-15 Rgs11  regulator of G-protein signaling 11  Rgs11_predicted  regulator of G-protein signaling 11 (predicted)  Data Merged 1643240 APPROVED
2005-01-12 Rgs11_predicted  regulator of G-protein signaling 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-06-10 Rgs11  regulator of G-protein signaling 11      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in specific regions of the brain 737641