 Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | RGD:3899 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TPM4 mRNA] | CTD | PMID:31150632 | 1,1-dichloroethene | increases expression | EXP | | 6480464 | vinylidene chloride results in increased expression of TPM4 mRNA | CTD | PMID:26682919 | 1-naphthyl isothiocyanate | increases expression | ISO | RGD:3899 | 6480464 | 1-Naphthylisothiocyanate results in increased expression of TPM4 mRNA | CTD | PMID:25380136 | 17beta-estradiol | increases expression | ISO | RGD:736665 | 6480464 | Estradiol results in increased expression of TPM4 mRNA | CTD | PMID:20106945 | 17beta-estradiol | multiple interactions | ISO | RGD:736665 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of TPM4 mRNA | CTD | PMID:30165855 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:3899 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TPM4 protein | CTD | PMID:16548065 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TPM4 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:3899 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TPM4 protein | CTD | PMID:19201780 | 2,4-dinitrotoluene | affects expression | ISO | RGD:3899 | 6480464 | 2, 4-dinitrotoluene affects the expression of TPM4 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | RGD:736665 | 6480464 | beta-methylcholine affects the expression of TPM4 mRNA | CTD | PMID:21179406 | 3-chloropropane-1,2-diol | decreases expression | ISO | RGD:3899 | 6480464 | alpha-Chlorohydrin results in decreased expression of TPM4 protein | CTD | PMID:26597043 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:736665 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TPM4 mRNA more ... | CTD | PMID:28628672 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:3899 | 6480464 | 4, 4'-diaminodiphenylmethane results in increased expression of TPM4 mRNA | CTD | PMID:25380136 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | RGD:736665 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TPM4 mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of TPM4 mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | decreases expression | ISO | RGD:736665 | 6480464 | Decitabine results in decreased expression of TPM4 protein | CTD | PMID:19294695 | aflatoxin B1 | increases expression | ISO | RGD:736665 | 6480464 | Aflatoxin B1 results in increased expression of TPM4 mRNA | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | RGD:736665 | 6480464 | Tretinoin results in decreased expression of TPM4 mRNA | CTD | PMID:16140955 | all-trans-retinoic acid | increases expression | ISO | RGD:736665 | 6480464 | Tretinoin results in increased expression of TPM4 mRNA | CTD | PMID:23830798 | ammonium chloride | affects expression | ISO | RGD:3899 | 6480464 | Ammonium Chloride affects the expression of TPM4 mRNA | CTD | PMID:16483693 | ampicillin | increases expression | ISO | RGD:736665 | 6480464 | Ampicillin results in increased expression of TPM4 mRNA | CTD | PMID:21632981 | Aroclor 1254 | decreases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of TPM4 mRNA | CTD | PMID:23650126 | arsenous acid | increases expression | ISO | RGD:736665 | 6480464 | Arsenic Trioxide results in increased expression of TPM4 mRNA | CTD | PMID:20458559 | asbestos | increases expression | ISO | RGD:736665 | 6480464 | Asbestos results in increased expression of TPM4 protein | CTD | PMID:22537621 | atrazine | increases expression | ISO | RGD:736665 | 6480464 | Atrazine results in increased expression of TPM4 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of TPM4 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases expression | ISO | RGD:736665 | 6480464 | Benzo(a)pyrene results in increased expression of TPM4 mRNA | CTD | PMID:21871943, PMID:26238291 | benzo[a]pyrene | multiple interactions | ISO | RGD:736665 | 6480464 | [Soot co-treated with Benzo(a)pyrene] results in increased expression of TPM4 protein modified form | CTD | PMID:24464499 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:736665 | 6480464 | 7 more ... | CTD | PMID:19150397, PMID:20018196 | benzo[a]pyrene diol epoxide I | increases expression | ISO | RGD:736665 | 6480464 | 7 more ... | CTD | PMID:20382639, PMID:26238291 | bexarotene | increases expression | ISO | RGD:3899 | 6480464 | bexarotene results in increased expression of TPM4 mRNA | CTD | PMID:16648578 | bisphenol A | increases expression | ISO | RGD:3899 | 6480464 | bisphenol A results in increased expression of TPM4 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | RGD:736665 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TPM4 mRNA | CTD | PMID:28628672 | bisphenol A | decreases expression | ISO | RGD:3899 | 6480464 | bisphenol A results in decreased expression of TPM4 mRNA | CTD | PMID:30816183 | bisphenol F | multiple interactions | ISO | RGD:736665 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TPM4 mRNA | CTD | PMID:28628672 | bleomycin A2 | increases expression | ISO | RGD:3899 | 6480464 | Bleomycin results in increased expression of TPM4 protein | CTD | PMID:25933445 | bleomycin A5 | increases expression | ISO | RGD:736665 | 6480464 | bleomycetin results in increased expression of TPM4 mRNA | CTD | PMID:21040473 | buspirone | decreases expression | ISO | RGD:3899 | 6480464 | Buspirone results in decreased expression of TPM4 mRNA | CTD | PMID:24136188 | butan-1-ol | multiple interactions | ISO | RGD:736665 | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of TPM4 mRNA | CTD | PMID:29432896 | cadmium atom | increases expression | ISO | RGD:736665 | 6480464 | Cadmium results in increased expression of TPM4 mRNA | CTD | PMID:24376830 | cadmium dichloride | decreases methylation | ISO | RGD:3899 | 6480464 | Cadmium Chloride results in decreased methylation of TPM4 promoter | CTD | PMID:22457795 | cadmium dichloride | decreases expression | ISO | RGD:736665 | 6480464 | Cadmium Chloride results in decreased expression of TPM4 protein | CTD | PMID:26220685 | carbon nanotube | affects expression | ISO | RGD:736665 | 6480464 | Nanotubes, Carbon affects the expression of TPM4 protein | CTD | PMID:22001959 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes, Carbon analog results in increased expression of TPM4 mRNA, Nanotubes, Carbon results in increased expression of TPM4 mRNA | CTD | PMID:25554681 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TPM4 more ... | CTD | PMID:20938992 | cisplatin | increases expression | ISO | RGD:736665 | 6480464 | Cisplatin results in increased expression of TPM4 mRNA | CTD | PMID:27594783 | cisplatin | decreases expression | ISO | RGD:736665 | 6480464 | Cisplatin results in decreased expression of TPM4 mRNA | CTD | PMID:27392435 | cisplatin | multiple interactions | ISO | RGD:736665 | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of TPM4 mRNA | CTD | PMID:27392435 | copper atom | multiple interactions | EXP | | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TPM4 mRNA | CTD | PMID:15467011 | copper(0) | multiple interactions | EXP | | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TPM4 mRNA | CTD | PMID:15467011 | copper(II) sulfate | increases expression | ISO | RGD:736665 | 6480464 | Copper Sulfate results in increased expression of TPM4 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | RGD:736665 | 6480464 | Cyclosporine results in increased expression of TPM4 mRNA | CTD | PMID:20106945, PMID:25562108 | decabromodiphenyl ether | decreases expression | ISO | RGD:3899 | 6480464 | decabromobiphenyl ether results in decreased expression of TPM4 mRNA | CTD | PMID:23640034 | dexamethasone | multiple interactions | ISO | RGD:736665 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TPM4 mRNA more ... | CTD | PMID:28628672 | diarsenic trioxide | increases expression | ISO | RGD:736665 | 6480464 | Arsenic Trioxide results in increased expression of TPM4 mRNA | CTD | PMID:20458559 | dibutyl phthalate | increases expression | ISO | RGD:3899 | 6480464 | Dibutyl Phthalate results in increased expression of TPM4 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of TPM4 mRNA | CTD | PMID:21266533 | dioxygen | multiple interactions | EXP | | 6480464 | [sulforafan affects the susceptibility to Oxygen] which affects the expression of TPM4 mRNA | CTD | PMID:30529165 | diuron | decreases expression | ISO | RGD:3899 | 6480464 | Diuron results in decreased expression of TPM4 mRNA | CTD | PMID:25152437 | dopamine | increases expression | ISO | RGD:3899 | 6480464 | Dopamine results in increased expression of TPM4 mRNA | CTD | PMID:21983523 | dorsomorphin | multiple interactions | ISO | RGD:736665 | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | increases oxidation | ISO | RGD:3899 | 6480464 | Doxorubicin results in increased oxidation of TPM4 protein | CTD | PMID:28818578 | doxorubicin | affects expression | ISO | RGD:736665 | 6480464 | Doxorubicin affects the expression of TPM4 mRNA, Doxorubicin affects the expression of TPM4 protein | CTD | PMID:29385562, PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | RGD:736665 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TPM4 protein | CTD | PMID:23301498 | fenamidone | increases expression | EXP | | 6480464 | fenamidone results in increased expression of TPM4 mRNA | CTD | PMID:27029645 | fenoldopam | increases expression | ISO | RGD:3899 | 6480464 | Fenoldopam results in increased expression of TPM4 mRNA | CTD | PMID:21983523 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TPM4 more ... | CTD | PMID:20938992 | geldanamycin | increases expression | ISO | RGD:736665 | 6480464 | geldanamycin results in increased expression of TPM4 mRNA | CTD | PMID:26705709 | gentamycin | increases expression | ISO | RGD:3899 | 6480464 | Gentamicins results in increased expression of TPM4 mRNA | CTD | PMID:22061828 | glafenine | increases expression | ISO | RGD:3899 | 6480464 | Glafenine results in increased expression of TPM4 mRNA | CTD | PMID:24136188 | indometacin | multiple interactions | ISO | RGD:736665 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TPM4 mRNA more ... | CTD | PMID:28628672 | ketamine | decreases expression | ISO | RGD:3899 | 6480464 | Ketamine results in decreased expression of TPM4 mRNA | CTD | PMID:20080153 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of TPM4 more ... | CTD | PMID:20938992 | leflunomide | increases expression | ISO | RGD:736665 | 6480464 | leflunomide results in increased expression of TPM4 mRNA | CTD | PMID:28988120 | leflunomide | decreases expression | ISO | RGD:3899 | 6480464 | leflunomide results in decreased expression of TPM4 mRNA | CTD | PMID:24136188 | methylmercury chloride | increases expression | ISO | RGD:736665 | 6480464 | methylmercuric chloride results in increased expression of TPM4 mRNA | CTD | PMID:23179753 more ... | methylmercury chloride | multiple interactions | ISO | RGD:736665 | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TPM4 mRNA | CTD | PMID:27188386 | microcystin RR | decreases expression | ISO | RGD:736665 | 6480464 | microcystin RR results in decreased expression of TPM4 protein | CTD | PMID:19111056 | N-nitrosodiethylamine | increases expression | ISO | RGD:3899 | 6480464 | Diethylnitrosamine results in increased expression of TPM4 mRNA | CTD | PMID:19638242 | N-nitrosodimethylamine | increases expression | ISO | RGD:3899 | 6480464 | Dimethylnitrosamine results in increased expression of TPM4 mRNA | CTD | PMID:25380136 | N-nitrosomorpholine | increases expression | ISO | RGD:3899 | 6480464 | N-nitrosomorpholine results in increased expression of TPM4 protein | CTD | PMID:19716841 | nefazodone | decreases expression | ISO | RGD:3899 | 6480464 | nefazodone results in decreased expression of TPM4 mRNA | CTD | PMID:24136188 | nickel atom | increases expression | ISO | RGD:736665 | 6480464 | Nickel results in increased expression of TPM4 mRNA | CTD | PMID:24768652, PMID:25583101 | nimesulide | decreases expression | ISO | RGD:3899 | 6480464 | nimesulide results in decreased expression of TPM4 mRNA | CTD | PMID:24136188 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of TPM4 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:736665 | 6480464 | Acetaminophen results in increased expression of TPM4 mRNA | CTD | PMID:29067470 | paracetamol | decreases expression | ISO | RGD:736665 | 6480464 | Acetaminophen results in decreased expression of TPM4 mRNA | CTD | PMID:22230336 | paraoxon | increases expression | ISO | RGD:736665 | 6480464 | Paraoxon results in increased expression of TPM4 protein | CTD | PMID:20931991 | phenethyl isothiocyanate | affects binding | ISO | RGD:736665 | 6480464 | TPM4 protein binds to phenethyl isothiocyanate | CTD | PMID:21838287 | pirinixic acid | multiple interactions | ISO | RGD:736665 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TPM4 mRNA | CTD | PMID:19710929 | quercetin | increases expression | ISO | RGD:736665 | 6480464 | Quercetin results in increased expression of TPM4 mRNA | CTD | PMID:21632981 | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of TPM4 mRNA, resveratrol results in decreased expression of TPM4 protein | CTD | PMID:22610192, PMID:25505154 | SB 431542 | multiple interactions | ISO | RGD:736665 | 6480464 | [NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide results in increased expression of TPM4 mRNA | CTD | PMID:23221170 | silver atom | increases expression | ISO | RGD:736665 | 6480464 | Silver results in increased expression of TPM4 mRNA | CTD | PMID:28959546 | silver(0) | increases expression | ISO | RGD:736665 | 6480464 | Silver results in increased expression of TPM4 mRNA | CTD | PMID:28959546 | Soman | increases expression | ISO | RGD:3899 | 6480464 | Soman results in increased expression of TPM4 mRNA | CTD | PMID:19281266 | sulforaphane | multiple interactions | EXP | | 6480464 | [sulforafan affects the susceptibility to Oxygen] which affects the expression of TPM4 mRNA | CTD | PMID:30529165 | sunitinib | decreases expression | ISO | RGD:736665 | 6480464 | Sunitinib results in decreased expression of TPM4 mRNA | CTD | PMID:31533062 | tetrachloromethane | increases expression | ISO | RGD:3899 | 6480464 | Carbon Tetrachloride results in increased expression of TPM4 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | ISO | RGD:3899 | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TPM4 mRNA] | CTD | PMID:31150632 | thimerosal | decreases expression | ISO | RGD:736665 | 6480464 | Thimerosal results in decreased expression of TPM4 mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | ISO | RGD:3899 | 6480464 | Thioacetamide results in increased expression of TPM4 mRNA | CTD | PMID:23411599 | torcetrapib | increases expression | ISO | RGD:736665 | 6480464 | torcetrapib results in increased expression of TPM4 mRNA | CTD | PMID:23228038 | trichostatin A | decreases expression | ISO | RGD:736665 | 6480464 | trichostatin A results in decreased expression of TPM4 mRNA, trichostatin A results in decreased expression of TPM4 protein | CTD | PMID:19294695, PMID:26272509 | trichostatin A | affects expression | ISO | RGD:736665 | 6480464 | trichostatin A affects the expression of TPM4 mRNA | CTD | PMID:28542535 | trichostatin A | multiple interactions | ISO | RGD:736665 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TPM4 mRNA | CTD | PMID:27188386 | urethane | decreases expression | ISO | RGD:736665 | 6480464 | Urethane results in decreased expression of TPM4 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | RGD:736665 | 6480464 | Valproic Acid results in increased methylation of TPM4 gene | CTD | PMID:29154799 | vancomycin | decreases expression | EXP | | 6480464 | Vancomycin results in decreased expression of TPM4 mRNA | CTD | PMID:18930951 | vinclozolin | affects expression | ISO | RGD:3899 | 6480464 | vinclozolin affects the expression of TPM4 mRNA | CTD | PMID:19015723 | vincristine | increases expression | ISO | RGD:736665 | 6480464 | Vincristine results in increased expression of TPM4 mRNA | CTD | PMID:23649840 | vorinostat | decreases expression | ISO | RGD:736665 | 6480464 | vorinostat results in decreased expression of TPM4 mRNA | CTD | PMID:27188386 | zinc atom | decreases expression | ISO | RGD:3899 | 6480464 | Zinc results in decreased expression of TPM4 mRNA | CTD | PMID:17074742 | zinc sulfate | decreases expression | ISO | RGD:3899 | 6480464 | Zinc Sulfate results in decreased expression of TPM4 mRNA | CTD | PMID:17074742 | zinc(0) | decreases expression | ISO | RGD:3899 | 6480464 | Zinc results in decreased expression of TPM4 mRNA | CTD | PMID:17074742 | | |||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations
