Tpm4 (tropomyosin 4) - Rat Genome Database

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Gene: Tpm4 (tropomyosin 4) Rattus norvegicus
Analyze
Symbol: Tpm4
Name: tropomyosin 4
RGD ID: 3899
Description: Enables actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and platelet formation. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human TPM4 (tropomyosin 4); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: TM-4; Tpm4.2; Tpm4.2cy; Tropomycin 4; tropomyosin alpha-4 chain; tropomyosin-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,718,442 - 17,732,483 (-)NCBIGRCr8
mRatBN7.21617,684,415 - 17,698,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,683,195 - 17,705,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,743,321 - 17,757,333 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,875,963 - 18,889,968 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,796,254 - 17,810,266 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,385,810 - 19,399,851 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,385,736 - 19,399,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,244,141 - 19,258,182 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,108,914 - 18,122,956 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,108,911 - 18,122,954 (-)NCBI
Celera1617,899,051 - 17,913,092 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bleomycin A5  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
fenamidone  (ISO)
fenoldopam  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
indometacin  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
leflunomide  (EXP,ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
microcystin RR  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
ochratoxin A  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
PCB138  (ISO)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly. Gimona M, etal., Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9776-80.
3. Structure and complete nucleotide sequence of the gene encoding rat fibroblast tropomyosin 4. Lees-Miller JP, etal., J Mol Biol 1990 Jun 5;213(3):399-405.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9. Isolation and characterization of cDNA clones encoding a low molecular weight nonmuscle tropomyosin isoform. Yamawaki-Kataoka Y and Helfman DM, J Biol Chem 1987 Aug 5;262(22):10791-800.
Additional References at PubMed
PMID:16210410   PMID:16236705   PMID:16765662   PMID:20458337   PMID:21423176   PMID:24625528   PMID:25002582   PMID:25369766   PMID:28259758   PMID:29476059   PMID:30361391   PMID:35352799  


Genomics

Comparative Map Data
Tpm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81617,718,442 - 17,732,483 (-)NCBIGRCr8
mRatBN7.21617,684,415 - 17,698,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,683,195 - 17,705,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,743,321 - 17,757,333 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,875,963 - 18,889,968 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,796,254 - 17,810,266 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,385,810 - 19,399,851 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,385,736 - 19,399,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,244,141 - 19,258,182 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,108,914 - 18,122,956 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11618,108,911 - 18,122,954 (-)NCBI
Celera1617,899,051 - 17,913,092 (-)NCBICelera
Cytogenetic Map16p14NCBI
TPM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381916,067,538 - 16,103,002 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1916,067,021 - 16,103,002 (+)EnsemblGRCh38hg38GRCh38
GRCh371916,178,348 - 16,213,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,048,325 - 16,074,408 (+)NCBINCBI36Build 36hg18NCBI36
Build 341916,048,324 - 16,074,408NCBI
Celera1916,080,322 - 16,115,740 (+)NCBICelera
Cytogenetic Map19p13.12-p13.11NCBI
HuRef1915,749,181 - 15,784,766 (+)NCBIHuRef
CHM1_11916,177,722 - 16,213,291 (+)NCBICHM1_1
T2T-CHM13v2.01916,201,542 - 16,237,074 (+)NCBIT2T-CHM13v2.0
Tpm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,889,132 - 72,906,986 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl872,884,018 - 72,906,986 (+)EnsemblGRCm39 Ensembl
GRCm38872,135,288 - 72,153,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,130,174 - 72,153,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,659,191 - 74,677,028 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36875,064,281 - 75,082,118 (+)NCBIMGSCv36mm8
Celera876,490,967 - 76,508,585 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.81NCBI
Tpm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555241,415,848 - 1,432,139 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555241,419,061 - 1,432,114 (-)NCBIChiLan1.0ChiLan1.0
TPM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22020,938,579 - 20,975,280 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11919,945,282 - 19,981,066 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01915,557,683 - 15,593,143 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11916,540,805 - 16,575,675 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1916,540,805 - 16,575,312 (+)Ensemblpanpan1.1panPan2
TPM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12046,354,808 - 46,376,489 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2046,355,736 - 46,376,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,269,322 - 46,291,014 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02046,844,446 - 46,864,961 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2046,821,781 - 46,864,926 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12046,077,842 - 46,099,527 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02046,489,401 - 46,511,083 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02046,765,733 - 46,787,433 (-)NCBIUU_Cfam_GSD_1.0
Tpm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118204,857,159 - 204,874,401 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365964,406,283 - 4,418,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365964,406,301 - 4,423,775 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,453,725 - 61,476,781 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,453,721 - 61,476,781 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,150,543 - 61,173,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q24-q29NCBI
TPM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,566,958 - 14,604,754 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl614,566,869 - 14,598,934 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660744,891,204 - 4,926,682 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,132,215 - 1,152,319 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,135,240 - 1,155,175 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpm4
127 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:63
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000021073
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
D16Mgh4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,696,791 - 17,696,911 (+)MAPPERmRatBN7.2
Rnor_6.01619,398,187 - 19,398,306NCBIRnor6.0
Rnor_5.01619,256,518 - 19,256,637UniSTSRnor5.0
RGSC_v3.41618,121,291 - 18,121,411RGDRGSC3.4
RGSC_v3.41618,121,292 - 18,121,411UniSTSRGSC3.4
RGSC_v3.11618,121,289 - 18,121,409RGD
Celera1617,911,428 - 17,911,547UniSTS
RH 3.4 Map16213.1UniSTS
RH 3.4 Map16213.1RGD
RH 2.0 Map16200.5RGD
FHH x ACI Map1612.2099RGD
Cytogenetic Map16p14UniSTS
D16Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,696,777 - 17,696,890 (+)MAPPERmRatBN7.2
Rnor_6.01619,398,173 - 19,398,285NCBIRnor6.0
Rnor_5.01619,256,504 - 19,256,616UniSTSRnor5.0
RGSC_v3.41618,121,277 - 18,121,390RGDRGSC3.4
RGSC_v3.41618,121,278 - 18,121,390UniSTSRGSC3.4
RGSC_v3.11618,121,275 - 18,121,388RGD
Celera1617,911,414 - 17,911,526UniSTS
Cytogenetic Map16p14UniSTS
D16Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,696,785 - 17,696,947 (+)MAPPERmRatBN7.2
Rnor_6.01619,398,181 - 19,398,342NCBIRnor6.0
Rnor_5.01619,256,512 - 19,256,673UniSTSRnor5.0
RGSC_v3.41618,121,285 - 18,121,447RGDRGSC3.4
RGSC_v3.41618,121,286 - 18,121,447UniSTSRGSC3.4
RGSC_v3.11618,121,283 - 18,121,445RGD
Celera1617,911,422 - 17,911,583UniSTS
RH 3.4 Map16180.5UniSTS
RH 3.4 Map16180.5RGD
RH 2.0 Map16164.4RGD
Cytogenetic Map16p14UniSTS
D16Arb9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,690,039 - 17,690,257 (+)MAPPERmRatBN7.2
Rnor_6.01619,391,435 - 19,391,652NCBIRnor6.0
Rnor_5.01619,249,766 - 19,249,983UniSTSRnor5.0
RGSC_v3.41618,114,538 - 18,114,756RGDRGSC3.4
RGSC_v3.41618,114,539 - 18,114,756UniSTSRGSC3.4
RGSC_v3.11618,114,536 - 18,114,754RGD
Celera1617,904,676 - 17,904,893UniSTS
SHRSP x BN Map165.71UniSTS
SHRSP x BN Map165.71RGD
FHH x ACI Map1612.1799RGD
Cytogenetic Map16p14UniSTS
D16Arb10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,696,780 - 17,696,886 (+)MAPPERmRatBN7.2
Rnor_6.01619,398,176 - 19,398,281NCBIRnor6.0
Rnor_5.01619,256,507 - 19,256,612UniSTSRnor5.0
RGSC_v3.41618,121,280 - 18,121,386RGDRGSC3.4
RGSC_v3.41618,121,281 - 18,121,386UniSTSRGSC3.4
RGSC_v3.11618,121,278 - 18,121,384RGD
Celera1617,911,417 - 17,911,522UniSTS
Cytogenetic Map16p14UniSTS
RH143324  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,697,615 - 17,697,822 (+)MAPPERmRatBN7.2
Rnor_6.01619,399,011 - 19,399,217NCBIRnor6.0
Rnor_5.01619,257,342 - 19,257,548UniSTSRnor5.0
RGSC_v3.41618,122,116 - 18,122,322UniSTSRGSC3.4
Celera1617,912,252 - 17,912,458UniSTS
RH 3.4 Map16178.6UniSTS
Cytogenetic Map16p14UniSTS
RH140074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,683,579 - 17,683,784 (+)MAPPERmRatBN7.2
Rnor_6.01619,384,975 - 19,385,179NCBIRnor6.0
Rnor_5.01619,243,306 - 19,243,510UniSTSRnor5.0
RGSC_v3.41618,108,079 - 18,108,283UniSTSRGSC3.4
Celera1617,898,216 - 17,898,420UniSTS
RH 3.4 Map16180.0UniSTS
Cytogenetic Map16p14UniSTS
GDB:434012  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,690,829 - 17,690,976 (+)MAPPERmRatBN7.2
mRatBN7.21062,628,003 - 62,628,052 (-)MAPPERmRatBN7.2
mRatBN7.21062,628,049 - 62,628,128 (-)MAPPERmRatBN7.2
Rnor_6.01065,106,752 - 65,106,879NCBIRnor6.0
Rnor_6.01619,392,225 - 19,392,371NCBIRnor6.0
Rnor_5.01619,250,556 - 19,250,702UniSTSRnor5.0
Rnor_5.01066,519,401 - 66,519,528UniSTSRnor5.0
RGSC_v3.41618,115,329 - 18,115,475UniSTSRGSC3.4
Celera1617,905,466 - 17,905,612UniSTS
Cytogenetic Map16p14UniSTS
TM4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21617,690,482 - 17,690,548 (+)MAPPERmRatBN7.2
Rnor_6.01619,391,878 - 19,391,943NCBIRnor6.0
Rnor_5.01619,250,209 - 19,250,274UniSTSRnor5.0
RGSC_v3.41618,114,982 - 18,115,047UniSTSRGSC3.4
Celera1617,905,119 - 17,905,184UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000021073   ⟹   ENSRNOP00000021073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,684,091 - 17,705,984 (-)Ensembl
Rnor_6.0 Ensembl1619,385,736 - 19,399,903 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089056   ⟹   ENSRNOP00000072238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,683,195 - 17,698,449 (-)Ensembl
Rnor_6.0 Ensembl1619,389,652 - 19,399,851 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115801   ⟹   ENSRNOP00000095693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,683,195 - 17,698,522 (-)Ensembl
RefSeq Acc Id: NM_012678   ⟹   NP_036810
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81617,718,442 - 17,732,483 (-)NCBI
mRatBN7.21617,684,415 - 17,698,456 (-)NCBI
Rnor_6.01619,385,810 - 19,399,851 (-)NCBI
Rnor_5.01619,244,141 - 19,258,182 (-)NCBI
RGSC_v3.41618,108,914 - 18,122,956 (-)RGD
Celera1617,899,051 - 17,913,092 (-)RGD
Sequence:
RefSeq Acc Id: NP_036810   ⟸   NM_012678
- UniProtKB: P09495 (UniProtKB/Swiss-Prot),   A6K9Q7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072238   ⟸   ENSRNOT00000089056
Ensembl Acc Id: ENSRNOP00000021073   ⟸   ENSRNOT00000021073
Ensembl Acc Id: ENSRNOP00000095693   ⟸   ENSRNOT00000115801

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09495-F1-model_v2 AlphaFold P09495 1-248 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699999
Promoter ID:EPDNEW_R10513
Type:initiation region
Name:Tpm4_1
Description:tropomyosin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,399,862 - 19,399,922EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3899 AgrOrtholog
BioCyc Gene G2FUF-11873 BioCyc
Ensembl Genes ENSRNOG00000015496 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010361 UniProtKB/Swiss-Prot
  ENSRNOG00060010959 UniProtKB/Swiss-Prot
  ENSRNOG00065021866 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021073.6 UniProtKB/TrEMBL
  ENSRNOT00000089056 UniProtKB/TrEMBL
  ENSRNOT00000089056.2 UniProtKB/Swiss-Prot
  ENSRNOT00000115801.1 UniProtKB/TrEMBL
  ENSRNOT00055017537 UniProtKB/Swiss-Prot
  ENSRNOT00060018545 UniProtKB/Swiss-Prot
  ENSRNOT00065037231 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.5.370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XRCC4-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24852 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24852 ENTREZGENE
PANTHER TROPOMYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TROPOMYOSIN ALPHA-4 CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tpm4 PhenoGen
PRINTS TROPOMYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TROPOMYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015496 RatGTEx
  ENSRNOG00055010361 RatGTEx
  ENSRNOG00060010959 RatGTEx
  ENSRNOG00065021866 RatGTEx
Superfamily-SCOP Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229658
UniProt A0A0G2K2G8_RAT UniProtKB/TrEMBL
  A0A8I6ATZ5_RAT UniProtKB/TrEMBL
  A0A8L2QBT8_RAT UniProtKB/TrEMBL
  A6K9Q7 ENTREZGENE, UniProtKB/TrEMBL
  P09495 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tpm4  Tropomycin 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology aa sequence contains 98% identity with equine platelet TM 730104
gene_protein protein contains 248 aa residues 729954
gene_transcript sequence contains 8 exons spanning approximately 16 kb 729954