Tpm4 (tropomyosin 4) - Rat Genome Database
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Gene: Tpm4 (tropomyosin 4) Mus musculus
Analyze
Symbol: Tpm4
Name: tropomyosin 4
RGD ID: 736666
MGI Page MGI
Description: Orthologous to human TPM4 (tropomyosin 4); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610528G24Rik; RIKEN cDNA 2610528G24 gene; Tpm4.2; Tpm4.2cy; tropomyosin alpha-4 chain; tropomyosin-4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm15693   Gm7809   Tpm4-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,889,132 - 72,906,986 (+)NCBIGRCm39mm39
GRCm39 Ensembl872,884,018 - 72,906,986 (+)Ensembl
GRCm38872,135,288 - 72,153,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,130,174 - 72,153,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,659,191 - 74,677,028 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,064,281 - 75,082,118 (+)NCBImm8
Celera876,490,967 - 76,508,585 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bleomycin A5  (ISO)
buspirone  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP,ISO)
choline  (EXP)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (EXP)
diuron  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
fenamidone  (EXP)
fenoldopam  (ISO)
folic acid  (EXP)
geldanamycin  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
indometacin  (ISO)
ketamine  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
methylmercury chloride  (ISO)
microcystin RR  (ISO)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
PCB138  (EXP)
phenethyl isothiocyanate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rimonabant  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
torcetrapib  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16236705   PMID:16765662   PMID:17968984   PMID:18036591   PMID:18270576   PMID:18799693   PMID:19118250   PMID:21677750   PMID:21873635   PMID:24457600   PMID:24614889  
PMID:25369766   PMID:26496610   PMID:28134622   PMID:30196744   PMID:31189591   PMID:32325033  


Genomics

Comparative Map Data
Tpm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,889,132 - 72,906,986 (+)NCBIGRCm39mm39
GRCm39 Ensembl872,884,018 - 72,906,986 (+)Ensembl
GRCm38872,135,288 - 72,153,142 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,130,174 - 72,153,142 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,659,191 - 74,677,028 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,064,281 - 75,082,118 (+)NCBImm8
Celera876,490,967 - 76,508,585 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
TPM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1916,067,021 - 16,103,002 (+)EnsemblGRCh38hg38GRCh38
GRCh381916,067,507 - 16,103,005 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371916,178,348 - 16,213,812 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,048,325 - 16,074,408 (+)NCBINCBI36hg18NCBI36
Build 341916,048,324 - 16,074,408NCBI
Celera1916,080,322 - 16,115,740 (+)NCBI
Cytogenetic Map19p13.12-p13.11NCBI
HuRef1915,749,181 - 15,784,766 (+)NCBIHuRef
CHM1_11916,177,722 - 16,213,291 (+)NCBICHM1_1
Tpm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21617,684,415 - 17,698,456 (-)NCBI
Rnor_6.0 Ensembl1619,385,736 - 19,399,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01619,385,810 - 19,399,851 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01619,244,141 - 19,258,182 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,108,914 - 18,122,956 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,108,911 - 18,122,954 (-)NCBI
Celera1617,899,051 - 17,913,092 (-)NCBICelera
Cytogenetic Map16p14NCBI
Tpm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555241,415,848 - 1,432,139 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555241,419,061 - 1,432,114 (-)NCBIChiLan1.0ChiLan1.0
TPM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11916,540,805 - 16,575,675 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1916,540,805 - 16,575,312 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01915,557,683 - 15,593,143 (+)NCBIMhudiblu_PPA_v0panPan3
TPM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2046,355,736 - 46,376,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12046,354,808 - 46,376,489 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tpm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365964,406,301 - 4,423,775 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,453,721 - 61,476,781 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,453,721 - 61,476,781 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,150,543 - 61,173,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q24-q29NCBI
TPM4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,566,958 - 14,604,754 (+)NCBI
ChlSab1.1 Ensembl614,566,869 - 14,598,934 (+)Ensembl
Tpm4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,135,240 - 1,155,175 (-)NCBI

Position Markers
RH126520  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8B3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:619
Count of miRNA genes:421
Interacting mature miRNAs:490
Transcripts:ENSMUST00000003575, ENSMUST00000123177
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001001491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC158898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY230591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000003575   ⟹   ENSMUSP00000003575
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,135,229 - 72,153,142 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123177
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,130,174 - 72,152,768 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238492   ⟹   ENSMUSP00000158818
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,135,808 - 72,153,140 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238752
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,135,258 - 72,137,320 (+)Ensembl
RefSeq Acc Id: NM_001001491   ⟹   NP_001001491
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,889,132 - 72,906,986 (+)NCBI
GRCm38872,135,288 - 72,153,142 (+)NCBI
MGSCv37874,659,191 - 74,677,028 (+)RGD
Celera876,490,967 - 76,508,585 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001001491 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH23701 (Get FASTA)   NCBI Sequence Viewer  
  AAH23827 (Get FASTA)   NCBI Sequence Viewer  
  AAH70421 (Get FASTA)   NCBI Sequence Viewer  
  EDL10782 (Get FASTA)   NCBI Sequence Viewer  
  Q6IRU2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001001491   ⟸   NM_001001491
- UniProtKB: Q6IRU2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000158818   ⟸   ENSMUST00000238492
RefSeq Acc Id: ENSMUSP00000003575   ⟸   ENSMUST00000003575

Promoters
RGD ID:8667449
Promoter ID:EPDNEW_M11756
Type:initiation region
Name:Tpm4_1
Description:Mus musculus tropomyosin 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38872,135,288 - 72,135,348EPDNEW
RGD ID:6843831
Promoter ID:MM_KWN:54854
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000054010,   OTTMUST00000054011
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,658,801 - 74,659,352 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2449202 AgrOrtholog
Ensembl Genes ENSMUSG00000031799 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000003575 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000158818 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000003575 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000238492 UniProtKB/TrEMBL
InterPro Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:326618 UniProtKB/Swiss-Prot
MGD MGI:2449202 ENTREZGENE
NCBI Gene 326618 ENTREZGENE
Pfam Tropomyosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tpm4 PhenoGen
PRINTS TROPOMYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TROPOMYOSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A571BEU1_MOUSE UniProtKB/TrEMBL
  Q6IRU2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Tpm4  tropomyosin 4  2610528G24Rik  RIKEN cDNA 2610528G24 gene  Data Merged 737654 PROVISIONAL