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Gene: POLA1 (DNA polymerase alpha 1, catalytic subunit) Homo sapiens
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Symbol: POLA1
Name: DNA polymerase alpha 1, catalytic subunit
Description: Exhibits several functions, including DNA-directed DNA polymerase activity; chromatin binding activity; and protein kinase binding activity. Involved in DNA metabolic process and cell population proliferation. Localizes to the cytosol; nuclear envelope; and nuclear lumen. Colocalizes with the chromatin. Implicated in syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686K1672; DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha p180 subunit; dna polymerase alpha subunit i; N syndrome (mental retardation, malformations, chromosome breakage); NSX; p180; POLA; polymerase (DNA directed), alpha 1; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit; polymerase (DNA-directed), alpha (70kD); VEODS
Orthologs:
Mus musculus (house mouse) : Pola1 (polymerase (DNA directed), alpha 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pola1 (DNA polymerase alpha 1, catalytic subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Canis lupus familiaris (dog) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
Sus scrofa (pig) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Chlorocebus sabaeus (green monkey) : POLA1 (DNA polymerase alpha 1, catalytic subunit)
Heterocephalus glaber (naked mole-rat) : Pola1 (DNA polymerase alpha 1, catalytic subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX24,693,909 - 24,996,986 (+)Ensembl
GRCh38X24,693,877 - 24,996,986 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X24,712,038 - 25,015,103 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X24,621,977 - 24,925,024 (+)NCBINCBI36hg18NCBI36
Build 34X24,471,720 - 24,774,757NCBI
CeleraX28,834,936 - 29,139,042 (+)NCBI
Cytogenetic MapXp22.11-p21.3NCBI
HuRefX22,454,314 - 22,756,924 (+)NCBIHuRef
CHM1_1X24,743,660 - 25,046,638 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on POLA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732365
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.