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Gene: Flcn (folliculin) Rattus norvegicus
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Symbol: Flcn
Name: folliculin
Description: Predicted to contribute to GTPase activator activity. Predicted to be involved in several processes, including negative regulation of cellular metabolic process; positive regulation of cellular metabolic process; and regulation of intracellular signal transduction. Predicted to colocalize with the cell-cell contact zone and midbody. Used to study renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin); PARTICIPATES IN mTOR signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 1-benzylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Bhd; Birt-Hogg-Dube syndrome protein homolog; MGC94558
Orthologs:
Homo sapiens (human) : FLCN (folliculin)  HGNC  Alliance
Mus musculus (house mouse) : Flcn (folliculin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flcn (folliculin)
Pan paniscus (bonobo/pygmy chimpanzee) : FLCN (folliculin)
Canis lupus familiaris (dog) : FLCN (folliculin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flcn (folliculin)
Sus scrofa (pig) : FLCN (folliculin)
more info ...
Is Marker For: Strains:   BHD/Dspe  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01046,153,185 - 46,172,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01045,909,609 - 45,928,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,110,527 - 46,129,613 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11046,124,152 - 46,143,236 (-)NCBI
Celera1043,850,423 - 43,869,275 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Flcn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735088
Created: 2004-02-05
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.