Brca2 (BRCA2, DNA repair associated)

Gene: Brca2 (BRCA2, DNA repair associated) Rattus norvegicus

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Symbol:

Brca2

Name:

BRCA2, DNA repair associated

Description:

Exhibits single-stranded DNA binding activity. Involved in several processes, including homologous chromosome orientation involved in meiotic metaphase I plate congression; response to estradiol; and spermatogenesis. Predicted to localize to several cellular components, including BRCA2-MAGE-D1 complex; centrosome; and nuclear lumen. Used to study cataract; infertility; and osteosarcoma. Biomarker of prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain cancer (multiple); hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ceramide signaling pathway; pancreatic cancer pathway; INTERACTS WITH acetamide; aflatoxin B1; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

breast cancer 2; breast cancer 2, early onset; breast cancer 2, mutation 1, University of Wisconsin-Madison; breast cancer susceptibility protein 2; breast cancer type 2 susceptibility protein homolog; fanconi anemia group D1 protein homolog

Orthologs:

Homo sapiens (human) : BRCA2 (BRCA2 DNA repair associated) HGNC Alliance
Mus musculus (house mouse) : Brca2 (breast cancer 2, early onset) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Brca2 (BRCA2 DNA repair associated)
Pan paniscus (bonobo/pygmy chimpanzee) : BRCA2 (BRCA2 DNA repair associated)
Canis lupus familiaris (dog) : BRCA2 (BRCA2 DNA repair associated)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Brca2 (BRCA2 DNA repair associated)
Sus scrofa (pig) : BRCA2 (BRCA2 DNA repair associated)
Chlorocebus sabaeus (African green monkey) : BRCA2 (BRCA2 DNA repair associated)
Heterocephalus glaber (naked mole-rat) : Brca2 (BRCA2 DNA repair associated)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BRCA2 (BRCA2 DNA repair associated)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Brca2 (breast cancer 2, early onset)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Brca2 (BRCA2 DNA repair associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BRCA2 (BRCA2 DNA repair associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BRCA2 (BRCA2 DNA repair associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Brca2 (BRCA2 DNA repair associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BRCA2 (BRCA2 DNA repair associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	BRCA2 (BRCA2 DNA repair associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Brca2 (BRCA2 DNA repair associated)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Brca2 (breast cancer 2, early onset)	Alliance	DIOPT (PANTHER\|PhylomeDB\|OrthoFinder\|InParanoid\|OrthoInspector\|Hieranoid\|TreeFam)
Homo sapiens (human):	BRCA2 (BRCA2 DNA repair associated)	Alliance	DIOPT (PANTHER\|HGNC\|PhylomeDB\|OrthoFinder\|InParanoid\|OrthoInspector\|Hieranoid\|TreeFam)
Danio rerio (zebrafish):	brca2 (BRCA2 DNA repair associated)	Alliance	DIOPT (PANTHER\|OrthoInspector\|OrthoFinder\|Hieranoid)

Allele / Splice:

Brca2^m1Uwm

Genetic Models:

SD-Brca2^m1Uwm

Is Marker For:

Strains: SD SD-Brca2^m1Uwm

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	12	503,660 - 544,754 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	504,007 - 544,748 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	490,733 - 535,090 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	4,282,952 - 4,323,693 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	12	4,282,951 - 4,323,693	NCBI
Celera	12	1,769,467 - 1,810,212 (+)	NCBI		Celera
Cytogenetic Map	12	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation (Toggle Annotation Detail/Summary View)

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - ClinVar