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| Gene: Flcn (folliculin) Rattus norvegicus |  Analyze |
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| Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:12204536 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube syndrome | ClinVar | PMID:12204536 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:23891399 PMID:28492532 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18234728 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18234728 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:14627671 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:19802896 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:28202063 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:22703879 PMID:28492532 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:15852235 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18234728 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:15805188 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube syndrome | ClinVar | PMID:12204536 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:12843323 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:25741868 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18234728 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:15852235 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by OMIM:135150 | ClinVar | PMID:15657874 PMID:19562744 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube syndrome | ClinVar | PMID:12204536 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:24033266 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:14627671 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18794106 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:24033266 PMID:25741868 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18234728 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18794106 PMID:21506000 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18234728 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by OMIM:135150 | ClinVar | PMID:18234728 PMID:19562744 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by OMIM:135150 | ClinVar | PMID:23414156 PMID:24033266 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by OMIM:135150 | ClinVar | PMID:25637381 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:12204536 PMID:23784378 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:22703879 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:15852235 PMID:18234728 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by OMIM:135150 | ClinVar | PMID:12204536 PMID:19562744 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:22703879 PMID:24728327 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by OMIM:135150 | ClinVar | | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18505456 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:11100034 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:24728327 PMID:28492532 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by OMIM:135150 | ClinVar | PMID:12204536 PMID:24033266 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:23264078 more ... | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:28492532 | Birt-Hogg-Dube Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Birt-Hogg-Dube Syndrome | ClinVar | PMID:18794106 more ... | Carcinoma, Renal Cell | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Renal cell carcinoma | ClinVar | PMID:18794106 more ... | Chromosome 17, Trisomy 17p11 2 | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Chromosome 17, trisomy 17p11 2 | ClinVar | PMID:28837307 | colon cancer | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Colon cancer | ClinVar | PMID:12843323 | colon cancer | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Colon cancer | ClinVar | PMID:12843323 more ... | colon carcinoma | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Colonic carcinoma | ClinVar | PMID:12843323 | colon carcinoma | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Colonic carcinoma | ClinVar | PMID:12843323 more ... | Colonic Neoplasms | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Colon cancer | ClinVar | PMID:12843323 | Colonic Neoplasms | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Colon cancer | ClinVar | PMID:12843323 more ... | colorectal cancer | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Colorectal cancer | ClinVar | PMID:12843323 | colorectal cancer | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Colorectal cancer | ClinVar | PMID:12843323 more ... | cutaneous malignant melanoma, susceptibility to, 1 | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Malignant melanoma | ClinVar | PMID:28492532 | Melanoma | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Malignant melanoma, somatic | ClinVar | PMID:28492532 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18794106 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar | PMID:22679611 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:12204536 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:12204536 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18234728 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar | PMID:15852235 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18234728 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:20403193 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar | PMID:18234728 PMID:28151982 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:14627671 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:19802896 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:28202063 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:15852235 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar | PMID:18505456 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18234728 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar | PMID:17611575 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:15805188 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:12204536 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:12843323 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18234728 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:15852235 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:12204536 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:24728327 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:24033266 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18794106 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:15657874 PMID:19562744 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:15805188 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18234728 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18794106 PMID:21506000 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18234728 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar | PMID:18505456 PMID:19802896 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:12204536 PMID:23784378 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:22703879 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by null | ClinVar | | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:18505456 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:11100034 more ... | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:24728327 PMID:28492532 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar | PMID:18579543 PMID:22068306 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar | PMID:15852235 PMID:18234728 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:28492532 | Neoplastic Syndromes, Hereditary | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary | ClinVar | PMID:23264078 more ... | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | PMID:24728327 PMID:28492532 | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Pneumothorax, primary spontaneous | ClinVar | PMID:20413710 | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Pneumothorax, primary spontaneous | ClinVar | PMID:17496196 PMID:19562744 | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Pneumothorax, primary spontaneous | ClinVar | PMID:15657874 PMID:19562744 | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | PMID:14627671 more ... | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Pneumothorax, primary spontaneous | ClinVar | PMID:18505456 PMID:19562744 | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Pneumothorax, primary spontaneous | ClinVar | PMID:12204536 more ... | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | PMID:12843323 more ... | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | PMID:25741868 | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | PMID:24033266 more ... | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | PMID:14627671 more ... | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | PMID:24033266 PMID:25741868 | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | PMID:22703879 more ... | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Pneumothorax, primary spontaneous | ClinVar | PMID:18505456 more ... | pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Spontaneous pneumothorax | ClinVar | PMID:28492532 | primary spontaneous pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by null | ClinVar | PMID:15657874 PMID:19562744 | primary spontaneous pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Pneumothorax, primary spontaneous | ClinVar | PMID:12204536 more ... | primary spontaneous pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by OMIM:173600 | ClinVar | | primary spontaneous pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by null | ClinVar | PMID:20413710 | primary spontaneous pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Pneumothorax, primary spontaneous | ClinVar | PMID:18505456 more ... | primary spontaneous pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by null | ClinVar | PMID:17496196 PMID:19562744 | primary spontaneous pneumothorax | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by null | ClinVar | PMID:18505456 PMID:19562744 | Tumor Predisposition Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Tumor predisposition syndrome | ClinVar | PMID:11100034 more ... | Tumor Predisposition Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Tumor predisposition syndrome | ClinVar | PMID:28492532 | Tumor Predisposition Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Tumor predisposition syndrome | ClinVar | PMID:20403193 | Tumor Predisposition Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Tumor predisposition syndrome | ClinVar | PMID:15852235 | Tumor Predisposition Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Tumor predisposition syndrome | ClinVar | PMID:18234728 more ... | Tumor Predisposition Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Tumor predisposition syndrome | ClinVar | | Tumor Predisposition Syndrome | | ISO | RGD:1604509 | 8554872 | ClinVar Annotator: match by term: Tumor predisposition syndrome | ClinVar | PMID:15657874 PMID:19562744 | |
Imported Annotations - CTD
Imported Annotations - OMIM
Gene-Chemical Interaction AnnotationsGene Ontology AnnotationsBiological Process
Cellular Component
Molecular Function
Molecular Pathway AnnotationsRGD Manual Annotations
Imported Annotations - KEGG (archival)
Phenotype AnnotationsMammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction AnnotationsGene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsPhenotype AnnotationsMammalian Phenotype
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References - curated| 1. | Goberdhan DC, etal., Cell Metab. 2016 Apr 12;23(4):580-9. doi: 10.1016/j.cmet.2016.03.013. |
| 2. | Nickerson ML, etal., Cancer Cell. 2002 Aug;2(2):157-64. |
| 3. | Okimoto K, etal., Proc Natl Acad Sci U S A 2004 Feb 17;101(7):2023-7. Epub 2004 Feb 09. |
| 4. | OMIM Disease Annotation Pipeline |
| 5. | Pipeline to import KEGG annotations from KEGG into RGD |
| 6. | RGD automated data pipeline |
| 7. | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 8. | RGD automated import pipeline for gene-chemical interactions |
| 9. | RGD comprehensive gene curation |
| 10. | Wang L, etal., FEBS Lett. 2010 Jan 4;584(1):39-43. doi: 10.1016/j.febslet.2009.11.033. Epub . |
References - uncurated| PubMed | 12477932 15489334 16447066 17028174 18182616 18663353 18974783 19234517 19695222 19843504 19850877 20573232 21209915 21258407 22709692 22965878 23150719 25126726 |
RGD Disease Portals| Flcn has been annotated in the following RGD Disease Portals. |
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Genomics
Comparative Map Data| Flcn (Rattus norvegicus - Norway rat) |
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| FLCN (Homo sapiens - human) |
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| Flcn (Mus musculus - house mouse) |
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| Flcn (Chinchilla lanigera - long-tailed chinchilla) |
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| FLCN (Pan paniscus - bonobo/pygmy chimpanzee) |
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| FLCN (Canis lupus familiaris - dog) |
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| Flcn (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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Position Markers| PMC357045P1 |
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| PMC357045P6 |
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| RH130087 |
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| PMC357045P10 |
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| PMC357045P11 |
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| PMC357045P12 |
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| PMC357045P2 |
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| PMC357045P3 |
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| PMC357045P4 |
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| PMC357045P5 |
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| PMC357045P7 |
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| PMC357045P8 |
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| PMC357045P9 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Related Rat StrainsmiRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_199390 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006246489 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006246490 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017597267 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017597269 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017597270 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHX01064213 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AAHX01064214 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01064215 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AB096213 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC097038 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC085848 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ212214 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | NM_199390 | ||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
GGACTCTTGGCTTGGAAGAGCGTAACGCAGCACAGCGTGGCTCGGCGCATCCTAGTCTCCTGTChide sequence |
| RefSeq Acc Id: | XM_006246490 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
CGATTGTTGCCGAGGGCGCTTGGACTCTTGGCTTGGAAGAGCGTAACGCAGCACAGCGTGGCTChide sequence |
| RefSeq Acc Id: | XM_006246489 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
TCACGCGCTAGACTCGGTGCAAGGGCCTGCGGAACGGGCGAGGGGCAGAACGGTGGCGACAGCChide sequence |
| RefSeq Acc Id: | XM_006246491 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
ACCAGGGAGAGGGAGGTGACAGGTTCCATCCCTCGGTCGGGGTAATTGCTGTAGTTTGAACACThide sequence |
| RefSeq Acc Id: | XM_006246492 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
AAAAAAAAAAAAAAAAAGAATTCAAGTATGGTGGTGAGGAGACTGTCTTCAGCTTGGAAAAGTThide sequence |
| RefSeq Acc Id: | XM_008767817 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| Sequence: |
GTCACGCGCTAGACTCGGTGCAAGGGCCTGCGGAACGGGCGAGGGGCAGAACGGTGGCGACAGChide sequence |
| RefSeq Acc Id: | XM_008767816 |
| RefSeq Status: | |
| Type: | CODING |
| Position: | No map positions available. |
| Sequence: |
GGGTCACGCGCTAGACTCGGTGCAAGGGCCTGCGGAACGGGCGAGGGGCAGAACGGTGGCGACAhide sequence |
| RefSeq Acc Id: | XM_017597270 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| RefSeq Acc Id: | XM_017597267 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| RefSeq Acc Id: | XM_017597269 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_955422 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006246551 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006246552 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017452756 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017452758 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017452759 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAH85848 | (Get FASTA) | NCBI Sequence Viewer |
| BAD01656 | (Get FASTA) | NCBI Sequence Viewer | |
| EDM04621 | (Get FASTA) | NCBI Sequence Viewer | |
| Q76JQ2 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| Protein Acc Id: | NP_955422 |
| Sequence: |
MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPAhide sequence |
| Protein Acc Id: | XP_006246552 |
| Peptide Label: | isoform X1 |
| Sequence: |
MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPAhide sequence |
| Protein Acc Id: | XP_006246551 |
| Peptide Label: | isoform X1 |
| Sequence: |
MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPAhide sequence |
| Protein Acc Id: | XP_006246553 |
| Peptide Label: | isoform X1 |
| Sequence: |
MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPAhide sequence |
| Protein Acc Id: | XP_006246554 |
| Sequence: |
MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPAhide sequence |
| Protein Acc Id: | XP_008766039 |
| Peptide Label: | isoform X3 |
| Sequence: |
MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPAhide sequence |
| Protein Acc Id: | XP_008766038 |
| Peptide Label: | isoform X2 |
| Sequence: |
MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPAhide sequence |
| Protein Acc Id: | XP_017452759 |
| Peptide Label: | isoform X3 |
| Protein Acc Id: | XP_017452756 |
| Peptide Label: | isoform X1 |
| Protein Acc Id: | XP_017452758 |
| Peptide Label: | isoform X2 |
TranscriptomeStrain Variation
Strain Sequence Variants
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000003302 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000004412 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000075720 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000004412 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000091052 | ENTREZGENE, UniProtKB/TrEMBL | |
| IMAGE_CLONE | IMAGE:7189414 | IMAGE-MGC_LOAD |
| InterPro | FLCN/SMCR8_DENN | UniProtKB/Swiss-Prot |
| Folliculin | UniProtKB/Swiss-Prot | |
| Folliculin_C | UniProtKB/Swiss-Prot | |
| Folliculin_N | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:303185 | UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:94558 | IMAGE-MGC_LOAD |
| NCBI Gene | 303185 | ENTREZGENE |
| PANTHER | PTHR31441 | UniProtKB/Swiss-Prot |
| Pfam | Folliculin | UniProtKB/Swiss-Prot |
| Folliculin_C | UniProtKB/Swiss-Prot | |
| PhenoGen | Flcn | PhenoGen |
| PROSITE | DENN_FLCN_SMCR8 | UniProtKB/Swiss-Prot |
| UniGene | Rn.12799 | ENTREZGENE |
| UniProt | A0A0G2KBA8 | ENTREZGENE, UniProtKB/TrEMBL |
| FLCN_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2005-07-08 | Flcn | folliculin | Bhd | Symbol updated | 1299863 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | in heterozygotes, a germline insertion of one nucleotide resulting in a nonsense mutation gives rise to renal adenocarcinomas by the age of 6 months; homozygosity is lethal at an early stage of embryogenesis | 1302869 |
| gene_homology | amino acid sequence is 93% and 97% homologous to human and mouse folliculin, respectively | 1302869 |
| gene_mutations_overexpression | 10 of 11 renal carcinomas showed a loss of heterozygosity at the Bhd locus and the one LOH-negative case displayed a spontaneous nonsense point mutation at the second Bhd locus | 1302869 |
| More on Flcn | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 735088 |
| Created: | 2004-02-05 |
| Species: | Rattus norvegicus |
| Last Modified: | 2018-04-10 |
| Status: | ACTIVE |
