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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3073
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc3a2
Name: solute carrier family 3 member 2
Acc ID: CHEBI:16283
Term: L-cystine
Definition: The L-enantiomer of the sulfur-containing amino acid cystine.
Chemical ID: MESH:D003553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc3a2multiple interactionsISORGD:7357166480464CTD[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of CystinePMID:22216172
Slc3a2multiple interactionsISORGD:7357176480464CTD[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]PMID:19576933
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