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Gene: Pola1 (DNA polymerase alpha 1, catalytic subunit) Rattus norvegicus
Symbol: Pola1
Name: DNA polymerase alpha 1, catalytic subunit
RGD ID: 621816
Description: Exhibits DNA-directed DNA polymerase activity; double-stranded DNA binding activity; and nucleotide binding activity. Involved in DNA biosynthetic process and DNA replication. Localizes to alpha DNA polymerase:primase complex. Predicted to colocalize with chromatin. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit); PARTICIPATES IN DNA replication pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; aphidicolin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha subunit I; polymerase (DNA directed), alpha 1; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit
Homo sapiens (human) : POLA1 (DNA polymerase alpha 1, catalytic subunit)  HGNC  Alliance
Mus musculus (house mouse) : Pola1 (polymerase (DNA directed), alpha 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Canis lupus familiaris (dog) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Sus scrofa (pig) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Chlorocebus sabaeus (African green monkey) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Heterocephalus glaber (naked mole-rat) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X62,382,604 - 62,698,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX62,382,608 - 62,698,830 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X62,976,409 - 63,270,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X63,279,367 - 63,291,732 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X80,650,454 - 80,965,833 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X80,724,688 - 81,039,135 (-)NCBI
CeleraX58,474,102 - 58,787,051 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pola1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621816
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.