Flcn (folliculin) - Rat Genome Database

Name: Flcn
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Flcn (folliculin) Rattus norvegicus

Analyze

Symbol:

Flcn

Name:

folliculin

RGD ID:

735088

Description:

Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including negative regulation of cellular metabolic process; positive regulation of cellular metabolic process; and regulation of intracellular signal transduction. Predicted to act upstream of or within positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule cytoskeleton. Predicted to be active in cytosol. Predicted to colocalize with cell-cell contact zone and midbody. Used to study renal cell carcinoma. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin); PARTICIPATES IN mTOR signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 1-benzylpiperazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

Bhd; Birt-Hogg-Dube syndrome protein homolog; MGC94558

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FLCN (folliculin)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Flcn (folliculin)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Flcn (folliculin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FLCN (folliculin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FLCN (folliculin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Flcn (folliculin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FLCN (folliculin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FLCN (folliculin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Flcn (folliculin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FLCN (folliculin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Flcn (folliculin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	flcn (folliculin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	BHD	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	LST7	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	flcn-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)

Is Marker For:

Strains: BHD/Dspe

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	44,588,621 - 44,607,808 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	10	44,588,624 - 44,607,769 (-)	Ensembl
Rnor_6.0	10	46,153,185 - 46,172,331 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	46,153,188 - 46,172,309 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	45,909,609 - 45,928,715 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,110,527 - 46,129,613 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	46,124,152 - 46,143,236 (-)	NCBI
Celera	10	43,850,423 - 43,869,275 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Birt-Hogg-Dube syndrome (ISO)

colon cancer (ISO)

colon carcinoma (ISO)

colorectal cancer (ISO)

Colorectal Neoplasms (ISO)

Cysts (ISO)

Hamartoma (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Hereditary Neoplastic Syndromes (ISO)

Liver Neoplasms (ISO)

nonpapillary renal cell carcinoma (ISO,ISS)

pilocytic astrocytoma (ISO)

pneumothorax (ISO)

Potocki-Lupski syndrome (ISO)

primary spontaneous pneumothorax (ISO)

renal cell carcinoma (IAGP,IMP,ISO)

renal oncocytoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-benzylpiperazine (EXP)

14-Deoxy-11,12-didehydroandrographolide (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

amiodarone (ISO)

antirheumatic drug (ISO)

aristolochic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

boron nitride (ISO)

bortezomib (ISO)

buspirone (EXP)

butanal (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

crotonaldehyde (ISO)

cyclosporin A (ISO)

dioxygen (ISO)

disulfiram (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

glafenine (EXP)

hydrogen peroxide (ISO)

leflunomide (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

menadione (ISO)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

nefazodone (EXP)

paracetamol (ISO)

pentanal (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

phorone (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

quercetin (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sunitinib (ISO)

testosterone (EXP)

tetrachloromethane (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

tributyl phosphate (ISO)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tris(2-chloroethyl) phosphate (ISO)

troglitazone (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cell-cell junction assembly (ISO,ISS)

cellular response to amino acid starvation (ISO,ISS)

cellular response to starvation (ISO,ISS)

energy homeostasis (ISO,ISS)

hemopoiesis (ISO,ISS)

in utero embryonic development (ISO,ISS)

lysosome localization (ISO,ISS)

negative regulation of ATP biosynthetic process (ISO,ISS)

negative regulation of brown fat cell differentiation (ISO,ISS)

negative regulation of cell growth (ISO,ISS)

negative regulation of cell migration (ISO,ISS)

negative regulation of cell population proliferation (ISO)

negative regulation of cell proliferation involved in kidney development (ISO,ISS)

negative regulation of cellular respiration (ISO)

negative regulation of cold-induced thermogenesis (ISO,ISS)

negative regulation of ERK1 and ERK2 cascade (ISO,ISS)

negative regulation of gene expression (ISO,ISS)

negative regulation of mitochondrial DNA metabolic process (ISO)

negative regulation of mitochondrion organization (ISO,ISS)

negative regulation of muscle tissue development (ISO)

negative regulation of post-translational protein modification (ISO)

negative regulation of protein kinase B signaling (ISO,ISS)

negative regulation of protein localization to nucleus (ISO,ISS)

negative regulation of Rho protein signal transduction (ISO,ISS)

negative regulation of TOR signaling (ISO,ISS)

negative regulation of transcription by RNA polymerase II (IBA,ISO,ISS)

negative regulation of transcription, DNA-templated (ISO)

positive regulation of apoptotic process (ISS)

positive regulation of autophagy (ISO,ISS)

positive regulation of cell adhesion (ISO,ISS)

positive regulation of GTPase activity (IBA)

positive regulation of intrinsic apoptotic signaling pathway (ISO)

positive regulation of protein phosphorylation (ISO,ISS)

positive regulation of TOR signaling (ISO,ISS)

positive regulation of TORC1 signaling (IBA)

positive regulation of transcription by RNA polymerase II (ISO,ISS)

positive regulation of transforming growth factor beta receptor signaling pathway (IBA,ISO,ISS)

regulation of catalytic activity (IEA)

regulation of cytokinesis (ISO,ISS)

regulation of histone acetylation (ISO,ISS)

regulation of pro-B cell differentiation (ISO,ISS)

regulation of protein phosphorylation (ISO,ISS)

regulation of Ras protein signal transduction (ISO,ISS)

regulation of TOR signaling (ISO,ISS)

TOR signaling (ISO,ISS)

Cellular Component

cell-cell contact zone (ISO,ISS)

cellular_component (ND)

centrosome (ISO,ISS)

cilium (IEA,ISO,ISS)

cytoplasm (ISO,ISS)

cytosol (IBA,IEA,ISO,ISS)

lysosomal membrane (IEA,ISO,ISS)

microtubule organizing center (IEA)

midbody (ISO,ISS)

mitotic spindle (ISO,ISS)

nucleus (IEA,ISO,ISS)

plasma membrane (ISO,ISS)

spindle (IEA)

Molecular Function

GTPase activator activity (ISO,ISS)

guanyl-nucleotide exchange factor activity (IEA)

molecular_function (ND)

protein binding (IPI,ISO)

protein-containing complex binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

renal cell carcinoma pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

embryonic lethality (IMP)

prenatal lethality (IAGP)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Goberdhan DC, etal., Cell Metab. 2016 Apr 12;23(4):580-9. doi: 10.1016/j.cmet.2016.03.013.
3.	Nickerson ML, etal., Cancer Cell. 2002 Aug;2(2):157-64.
4.	Okimoto K, etal., Proc Natl Acad Sci U S A 2004 Feb 17;101(7):2023-7. Epub 2004 Feb 09.
5.	OMIM Disease Annotation Pipeline
6.	Pipeline to import KEGG annotations from KEGG into RGD
7.	RGD automated data pipeline
8.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	RGD automated import pipeline for gene-chemical interactions
10.	RGD comprehensive gene curation
11.	Togashi Y, etal., Oncogene. 2006 May 11;25(20):2885-9. doi: 10.1038/sj.onc.1209317.
12.	Wang L, etal., FEBS Lett. 2010 Jan 4;584(1):39-43. doi: 10.1016/j.febslet.2009.11.033. Epub .
13.	Yan M, etal., Genes Dev. 2016 May 1;30(9):1034-46. doi: 10.1101/gad.281410.116.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16447066	PMID:17028174	PMID:18182616	PMID:18663353	PMID:18974783	PMID:19234517	PMID:19695222	PMID:19843504	PMID:19850877	PMID:20573232
PMID:21209915	PMID:21258407	PMID:22709692	PMID:22965878	PMID:23150719	PMID:23784378	PMID:24081491	PMID:24095279	PMID:25126726	PMID:25775561	PMID:27113757	PMID:27913603
PMID:29848618	PMID:31672913	PMID:31704029

Genomics

Comparative Map Data

Flcn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	44,588,621 - 44,607,808 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	10	44,588,624 - 44,607,769 (-)	Ensembl
Rnor_6.0	10	46,153,185 - 46,172,331 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	46,153,188 - 46,172,309 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	45,909,609 - 45,928,715 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,110,527 - 46,129,613 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	46,124,152 - 46,143,236 (-)	NCBI
Celera	10	43,850,423 - 43,869,275 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

FLCN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	17,212,212 - 17,237,188 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	17,206,946 - 17,237,188 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	17,115,526 - 17,140,482 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	17,056,251 - 17,081,221 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	17	18,055,113 - 18,080,089 (-)	NCBI
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	16,868,444 - 16,893,256 (-)	NCBI		HuRef
CHM1_1	17	17,125,252 - 17,150,222 (-)	NCBI		CHM1_1

Flcn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	59,682,234 - 59,706,138 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	11	59,682,234 - 59,700,842 (-)	Ensembl
GRCm38	11	59,791,408 - 59,810,039 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	59,791,408 - 59,810,016 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	59,605,252 - 59,623,275 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	59,607,945 - 59,625,968 (-)	NCBI			mm8
MGSCv36	11	60,328,330 - 60,346,353 (-)	NCBI			mm8
Cytogenetic Map	11	B1.3	NCBI

Flcn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955577	672,774 - 694,140 (+)	NCBI	ChiLan1.0	ChiLan1.0

FLCN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	38,988,520 - 39,013,189 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	38,988,518 - 39,013,160 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	17	34,057,127 - 34,081,637 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

FLCN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	42,176,093 - 42,195,718 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	42,176,291 - 42,195,711 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	42,316,328 - 42,335,442 (+)	NCBI
ROS_Cfam_1.0	5	42,284,487 - 42,304,049 (+)	NCBI
UMICH_Zoey_3.1	5	42,251,943 - 42,271,053 (+)	NCBI
UNSW_CanFamBas_1.0	5	42,199,268 - 42,218,373 (+)	NCBI
UU_Cfam_GSD_1.0	5	42,391,398 - 42,410,513 (+)	NCBI

Flcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	61,965,873 - 61,986,098 (+)	NCBI
SpeTri2.0	NW_004936741	881,150 - 901,296 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FLCN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	12	61,029,186 - 61,045,400 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

FLCN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	16,245,840 - 16,271,465 (-)	NCBI
ChlSab1.1 Ensembl	16	16,245,715 - 16,267,698 (-)	Ensembl
Vero_WHO_p1.0	NW_023666059	4,642,225 - 4,670,076 (+)	NCBI

Flcn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624849	4,157,683 - 4,179,724 (+)	NCBI

Position Markers

PMC357045P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,590,918 - 44,591,095 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,155,482 - 46,155,658	NCBI	Rnor6.0
Rnor_5.0	10	45,911,905 - 45,912,081	UniSTS	Rnor5.0
RGSC_v3.4	10	46,112,824 - 46,113,000	UniSTS	RGSC3.4
Celera	10	43,852,773 - 43,852,949	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P6

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,597,626 - 44,597,890 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,162,190 - 46,162,453	NCBI	Rnor6.0
Rnor_5.0	10	45,918,578 - 45,918,841	UniSTS	Rnor5.0
RGSC_v3.4	10	46,119,494 - 46,119,757	UniSTS	RGSC3.4
Celera	10	43,859,156 - 43,859,419	UniSTS
Cytogenetic Map	10	q22	UniSTS

RH130087

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,588,656 - 44,588,840 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,153,221 - 46,153,404	NCBI	Rnor6.0
Rnor_5.0	10	45,909,645 - 45,909,828	UniSTS	Rnor5.0
RGSC_v3.4	10	46,110,563 - 46,110,746	UniSTS	RGSC3.4
Celera	10	43,850,459 - 43,850,642	UniSTS
RH 3.4 Map	10	499.3	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P10

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,591,953 - 44,592,131 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,156,517 - 46,156,694	NCBI	Rnor6.0
Rnor_5.0	10	45,912,940 - 45,913,117	UniSTS	Rnor5.0
RGSC_v3.4	10	46,113,859 - 46,114,036	UniSTS	RGSC3.4
Celera	10	43,853,796 - 43,853,973	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P11

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,590,841 - 44,591,222 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,155,405 - 46,155,785	NCBI	Rnor6.0
Rnor_5.0	10	45,911,828 - 45,912,208	UniSTS	Rnor5.0
RGSC_v3.4	10	46,112,747 - 46,113,127	UniSTS	RGSC3.4
Celera	10	43,852,696 - 43,853,076	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P12

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,589,395 - 44,589,664 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,153,960 - 46,154,228	NCBI	Rnor6.0
Rnor_5.0	10	45,910,384 - 45,910,652	UniSTS	Rnor5.0
RGSC_v3.4	10	46,111,302 - 46,111,570	UniSTS	RGSC3.4
Celera	10	43,851,198 - 43,851,466	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,600,366 - 44,601,103 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,164,930 - 46,165,666	NCBI	Rnor6.0
Rnor_5.0	10	45,921,318 - 45,922,054	UniSTS	Rnor5.0
RGSC_v3.4	10	46,122,234 - 46,122,970	UniSTS	RGSC3.4
Celera	10	43,861,896 - 43,862,632	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,601,043 - 44,601,372 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,165,607 - 46,165,935	NCBI	Rnor6.0
Rnor_5.0	10	45,921,995 - 45,922,323	UniSTS	Rnor5.0
RGSC_v3.4	10	46,122,911 - 46,123,239	UniSTS	RGSC3.4
Celera	10	43,862,573 - 43,862,901	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,600,233 - 44,600,465 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,164,797 - 46,165,028	NCBI	Rnor6.0
Rnor_5.0	10	45,921,185 - 45,921,416	UniSTS	Rnor5.0
RGSC_v3.4	10	46,122,101 - 46,122,332	UniSTS	RGSC3.4
Celera	10	43,861,763 - 43,861,994	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,598,612 - 44,598,911 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,163,176 - 46,163,474	NCBI	Rnor6.0
Rnor_5.0	10	45,919,564 - 45,919,862	UniSTS	Rnor5.0
RGSC_v3.4	10	46,120,480 - 46,120,778	UniSTS	RGSC3.4
Celera	10	43,860,142 - 43,860,440	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,596,237 - 44,596,458 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,160,801 - 46,161,021	NCBI	Rnor6.0
Rnor_5.0	10	45,917,189 - 45,917,409	UniSTS	Rnor5.0
RGSC_v3.4	10	46,118,105 - 46,118,325	UniSTS	RGSC3.4
Celera	10	43,857,767 - 43,857,987	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,595,303 - 44,595,562 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,159,867 - 46,160,125	NCBI	Rnor6.0
Rnor_5.0	10	45,916,255 - 45,916,513	UniSTS	Rnor5.0
RGSC_v3.4	10	46,117,171 - 46,117,429	UniSTS	RGSC3.4
Celera	10	43,856,833 - 43,857,091	UniSTS
Cytogenetic Map	10	q22	UniSTS

PMC357045P9

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	44,592,599 - 44,592,774 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	46,157,163 - 46,157,337	NCBI	Rnor6.0
Rnor_5.0	10	45,913,586 - 45,913,760	UniSTS	Rnor5.0
RGSC_v3.4	10	46,114,505 - 46,114,679	UniSTS	RGSC3.4
Celera	10	43,854,442 - 43,854,616	UniSTS
Cytogenetic Map	10	q22	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	cortical volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat
1354614	Hpcl1	Hepatic cholesterol level QTL 1	3.3		liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	35392267	51793994	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	41944526	78307017	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	42876766	79813922	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat

Related Rat Strains

The following Strains have been annotated to Flcn

BHD/Dspe

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	276
Count of miRNA genes:	186
Interacting mature miRNAs:	227
Transcripts:	ENSRNOT00000004412
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	52	36	19	36	8	11	74	35	41	11	8
Low			5	5		5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246489	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB096213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC097038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC085848	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000004412 ⟹ ENSRNOP00000004412

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	44,588,624 - 44,607,769 (-)	Ensembl
Rnor_6.0 Ensembl	10	46,153,188 - 46,172,309 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000091052 ⟹ ENSRNOP00000075720

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	46,154,745 - 46,172,166 (-)	Ensembl

RefSeq Acc Id:

NM_199390 ⟹ NP_955422

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	44,588,621 - 44,607,749 (-)	NCBI
Rnor_6.0	10	46,153,185 - 46,172,309 (-)	NCBI
Rnor_5.0	10	45,909,609 - 45,928,715 (-)	NCBI
RGSC_v3.4	10	46,110,527 - 46,129,613 (-)	RGD
Celera	10	43,850,423 - 43,869,275 (-)	RGD

Sequence:

show sequence

GGACTCTTGGCTTGGAAGAGCGTAACGCAGCACAGCGTGGCTCGGCGCATCCTAGTCTCCTGTC
GGCGCCGCGGCACCGCTCGCCGTGGCTAGTCTCTGGCGTTGCCTTCCCTCCGCCAGCCTGCGGA
TGGTTCGGTCCGGCTGGGTCACGCGCTAGACTCGGTGCAAGGGCCTGCGGAACGGGCGAGGGGC
AGAACGGTGGCGACAGCCTCAGGACAGTTGCGAGCGGGTTCCGGCCCAGCATCCGGGAGACGGC
GGCGAGCGCCCCAGCTGAGTTGACAACCTCAAGCCTTTGAATTCGAGTGCAGTTTGCATACCAT
ACCTGACTCATCCGGCAGGCCTCGTACACGTTCTGGTCTAGGCAGGATGGTGCAGCCGTGATCT
GTCAAGCATAAGGCCTCGGCCATTCTCCAGCACCATGAACGCCATTGTGGCTCTCTGCCACTTC
TGCGAGCTCCATGGCCCCCGCACGCTCTTCTGCACGGAGGTTCTACACGCTCCCCTGCCCCAGG
GTGCCGGAAGTGGGGACAGTCCTGGCCAGGTTGAGCAGGCTGAGGAAGAAGAGGGCGGCATCCA
GATGAGCAGCCGAGTCCGTGCCCACAGCCCAGCCGAGGGCGCCAGCACTGACTCCAGCAGCCCG
GGGCCCAAGAAGTCAGACATGTGCGAGGGCTGCCGCTCGCTTGCTGTAGGGCACCCAGGTTATA
TCAGTCATGATAAGGAGACCTCTATCAAGTACGTCAGCCACCAGCACCCCAACCACCCACAGCT
CTTCAGCATTGTCCGCCAGGCCTGTGTCCGCAGCCTGAGCTGTGAGGTGTGCCCTGGTCGTGAA
GGCCCCATCTTCTTTGGTGATGAGCAACATGGCTTTGTGTTCAGCCACACCTTCTTCATCAAAG
ACAGCCTGGCCAGAGGCTTCCAGCGCTGGTACAGCATCATCGCCATCATGATGGATCGGATCTA
CCTCATCAACTCCTGGCCCTTCCTGCTGGGCAAGATCCGCGGGATCATCAGCGAGCTCCAGGGC
AAGGCCCTCAAGGTGTTTGAGGCAGAACAGTTTGGATGTCCACAGCGTGCCCAGAGGATGAACA
CTGCCTTCACACCCTTCCTGCACCAGAGGAACGGCAACGCTGCCCGCTCTCTGACCTCCTTGAC
CAGTGATGACAACTTGTGGGCCTGTCTGCATACTTCCTTTGCCTGGCTCCTGAAGGCATGTGGT
AGCCGGCTGACAGAAAAGCTCTTAGAGGGTGCTCCCACAGAGGACACCCTGGTCCAGATGGAGA
AGCTTGCTGACTTAGAGGAAGAATCAGAAAGTTGGGATAATTCAGAGGCTGAAGAGGAGGAGAA
AGCCCCTGCTACGGCAGAGGGTGCTGAAGGGCGAGAGCTGGCCAGTTGCCCAACAGAATCATCC
TTTCTCTCAGCCTGTGGGAGCTGGCAGCCCCCAAAGCTTTCTGTCTTCAAGTCCCTTCGACACA
TGAGACAGGTCTTGGGAGCCCCATCTTTCCGAATGTTGGCCTGGCATGTCCTCATGGGTAATCA
GGTGATCTGGAAAAGCAGAGATGTGAACCTTGTCCATTCCGCATTTGAAGTCCTCCGGACCATG
CTGCCTGTAGGCTGTGTGCGAATCATCCCTTACAGCAGCCAGTATGAGGAGGCCTATCGCTGCA
ACTTCCTAGGGCTCAGCCCTCCGGTGCCTATCCCTGCTCATGTCCTGGCCTCTGAGTTCGTAGT
TGTCGTGGAGGTACACACAGCCACTCGCTCAAACCCGCACCCGGCTGGATGTGAGGACGACCAG
TCCCTCAGCAAGTATGAGTTTGTGGTGACCAGCGGTAGCCCTGTGGCTGCAGACAGAGTTGGGC
CCACCATCCTGAATAAAATGGAGGCAGCTCTGACCAACCAGAACCTGTCTGTGGATGTGGTGGA
CCAGTGCCTCGTCTGTCTCAAGGAGGAGTGGATGAACAAAGTGAAAGTCCTGTTCAAATTCACC
AAGGTGGACAGCCGCCCCAAGGAGGACACCCAGAAGCTCCTGAGCGTCCTCGGCGCATCAGAGG
AGGACAACGTTAAGCTACTGAAGTTCTGGATGACGGGCCTGAGCAAAACCTACAAGTCACACCT
CATGTCCACAGTCCGAAGCCCGACAGCCGCAGAGTCACGGAACTGACTCCGAGAACACCGTCTG
GAAGGTGGTGTACATCTTAGCTCTGTGGGAAAGACTGCCCTTGGGTTTCTGAGTGCTGGCGTGA
GATCCTGTTTGAGGAGTGAAGACTTACGGGCTAGGCCTCGCCCTCCTTGTGAGGCTCTCTTAGC
CCATGTTGAAGTGTAGGGGACACAGGGACAGTGGTCCCACTGCATAAAATTGCTCTGTCAGGAA
CTGGTGAGATGTGCTATGTGCCTCTTGAGGAGAAAGGCTGGGAGCTGAGAGGAGTCTACGAGCC
AGCCTCTGAGGTTTTGTTGTTGCAGGATGTCCTCGTGGGCTTAGGACAACACCTTCCCACCATG
GAAGACCAAGCATCCTGGATCGTTTGTCTTTGGGTTGATGACTTCTCAGGTCATGTGCACACCC
GTGGCCTCTGGACATCAAGACCATGGCTGTTTTGTTTTTGTTTTTTTAATTTTAGTCTTTGAGT
CAGGGTCTTATTCTGTCTCCTATCCCAGTTTAGAACTCACGGTGTGGCCTATGCTACTTCCAGA
CTTGTAGCAGTCCTCCTGCCTCAGCTTCCCAAGTGCTGGGAGTACAGAACTGAGCCATCAGAAC
CTTACGTTGCTTTCTTCTCTGTTGCTGCCATAGCATTAACCAGCGACTGTAGACTGTGGTGGGG
TTGAGGCGGAGTGCCTCTCACCGTAGCAGCTTAGACTCCCTGAAGCTTTCCCAATTTGTTCATA
ATTTAACACGAAGACTACGTTTGTGTGTCTTGGTCTCTGTACAGTTGCAAGAATGTTGAAACAC
AATAAATCTGTATTTTTGTAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006246489 ⟹ XP_006246551

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	44,588,879 - 44,607,807 (-)	NCBI
Rnor_6.0	10	46,153,967 - 46,172,154 (-)	NCBI
Rnor_5.0	10	45,909,609 - 45,928,715 (-)	NCBI

Sequence:

show sequence

AGACTCGGTGCAAGGGCCTGCGGAACGGGCGAGGGGCAGAACGGTGGCGACAGCCTCAGGACAG
TTGCGAGCGGGTTCCGGCCCAGCATCCGGGAGACGGCGGCGAGCGCCCCAGCTGAGTTGGTATT
GGCCCATAGGGCTGAATGGAAAGTGGGGATGACAACCTCAAGCCTTTGAATTCGAGTGCAGTTT
GCATACCATACCTGACTCATCCGGCAGGCCTCGTACACGTTCTGGTCTAGGCAGGATGGTGCAG
CCGTGATCTGTCAAGCATAAGGCCTCGGCCATTCTCCAGCACCATGAACGCCATTGTGGCTCTC
TGCCACTTCTGCGAGCTCCATGGCCCCCGCACGCTCTTCTGCACGGAGGTTCTACACGCTCCCC
TGCCCCAGGGTGCCGGAAGTGGGGACAGTCCTGGCCAGGTTGAGCAGGCTGAGGAAGAAGAGGG
CGGCATCCAGATGAGCAGCCGAGTCCGTGCCCACAGCCCAGCCGAGGGCGCCAGCACTGACTCC
AGCAGCCCGGGGCCCAAGAAGTCAGACATGTGCGAGGGCTGCCGCTCGCTTGCTGTAGGGCACC
CAGGTTATATCAGTCATGATAAGGAGACCTCTATCAAGTACGTCAGCCACCAGCACCCCAACCA
CCCACAGCTCTTCAGCATTGTCCGCCAGGCCTGTGTCCGCAGCCTGAGCTGTGAGGTGTGCCCT
GGTCGTGAAGGCCCCATCTTCTTTGGTGATGAGCAACATGGCTTTGTGTTCAGCCACACCTTCT
TCATCAAAGACAGCCTGGCCAGAGGCTTCCAGCGCTGGTACAGCATCATCGCCATCATGATGGA
TCGGATCTACCTCATCAACTCCTGGCCCTTCCTGCTGGGCAAGATCCGCGGGATCATCAGCGAG
CTCCAGGGCAAGGCCCTCAAGGTGTTTGAGGCAGAACAGTTTGGATGTCCACAGCGTGCCCAGA
GGATGAACACTGCCTTCACACCCTTCCTGCACCAGAGGAACGGCAACGCTGCCCGCTCTCTGAC
CTCCTTGACCAGTGATGACAACTTGTGGGCCTGTCTGCATACTTCCTTTGCCTGGCTCCTGAAG
GCATGTGGTAGCCGGCTGACAGAAAAGCTCTTAGAGGGTGCTCCCACAGAGGACACCCTGGTCC
AGATGGAGAAGCTTGCTGACTTAGAGGAAGAATCAGAAAGTTGGGATAATTCAGAGGCTGAAGA
GGAGGAGAAAGCCCCTGCTACGGCAGAGGGTGCTGAAGGGCGAGAGCTGGCCAGTTGCCCAACA
GAATCATCCTTTCTCTCAGCCTGTGGGAGCTGGCAGCCCCCAAAGCTTTCTGTCTTCAAGTCCC
TTCGACACATGAGACAGGTCTTGGGAGCCCCATCTTTCCGAATGTTGGCCTGGCATGTCCTCAT
GGGTAATCAGGTGATCTGGAAAAGCAGAGATGTGAACCTTGTCCATTCCGCATTTGAAGTCCTC
CGGACCATGCTGCCTGTAGGCTGTGTGCGAATCATCCCTTACAGCAGCCAGTATGAGGAGGCCT
ATCGCTGCAACTTCCTAGGGCTCAGCCCTCCGGTGCCTATCCCTGCTCATGTCCTGGCCTCTGA
GTTCGTAGTTGTCGTGGAGGTACACACAGCCACTCGCTCAAACCCGCACCCGGCTGGATGTGAG
GACGACCAGTCCCTCAGCAAGTATGAGTTTGTGGTGACCAGCGGTAGCCCTGTGGCTGCAGACA
GAGTTGGGCCCACCATCCTGAATAAAATGGAGGCAGCTCTGACCAACCAGAACCTGTCTGTGGA
TGTGGTGGACCAGTGCCTCGTCTGTCTCAAGGAGGAGTGGATGAACAAAGTGAAAGTCCTGTTC
AAATTCACCAAGGTGGACAGCCGCCCCAAGGAGGACACCCAGAAGCTCCTGAGCGTCCTCGGCG
CATCAGAGGAGGACAACGTTAAGCTACTGAAGTTCTGGATGACGGGCCTGAGCAAAACCTACAA
GTCACACCTCATGTCCACAGTCCGAAGCCCGACAGCCGCAGAGTCACGGAACTGACTCCGAGAA
CACCGTCTGGAAGGTGG

hide sequence

RefSeq Acc Id:

XM_006246490 ⟹ XP_006246552

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	44,588,621 - 44,607,769 (-)	NCBI
Rnor_6.0	10	46,153,185 - 46,172,329 (-)	NCBI
Rnor_5.0	10	45,909,609 - 45,928,715 (-)	NCBI

Sequence:

show sequence

GATTGTTGCCGAGGGCGCTTGGACTCTTGGCTTGGAAGAGCGTAACGCAGCACAGCGTGGCTCG
GCGCATCCTAGTCTCCTGTCGGCGCCGCGGCACCGCTCGCCGTGGCTAGTCTCTGGCGTTGCCT
TCCCTCCGCCAGCCTGCGGATGGTTCGGTCCGGCTGGGTCACGCGCTAGACTCGGTGCAAGGGC
CTGCGGAACGGGCGAGGGGCAGAACGGTGGCGACAGCCTCAGGACAGTTGCGAGCGGGTTCCGG
CCCAGCATCCGGGAGACGGCGGCGAGCGCCCCAGCTGAACAACCTCAAGCCTTTGAATTCGAGT
GCAGTTTGCATACCATACCTGACTCATCCGGCAGGCCTCGTACACGTTCTGGTCTAGGCAGGAT
GGTGCAGCCGTGATCTGTCAAGCATAAGGCCTCGGCCATTCTCCAGCACCATGAACGCCATTGT
GGCTCTCTGCCACTTCTGCGAGCTCCATGGCCCCCGCACGCTCTTCTGCACGGAGGTTCTACAC
GCTCCCCTGCCCCAGGGTGCCGGAAGTGGGGACAGTCCTGGCCAGGTTGAGCAGGCTGAGGAAG
AAGAGGGCGGCATCCAGATGAGCAGCCGAGTCCGTGCCCACAGCCCAGCCGAGGGCGCCAGCAC
TGACTCCAGCAGCCCGGGGCCCAAGAAGTCAGACATGTGCGAGGGCTGCCGCTCGCTTGCTGTA
GGGCACCCAGGTTATATCAGTCATGATAAGGAGACCTCTATCAAGTACGTCAGCCACCAGCACC
CCAACCACCCACAGCTCTTCAGCATTGTCCGCCAGGCCTGTGTCCGCAGCCTGAGCTGTGAGGT
GTGCCCTGGTCGTGAAGGCCCCATCTTCTTTGGTGATGAGCAACATGGCTTTGTGTTCAGCCAC
ACCTTCTTCATCAAAGACAGCCTGGCCAGAGGCTTCCAGCGCTGGTACAGCATCATCGCCATCA
TGATGGATCGGATCTACCTCATCAACTCCTGGCCCTTCCTGCTGGGCAAGATCCGCGGGATCAT
CAGCGAGCTCCAGGGCAAGGCCCTCAAGGTGTTTGAGGCAGAACAGTTTGGATGTCCACAGCGT
GCCCAGAGGATGAACACTGCCTTCACACCCTTCCTGCACCAGAGGAACGGCAACGCTGCCCGCT
CTCTGACCTCCTTGACCAGTGATGACAACTTGTGGGCCTGTCTGCATACTTCCTTTGCCTGGCT
CCTGAAGGCATGTGGTAGCCGGCTGACAGAAAAGCTCTTAGAGGGTGCTCCCACAGAGGACACC
CTGGTCCAGATGGAGAAGCTTGCTGACTTAGAGGAAGAATCAGAAAGTTGGGATAATTCAGAGG
CTGAAGAGGAGGAGAAAGCCCCTGCTACGGCAGAGGGTGCTGAAGGGCGAGAGCTGGCCAGTTG
CCCAACAGAATCATCCTTTCTCTCAGCCTGTGGGAGCTGGCAGCCCCCAAAGCTTTCTGTCTTC
AAGTCCCTTCGACACATGAGACAGGTCTTGGGAGCCCCATCTTTCCGAATGTTGGCCTGGCATG
TCCTCATGGGTAATCAGGTGATCTGGAAAAGCAGAGATGTGAACCTTGTCCATTCCGCATTTGA
AGTCCTCCGGACCATGCTGCCTGTAGGCTGTGTGCGAATCATCCCTTACAGCAGCCAGTATGAG
GAGGCCTATCGCTGCAACTTCCTAGGGCTCAGCCCTCCGGTGCCTATCCCTGCTCATGTCCTGG
CCTCTGAGTTCGTAGTTGTCGTGGAGGTACACACAGCCACTCGCTCAAACCCGCACCCGGCTGG
ATGTGAGGACGACCAGTCCCTCAGCAAGTATGAGTTTGTGGTGACCAGCGGTAGCCCTGTGGCT
GCAGACAGAGTTGGGCCCACCATCCTGAATAAAATGGAGGCAGCTCTGACCAACCAGAACCTGT
CTGTGGATGTGGTGGACCAGTGCCTCGTCTGTCTCAAGGAGGAGTGGATGAACAAAGTGAAAGT
CCTGTTCAAATTCACCAAGGTGGACAGCCGCCCCAAGGAGGACACCCAGAAGCTCCTGAGCGTC
CTCGGCGCATCAGAGGAGGACAACGTTAAGCTACTGAAGTTCTGGATGACGGGCCTGAGCAAAA
CCTACAAGTCACACCTCATGTCCACAGTCCGAAGCCCGACAGCCGCAGAGTCACGGAACTGACT
CCGAGAACACCGTCTGGAAGGTGGTGTACATCTTAGCTCTGTGGGAAAGACTGCCCTTGGGTTT
CTGAGTGCTGGCGTGAGATCCTGTTTGAGGAGTGAAGACTTACGGGCTAGGCCTCGCCCTCCTT
GTGAGGCTCTCTTAGCCCATGTTGAAGTGTAGGGGACACAGGGACAGTGGTCCCACTGCATAAA
ATTGCTCTGTCAGGAACTGGTGAGATGTGCTATGTGCCTCTTGAGGAGAAAGGCTGGGAGCTGA
GAGGAGTCTACGAGCCAGCCTCTGAGGTTTTGTTGTTGCAGGATGTCCTCGTGGGCTTAGGACA
ACACCTTCCCACCATGGAAGACCAAGCATCCTGGATCGTTTGTCTTTGGGTTGATGACTTCTCA
GGTCATGTGCACACCCGTGGCCTCTGGACATCAAGACCATGGCTGTTTTGTTTTTGTTTTTTTA
ATTTTAGTCTTTGAGTCAGGGTCTTATTCTGTCTCCTATCCCAGTTTAGAACTCACGGTGTGGC
CTATGCTACTTCCAGACTTGTAGCAGTCCTCCTGCCTCAGCTTCCCAAGTGCTGGGAGTACAGA
ACTGAGCCATCAGAACCTTACGTTGCTTTCTTCTCTGTTGCTGCCATAGCATTAACCAGCGACT
GTAGACTGTGGTGGGGTTGAGGCGGAGTGCCTCTCACCGTAGCAGCTTAGACTCCCTGAAGCTT
TCCCAATTTGTTCATAATTTAACACGAAGACTACGTTTGTGTGTCTTGGTCTCTGTACAGTTGC
AAGAATGTTGAAACACAATAAATCTGTATTTTTGTAAA

hide sequence

RefSeq Acc Id:

XM_017597267 ⟹ XP_017452756

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	44,588,621 - 44,607,807 (-)	NCBI
Rnor_6.0	10	46,153,185 - 46,171,022 (-)	NCBI

Sequence:

show sequence

GTATGGTGGTGAGGAGACTGTCTTCAGCTTGGAAAAGTTACTAGGAAGGGGTGGTTAGGCACAC
TCACAGACGCCAGCTTAGTAAGAATGTGGTAGGCATTGGACTTGGAGAGTGACTGAAGAACTGG
GCTCTTCCTGGCAGGGAGTCGGGTGTCATATGCAGTACAGTCTGAGAAGCCTGTGAAGCCTGTT
CTCCAGTACCCAGGAGGACTTCCAGGGGACAACCTCAAGCCTTTGAATTCGAGTGCAGTTTGCA
TACCATACCTGACTCATCCGGCAGGCCTCGTACACGTTCTGGTCTAGGCAGGATGGTGCAGCCG
TGATCTGTCAAGCATAAGGCCTCGGCCATTCTCCAGCACCATGAACGCCATTGTGGCTCTCTGC
CACTTCTGCGAGCTCCATGGCCCCCGCACGCTCTTCTGCACGGAGGTTCTACACGCTCCCCTGC
CCCAGGGTGCCGGAAGTGGGGACAGTCCTGGCCAGGTTGAGCAGGCTGAGGAAGAAGAGGGCGG
CATCCAGATGAGCAGCCGAGTCCGTGCCCACAGCCCAGCCGAGGGCGCCAGCACTGACTCCAGC
AGCCCGGGGCCCAAGAAGTCAGACATGTGCGAGGGCTGCCGCTCGCTTGCTGTAGGGCACCCAG
GTTATATCAGTCATGATAAGGAGACCTCTATCAAGTACGTCAGCCACCAGCACCCCAACCACCC
ACAGCTCTTCAGCATTGTCCGCCAGGCCTGTGTCCGCAGCCTGAGCTGTGAGGTGTGCCCTGGT
CGTGAAGGCCCCATCTTCTTTGGTGATGAGCAACATGGCTTTGTGTTCAGCCACACCTTCTTCA
TCAAAGACAGCCTGGCCAGAGGCTTCCAGCGCTGGTACAGCATCATCGCCATCATGATGGATCG
GATCTACCTCATCAACTCCTGGCCCTTCCTGCTGGGCAAGATCCGCGGGATCATCAGCGAGCTC
CAGGGCAAGGCCCTCAAGGTGTTTGAGGCAGAACAGTTTGGATGTCCACAGCGTGCCCAGAGGA
TGAACACTGCCTTCACACCCTTCCTGCACCAGAGGAACGGCAACGCTGCCCGCTCTCTGACCTC
CTTGACCAGTGATGACAACTTGTGGGCCTGTCTGCATACTTCCTTTGCCTGGCTCCTGAAGGCA
TGTGGTAGCCGGCTGACAGAAAAGCTCTTAGAGGGTGCTCCCACAGAGGACACCCTGGTCCAGA
TGGAGAAGCTTGCTGACTTAGAGGAAGAATCAGAAAGTTGGGATAATTCAGAGGCTGAAGAGGA
GGAGAAAGCCCCTGCTACGGCAGAGGGTGCTGAAGGGCGAGAGCTGGCCAGTTGCCCAACAGAA
TCATCCTTTCTCTCAGCCTGTGGGAGCTGGCAGCCCCCAAAGCTTTCTGTCTTCAAGTCCCTTC
GACACATGAGACAGGTCTTGGGAGCCCCATCTTTCCGAATGTTGGCCTGGCATGTCCTCATGGG
TAATCAGGTGATCTGGAAAAGCAGAGATGTGAACCTTGTCCATTCCGCATTTGAAGTCCTCCGG
ACCATGCTGCCTGTAGGCTGTGTGCGAATCATCCCTTACAGCAGCCAGTATGAGGAGGCCTATC
GCTGCAACTTCCTAGGGCTCAGCCCTCCGGTGCCTATCCCTGCTCATGTCCTGGCCTCTGAGTT
CGTAGTTGTCGTGGAGGTACACACAGCCACTCGCTCAAACCCGCACCCGGCTGGATGTGAGGAC
GACCAGTCCCTCAGCAAGTATGAGTTTGTGGTGACCAGCGGTAGCCCTGTGGCTGCAGACAGAG
TTGGGCCCACCATCCTGAATAAAATGGAGGCAGCTCTGACCAACCAGAACCTGTCTGTGGATGT
GGTGGACCAGTGCCTCGTCTGTCTCAAGGAGGAGTGGATGAACAAAGTGAAAGTCCTGTTCAAA
TTCACCAAGGTGGACAGCCGCCCCAAGGAGGACACCCAGAAGCTCCTGAGCGTCCTCGGCGCAT
CAGAGGAGGACAACGTTAAGCTACTGAAGTTCTGGATGACGGGCCTGAGCAAAACCTACAAGTC
ACACCTCATGTCCACAGTCCGAAGCCCGACAGCCGCAGAGTCACGGAACTGACTCCGAGAACAC
CGTCTGGAAGGTGGTGTACATCTTAGCTCTGTGGGAAAGACTGCCCTTGGGTTTCTGAGTGCTG
GCGTGAGATCCTGTTTGAGGAGTGAAGACTTACGGGCTAGGCCTCGCCCTCCTTGTGAGGCTCT
CTTAGCCCATGTTGAAGTGTAGGGGACACAGGGACAGTGGTCCCACTGCATAAAATTGCTCTGT
CAGGAACTGGTGAGATGTGCTATGTGCCTCTTGAGGAGAAAGGCTGGGAGCTGAGAGGAGTCTA
CGAGCCAGCCTCTGAGGTTTTGTTGTTGCAGGATGTCCTCGTGGGCTTAGGACAACACCTTCCC
ACCATGGAAGACCAAGCATCCTGGATCGTTTGTCTTTGGGTTGATGACTTCTCAGGTCATGTGC
ACACCCGTGGCCTCTGGACATCAAGACCATGGCTGTTTTGTTTTTGTTTTTTTAATTTTAGTCT
TTGAGTCAGGGTCTTATTCTGTCTCCTATCCCAGTTTAGAACTCACGGTGTGGCCTATGCTACT
TCCAGACTTGTAGCAGTCCTCCTGCCTCAGCTTCCCAAGTGCTGGGAGTACAGAACTGAGCCAT
CAGAACCTTACGTTGCTTTCTTCTCTGTTGCTGCCATAGCATTAACCAGCGACTGTAGACTGTG
GTGGGGTTGAGGCGGAGTGCCTCTCACCGTAGCAGCTTAGACTCCCTGAAGCTTTCCCAATTTG
TTCATAATTTAACACGAAGACTACGTTTGTGTGTCTTGGTCTCTGTACAGTTGCAAGAATGTTG
AAACACAATAAATCTGTATTTTTGTAAA

hide sequence

RefSeq Acc Id:

XM_017597270 ⟹ XP_017452759

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	44,588,621 - 44,607,808 (-)	NCBI
Rnor_6.0	10	46,153,185 - 46,172,331 (-)	NCBI

Sequence:

show sequence

GCGATTGTTGCCGAGGGCGCTTGGACTCTTGGCTTGGAAGAGCGTAACGCAGCACAGCGTGGCT
CGGCGCATCCTAGTCTCCTGTCGGCGCCGCGGCACCGCTCGCCGTGGCTAGTCTCTGGCGTTGC
CTTCCCTCCGCCAGCCTGCGGATGGTTCGGTCCGGCTGGGTCACGCGCTAGACTCGGTGCAAGG
GCCTGCGGAACGGGCGAGGGGCAGAACGGTGGCGACAGCCTCAGGACAGTTGCGAGCGGGTTCC
GGCCCAGCATCCGGGAGACGGCGGCGAGCGCCCCAGCTGAGTTGACAACCTCAAGCCTTTGAAT
TCGAGTGCAGTTTGCATACCATACCTGACTCATCCGGCAGGCCTCGTACACGTTCTGGTCTAGG
CAGGATGGTGCAGCCGTGATCTGTCAAGCATAAGGCCTCGGCCATTCTCCAGCACCATGAACGC
CATTGTGGCTCTCTGCCACTTCTGCGAGCTCCATGGCCCCCGCACGCTCTTCTGCACGGAGGTT
CTACACGCTCCCCTGCCCCAGGGTGCCGGAAGTGGGGACAGTCCTGGCCAGGTTGAGCAGGCTG
AGGAAGAAGAGGGCGGCATCCAGATGAGCAGCCGAGTCCGTGCCCACAGCCCAGCCGAGGGCGC
CAGCACTGACTCCAGCAGCCCGGGGCCCAAGAAGTCAGACATGTGCGAGGGCTGCCGCTCGCTT
GCTGTAGGGCACCCAGGTTATATCAGTCATGATAAGGAGACCTCTATCAAGTACGTCAGCCACC
AGCACCCCAACCACCCACAGCTCTTCAGCATTGTCCGCCAGGCCTGTGTCCGCAGCCTGAGCTG
TGAGGTGTGCCCTGGTCGTGAAGGCCCCATCTTCTTTGGTGATGAGCAACATGGCTTTGTGTTC
AGCCACACCTTCTTCATCAAAGACAGCCTGGCCAGAGGCTTCCAGCGCTGGTACAGCATCATCG
CCATCATGATGGATCGGATCTACCTCATCAACTCCTGGCCCTTCCTGCTGGGCAAGATCCGCGG
GATCATCAGCGAGCTCCAGGGCAAGGCCCTCAAGGTGTTTGAGGCAGAACAGTTTGGATGTCCA
CAGCGTGCCCAGAGGATGAACACTGCCTTCACACCCTTCCTGCACCAGAGGAACGGCAACGCTG
CCCGCTCTCTGACCTCCTTGACCAGTGATGACAACTTGTGGGCCTGTCTGCATACTTCCTTTGC
CTGGCTCCTGAAGGCATGTGGTAGCCGGCTGACAGAAAAGCTCTTAGAGGGTGCTCCCACAGAG
GACACCCTGGTCCAGATGGAGAAGCTTGCTGACTTAGAGGAAGAATCAGAAAGTTGGGATAATT
CAGAGGCTGAAGAGGAGGAGAAAGCCCCTGCTACGGCAGAGGGTGCTGAAGGGCGAGAGCTGGC
CAGTTGCCCAACAGAATCATCCTTTCTCTCAGCCTGTGGGAGCTGGCAGCCCCCAAAGCTTTCT
GTCTTCAAGTCCCTTCGACACATGAGACAGGTCTTGGGAGCCCCATCTTTCCGAATGTTGGCCT
GGCATGTCCTCATGGGTAATCAGGTGATCTGGAAAAGCAGAGATGTGAACCTTGTCCATTCCGC
ATTTGAAGTCCTCCGGACCATGCTGCCTGTAGGCTGTGTGCGAATCATCCCTTACAGCAGCCAG
TATGAGGAGGCCTATCGCTGCAACTTCCTAGGGCTCAGCCCTCCGGTGCCTATCCCTGCTCATG
TCCTGGCCTCTGAGTTCGTAGTTGTCGTGGAGGTACACACAGCCACTCGCTCAAACCCGCACCC
GGCTGGATGTGAGGACGACCAGTCCCTCAGCAAGTATGAGTTTGTGGTGACCAGCGGTAGCCCT
GTGGCTGCAGACAGAGCAAAGTGAAAGTCCTGTTCAAATTCACCAAGGTGGACAGCCGCCCCAA
GGAGGACACCCAGAAGCTCCTGAGCGTCCTCGGCGCATCAGAGGAGGACAACGTTAAGCTACTG
AAGTTCTGGATGACGGGCCTGAGCAAAACCTACAAGTCACACCTCATGTCCACAGTCCGAAGCC
CGACAGCCGCAGAGTCACGGAACTGACTCCGAGAACACCGTCTGGAAGGTGGTGTACATCTTAG
CTCTGTGGGAAAGACTGCCCTTGGGTTTCTGAGTGCTGGCGTGAGATCCTGTTTGAGGAGTGAA
GACTTACGGGCTAGGCCTCGCCCTCCTTGTGAGGCTCTCTTAGCCCATGTTGAAGTGTAGGGGA
CACAGGGACAGTGGTCCCACTGCATAAAATTGCTCTGTCAGGAACTGGTGAGATGTGCTATGTG
CCTCTTGAGGAGAAAGGCTGGGAGCTGAGAGGAGTCTACGAGCCAGCCTCTGAGGTTTTGTTGT
TGCAGGATGTCCTCGTGGGCTTAGGACAACACCTTCCCACCATGGAAGACCAAGCATCCTGGAT
CGTTTGTCTTTGGGTTGATGACTTCTCAGGTCATGTGCACACCCGTGGCCTCTGGACATCAAGA
CCATGGCTGTTTTGTTTTTGTTTTTTTAATTTTAGTCTTTGAGTCAGGGTCTTATTCTGTCTCC
TATCCCAGTTTAGAACTCACGGTGTGGCCTATGCTACTTCCAGACTTGTAGCAGTCCTCCTGCC
TCAGCTTCCCAAGTGCTGGGAGTACAGAACTGAGCCATCAGAACCTTACGTTGCTTTCTTCTCT
GTTGCTGCCATAGCATTAACCAGCGACTGTAGACTGTGGTGGGGTTGAGGCGGAGTGCCTCTCA
CCGTAGCAGCTTAGACTCCCTGAAGCTTTCCCAATTTGTTCATAATTTAACACGAAGACTACGT
TTGTGTGTCTTGGTCTCTGTACAGTTGCAAGAATGTTGAAACACAATAAATCTGTATTTTTGTA
AA

hide sequence

RefSeq Acc Id:

XM_039085951 ⟹ XP_038941879

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	44,588,621 - 44,607,807 (-)	NCBI

RefSeq Acc Id:

XM_039085952 ⟹ XP_038941880

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	44,588,621 - 44,607,807 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_955422	(Get FASTA)	NCBI Sequence Viewer
	XP_006246551	(Get FASTA)	NCBI Sequence Viewer
	XP_006246552	(Get FASTA)	NCBI Sequence Viewer
	XP_017452756	(Get FASTA)	NCBI Sequence Viewer
	XP_017452759	(Get FASTA)	NCBI Sequence Viewer
	XP_038941879	(Get FASTA)	NCBI Sequence Viewer
	XP_038941880	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85848	(Get FASTA)	NCBI Sequence Viewer
	BAD01656	(Get FASTA)	NCBI Sequence Viewer
	EDM04621	(Get FASTA)	NCBI Sequence Viewer
	Q76JQ2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_955422 ⟸ NM_199390

- UniProtKB:

Q76JQ2 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPA
EGASTDSSSPGPKKSDMCEGCRSLAVGHPGYISHDKETSIKYVSHQHPNHPQLFSIVRQACVRS
LSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINSWPFLLGK
IRGIISELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHT
SFAWLLKACGSRLTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPATAEGAEGR
ELASCPTESSFLSACGSWQPPKLSVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLV
HSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVPIPAHVLASEFVVVVEVHTATRSN
PHPAGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKMEAALTNQNLSVDVVDQCLVCLKEEWM
NKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLMSTVRSPTAAE
SRN

hide sequence

RefSeq Acc Id:	XP_006246552 ⟸ XM_006246490
- Peptide Label:	isoform X1
- UniProtKB:	Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPA EGASTDSSSPGPKKSDMCEGCRSLAVGHPGYISHDKETSIKYVSHQHPNHPQLFSIVRQACVRS LSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINSWPFLLGK IRGIISELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHT SFAWLLKACGSRLTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPATAEGAEGR ELASCPTESSFLSACGSWQPPKLSVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLV HSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVPIPAHVLASEFVVVVEVHTATRSN PHPAGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKMEAALTNQNLSVDVVDQCLVCLKEEWM NKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLMSTVRSPTAAE SRN hide sequence

RefSeq Acc Id:	XP_006246551 ⟸ XM_006246489
- Peptide Label:	isoform X1
- UniProtKB:	Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPA EGASTDSSSPGPKKSDMCEGCRSLAVGHPGYISHDKETSIKYVSHQHPNHPQLFSIVRQACVRS LSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINSWPFLLGK IRGIISELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHT SFAWLLKACGSRLTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPATAEGAEGR ELASCPTESSFLSACGSWQPPKLSVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLV HSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVPIPAHVLASEFVVVVEVHTATRSN PHPAGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKMEAALTNQNLSVDVVDQCLVCLKEEWM NKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLMSTVRSPTAAE SRN hide sequence

RefSeq Acc Id:

XP_017452759 ⟸ XM_017597270

- Peptide Label:

isoform X2

- Sequence:

show sequence

MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPA
EGASTDSSSPGPKKSDMCEGCRSLAVGHPGYISHDKETSIKYVSHQHPNHPQLFSIVRQACVRS
LSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINSWPFLLGK
IRGIISELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHT
SFAWLLKACGSRLTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPATAEGAEGR
ELASCPTESSFLSACGSWQPPKLSVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLV
HSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVPIPAHVLASEFVVVVEVHTATRSN
PHPAGCEDDQSLSKYEFVVTSGSPVAADRAK

hide sequence

RefSeq Acc Id:	XP_017452756 ⟸ XM_017597267
- Peptide Label:	isoform X1
- UniProtKB:	Q76JQ2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPA EGASTDSSSPGPKKSDMCEGCRSLAVGHPGYISHDKETSIKYVSHQHPNHPQLFSIVRQACVRS LSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINSWPFLLGK IRGIISELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHT SFAWLLKACGSRLTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPATAEGAEGR ELASCPTESSFLSACGSWQPPKLSVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLV HSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVPIPAHVLASEFVVVVEVHTATRSN PHPAGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKMEAALTNQNLSVDVVDQCLVCLKEEWM NKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLMSTVRSPTAAE SRN hide sequence

RefSeq Acc Id:

ENSRNOP00000004412 ⟸ ENSRNOT00000004412

RefSeq Acc Id:

ENSRNOP00000075720 ⟸ ENSRNOT00000091052

RefSeq Acc Id:	XP_038941880 ⟸ XM_039085952
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941879 ⟸ XM_039085951
- Peptide Label:	isoform X1

Protein Domains

cDENN FLCN/SMCR8-type dDENN FLCN/SMCR8-type uDENN FLCN/SMCR8-type

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697243

Promoter ID:

EPDNEW_R7764

Type:

initiation region

Name:

Flcn_1

Description:

folliculin

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	46,172,116 - 46,172,176	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN-Lx/CubMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BUF/N (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

DA/OlaHsd (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

F344/Stm (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FXLE16/Stm (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/FarMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

HXB10/IpcvMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEXF10A/StmMcwi (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrcAek (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrcAek (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrcAek (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

M520/NRrrcMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MWF/Hsd (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/OlalpcvMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/RijCrl (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (2019)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (2020)

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Sequenced By:	MCW
Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735088	AgrOrtholog
Ensembl Genes	ENSRNOG00000003302	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000004412	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000075720	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004412	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000091052	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7189414	IMAGE-MGC_LOAD
InterPro	FLCN/SMCR8_DENN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Folliculin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Folliculin/SMCR8_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Folliculin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:303185	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94558	IMAGE-MGC_LOAD
NCBI Gene	303185	ENTREZGENE
PANTHER	PTHR31441	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Folliculin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Folliculin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Flcn	PhenoGen
PROSITE	DENN_FLCN_SMCR8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2KBA8_RAT	UniProtKB/TrEMBL
	FLCN_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-07-08	Flcn	folliculin	Bhd		Symbol updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	in heterozygotes, a germline insertion of one nucleotide resulting in a nonsense mutation gives rise to renal adenocarcinomas by the age of 6 months; homozygosity is lethal at an early stage of embryogenesis	1302869
gene_homology	amino acid sequence is 93% and 97% homologous to human and mouse folliculin, respectively	1302869
gene_mutations_overexpression	10 of 11 renal carcinomas showed a loss of heterozygosity at the Bhd locus and the one LOH-negative case displayed a spontaneous nonsense point mutation at the second Bhd locus	1302869

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)