Pola1 (DNA polymerase alpha 1, catalytic subunit) - Rat Genome Database

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Gene: Pola1 (DNA polymerase alpha 1, catalytic subunit) Rattus norvegicus
Analyze
Symbol: Pola1
Name: DNA polymerase alpha 1, catalytic subunit
RGD ID: 621816
Description: Enables DNA-directed DNA polymerase activity; double-stranded DNA binding activity; and nucleotide binding activity. Involved in DNA biosynthetic process and DNA replication. Part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit); PARTICIPATES IN DNA replication pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; aphidicolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha subunit I; polymerase (DNA directed), alpha 1; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X62,028,475 - 62,342,455 (-)NCBIGRCr8
mRatBN7.2X58,034,617 - 58,348,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX58,034,619 - 58,348,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX59,461,083 - 59,780,537 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X62,962,191 - 63,281,641 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X60,520,221 - 60,834,715 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X62,382,604 - 62,698,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX62,382,608 - 62,698,830 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X63,279,367 - 63,291,732 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X62,976,409 - 63,270,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X80,650,454 - 80,965,833 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X80,724,688 - 81,039,135 (-)NCBI
CeleraX58,474,102 - 58,787,051 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aphidicolin  (EXP,ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
folic acid  (ISO)
FR900359  (ISO)
geraniol  (ISO)
indometacin  (ISO)
irinotecan  (EXP,ISO)
iron(III) nitrilotriacetate  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
succimer  (ISO)
tetrachloromethane  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
alpha DNA polymerase:primase complex  (IBA,IC,IDA,IEA,ISO,ISS)
chromatin  (ISO,ISS)
cytosol  (IEA,ISO,ISS)
intracellular non-membrane-bounded organelle  (IEA)
nuclear envelope  (ISO,ISS)
nuclear lumen  (IEA)
nuclear matrix  (ISO,ISS)
nucleolus  (ISO,ISS)
nucleoplasm  (IEA,ISO,ISS)
nucleus  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Preferential inhibition of DNA polymerases alpha, delta, and epsilon from Novikoff hepatoma cells by inhibitors of cell proliferation. Fox G, etal., J Cancer Res Clin Oncol. 1996;122(2):78-94.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. Lopez-Girona A, etal., Biochem Biophys Res Commun. 1995 Dec 14;217(2):566-74.
5. Eukaryotic DNA polymerase alpha. Structural analysis of the enzyme from regenerating rat liver. Mechali M, etal., J Biol Chem 1980 Mar 10;255(5):2114-22.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Damage to DNA and activity of nuclear DNA repair and replicative enzymes following N-nitrosodiethylamine treatment to rats. Pasupathy K and Bhattacharya RK, J Biochem Mol Toxicol. 2000;14(5):277-82.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. DNA polymerases alpha, delta, and epsilon of Novikoff hepatoma cells differ from those of normal rat liver in physicochemical and catalytic properties. Popanda O, etal., J Mol Med. 1995 May;73(5):259-68.
12. A mutation in subunit B of the DNA polymerase alpha-primase complex from Novikoff hepatoma cells concomitant with a conformational change and abnormal catalytic properties of the DNA polymerase alpha-primase complex. Popanda O, etal., Mol Carcinog 2001 Aug;31(4):171-83.
13. DNA polymerases delta and epsilon in developing and aging rat brain. Prapurna DR and Rao KS, Int J Dev Neurosci. 1997 Feb;15(1):67-73.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:893425   PMID:1508673   PMID:1730053   PMID:1903085   PMID:2175912   PMID:3139084   PMID:3335506   PMID:3359994   PMID:3917431   PMID:4084590   PMID:7045121   PMID:7910375  
PMID:8106564   PMID:8125989   PMID:8889548   PMID:9506968   PMID:9518481   PMID:9584195   PMID:9815285   PMID:10541966   PMID:11470886   PMID:15615704   PMID:16762037   PMID:22465957  
PMID:27019227   PMID:31006512  


Genomics

Comparative Map Data
Pola1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X62,028,475 - 62,342,455 (-)NCBIGRCr8
mRatBN7.2X58,034,617 - 58,348,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX58,034,619 - 58,348,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX59,461,083 - 59,780,537 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X62,962,191 - 63,281,641 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X60,520,221 - 60,834,715 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X62,382,604 - 62,698,830 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX62,382,608 - 62,698,830 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X63,279,367 - 63,291,732 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X62,976,409 - 63,270,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X80,650,454 - 80,965,833 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X80,724,688 - 81,039,135 (-)NCBI
CeleraX58,474,102 - 58,787,051 (-)NCBICelera
Cytogenetic MapXq22NCBI
POLA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X24,693,918 - 24,996,986 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX24,693,873 - 24,996,986 (+)EnsemblGRCh38hg38GRCh38
GRCh37X24,712,035 - 25,015,103 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X24,621,977 - 24,925,024 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X24,471,720 - 24,774,757NCBI
CeleraX28,834,936 - 29,139,042 (+)NCBICelera
Cytogenetic MapXp22.11-p21.3NCBI
HuRefX22,454,314 - 22,756,924 (+)NCBIHuRef
CHM1_1X24,743,660 - 25,046,638 (+)NCBICHM1_1
T2T-CHM13v2.0X24,278,197 - 24,581,230 (+)NCBIT2T-CHM13v2.0
Pola1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X92,348,372 - 92,675,993 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX92,348,373 - 92,675,761 (-)EnsemblGRCm39 Ensembl
GRCm38X93,304,766 - 93,632,387 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX93,304,767 - 93,632,155 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X90,550,105 - 90,877,494 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X89,557,486 - 89,884,874 (-)NCBIMGSCv36mm8
CeleraX80,226,588 - 80,553,952 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX41.06NCBI
Pola1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555095,007,182 - 5,319,894 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555095,007,385 - 5,319,683 (+)NCBIChiLan1.0ChiLan1.0
POLA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X26,492,211 - 26,793,735 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X26,495,715 - 26,797,116 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X17,290,805 - 17,592,163 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X24,657,810 - 24,958,599 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX24,657,878 - 24,960,231 (+)Ensemblpanpan1.1panPan2
POLA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X20,227,808 - 20,537,893 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX20,227,886 - 20,537,902 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X20,182,948 - 20,491,763 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX20,182,783 - 20,491,752 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X20,220,608 - 20,530,777 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X20,254,024 - 20,564,294 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X20,311,257 - 20,621,342 (+)NCBIUU_Cfam_GSD_1.0
Pola1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X13,138,978 - 13,525,949 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049368361,151 - 287,438 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX20,756,725 - 21,062,175 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X20,756,674 - 21,064,265 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
POLA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X23,184,921 - 23,492,836 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX23,185,046 - 23,492,992 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605625,050,126 - 25,357,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pola1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624897969,479 - 1,272,803 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624897969,431 - 1,272,762 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pola1
976 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:562
Count of miRNA genes:273
Interacting mature miRNAs:331
Transcripts:ENSRNOT00000018147
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
RH132880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X58,034,887 - 58,035,083 (+)MAPPERmRatBN7.2
Rnor_6.0X62,382,875 - 62,383,070NCBIRnor6.0
Rnor_5.0X62,976,680 - 62,976,875UniSTSRnor5.0
RGSC_v3.4X80,650,725 - 80,650,920UniSTSRGSC3.4
CeleraX58,474,373 - 58,474,568UniSTS
Cytogenetic MapXq22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 22 28 18 17 18 33 20 32 8
Low 2 21 29 23 2 23 8 10 41 15 7 3 8
Below cutoff 1 2

Sequence


Ensembl Acc Id: ENSRNOT00000018147   ⟹   ENSRNOP00000018147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX58,034,619 - 58,348,536 (-)Ensembl
Rnor_6.0 EnsemblX62,491,491 - 62,690,806 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000075997   ⟹   ENSRNOP00000068341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX58,034,619 - 58,348,536 (-)Ensembl
Rnor_6.0 EnsemblX62,382,608 - 62,661,152 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076359   ⟹   ENSRNOP00000068175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX62,664,787 - 62,698,830 (-)Ensembl
RefSeq Acc Id: NM_053479   ⟹   NP_445931
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,028,475 - 62,342,355 (-)NCBI
mRatBN7.2X58,034,617 - 58,348,512 (-)NCBI
Rnor_6.0X62,382,604 - 62,698,830 (-)NCBI
Rnor_5.0X62,976,409 - 63,270,153 (-)NCBI
Rnor_5.0X63,279,367 - 63,291,732 (-)NCBI
CeleraX58,474,102 - 58,787,051 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100121   ⟹   XP_038956049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,217,022 - 62,342,455 (-)NCBI
mRatBN7.2X58,223,177 - 58,348,612 (-)NCBI
RefSeq Acc Id: XM_039100122   ⟹   XP_038956050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X62,284,791 - 62,342,455 (-)NCBI
mRatBN7.2X58,290,945 - 58,348,612 (-)NCBI
Protein Sequences
Protein RefSeqs NP_445931 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956049 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956050 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA09720 (Get FASTA)   NCBI Sequence Viewer  
  EDL96016 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018147.8
  ENSRNOP00000068341.2
GenBank Protein O89042 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445931   ⟸   NM_053479
- UniProtKB: O89042 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018147   ⟸   ENSRNOT00000018147
Ensembl Acc Id: ENSRNOP00000068341   ⟸   ENSRNOT00000075997
Ensembl Acc Id: ENSRNOP00000068175   ⟸   ENSRNOT00000076359
RefSeq Acc Id: XP_038956049   ⟸   XM_039100121
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038956050   ⟸   XM_039100122
- Peptide Label: isoform X2
Protein Domains
DNA polymerase alpha catalytic subunit N-terminal   DNA-directed DNA polymerase family B   DNA-directed DNA polymerase family B exonuclease   Zinc finger DNA-directed DNA polymerase family B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89042-F1-model_v2 AlphaFold O89042 1-1451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701838
Promoter ID:EPDNEW_R12361
Type:multiple initiation site
Name:Pola1_1
Description:DNA polymerase alpha 1, catalytic subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X62,698,833 - 62,698,893EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621816 AgrOrtholog
BioCyc Gene G2FUF-2267 BioCyc
Ensembl Genes ENSRNOG00000013322 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018147.9 UniProtKB/TrEMBL
  ENSRNOT00000075997.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.132.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.3200.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.50.730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.2820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1600.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA-dir_DNA_pol_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_DNA_pol_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_DNA_pol_B_exonuc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA-dir_DNA_pol_B_multi_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA/RNA_pol_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_a_cat_su_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_palm_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pol_alpha_znc_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLBc_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_DNA-dir_DNA_pol_B_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85241 UniProtKB/Swiss-Prot
NCBI Gene 85241 ENTREZGENE
PANTHER DNA POLYMERASE ALPHA CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
  DNA POLYMERASE ALPHA CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
  DNA POLYMERASE ALPHA CATALYTIC SUBUNIT UniProtKB/TrEMBL
  DNA POLYMERASE ALPHA CATALYTIC SUBUNIT UniProtKB/TrEMBL
Pfam DNA_pol_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_pol_B_exo1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-DNA_Pol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pola1 PhenoGen
PRINTS DNAPOLB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DNA_POLYMERASE_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013322 RatGTEx
SMART POLBc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56672 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Zinc finger domain of DNA polymerase-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MK13_RAT UniProtKB/TrEMBL
  DPOLA_RAT UniProtKB/Swiss-Prot
  F1LRJ6_RAT UniProtKB/TrEMBL
  O89042 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Pola1  DNA polymerase alpha 1, catalytic subunit  Pola1  polymerase (DNA) alpha 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-16 Pola1  polymerase (DNA) alpha 1, catalytic subunit  Pola1  polymerase (DNA directed), alpha 1, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Pola1  polymerase (DNA directed), alpha 1, catalytic subunit  Pola1  polymerase (DNA directed), alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pola1  polymerase (DNA directed), alpha 1    DNA polymerase alpha subunit I  Name updated 1299863 APPROVED
2002-08-07 Pola1  DNA polymerase alpha subunit I      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression activity present in liver 724599