Ebp (EBP, cholestenol delta-isomerase) - Rat Genome Database

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Gene: Ebp (EBP, cholestenol delta-isomerase) Rattus norvegicus
Analyze
Symbol: Ebp
Name: EBP, cholestenol delta-isomerase
RGD ID: 620957
Description: Enables C-8 sterol isomerase activity. Involved in cholesterol biosynthetic process. Predicted to be located in nuclear membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in MEND syndrome; X-linked chondrodysplasia punctata 2; and chondrodysplasia punctata. Orthologous to human EBP (EBP cholestenol delta-isomerase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; cholestenol Delta-isomerase; D8-D7 sterol isomerase; delta(8)-Delta(7) sterol isomerase; emopamil binding protein (sterol isomerase); emopamil-binding protein; phenylalkylamine Ca2+ antagonist (emopamil) binding protein; sterol 8-isomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,971,372 - 16,977,782 (+)NCBIGRCr8
mRatBN7.2X14,299,427 - 14,305,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,299,448 - 14,305,826 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,112,990 - 19,119,361 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,963,718 - 20,970,092 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X17,228,913 - 17,235,289 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,049,394 - 15,055,782 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,049,462 - 15,055,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,832,710 - 15,839,093 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,331,199 - 26,337,542 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,384,667 - 26,391,010 (+)NCBI
CeleraX14,384,941 - 14,391,269 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
Archazolid B  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (EXP)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dipentyl phthalate  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
Erionite  (ISO)
ethyl methanesulfonate  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
tolcapone  (EXP)
triacsin C  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions. Bae S, etal., Biochem J 2001 Feb 1;353(Pt 3):689-99.
2. Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Derry JM, etal., Nat Genet 1999 Jul;22(3):286-90.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:8798407   PMID:9894009   PMID:10391219   PMID:10406945   PMID:10987663  


Genomics

Comparative Map Data
Ebp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,971,372 - 16,977,782 (+)NCBIGRCr8
mRatBN7.2X14,299,427 - 14,305,826 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,299,448 - 14,305,826 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,112,990 - 19,119,361 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,963,718 - 20,970,092 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X17,228,913 - 17,235,289 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,049,394 - 15,055,782 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,049,462 - 15,055,781 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,832,710 - 15,839,093 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,331,199 - 26,337,542 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,384,667 - 26,391,010 (+)NCBI
CeleraX14,384,941 - 14,391,269 (+)NCBICelera
Cytogenetic MapXq12NCBI
EBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,521,808 - 48,528,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,521,799 - 48,528,716 (+)EnsemblGRCh38hg38GRCh38
GRCh37X48,380,196 - 48,387,104 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,265,201 - 48,272,048 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X48,136,510 - 48,143,356NCBI
CeleraX53,278,627 - 53,285,567 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,043,290 - 46,050,391 (+)NCBIHuRef
CHM1_1X48,411,425 - 48,418,366 (+)NCBICHM1_1
T2T-CHM13v2.0X47,930,820 - 47,937,730 (+)NCBIT2T-CHM13v2.0
Ebp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X8,051,568 - 8,059,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX8,051,568 - 8,059,751 (-)EnsemblGRCm39 Ensembl
GRCm38X8,185,329 - 8,193,512 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX8,185,329 - 8,193,512 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,762,457 - 7,770,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,342,290 - 7,350,471 (-)NCBIMGSCv36mm8
CeleraX3,276,541 - 3,284,699 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.7NCBI
Ebp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495554392,122 - 98,370 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495554392,553 - 98,370 (+)NCBIChiLan1.0ChiLan1.0
EBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,010,179 - 50,017,556 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,014,011 - 50,020,928 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,820,042 - 40,826,957 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,683,531 - 48,690,829 (+)NCBIpanpan1.1PanPan1.1panPan2
PORCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,774,857 - 41,779,474 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,762,692 - 41,779,476 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,151,069 - 16,155,685 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,014,717 - 42,019,084 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,014,187 - 42,019,315 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,897,937 - 41,902,543 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,886,230 - 41,890,855 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,979,795 - 41,984,410 (+)NCBIUU_Cfam_GSD_1.0
Ebp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,268,094 - 34,275,579 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721509,374 - 515,918 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721508,716 - 515,968 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,670,633 - 42,678,570 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,670,592 - 42,678,571 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,619,482 - 47,627,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,652,398 - 45,660,551 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,653,356 - 45,660,291 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,104,334 - 11,112,368 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ebp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893341,129 - 347,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893340,843 - 346,560 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ebp
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000007015
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
DXS7465E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,298,223 - 14,298,326 (+)MAPPERmRatBN7.2
Rnor_6.0X15,048,183 - 15,048,285NCBIRnor6.0
Rnor_5.0X15,831,494 - 15,831,596UniSTSRnor5.0
RGSC_v3.4X26,329,920 - 26,330,022UniSTSRGSC3.4
CeleraX14,383,662 - 14,383,764UniSTS
Cytogenetic MapXq13UniSTS
RH131140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,305,517 - 14,305,704 (+)MAPPERmRatBN7.2
Rnor_6.0X15,055,474 - 15,055,660NCBIRnor6.0
Rnor_5.0X15,838,785 - 15,838,971UniSTSRnor5.0
RGSC_v3.4X26,337,234 - 26,337,420UniSTSRGSC3.4
CeleraX14,390,961 - 14,391,147UniSTS
Cytogenetic MapXq13UniSTS
RH131962  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,298,187 - 14,298,369 (+)MAPPERmRatBN7.2
Rnor_6.0X15,048,147 - 15,048,328NCBIRnor6.0
Rnor_5.0X15,831,458 - 15,831,639UniSTSRnor5.0
RGSC_v3.4X26,329,884 - 26,330,065UniSTSRGSC3.4
CeleraX14,383,626 - 14,383,807UniSTS
RH 3.4 MapX135.7UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 12 41 41 3 41 66 27 28 3
Low 31 16 16 8 11 8 8 13 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000007015   ⟹   ENSRNOP00000007015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,299,448 - 14,305,826 (+)Ensembl
Rnor_6.0 EnsemblX15,049,462 - 15,055,781 (+)Ensembl
RefSeq Acc Id: NM_057137   ⟹   NP_476478
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X16,971,462 - 16,977,782 (+)NCBI
mRatBN7.2X14,299,503 - 14,305,826 (+)NCBI
Rnor_6.0X15,049,462 - 15,055,782 (+)NCBI
Rnor_5.0X15,832,710 - 15,839,093 (+)NCBI
RGSC_v3.4X26,331,199 - 26,337,542 (+)RGD
CeleraX14,384,941 - 14,391,269 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256699   ⟹   XP_006256761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X16,971,372 - 16,977,782 (+)NCBI
mRatBN7.2X14,299,427 - 14,305,826 (+)NCBI
Rnor_6.0X15,049,394 - 15,055,782 (+)NCBI
Rnor_5.0X15,832,710 - 15,839,093 (+)NCBI
Sequence:
RefSeq Acc Id: NP_476478   ⟸   NM_057137
- UniProtKB: Q548M8 (UniProtKB/Swiss-Prot),   Q9JJ46 (UniProtKB/Swiss-Prot),   A6KP43 (UniProtKB/TrEMBL),   A6KP42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256761   ⟸   XM_006256699
- Peptide Label: isoform X1
- UniProtKB: Q548M8 (UniProtKB/Swiss-Prot),   Q9JJ46 (UniProtKB/Swiss-Prot),   A6KP43 (UniProtKB/TrEMBL),   A6KP42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007015   ⟸   ENSRNOT00000007015
Protein Domains
EXPERA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ46-F1-model_v2 AlphaFold Q9JJ46 1-230 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701728
Promoter ID:EPDNEW_R12252
Type:initiation region
Name:Ebp_1
Description:emopamil binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,049,448 - 15,049,508EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620957 AgrOrtholog
BioCyc Gene G2FUF-2949 BioCyc
Ensembl Genes ENSRNOG00000004903 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055022904 UniProtKB/Swiss-Prot
  ENSRNOG00060024445 UniProtKB/Swiss-Prot
  ENSRNOG00065011424 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007015 ENTREZGENE
  ENSRNOT00000007015.7 UniProtKB/Swiss-Prot
  ENSRNOT00055039331 UniProtKB/Swiss-Prot
  ENSRNOT00060042338 UniProtKB/Swiss-Prot
  ENSRNOT00065018558 UniProtKB/Swiss-Prot
InterPro EBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EXPERA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117278 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117278 ENTREZGENE
PANTHER 3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14207 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ebp PhenoGen
PROSITE EXPERA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004903 RatGTEx
  ENSRNOG00055022904 RatGTEx
  ENSRNOG00060024445 RatGTEx
  ENSRNOG00065011424 RatGTEx
UniProt A6KP42 ENTREZGENE, UniProtKB/TrEMBL
  A6KP43 ENTREZGENE, UniProtKB/TrEMBL
  EBP_RAT UniProtKB/Swiss-Prot
  Q548M8 ENTREZGENE
  Q9JJ46 ENTREZGENE
UniProt Secondary Q548M8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-18 Ebp  EBP, cholestenol delta-isomerase  Ebp  emopamil binding protein (sterol isomerase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 Ebp  emopamil binding protein (sterol isomerase)  Ebp  phenylalkylamine Ca2+ antagonist (emopamil) binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ebp  phenylalkylamine Ca2+ antagonist (emopamil) binding protein      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ebp  phenylalkylamine Ca2+ antagonist (emopamil) binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease mutations in the human homolog are associated with Conradi-Hunermann syndrome 628445
gene_drugs 25-hydroxycholesterol suppressed the mRNA in H4IIE cells, no effect observed in emopamil-treated cells 628445
gene_expression expressed in hepatocytes 628445
gene_function acts as a catalyst in the cholesterol pathway converting 8-ene isomer to 7-ene isomer 628445
gene_homology 87% and 80% amino-acid identity to mouse and human, respectively 628445
gene_other does not reqiure any additional reducing cofactor for its catalytic activities unlike any other cholesterol biosynthetic enzymes 628445
gene_pathway involved in the cholesterol binding pathway 628445
gene_product member of the Ebp family 628445
gene_protein 230 amino acids; 26.7 kDa 628445
gene_regulation transcription is regulated by an oestrogen receptor antagonist tamoxifen 628445