(-)-demecolcine decreases expression ISO RGD:732365 6480464 Demecolcine results in decreased expression of POLA1 mRNA CTD PMID:23649840 1,1-dichloroethene increases expression ISO RGD:732366 6480464 vinylidene chloride results in increased expression of POLA1 mRNA CTD PMID:26682919 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:732366 6480464 Dinitrochlorobenzene results in increased expression of POLA1 mRNA CTD PMID:21404309 1-nitropyrene increases expression ISO RGD:732365 6480464 1-nitropyrene results in increased expression of POLA1 mRNA CTD PMID:19041380 14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:732365 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of POLA1 mRNA CTD PMID:22101062 17beta-estradiol increases expression ISO RGD:732365 6480464 Estradiol results in increased expression of POLA1 mRNA CTD PMID:19167446 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:732366 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:732366 6480464 [2 more ... CTD PMID:25510870 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:732366 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732366 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to POLA1 promoter] CTD PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of POLA1 mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732366 6480464 Tetrachlorodibenzodioxin results in increased expression of POLA1 mRNA CTD PMID:15667827 2,4-diaminotoluene increases expression ISO RGD:732366 6480464 2, 4-diaminotoluene results in increased expression of POLA1 mRNA CTD PMID:20713471 2-methylcholine affects expression ISO RGD:732365 6480464 beta-methylcholine affects the expression of POLA1 mRNA CTD PMID:21179406 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:732365 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of POLA1 mRNA CTD PMID:28628672 3-methylcholanthrene increases expression ISO RGD:732366 6480464 Methylcholanthrene results in increased expression of POLA1 mRNA CTD PMID:20713471 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO RGD:732366 6480464 Oxazolone results in increased expression of POLA1 mRNA CTD PMID:21404309 4-hydroxyphenyl retinamide increases expression ISO RGD:732366 6480464 Fenretinide results in increased expression of POLA1 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine affects methylation ISO RGD:732365 6480464 Decitabine affects the methylation of POLA1 gene CTD PMID:17630775 5-fluorouracil decreases expression ISO RGD:732365 6480464 Fluorouracil results in decreased expression of POLA1 mRNA CTD PMID:19219653 aflatoxin B1 decreases expression ISO RGD:732366 6480464 Aflatoxin B1 results in decreased expression of POLA1 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:732365 6480464 Aflatoxin B1 results in decreased methylation of POLA1 gene CTD PMID:27153756 aflatoxin B1 affects expression ISO RGD:732365 6480464 Aflatoxin B1 affects the expression of POLA1 protein CTD PMID:20106945 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of POLA1 mRNA CTD PMID:30779732 antirheumatic drug increases expression ISO RGD:732365 6480464 Antirheumatic Agents results in increased expression of POLA1 mRNA CTD PMID:24449571 aphidicolin decreases activity EXP 6480464 Aphidicolin results in decreased activity of POLA1 protein CTD PMID:224865 aphidicolin decreases activity ISO RGD:732365 6480464 Aphidicolin results in decreased activity of POLA1 protein CTD PMID:224865 aristolochic acid A decreases expression ISO RGD:732365 6480464 aristolochic acid I results in decreased expression of POLA1 mRNA CTD PMID:33212167 arsenite(3-) multiple interactions ISO RGD:732365 6480464 arsenite inhibits the reaction [G3BP1 protein binds to POLA1 mRNA] CTD PMID:32406909 atrazine increases expression ISO RGD:732365 6480464 Atrazine results in increased expression of POLA1 mRNA CTD PMID:22378314 azathioprine decreases expression ISO RGD:732365 6480464 Azathioprine results in decreased expression of POLA1 mRNA CTD PMID:22623647 benzo[a]pyrene decreases expression ISO RGD:732366 6480464 Benzo(a)pyrene results in decreased expression of POLA1 mRNA CTD PMID:17942131 , PMID:19770486 benzo[a]pyrene increases expression ISO RGD:732365 6480464 Benzo(a)pyrene results in increased expression of POLA1 mRNA CTD PMID:32234424 benzo[a]pyrene decreases methylation ISO RGD:732366 6480464 Benzo(a)pyrene results in decreased methylation of POLA1 intron CTD PMID:27901495 benzo[a]pyrene affects methylation ISO RGD:732365 6480464 Benzo(a)pyrene affects the methylation of POLA1 intron, Benzo(a)pyrene affects the methylation of POLA1 promoter CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene increases methylation ISO RGD:732365 6480464 Benzo(a)pyrene results in increased methylation of POLA1 exon CTD PMID:27901495 benzo[a]pyrene decreases methylation ISO RGD:732365 6480464 Benzo(a)pyrene results in decreased methylation of POLA1 3' UTR CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:732365 6480464 Benzo(a)pyrene results in decreased expression of POLA1 mRNA CTD PMID:20064835 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:732365 6480464 7 more ... CTD PMID:20382639 bexarotene increases expression EXP 6480464 bexarotene results in increased expression of POLA1 mRNA CTD PMID:16648578 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of POLA1 mRNA CTD PMID:25181051 bisphenol A decreases methylation ISO RGD:732365 6480464 bisphenol A results in decreased methylation of POLA1 gene CTD PMID:31601247 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of POLA1 mRNA CTD PMID:33296240 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of POLA1 mRNA CTD PMID:30816183 , PMID:34947998 bisphenol A decreases expression ISO RGD:732365 6480464 bisphenol A results in decreased expression of POLA1 mRNA CTD PMID:29275510 bisphenol F multiple interactions ISO RGD:732365 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of POLA1 mRNA CTD PMID:28628672 cadmium atom multiple interactions ISO RGD:732365 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of POLA1 mRNA CTD PMID:35301059 cadmium dichloride multiple interactions ISO RGD:732365 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of POLA1 mRNA CTD PMID:35301059 cannabidiol decreases expression ISO RGD:732365 6480464 Cannabidiol results in decreased expression of POLA1 mRNA CTD PMID:36519830 carbamazepine affects expression ISO RGD:732365 6480464 Carbamazepine affects the expression of POLA1 mRNA CTD PMID:25979313 carbon nanotube increases expression ISO RGD:732366 6480464 Nanotubes more ... CTD PMID:25554681 chlorpromazine decreases expression ISO RGD:732365 6480464 Chlorpromazine analog results in decreased expression of POLA1 mRNA CTD PMID:15924885 choline multiple interactions ISO RGD:732366 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of POLA1 gene CTD PMID:20938992 chromium(6+) increases expression EXP 6480464 chromium hexavalent ion results in increased expression of POLA1 mRNA CTD PMID:30690063 chromium(6+) increases expression ISO RGD:732365 6480464 chromium hexavalent ion results in increased expression of POLA1 mRNA CTD PMID:30690063 cisplatin increases expression ISO RGD:732365 6480464 Cisplatin results in increased expression of POLA1 mRNA CTD PMID:27594783 cisplatin multiple interactions ISO RGD:732365 6480464 Cisplatin promotes the reaction [jinfukang results in decreased expression of POLA1 mRNA], jinfukang promotes the reaction [Cisplatin results in decreased expression of POLA1 mRNA] CTD PMID:27392435 cisplatin decreases expression ISO RGD:732365 6480464 Cisplatin results in decreased expression of POLA1 mRNA CTD PMID:27392435 cisplatin increases response to substance ISO RGD:732365 6480464 POLA1 protein results in increased susceptibility to Cisplatin CTD PMID:16734730 cobalt dichloride decreases expression ISO RGD:732365 6480464 cobaltous chloride results in decreased expression of POLA1 mRNA CTD PMID:19320972 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of POLA1 protein CTD PMID:24386269 copper atom multiple interactions ISO RGD:732365 6480464 [NSC 689534 binds to Copper] which results in decreased expression of POLA1 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:732365 6480464 [NSC 689534 binds to Copper] which results in decreased expression of POLA1 mRNA CTD PMID:20971185 coumestrol multiple interactions ISO RGD:732365 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression ISO RGD:732365 6480464 Coumestrol results in increased expression of POLA1 mRNA CTD PMID:19167446 cyclosporin A decreases expression ISO RGD:732366 6480464 Cyclosporine results in decreased expression of POLA1 mRNA CTD PMID:17942131 cyclosporin A decreases expression ISO RGD:732365 6480464 Cyclosporine results in decreased expression of POLA1 mRNA CTD PMID:20106945 , PMID:25562108 dexamethasone multiple interactions ISO RGD:732365 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of POLA1 mRNA CTD PMID:28628672 diethylstilbestrol increases expression ISO RGD:732365 6480464 Diethylstilbestrol results in increased expression of POLA1 mRNA CTD PMID:15766595 dimethylarsinic acid increases expression ISO RGD:732366 6480464 Cacodylic Acid results in increased expression of POLA1 mRNA CTD PMID:17441966 dioxygen decreases expression ISO RGD:732365 6480464 Oxygen deficiency results in decreased expression of POLA1 mRNA CTD PMID:26516004 doxorubicin multiple interactions ISO RGD:732366 6480464 [[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of POLA1 mRNA CTD PMID:21040762 Enterolactone multiple interactions ISO RGD:732365 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of POLA1 mRNA CTD PMID:19167446 folic acid multiple interactions ISO RGD:732366 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of POLA1 gene CTD PMID:20938992 folic acid decreases expression ISO RGD:732366 6480464 Folic Acid results in decreased expression of POLA1 mRNA CTD PMID:25629700 geraniol decreases expression ISO RGD:732365 6480464 geraniol results in decreased expression of POLA1 mRNA CTD PMID:27683099 indometacin multiple interactions ISO RGD:732365 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of POLA1 mRNA CTD PMID:28628672 irinotecan increases response to substance ISO RGD:732365 6480464 POLA1 protein results in increased susceptibility to Irinotecan CTD PMID:16734730 irinotecan affects expression EXP 6480464 Irinotecan affects the expression of POLA1 mRNA CTD PMID:20097248 iron(III) nitrilotriacetate increases expression EXP 6480464 ferric nitrilotriacetate results in increased expression of POLA1 mRNA CTD PMID:10854235 ivermectin decreases expression ISO RGD:732365 6480464 Ivermectin results in decreased expression of POLA1 protein CTD PMID:32959892 ketamine decreases expression EXP 6480464 Ketamine results in decreased expression of POLA1 mRNA CTD PMID:20080153 L-methionine multiple interactions ISO RGD:732366 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of POLA1 gene CTD PMID:20938992 lidocaine increases expression EXP 6480464 Lidocaine results in increased expression of POLA1 mRNA CTD PMID:35283115 lipopolysaccharide increases expression ISO RGD:732366 6480464 Lipopolysaccharides results in increased expression of POLA1 mRNA CTD PMID:12057914 methylseleninic acid decreases expression ISO RGD:732365 6480464 methylselenic acid results in decreased expression of POLA1 mRNA CTD PMID:12517777 N-nitrosodiethylamine increases expression ISO RGD:732366 6480464 Diethylnitrosamine results in increased expression of POLA1 mRNA CTD PMID:17854601 N-nitrosodiethylamine multiple interactions ISO RGD:732366 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of POLA1 mRNA] CTD PMID:17854601 N-Nitrosopyrrolidine decreases expression ISO RGD:732365 6480464 N-Nitrosopyrrolidine results in decreased expression of POLA1 mRNA CTD PMID:32234424 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of POLA1 mRNA CTD PMID:25729387 oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of POLA1 mRNA CTD PMID:25729387 paracetamol decreases expression ISO RGD:732366 6480464 Acetaminophen results in decreased expression of POLA1 mRNA CTD PMID:17942131 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of POLA1 mRNA CTD PMID:33387578 PCB138 multiple interactions ISO RGD:732366 6480464 [2 more ... CTD PMID:25510870 phenethyl isothiocyanate decreases expression ISO RGD:732365 6480464 phenethyl isothiocyanate results in decreased expression of POLA1 mRNA CTD PMID:26678675 phenobarbital affects expression ISO RGD:732366 6480464 Phenobarbital affects the expression of POLA1 mRNA CTD PMID:23091169 potassium chromate increases expression ISO RGD:732365 6480464 potassium chromate(VI) results in increased expression of POLA1 mRNA CTD PMID:22714537 quercetin decreases expression ISO RGD:732365 6480464 Quercetin results in decreased expression of POLA1 mRNA CTD PMID:15309432 resveratrol decreases expression ISO RGD:732365 6480464 resveratrol results in decreased expression of POLA1 mRNA CTD PMID:15767336 resveratrol multiple interactions ISO RGD:732365 6480464 [Coumestrol co-treated with Resveratrol] results in increased expression of POLA1 mRNA, [Plant Extracts co-treated with Resveratrol] results in increased expression of POLA1 mRNA CTD PMID:19167446 , PMID:23557933 rotenone increases expression ISO RGD:732365 6480464 Rotenone results in increased expression of POLA1 mRNA CTD PMID:18191903 rotenone decreases expression ISO RGD:732365 6480464 Rotenone results in decreased expression of POLA1 mRNA CTD PMID:29955902 silicon dioxide decreases expression ISO RGD:732366 6480464 Silicon Dioxide results in decreased expression of POLA1 mRNA CTD PMID:23221170 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of POLA1 mRNA CTD PMID:35314868 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of POLA1 mRNA CTD PMID:12325037 succimer multiple interactions ISO RGD:732366 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of POLA1 mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of POLA1 mRNA CTD PMID:21641980 , PMID:26378955 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of POLA1 mRNA CTD PMID:31150632 tetrachloromethane increases expression ISO RGD:732366 6480464 Carbon Tetrachloride results in increased expression of POLA1 mRNA CTD PMID:31919559 toluene 2,4-diisocyanate increases expression ISO RGD:732366 6480464 Toluene 2, 4-Diisocyanate results in increased expression of POLA1 mRNA CTD PMID:21404309 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of POLA1 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of POLA1 mRNA CTD PMID:25729387 Tributyltin oxide decreases expression ISO RGD:732366 6480464 bis(tri-n-butyltin)oxide results in decreased expression of POLA1 mRNA CTD PMID:17942131 trimellitic anhydride increases expression ISO RGD:732366 6480464 trimellitic anhydride results in increased expression of POLA1 mRNA CTD PMID:19042947 trovafloxacin decreases expression ISO RGD:732366 6480464 trovafloxacin results in decreased expression of POLA1 mRNA CTD PMID:35537566 urethane decreases expression ISO RGD:732365 6480464 Urethane results in decreased expression of POLA1 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:732366 6480464 Valproic Acid affects the expression of POLA1 mRNA CTD PMID:17963808 valproic acid decreases methylation ISO RGD:732365 6480464 Valproic Acid results in decreased methylation of POLA1 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:732365 6480464 Valproic Acid affects the expression of POLA1 mRNA CTD PMID:25979313 vincristine decreases expression ISO RGD:732365 6480464 Vincristine results in decreased expression of POLA1 mRNA CTD PMID:23649840
