Brca2 (BRCA2, DNA repair associated) - Rat Genome Database

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Gene: Brca2 (BRCA2, DNA repair associated) Rattus norvegicus
Symbol: Brca2
Name: BRCA2, DNA repair associated
RGD ID: 2219
Description: Enables single-stranded DNA binding activity. Involved in several processes, including homologous chromosome orientation involved in meiotic metaphase I plate congression; response to estradiol; and spermatogenesis. Predicted to be located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear lumen. Predicted to be part of BRCA2-MAGE-D1 complex; DNA repair complex; and nuclear ubiquitin ligase complex. Predicted to be active in nucleus. Used to study atrophy of testis; cancer; cataract; infertility; and osteosarcoma. Biomarker of ductal carcinoma in situ and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain cancer (multiple); hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ceramide signaling pathway; pancreatic cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: breast cancer 2; breast cancer 2, early onset; breast cancer 2, mutation 1, University of Wisconsin-Madison; breast cancer susceptibility protein 2; breast cancer type 2 susceptibility protein homolog; fanconi anemia group D1 protein homolog
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Brca2m1Uwm  
Genetic Models: SD-Brca2m1Uwm
Is Marker For: Strains:   SD  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21259,492 - 103,789 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1259,819 - 100,567 (+)Ensembl
Rnor_6.012503,660 - 544,754 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12504,007 - 544,748 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.012490,733 - 535,090 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4124,282,952 - 4,323,693 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1124,282,951 - 4,323,693NCBI
Celera121,769,467 - 1,810,212 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)