Flcn (folliculin) - Rat Genome Database

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Gene: Flcn (folliculin) Rattus norvegicus
Analyze
Symbol: Flcn
Name: folliculin
RGD ID: 735088
Description: Predicted to enable enzyme binding activity and enzyme inhibitor activity. Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including regulation of intracellular signal transduction; regulation of nucleobase-containing compound metabolic process; and regulation of protein modification process. Predicted to act upstream of or within with a positive effect on negative regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of epithelial cell proliferation and positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule cytoskeleton. Predicted to be active in cytosol. Predicted to colocalize with cell-cell contact zone and midbody. Used to study renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin); PARTICIPATES IN mTOR signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 1-benzylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bhd; Birt-Hogg-Dube syndrome protein homolog; MGC94558
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BHD/Dspe  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,588,621 - 44,607,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,588,624 - 44,607,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,289,172 - 49,308,120 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01048,779,533 - 48,798,481 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01044,283,137 - 44,302,086 (-)NCBIRnor_WKY
Rnor_6.01046,153,185 - 46,172,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,153,188 - 46,172,309 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,909,609 - 45,928,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,110,527 - 46,129,613 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11046,124,152 - 46,143,236 (-)NCBI
Celera1043,850,423 - 43,869,275 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amiodarone  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
boron nitride  (ISO)
bortezomib  (ISO)
buspirone  (EXP)
butanal  (ISO)
caffeine  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
Octicizer  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorone  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
quercetin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tributyl phosphate  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biological_process  (ND)
cell proliferation involved in kidney development  (ISO)
cell-cell junction assembly  (ISO,ISS)
cellular response to amino acid starvation  (ISO,ISS)
cellular response to starvation  (ISO,ISS)
energy homeostasis  (ISO,ISS)
epithelial cell proliferation  (ISO)
ERK1 and ERK2 cascade  (ISO)
hemopoiesis  (ISO,ISS)
in utero embryonic development  (ISO,ISS)
intrinsic apoptotic signaling pathway  (ISO)
lysosome localization  (ISO,ISS)
negative regulation of ATP biosynthetic process  (ISO,ISS)
negative regulation of brown fat cell differentiation  (ISO,ISS)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell migration  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell proliferation involved in kidney development  (ISO,ISS)
negative regulation of cellular respiration  (ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO,ISS)
negative regulation of gene expression  (ISO,ISS)
negative regulation of glycolytic process  (ISO)
negative regulation of mitochondrial DNA metabolic process  (ISO)
negative regulation of mitochondrion organization  (ISO,ISS)
negative regulation of muscle tissue development  (ISO)
negative regulation of post-translational protein modification  (ISO)
negative regulation of protein kinase B signaling  (ISO,ISS)
negative regulation of protein localization to nucleus  (ISO,ISS)
negative regulation of Rho protein signal transduction  (ISO,ISS)
negative regulation of TOR signaling  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
positive regulation of apoptotic process  (ISS)
positive regulation of autophagy  (ISO,ISS)
positive regulation of cell adhesion  (ISO,ISS)
positive regulation of GTPase activity  (IBA)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of TOR signaling  (ISO,ISS)
positive regulation of TORC1 signaling  (IBA)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of transforming growth factor beta receptor signaling pathway  (IBA,ISO,ISS)
protein kinase B signaling  (ISO)
regulation of cytokinesis  (ISO,ISS)
regulation of histone acetylation  (ISS)
regulation of pro-B cell differentiation  (ISO,ISS)
regulation of protein phosphorylation  (ISO,ISS)
regulation of Ras protein signal transduction  (ISO,ISS)
regulation of TOR signaling  (ISO,ISS)
TOR signaling  (ISO,ISS)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component
cell-cell contact zone  (ISO,ISS)
centrosome  (ISO,ISS)
cilium  (ISO,ISS)
cytoplasm  (ISO,ISS)
cytosol  (IBA,ISO,ISS)
lysosomal membrane  (ISO,ISS)
midbody  (ISO,ISS)
mitotic spindle  (ISO,ISS)
nucleus  (ISO,ISS)
plasma membrane  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot. Goberdhan DC, etal., Cell Metab. 2016 Apr 12;23(4):580-9. doi: 10.1016/j.cmet.2016.03.013.
3. Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome. Nickerson ML, etal., Cancer Cell. 2002 Aug;2(2):157-64.
4. A germ-line insertion in the Birt-Hogg-Dube (BHD) gene gives rise to the Nihon rat model of inherited renal cancer. Okimoto K, etal., Proc Natl Acad Sci U S A 2004 Feb 17;101(7):2023-7. Epub 2004 Feb 09.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene. Togashi Y, etal., Oncogene. 2006 May 11;25(20):2885-9. doi: 10.1038/sj.onc.1209317.
12. Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dube gene product. Wang L, etal., FEBS Lett. 2010 Jan 4;584(1):39-43. doi: 10.1016/j.febslet.2009.11.033. Epub .
13. Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1a/ERRa. Yan M, etal., Genes Dev. 2016 May 1;30(9):1034-46. doi: 10.1101/gad.281410.116.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16447066   PMID:17028174   PMID:18182616   PMID:18663353   PMID:18974783   PMID:19234517   PMID:19695222   PMID:19843504   PMID:19850877   PMID:20573232  
PMID:21209915   PMID:21258407   PMID:22709692   PMID:22965878   PMID:23150719   PMID:23784378   PMID:24081491   PMID:24095279   PMID:25126726   PMID:25775561   PMID:27113757   PMID:27913603  
PMID:29848618   PMID:31672913   PMID:31704029  


Genomics

Comparative Map Data
Flcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21044,588,621 - 44,607,808 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,588,624 - 44,607,769 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,289,172 - 49,308,120 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01048,779,533 - 48,798,481 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01044,283,137 - 44,302,086 (-)NCBIRnor_WKY
Rnor_6.01046,153,185 - 46,172,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,153,188 - 46,172,309 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,909,609 - 45,928,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,110,527 - 46,129,613 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11046,124,152 - 46,143,236 (-)NCBI
Celera1043,850,423 - 43,869,275 (-)NCBICelera
Cytogenetic Map10q22NCBI
FLCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,212,212 - 17,237,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1717,212,212 - 17,237,188 (-)EnsemblGRCh38hg38GRCh38
GRCh371717,115,526 - 17,140,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,056,251 - 17,081,221 (-)NCBINCBI36Build 36hg18NCBI36
Celera1718,055,113 - 18,080,089 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1716,868,444 - 16,893,256 (-)NCBIHuRef
CHM1_11717,125,252 - 17,150,222 (-)NCBICHM1_1
T2T-CHM13v2.01717,158,255 - 17,183,608 (-)NCBIT2T-CHM13v2.0
Flcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,682,234 - 59,706,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,682,234 - 59,700,842 (-)EnsemblGRCm39 Ensembl
GRCm381159,791,408 - 59,810,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,791,408 - 59,810,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv371159,605,252 - 59,623,275 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361159,607,945 - 59,625,968 (-)NCBIMGSCv36mm8
MGSCv361160,328,330 - 60,346,353 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
Flcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577672,410 - 694,140 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577672,774 - 694,140 (+)NCBIChiLan1.0ChiLan1.0
FLCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11756,441,317 - 56,466,479 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01734,057,127 - 34,081,637 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,988,520 - 39,013,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,988,518 - 39,013,160 (+)Ensemblpanpan1.1panPan2
FLCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1542,176,093 - 42,195,718 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl542,176,291 - 42,195,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,316,328 - 42,335,442 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0542,284,487 - 42,304,049 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl542,284,690 - 42,304,044 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1542,251,943 - 42,271,053 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0542,199,268 - 42,218,373 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0542,391,398 - 42,410,513 (+)NCBIUU_Cfam_GSD_1.0
Flcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,965,873 - 61,986,098 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936741880,736 - 901,468 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936741881,150 - 901,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,031,157 - 61,045,392 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,029,186 - 61,045,400 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FLCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,245,840 - 16,271,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,245,715 - 16,267,698 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660594,642,225 - 4,670,076 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248494,157,683 - 4,179,724 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Flcn
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:186
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000004412
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat

Markers in Region
PMC357045P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,590,918 - 44,591,095 (+)MAPPERmRatBN7.2
Rnor_6.01046,155,482 - 46,155,658NCBIRnor6.0
Rnor_5.01045,911,905 - 45,912,081UniSTSRnor5.0
RGSC_v3.41046,112,824 - 46,113,000UniSTSRGSC3.4
Celera1043,852,773 - 43,852,949UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,597,626 - 44,597,890 (+)MAPPERmRatBN7.2
Rnor_6.01046,162,190 - 46,162,453NCBIRnor6.0
Rnor_5.01045,918,578 - 45,918,841UniSTSRnor5.0
RGSC_v3.41046,119,494 - 46,119,757UniSTSRGSC3.4
Celera1043,859,156 - 43,859,419UniSTS
Cytogenetic Map10q22UniSTS
RH130087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,588,656 - 44,588,840 (+)MAPPERmRatBN7.2
Rnor_6.01046,153,221 - 46,153,404NCBIRnor6.0
Rnor_5.01045,909,645 - 45,909,828UniSTSRnor5.0
RGSC_v3.41046,110,563 - 46,110,746UniSTSRGSC3.4
Celera1043,850,459 - 43,850,642UniSTS
RH 3.4 Map10499.3UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,591,953 - 44,592,131 (+)MAPPERmRatBN7.2
Rnor_6.01046,156,517 - 46,156,694NCBIRnor6.0
Rnor_5.01045,912,940 - 45,913,117UniSTSRnor5.0
RGSC_v3.41046,113,859 - 46,114,036UniSTSRGSC3.4
Celera1043,853,796 - 43,853,973UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,590,841 - 44,591,222 (+)MAPPERmRatBN7.2
Rnor_6.01046,155,405 - 46,155,785NCBIRnor6.0
Rnor_5.01045,911,828 - 45,912,208UniSTSRnor5.0
RGSC_v3.41046,112,747 - 46,113,127UniSTSRGSC3.4
Celera1043,852,696 - 43,853,076UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,589,395 - 44,589,664 (+)MAPPERmRatBN7.2
Rnor_6.01046,153,960 - 46,154,228NCBIRnor6.0
Rnor_5.01045,910,384 - 45,910,652UniSTSRnor5.0
RGSC_v3.41046,111,302 - 46,111,570UniSTSRGSC3.4
Celera1043,851,198 - 43,851,466UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,600,366 - 44,601,103 (+)MAPPERmRatBN7.2
Rnor_6.01046,164,930 - 46,165,666NCBIRnor6.0
Rnor_5.01045,921,318 - 45,922,054UniSTSRnor5.0
RGSC_v3.41046,122,234 - 46,122,970UniSTSRGSC3.4
Celera1043,861,896 - 43,862,632UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,601,043 - 44,601,372 (+)MAPPERmRatBN7.2
Rnor_6.01046,165,607 - 46,165,935NCBIRnor6.0
Rnor_5.01045,921,995 - 45,922,323UniSTSRnor5.0
RGSC_v3.41046,122,911 - 46,123,239UniSTSRGSC3.4
Celera1043,862,573 - 43,862,901UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,600,233 - 44,600,465 (+)MAPPERmRatBN7.2
Rnor_6.01046,164,797 - 46,165,028NCBIRnor6.0
Rnor_5.01045,921,185 - 45,921,416UniSTSRnor5.0
RGSC_v3.41046,122,101 - 46,122,332UniSTSRGSC3.4
Celera1043,861,763 - 43,861,994UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,598,612 - 44,598,911 (+)MAPPERmRatBN7.2
Rnor_6.01046,163,176 - 46,163,474NCBIRnor6.0
Rnor_5.01045,919,564 - 45,919,862UniSTSRnor5.0
RGSC_v3.41046,120,480 - 46,120,778UniSTSRGSC3.4
Celera1043,860,142 - 43,860,440UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,596,237 - 44,596,458 (+)MAPPERmRatBN7.2
Rnor_6.01046,160,801 - 46,161,021NCBIRnor6.0
Rnor_5.01045,917,189 - 45,917,409UniSTSRnor5.0
RGSC_v3.41046,118,105 - 46,118,325UniSTSRGSC3.4
Celera1043,857,767 - 43,857,987UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,595,303 - 44,595,562 (+)MAPPERmRatBN7.2
Rnor_6.01046,159,867 - 46,160,125NCBIRnor6.0
Rnor_5.01045,916,255 - 45,916,513UniSTSRnor5.0
RGSC_v3.41046,117,171 - 46,117,429UniSTSRGSC3.4
Celera1043,856,833 - 43,857,091UniSTS
Cytogenetic Map10q22UniSTS
PMC357045P9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21044,592,599 - 44,592,774 (+)MAPPERmRatBN7.2
Rnor_6.01046,157,163 - 46,157,337NCBIRnor6.0
Rnor_5.01045,913,586 - 45,913,760UniSTSRnor5.0
RGSC_v3.41046,114,505 - 46,114,679UniSTSRGSC3.4
Celera1043,854,442 - 43,854,616UniSTS
Cytogenetic Map10q22UniSTS


Related Rat Strains
The following Strains have been annotated to Flcn


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 52 36 19 36 8 11 74 35 41 11 8
Low 5 5 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004412   ⟹   ENSRNOP00000004412
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,588,624 - 44,607,769 (-)Ensembl
Rnor_6.0 Ensembl1046,153,188 - 46,172,309 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091052   ⟹   ENSRNOP00000075720
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1046,154,745 - 46,172,166 (-)Ensembl
RefSeq Acc Id: NM_199390   ⟹   NP_955422
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,588,621 - 44,607,749 (-)NCBI
Rnor_6.01046,153,185 - 46,172,309 (-)NCBI
Rnor_5.01045,909,609 - 45,928,715 (-)NCBI
RGSC_v3.41046,110,527 - 46,129,613 (-)RGD
Celera1043,850,423 - 43,869,275 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246489   ⟹   XP_006246551
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,588,879 - 44,607,807 (-)NCBI
Rnor_6.01046,153,967 - 46,172,154 (-)NCBI
Rnor_5.01045,909,609 - 45,928,715 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246490   ⟹   XP_006246552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,588,621 - 44,607,769 (-)NCBI
Rnor_6.01046,153,185 - 46,172,329 (-)NCBI
Rnor_5.01045,909,609 - 45,928,715 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597267   ⟹   XP_017452756
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,588,621 - 44,607,807 (-)NCBI
Rnor_6.01046,153,185 - 46,171,022 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597270   ⟹   XP_017452759
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,588,621 - 44,607,808 (-)NCBI
Rnor_6.01046,153,185 - 46,172,331 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085951   ⟹   XP_038941879
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,588,621 - 44,607,807 (-)NCBI
RefSeq Acc Id: XM_039085952   ⟹   XP_038941880
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21044,588,621 - 44,607,807 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_955422   ⟸   NM_199390
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246552   ⟸   XM_006246490
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246551   ⟸   XM_006246489
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017452759   ⟸   XM_017597270
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452756   ⟸   XM_017597267
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004412   ⟸   ENSRNOT00000004412
RefSeq Acc Id: ENSRNOP00000075720   ⟸   ENSRNOT00000091052
RefSeq Acc Id: XP_038941880   ⟸   XM_039085952
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038941879   ⟸   XM_039085951
- Peptide Label: isoform X1
- UniProtKB: Q76JQ2 (UniProtKB/Swiss-Prot)
Protein Domains
cDENN FLCN/SMCR8-type   dDENN FLCN/SMCR8-type   uDENN FLCN/SMCR8-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q76JQ2-F1-model_v2 AlphaFold Q76JQ2 1-579 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697243
Promoter ID:EPDNEW_R7764
Type:initiation region
Name:Flcn_1
Description:folliculin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01046,172,116 - 46,172,176EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735088 AgrOrtholog
BioCyc Gene G2FUF-24874 BioCyc
Ensembl Genes ENSRNOG00000003302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004412 ENTREZGENE
  ENSRNOP00000004412.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004412 ENTREZGENE
  ENSRNOT00000004412.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.1730 UniProtKB/Swiss-Prot
  3.40.50.12430 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7189414 IMAGE-MGC_LOAD
InterPro FLCN/SMCR8_DENN UniProtKB/Swiss-Prot
  FLCN_DENN_C_sf UniProtKB/Swiss-Prot
  Folliculin UniProtKB/Swiss-Prot
  Folliculin/SMCR8_N UniProtKB/Swiss-Prot
  Folliculin_C UniProtKB/Swiss-Prot
KEGG Report rno:303185 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94558 IMAGE-MGC_LOAD
NCBI Gene 303185 ENTREZGENE
PANTHER FOLLICULIN UniProtKB/Swiss-Prot
  PTHR31441 UniProtKB/Swiss-Prot
Pfam Folliculin UniProtKB/Swiss-Prot
  Folliculin_C UniProtKB/Swiss-Prot
PhenoGen Flcn PhenoGen
PROSITE DENN_FLCN_SMCR8 UniProtKB/Swiss-Prot
UniProt FLCN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Flcn  folliculin  Bhd    Symbol updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease in heterozygotes, a germline insertion of one nucleotide resulting in a nonsense mutation gives rise to renal adenocarcinomas by the age of 6 months; homozygosity is lethal at an early stage of embryogenesis 1302869
gene_homology amino acid sequence is 93% and 97% homologous to human and mouse folliculin, respectively 1302869
gene_mutations_overexpression 10 of 11 renal carcinomas showed a loss of heterozygosity at the Bhd locus and the one LOH-negative case displayed a spontaneous nonsense point mutation at the second Bhd locus 1302869