Fxr1 (FMR1 autosomal homolog 1) - Rat Genome Database

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Gene: Fxr1 (FMR1 autosomal homolog 1) Rattus norvegicus
Analyze
Symbol: Fxr1
Name: FMR1 autosomal homolog 1
RGD ID: 1311733
Description: Predicted to enable several functions, including RNA binding activity; molecular condensate scaffold activity; and protein dimerization activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; nucleus organization; and regulation of gene expression. Predicted to be located in several cellular components, including costamere; dendritic spine; and ribosome. Predicted to be active in several cellular components, including cytoplasmic stress granule; glutamatergic synapse; and nuclear envelope. Human ortholog(s) of this gene implicated in congenital myopathy 9A and congenital myopathy 9B. Orthologous to human FXR1 (FMR1 autosomal homolog 1); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fragile X mental retardation gene 1, autosomal homolog; fragile X mental retardation syndrome-related protein 1; fragile X mental retardation, autosomal homolog 1; Fxr1h; LOC100366044; LOC361927; rCG41429-like; RNA-binding protein FXR1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82118,812,287 - 118,865,813 (+)NCBIGRCr8
mRatBN7.22116,884,167 - 116,937,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2116,884,248 - 116,937,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2123,473,867 - 123,526,115 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02121,586,534 - 121,638,784 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02116,215,601 - 116,266,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02120,529,716 - 120,570,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2120,512,899 - 120,570,355 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02140,165,289 - 140,213,149 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42120,330,045 - 120,378,482 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12120,275,008 - 120,323,418 (+)NCBI
Celera2111,923,546 - 111,975,799 (+)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP,ISO)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
decabromodiphenyl ether  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
glafenine  (EXP)
glufosinate  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
paracetamol  (ISO)
phenethyl isothiocyanate  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7489725   PMID:11178106   PMID:12477932   PMID:15128702   PMID:15489334   PMID:15548538   PMID:17057366   PMID:17170008   PMID:19946888   PMID:22022532   PMID:22658674   PMID:22681889  
PMID:27770568   PMID:29101288   PMID:29476059   PMID:30361391   PMID:31831836   PMID:32333305  


Genomics

Comparative Map Data
Fxr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82118,812,287 - 118,865,813 (+)NCBIGRCr8
mRatBN7.22116,884,167 - 116,937,590 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2116,884,248 - 116,937,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2123,473,867 - 123,526,115 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02121,586,534 - 121,638,784 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02116,215,601 - 116,266,541 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02120,529,716 - 120,570,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2120,512,899 - 120,570,355 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02140,165,289 - 140,213,149 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42120,330,045 - 120,378,482 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12120,275,008 - 120,323,418 (+)NCBI
Celera2111,923,546 - 111,975,799 (+)NCBICelera
Cytogenetic Map2q24NCBI
FXR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383180,912,670 - 180,982,753 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3180,868,141 - 180,982,753 (+)EnsemblGRCh38hg38GRCh38
GRCh373180,630,458 - 180,700,541 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363182,113,146 - 182,177,644 (+)NCBINCBI36Build 36hg18NCBI36
Build 343182,113,163 - 182,177,036NCBI
Celera3179,062,664 - 179,132,978 (+)NCBICelera
Cytogenetic Map3q26.33NCBI
HuRef3178,034,321 - 178,104,537 (+)NCBIHuRef
CHM1_13180,593,505 - 180,663,825 (+)NCBICHM1_1
T2T-CHM13v2.03183,714,436 - 183,784,535 (+)NCBIT2T-CHM13v2.0
Fxr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39334,074,133 - 34,124,129 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl334,074,092 - 34,124,471 (+)EnsemblGRCm39 Ensembl
GRCm38334,020,058 - 34,069,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl334,019,943 - 34,070,322 (+)EnsemblGRCm38mm10GRCm38
MGSCv37333,919,001 - 33,968,267 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36334,211,657 - 34,260,887 (+)NCBIMGSCv36mm8
Celera333,916,172 - 33,965,473 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map316.41NCBI
Fxr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554209,903,736 - 9,966,100 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554209,903,736 - 9,966,100 (+)NCBIChiLan1.0ChiLan1.0
FXR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22178,783,206 - 178,848,482 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13178,787,916 - 178,853,817 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03177,948,040 - 178,012,705 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13186,119,331 - 186,187,126 (+)NCBIpanpan1.1PanPan1.1panPan2
FXR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13414,129,978 - 14,192,016 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3414,130,017 - 14,191,370 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3418,212,277 - 18,274,019 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03414,031,339 - 14,093,392 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3414,031,378 - 14,093,391 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13414,077,460 - 14,139,011 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03414,059,493 - 14,121,524 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03414,303,530 - 14,365,583 (+)NCBIUU_Cfam_GSD_1.0
Fxr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602110,795,745 - 110,866,441 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365662,354,441 - 2,425,176 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365662,354,301 - 2,425,140 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FXR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13118,839,338 - 118,900,136 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113118,839,314 - 118,899,804 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213128,089,495 - 128,175,102 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FXR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,420,789 - 8,486,681 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,421,654 - 8,486,384 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606317,252,536 - 17,318,234 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fxr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473058,680,030 - 58,743,229 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473058,679,945 - 58,743,688 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fxr1
116 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000074060
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527143657569Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527143657569Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2112103657148076632Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat

Markers in Region
RH123299  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02140,184,741 - 140,185,213NCBIRnor5.0
RGSC_v3.42120,358,866 - 120,359,337UniSTSRGSC3.4
Celera2111,952,036 - 111,952,507UniSTS
Cytogenetic Map2q25UniSTS
RH132222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22116,932,491 - 116,932,685 (-)MAPPERmRatBN7.2
Rnor_6.02120,516,718 - 120,516,911NCBIRnor6.0
Rnor_5.02140,162,560 - 140,162,753UniSTSRnor5.0
RGSC_v3.42120,379,472 - 120,379,665UniSTSRGSC3.4
Celera2111,971,786 - 111,971,979UniSTS
RH 3.4 Map2683.6UniSTS
Cytogenetic Map2q25UniSTS
X90875  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02140,158,874 - 140,159,032UniSTSRnor5.0
Rnor_5.02140,165,423 - 140,165,581UniSTSRnor5.0
Celera2111,975,507 - 111,975,665UniSTS
Cytogenetic Map2q25UniSTS
RH139070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22116,924,570 - 116,924,704 (-)MAPPERmRatBN7.2
Rnor_6.02120,530,350 - 120,530,483NCBIRnor6.0
Rnor_5.02140,173,143 - 140,173,276UniSTSRnor5.0
Celera2111,963,863 - 111,963,996UniSTS
RH 3.4 Map2684.9UniSTS
Cytogenetic Map2q25UniSTS
BI274570  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22116,935,372 - 116,936,240 (-)MAPPERmRatBN7.2
Rnor_6.02120,519,947 - 120,520,151NCBIRnor6.0
Rnor_6.02120,513,163 - 120,514,030NCBIRnor6.0
Rnor_5.02140,159,005 - 140,159,872UniSTSRnor5.0
Rnor_5.02140,165,554 - 140,165,758UniSTSRnor5.0
Celera2111,974,667 - 111,975,534UniSTS
RH 3.4 Map116.7UniSTS
Cytogenetic Map2q25UniSTS
BI281166  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02120,520,007 - 120,520,204NCBIRnor6.0
Rnor_5.02140,165,614 - 140,165,811UniSTSRnor5.0
RH 3.4 Map116.7UniSTS
Cytogenetic Map2q25UniSTS
UniSTS:479111  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02120,520,193 - 120,520,822NCBIRnor6.0
Rnor_5.02140,165,800 - 140,166,429UniSTSRnor5.0
Cytogenetic Map2q25UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC083807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC099129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG938503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000088442   ⟹   ENSRNOP00000069834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,884,257 - 116,936,504 (+)Ensembl
Rnor_6.0 Ensembl2120,512,899 - 120,570,355 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101775   ⟹   ENSRNOP00000084548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,884,248 - 116,937,590 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102612   ⟹   ENSRNOP00000095711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,884,251 - 116,936,347 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103508   ⟹   ENSRNOP00000081168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,884,248 - 116,937,590 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117973   ⟹   ENSRNOP00000084892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2116,905,868 - 116,932,847 (+)Ensembl
RefSeq Acc Id: NM_001012179   ⟹   NP_001012179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
Rnor_6.02120,529,716 - 120,570,356 (-)NCBI
Rnor_5.02140,165,289 - 140,213,149 (-)NCBI
RGSC_v3.42120,330,045 - 120,378,482 (+)RGD
Celera2111,923,546 - 111,975,799 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001415068   ⟹   NP_001401997
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
RefSeq Acc Id: NM_001415069   ⟹   NP_001401998
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
RefSeq Acc Id: NM_001415070   ⟹   NP_001401999
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
RefSeq Acc Id: NM_001415071   ⟹   NP_001402000
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,479 - 118,865,813 (+)NCBI
mRatBN7.22116,884,250 - 116,937,590 (+)NCBI
RefSeq Acc Id: XM_039102584   ⟹   XP_038958512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,320 - 118,865,353 (+)NCBI
mRatBN7.22116,884,167 - 116,937,586 (+)NCBI
RefSeq Acc Id: XM_063282053   ⟹   XP_063138123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,813,263 - 118,865,353 (+)NCBI
RefSeq Acc Id: XM_063282054   ⟹   XP_063138124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,287 - 118,865,353 (+)NCBI
RefSeq Acc Id: XM_063282055   ⟹   XP_063138125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,813,263 - 118,865,353 (+)NCBI
RefSeq Acc Id: XM_063282057   ⟹   XP_063138127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,842,850 - 118,865,353 (+)NCBI
RefSeq Acc Id: XM_063282058   ⟹   XP_063138128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,320 - 118,848,436 (+)NCBI
RefSeq Acc Id: XM_063282059   ⟹   XP_063138129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82118,812,320 - 118,848,492 (+)NCBI
RefSeq Acc Id: NP_001012179   ⟸   NM_001012179
- Peptide Label: isoform 4
- UniProtKB: Q5XI81 (UniProtKB/Swiss-Prot),   A0A3G2LW22 (UniProtKB/TrEMBL),   A0A0G2JWD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069834   ⟸   ENSRNOT00000088442
RefSeq Acc Id: XP_038958512   ⟸   XM_039102584
- Peptide Label: isoform X2
- UniProtKB: Q5XI81 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000084892   ⟸   ENSRNOT00000117973
RefSeq Acc Id: ENSRNOP00000081168   ⟸   ENSRNOT00000103508
RefSeq Acc Id: ENSRNOP00000084548   ⟸   ENSRNOT00000101775
RefSeq Acc Id: ENSRNOP00000095711   ⟸   ENSRNOT00000102612
RefSeq Acc Id: NP_001401997   ⟸   NM_001415068
- Peptide Label: isoform 1
- UniProtKB: Q5XI81 (UniProtKB/Swiss-Prot),   A0A8I6AM03 (UniProtKB/TrEMBL),   A6IHT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001401998   ⟸   NM_001415069
- Peptide Label: isoform 2
- UniProtKB: Q5XI81 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001401999   ⟸   NM_001415070
- Peptide Label: isoform 3
- UniProtKB: Q5XI81 (UniProtKB/Swiss-Prot),   A0A8I5ZRV6 (UniProtKB/TrEMBL),   A6IHT3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402000   ⟸   NM_001415071
- Peptide Label: isoform 5
- UniProtKB: Q5XI81 (UniProtKB/Swiss-Prot),   A6IHT4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138124   ⟸   XM_063282054
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063138129   ⟸   XM_063282059
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063138128   ⟸   XM_063282058
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063138123   ⟸   XM_063282053
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063138125   ⟸   XM_063282055
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063138127   ⟸   XM_063282057
- Peptide Label: isoform X5
Protein Domains
Agenet-like   KH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XI81-F1-model_v2 AlphaFold Q5XI81 1-568 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311733 AgrOrtholog
BioCyc Gene G2FUF-53396 BioCyc
Ensembl Genes ENSRNOG00000051480 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088442 ENTREZGENE
  ENSRNOT00000088442.2 UniProtKB/TrEMBL
  ENSRNOT00000101775.1 UniProtKB/TrEMBL
  ENSRNOT00000102612 ENTREZGENE
  ENSRNOT00000102612.1 UniProtKB/TrEMBL
  ENSRNOT00000103508 ENTREZGENE
  ENSRNOT00000103508.1 UniProtKB/TrEMBL
  ENSRNOT00000117973.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109902 IMAGE-MGC_LOAD
InterPro Agenet-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMRP_KH0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXMRP1_C_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXR_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXR_C3 UniProtKB/TrEMBL
  KH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_I_FXR1_rpt1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_I_FXR1_rpt2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_I_FXR1_rpt3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_Agenet_FXR1_rpt1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_Agenet_FXR1_rpt2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_FRX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94858 IMAGE-MGC_LOAD
NCBI Gene 361927 ENTREZGENE
PANTHER FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10603 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Agenet UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXMRP1_C_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXR_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXR_C3 UniProtKB/TrEMBL
  KH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor_FRX1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fxr1 PhenoGen
PROSITE AGENET_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_TYPE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051480 RatGTEx
SMART SM00322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWD2 ENTREZGENE, UniProtKB/TrEMBL
  A0A3G2LW22 ENTREZGENE
  A0A8I5ZRV6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A275_RAT UniProtKB/TrEMBL
  A0A8I6AM03 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBZ3_RAT UniProtKB/TrEMBL
  A6IHT2 ENTREZGENE, UniProtKB/TrEMBL
  A6IHT3 ENTREZGENE, UniProtKB/TrEMBL
  A6IHT4 ENTREZGENE, UniProtKB/TrEMBL
  FXR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A3G2LW22 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fxr1  FMR1 autosomal homolog 1  LOC100366044  rCG41429-like  Data merged from RGD:2324412 737654 PROVISIONAL
2016-02-24 Fxr1  FMR1 autosomal homolog 1  Fxr1  fragile X mental retardation, autosomal homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-09 Fxr1  fragile X mental retardation, autosomal homolog 1  Fxr1  fragile X mental retardation gene 1, autosomal homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-17 Fxr1  fragile X mental retardation gene 1, autosomal homolog  Fxr1  fragile X mental retardation, autosomal homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100366044  rCG41429-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Fxr1  fragile X mental retardation, autosomal homolog 1  Fxr1h  fragile X mental retardation gene 1, autosomal homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Fxr1h  fragile X mental retardation gene 1, autosomal homolog  Fxr1h_predicted  fragile X mental retardation gene 1, autosomal homolog (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fxr1h_predicted  fragile X mental retardation gene 1, autosomal homolog (predicted)      Symbol and Name status set to approved 70820 APPROVED